October 2022 - Page 353 of 406 - Alcohols-buliding-blocks

Ubeda, Cristina’s team published research in Food Research International in 2019-05-31 | 104-76-7

Food Research International published new progress about Acids Role: BSU (Biological Study, Unclassified), PUR (Purification or Recovery), BIOL (Biological Study), PREP (Preparation). 104-76-7 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H18O, Application In Synthesis of 104-76-7.

Ubeda, Cristina; Kania-Zelada, Ingeborg; del Barrio-Galan, Ruben; Medel-Maraboli, Marcela; Gil, Mariona; Pena-Neira, Alvaro published the artcile< Study of the changes in volatile compounds, aroma and sensory attributes during the production process of sparkling wine by traditional method>, Application In Synthesis of 104-76-7, the main research area is sparkling wine aroma sensory property volatile compound; Aging; Impact aroma compounds; Olfactometry; País grape variety; Sensory analysis; Volatile compounds; sparkling wine.

One of the strongest factors that affects the volatile profile of sparkling wine is the winemaking process. Here we focus on determining the effects of the second fermentation and aging on lees of sparkling wine from Pais grape variety combining different anal. techniques for the first time in sparkling wine: gas chromatog./mass spectrometry/olfactometry and sensorial anal. During the second fermentation and aging, there was a significant loss of esters that might be related to the adsorption on lees and ester volatility and chem. hydrolysis. The concentration of several compounds such as some esters (di-Et succinate, Et lactate, and Et isovalerate) increased during aging and could be used as aging markers. Vitispiranes were identified as the best norisoprenoids aging markers for young sparkling wines (12 mo of aging). Also, PCA showed that time of aging on lees affected mostly esters and terpenes. On the other hand, the diminution of fruity/floral impact odorants during aging was not perceived in sensorial trials. Our results suggest that the responsibility for fruity/floral nuances in sparkling wine might reside in a few high-impact aromatic compounds, such as Et isobutyrate, isoamyl acetate, Et hexanoate, β-phenylethanol and di-Et succinate.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Komura, Naoko’s team published research in Science (Washington, DC, United States) in 2019-05-17 | 4064-06-6

Science (Washington, DC, United States) published new progress about Glycosides Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 4064-06-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C12H20O6, COA of Formula: C12H20O6.

Komura, Naoko; Kato, Keiichi; Udagawa, Taro; Asano, Sachi; Tanaka, Hide-Nori; Imamura, Akihiro; Ishida, Hideharu; Kiso, Makoto; Ando, Hiromune published the artcile< Constrained sialic acid donors enable selective synthesis of α-glycosides>, COA of Formula: C12H20O6, the main research area is sialic acid synthesis glycoside stereoselective glycosylation sialooligosaccharide.

Sialic acid is a sugar residue present in many biol. significant glycans of mammals, commonly as a terminal α-glycoside. The chem. structure of sialic acid, which features an anomeric center with carboxyl and methylene substituents, poses a challenge for synthesis of the α-glycoside, thus impeding biol. and therapeutic studies on sialic acid-containing glycans. We present a robust method for the selective α-glycosylation of sialic acid using macro-bicyclized sialic acid donors as synthetic equivalent of structurally constrained oxocarbenium ions to impart stereoselectivity. We demonstrate the power of our method by showcasing broad substrate scope and applicability in the preparation of diverse sialic acid-containing architectures.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Wu, Xu’s team published research in Journal of Proteomics in 2019-07-30 | 434-16-2

Journal of Proteomics published new progress about Cairina moschata Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 434-16-2 belongs to class alcohols-buliding-blocks, and the molecular formula is C27H44O, Formula: C27H44O.

Wu, Xu; Pan, Xiaoli; Cao, Sumei; Xu, Faqiong; Lan, Liming; Zhang, Yingyan; Lian, Senyang; Yan, Meijiao; Li, Ang published the artcile< iTRAQ-based quantitative proteomic analysis provides insights into strong broodiness in Muscovy duck (Cairina moschata) combined with metabolomics analysis>, Formula: C27H44O, the main research area is proteome metabolome APOV1 SAA VLDLR Cairina; Broodiness; Metabolomics; Muscovy duck; Ovary; Proteomics; iTRAQ.

Much attention has been paid to the broodiness of the Muscovy duck, but the mol. mechanism of broodiness remains largely unknown. In this study, the ovary tissues of Muscovy ducks during the broody and laying periods were used to investigate differentially expressed proteins (DEPs) by the iTRAQ-based proteomics approach. A total of 335 DEPs were identified, including 139 up-regulated and 196 down-regulated proteins. Six proteins (APOV1, GAL, SAA, GNB5, VLDLR and CDK1) with higher changes in expression were selected, and these proteins are mainly involved in the pathways related to reproductive performance, such as Oocyte meiosis, and PI3K-Akt signaling pathway. Steroid biosynthesis was the most significantly enriched pathway by KEGG pathway enriched anal. The qRT-PCR anal. was applied to verify the proteomic anal. Meanwhile, metabolomics anal. found that several important differentially expressed metabolites (DEMs) (7-dehydrodesmosterol, 25-Hydroxyvitamin D3, 7-Dehydrocholesterol, Pregnanolone, Allopregnanolone and estrogen) that were also mainly involved in Steroid biosynthesis, Steroid hormone biosynthesis and Metabolic pathways. Crucially, the changes in the abundance of these metabolites are closely related to the changes in the protein abundance of proteins identified in the same pathway, and it is always the upstream key enzymes that influence the production of downstream metabolites.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Dang, Huiping’s team published research in Journal of Colloid and Interface Science in 2022-04-15 | 4064-06-6

Journal of Colloid and Interface Science published new progress about Cytotoxicity. 4064-06-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C12H20O6, Computed Properties of 4064-06-6.

Dang, Huiping; Tian, Youliang; Cheng, Quan; Teng, Changchang; Xie, Kai; Yan, Lifeng published the artcile< Galactose conjugated boron dipyrromethene and hydrogen bonding promoted J-aggregates for efficiently targeted NIR-II fluorescence assistant photothermal therapy>, Computed Properties of 4064-06-6, the main research area is galactose conjugated boron dipyrromethene hydrogen bond fluorecence tumor imaging; 4, 4-difluoro-4-bora-3a, 4a-diazas-indacene (BODIPY); Galactose conjugated; Imaging-guided; NIR-II fluorescence; Photothermal therapy.

It is essential to develop novel multifunctional and easily synthesized stable NIR-II fluorescent probes to guide photothermal therapy for tumors. Here, we propose a new strategy to construct boron dipyrromethene (BODIPY) J-aggregates by intermol. hydrogen bonding (H-bond) and π-π stacking interactions to achieve fluorescence emission in the second near-IR window (NIR-II, 1000-1700 nm). A novel meso-benzamide galactose hexanoate-BODIPY (Gal-OH-BDP) amphiphilic small mol. dye was synthesized and it formed nanoparticles spontaneously in aqueous solution with a maximum emission wavelength near 1060 nm, which works as a smart nanomedicine for targeting NIR-II imaging-guided photothermal therapy (PTT) of hepatocellular carcinoma. Galactose not only provided hydrogen bonds to regulate the aggregation pattern of the mols. but also effectively targeted hepatocellular carcinoma cells and promoted the formation of well-dispersed nanoparticles of dye mols. due to their hydrophilicity. Moreover, due to high photothermal conversion efficiency (PCE = 55%), Gal-OH-BDP NPs achieve galactose-targeted NIR-II imaging and PTT, which is important for the precise diagnosis and treatment of tumors (Scheme 1). In the present research work, H-bond was introduced for the first time into BODIPY for building J-aggregates to achieve the NIR-II fluorescence.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Larsen, Finn Ole’s team published research in Oncology in 2019 | 1492-18-8

Oncology published new progress about Animal gene, N-ras Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 1492-18-8 belongs to class alcohols-buliding-blocks, and the molecular formula is C20H21CaN7O7, COA of Formula: C20H21CaN7O7.

Larsen, Finn Ole; Jensen, Benny V.; Norgaard, Hans Henrik; Hermann, Helle Kirstine; Larsen, Peter N.; Markussen, Alice; Hogdall, Estrid; Nielsen, Dorte published the artcile< Intrahepatic Oxaliplatin and Systemic 5-FU +/- Cetuximab in Chemo-Naive Patients with Liver Metastases from Colorectal Cancer>, COA of Formula: C20H21CaN7O7, the main research area is oxaliplatin fluorouracil cetuximab anticancer agent liver metastasis colorectal cancer; Colorectal cancer; Intrahepatic infusion; Oxaliplatin; Transarterial chemoembolization.

In case of response to chemotherapy, unresectable liver metastases from colorectal cancer can be converted to resectable and thereby obtain a chance of cure. The primary aim of this trial was to evaluate the response rate with intrahepatic oxaliplatin in combination with systemic 5-FU +/- cetuximab. Secondary aims were to evaluate the conversion rate from unresectable to resectable liver metastases, median progression-free survival, median overall survival, and toxicity. Forty-five chemo-naive patients with liver metastases from colorectal cancer were treated in a prospective phase II trial. Calcium folinate and 5-FU were delivered systemically while oxaliplatin was delivered alternating between systemic and intrahepatic administration. When oxaliplatin was delivered intrahepatic-ally, infusion time was reduced to 10 min followed by embolic material. In patients with KRAS wild-type tumors, cetuximab was added. The treatment was well tolerated and only pain in the liver and a mild increase in liver enzymes were observed after intrahepatic oxaliplatin. The patients obtained a response rate of 82%. Further, 58% converted from having unresectable to resectable liver metastases. The median overall survival and progression-free survival were 38.7 mo (95% confidence interval [CI] 33.0-44.3) and 12.9 mo (95% CI 10.2-15.6), resp. Intrahepatic infusion of oxaliplatin in 10 min with systemic 5-FU to patients with chemo-naive colorectal cancer is feasible and with low toxicity. A high response rate and long median overall survival were obtained.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Zhang, Cheng’s team published research in ACS Catalysis in 2019-03-01 | 4064-06-6

ACS Catalysis published new progress about Alkynes Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation) (diazo esters). 4064-06-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C12H20O6, Category: alcohols-buliding-blocks.

Zhang, Cheng; Li, Hongli; Pei, Chao; Qiu, Lihua; Hu, Wenhao; Bao, Xiaoguang; Xu, Xinfang published the artcile< Selective Vinylogous Reactivity of Carbene Intermediate in Gold-Catalyzed Alkyne Carbocyclization: Synthesis of Indenols>, Category: alcohols-buliding-blocks, the main research area is diazo alkyne nucleophile gold catalyst regioselective regioselective carbocyclization DFT; indenol preparation.

A gold-catalyzed carbocyclization of alkynes with a pendant diazo group that is completed by reaction with a protic nucleophile for the synthesis of indenol derivatives with a tertiary center is described. Mechanistic studies and DFT calculations indicate that the transformation is initiated by a gold-promoted 5-endo-dig carbocyclization to form the key intermediate vinyl gold carbene, which is intercepted by an unprecedented vinylogous addition and followed by external protic nucleophile-assisted protodeauration. Furthermore, in this catalytic alkyne transformation, various nucleophiles, including water, com. available 1°, 2°, and 3° alcs., menthol, D-galactose, cholesterol, steroid, etc., all perform well under these mild conditions to produce the corresponding indenol derivatives in high yields with structural diversity.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Guo, Huan’s team published research in Polymers (Basel, Switzerland) in 2019 | 3458-28-4

Polymers (Basel, Switzerland) published new progress about Antioxidants. 3458-28-4 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H12O6, SDS of cas: 3458-28-4.

Guo, Huan; Yuan, Qin; Fu, Yuan; Liu, Wen; Su, Ya-Hong; Liu, Hui; Wu, Chao-Yi; Zhao, Li; Zhang, Qing; Lin, De-Rong; Chen, Hong; Qin, Wen; Wu, Ding-Tao published the artcile< Extraction optimization and effects of extraction methods on the chemical structures and antioxidant activities of polysaccharides from snow chrysanthemum (Coreopsis tinctoria)>, SDS of cas: 3458-28-4, the main research area is coreopsis polysaccharide uronic acid monosaccharide antioxidant UAE MAE; Coreopsis tinctoria; antioxidant activity; chemical structure; extraction optimization; polysaccharide.

In order to explore snow chrysanthemum polysaccharides (SCPs) as functional food ingredients and natural antioxidants for industrial applications, both microwave-assisted extraction (MAE) and ultrasonic-assisted extraction (UAE) were firstly optimized for the extraction of SCPs. Furthermore, the effects of conventional hot water extraction, UAE, and MAE on the chem. structures and antioxidant activities of SCPs were investigated. The maximum extraction yields of SCPs extracted by UAE (4.13 ± 0.24%) and MAE (4.26 ± 0.21%) were achieved at the optimized extraction parameters as follows: ultrasound amplitude (68%) and microwave power (500 W), ultrasound extraction time (21 min) and microwave extraction time (6.5 min), and ratio of liquid to raw material (42.0 mL/g for UAE and 59.0 mL/g for MAE). In addition, different extraction methods significantly affected the contents of uronic acids, the mol. weights, the molar ratio of constituent monosaccharides, and the degree of esterification of SCPs. SCPs exhibited remarkable DPPH (IC50 = 1.702 mg/mL), ABTS (IC50 = 1.121 mg/mL), and nitric oxide (IC50 = 0.277 mg/mL) radical scavenging activities, as well as reducing power (= 80.17 ± 4.8μg Trolox/mg), which suggested that SCPs might be one of the major contributors toward the antioxidant activities of snow chrysanthemum tea. The high antioxidant activities (DPPH, IC50 = 0.693 mg/mL; ABTS, IC50 = 0.299 mg/mL; nitric oxide, IC50 = 0.105 mg/mL; and reducing power, 127.79 ± 2.57μg Trolox/mg) observed in SCP-M extracted by the MAE method might be partially attributed to its low mol. weight and high content of unmethylated galacturonic acids. Results suggested that the MAE method could be an efficient technique for the extraction of SCPs with high antioxidant activity, and SCPs could be further explored as natural antioxidants for industrial application.

Polymers (Basel, Switzerland) published new progress about Antioxidants. 3458-28-4 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H12O6, SDS of cas: 3458-28-4.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Gabriel, Christopher M’s team published research in Organic Letters in 2017-01-06 | 660867-80-1

Organic Letters published new progress about Amidation. 660867-80-1 belongs to class alcohols-buliding-blocks, and the molecular formula is C12H18BNO2, Name: 2-Methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine.

Gabriel, Christopher M.; Lee, Nicholas R.; Bigorne, Florence; Klumphu, Piyatida; Parmentier, Michael; Gallou, Fabrice; Lipshutz, Bruce H. published the artcile< Effects of Co-solvents on Reactions Run under Micellar Catalysis Conditions>, Name: 2-Methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine, the main research area is cosolvent water micelle organic reaction TPGS750M green E factor.

The impact of varying percentages of an organic solvent added to reactions run in aqueous nanomicelles as the reaction medium was studied. Issues such as rates of reaction, percent conversion, and yield, as well as various practical aspects (e.g., effect on stirring, etc.), are discussed, leading to an operationally simple method for the general improvement of potentially problematic systems across a broad range of reaction types, in particular for reactions run at scale.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Tan, Zhenda’s team published research in ACS Catalysis in 2020-05-01 | 5344-90-1

ACS Catalysis published new progress about Amino alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 5344-90-1 belongs to class alcohols-buliding-blocks, and the molecular formula is C7H9NO, HPLC of Formula: 5344-90-1.

Tan, Zhenda; Ci, Chenggang; Yang, Jian; Wu, Yang; Cao, Liang; Jiang, Huanfeng; Zhang, Min published the artcile< Catalytic Conversion of N-Heteroaromatics to Functionalized Arylamines by Merging Hydrogen Transfer and Selective Coupling>, HPLC of Formula: 5344-90-1, the main research area is azaarene alkyl bromide amino arylmethanol ruthenium hydrogen transfer coupling; alkylaminoaryl methylazaarene preparation chemoselective.

A ruthenium-catalyzed deconstruction of N-heteroaromatics to functionalized arylamines with 2-aminoaryl methanols via hydrogen transfer and selective coupling was reported. The reaction was achieved via sequential functionalization of the β and α-sites of the initially formed N-heteroarenium salts followed by a C-N cleavage, proceeding with the striking features of broad substrate scope, excellent functional groups tolerance, high chemoselectivity and atom-efficiency, and applicable for streamline synthesis of some biomedical mols. The strategy utilized will pave the avenues for further development of catalytic transformations of inert organo-systems to functional frameworks.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Kiourtzidis, Mikis’s team published research in Nutrients in 2020 | 434-16-2

Nutrients published new progress about Adipose tissue. 434-16-2 belongs to class alcohols-buliding-blocks, and the molecular formula is C27H44O, Recommanded Product: (3S,9S,10R,13R,14R,17R)-10,13-Dimethyl-17-((R)-6-methylheptan-2-yl)-2,3,4,9,10,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-ol.

Kiourtzidis, Mikis; Kuehn, Julia; Brandsch, Corinna; Stangl, Gabriele I. published the artcile< Vitamin d status of mice deficient in scavenger receptor class B Type 1, cluster determinant 36 and ATP-binding cassette proteins G5/G8>, Recommanded Product: (3S,9S,10R,13R,14R,17R)-10,13-Dimethyl-17-((R)-6-methylheptan-2-yl)-2,3,4,9,10,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-ol, the main research area is kidney liver heart vitamin D Srb1 Cd36 Abcg5; ATP-binding cassette transporters G5/G8; cluster determinant 36; mice; scavenger receptor class B type 1; vitamin D.

Classical lipid transporters are suggested to modulate cellular vitamin D uptake. This study investigated the vitamin D levels in serum and tissues of mice deficient in SR-B1 (Srb1-/-), CD36 (Cd36-/-) and ABC-G5/G8 (Abcg5/g8-/-) and compared them with corresponding wild-type (WT) mice. All mice received triple-deuterated vitamin D3 (vitamin D3-d3) for six weeks. All knockout mice vs. WT mice showed specific alterations in their vitamin D concentrations Srb1-/- mice had higher levels of vitamin D3-d3 in the serum, adipose tissue, kidney and heart, whereas liver levels of vitamin D3-d3 remained unaffected. Addnl., Srb1-/- mice had lower levels of deuterated 25-hydroxyvitamin D3 (25(OH)D3-d3) in the serum, liver and kidney compared to WT mice. In contrast, Cd36-/- and WT mice did not differ in the serum and tissue levels of vitamin D3-d3, but Cd36-/- vs. WT mice were characterized by lower levels of 25(OH)D3-d3 in the serum, liver and kidney. Finally, Abcg5/g8-/- mice tended to have higher levels of vitamin D3-d3 in the serum and liver. Major alterations in Abcg5/g8-/- mice were notably higher levels of 25(OH)D3-d3 in the serum and kidney, accompanied by a higher hepatic mRNA abundance of Cyp27a1 hydroxylase. To conclude, the current data emphasize the significant role of lipid transporters in the uptake, tissue distribution and activation of vitamin D.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts