Month: October 2022

Hou, Jianshen; Gao, Cong; Guo, Liang; Nielsen, Jens; Ding, Qiang; Tang, Wenxiu; Hu, Guipeng; Chen, Xiulai; Liu, Liming published the artcile< Rewiring carbon flux in Escherichia coli using a bifunctional molecular switch>, Category: alcohols-buliding-blocks, the main research area is glucaric acid shikimic acid Escherichia coli metabolic engineering; Dynamic regulation; Metabolic engineering; Metabolic flux regulation; Synthetic biology.

The unbalanced distribution of carbon flux in microbial cell factories can lead to inefficient production and poor cell growth. Uncoupling cell growth and chem. synthesis can therefore improve microbial cell factory efficiency. Such uncoupling, which requires precise manipulation of carbon fluxes, can be achieved by up-regulating or down-regulating the expression of enzymes of various pathways. In this study, a dynamic turn-off switch (dTFS) and a dynamic turn-on switch (dTNS) were constructed using growth phase-dependent promoters and degrons. By combining the dTFS and dTNS, a bifunctional mol. switch that could orthogonally regulate two target proteins was introduced. This bifunctional mol. switch was used to uncouple cell growth from shikimic acid and D-glucaric acid synthesis, resulting in the production of 14.33 g/L shikimic acid and the highest reported productivity of D-glucaric acid (0.0325 g/L/h) in Escherichia coli MG1655. This proved that the bifunctional mol. switch could rewire carbon fluxes by controlling target protein abundance.

Metabolic Engineering published new progress about Escherichia coli. 87-73-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H10O8, Category: alcohols-buliding-blocks.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Donthireddy, S. N. R.; Singh, Vivek Kumar; Rit, Arnab published the artcile< A heteroditopic NHC and phosphine ligand supported ruthenium(II)-complex: an effective catalyst for the N-alkylation of amides using alcohols>, Name: (2-Aminophenyl)methanol, the main research area is alkylation aromatic amide aralkyl alc ruthenium chelate carbene catalyst; ruthenium imidazolylidene triazolylidene mesoionic carbene preparation amide alkylation catalyst; secondary aromatic amide benzyl preparation alkylation arenemethanol ruthenium catalyst.

A ruthenium(II) complexes [(p-cymene)RuCl(1-MeIm-3-CH2Trz-1-C6H4R)] (Im = 2-imidazolylidene, Trz = 1,2,3-triazol-4-yl-5-ylidene; R = 2,4,6-Me3, 4-MeO, 4-CF3) supported by chelate NHC and mesoionic carbene ligands in combination with a diphosphine ligand (dppe, dppf) was shown to be a highly effective catalyst for the N-alkylation of diverse aromatic amides ArCONH2 using readily available primary aralkyl alcs. Ar1CH2OH, yielding N-benzylamides ArCONHCH2Ar1 (Ar, Ar1 = substituted Ph, pyridyl, thienyl, naphthyl). A wide range of secondary amides was thus obtained in excellent yields (up to 98%) employing a low catalyst loading of 0.2 mol% and a substoichiometric amount of base. The 1H NMR and ESI-MS analyses support the participation of a N-heterocyclic carbene and phosphine supported Ru-H species in the catalytic cycle and the mechanistic studies including the deuterium labeling experiment suggest the involvement of a borrowing hydrogen protocol. Addnl., the present catalytic system was also revealed to be efficient for the selective mono-alkylation and unsym. di-alkylation of 4-aminobenzamides which have not been studied before to the extent of our knowledge.

Catalysis Science & Technology published new progress about Alkylation catalysts. 5344-90-1 belongs to class alcohols-buliding-blocks, and the molecular formula is C7H9NO, Name: (2-Aminophenyl)methanol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Aman, Hasil; Chen, Yuan-Ching; Tu, Jing-Wen; Chang, Chia-Chi; Chuang, Gary Jing published the artcile< Catalyst/Additive Free Oxidation of Benzyl Bromides to Benzaldehydes>, Recommanded Product: Triphenylmethanol, the main research area is benzyl bromide Kornblum oxidation; benzaldehyde preparation green chem.

An effective approach for the synthesis of aryl aldehydes from the corresponding benzyl bromides was accomplished. Without need of addnl. additives or stoichiometric oxidants, this environmental friendly and milder version of Kornblum oxidation simply utilized the irradiation of visible light in DMSO under O2, and was compatible with the substrate with different functional groups.

ChemistrySelect published new progress about Aralkyl alcohols Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 76-84-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C19H16O, Recommanded Product: Triphenylmethanol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Labarthe, Benoit; Idee, Jean-Marc; Burnett, Roger; Corot, Claire published the artcile< In Vivo Comparative Antithrombotic Effects of Ioxaglate and Iohexol and Interaction With the Platelet Antiaggregant Clopidogrel>, Synthetic Route of 35564-86-4, the main research area is ionic nonionic contrast media antithrombotic interaction clopidogrel.

RATIONALE AND OBJECTIVES. Experiments were designed to (1) compare the effects of iodinated contrast media (CM) on a rat model of arterial thrombosis, (2) evaluate which element of the ioxaglate solution supports its antithrombotic activity, and (3) investigate the interaction of ionic and non-ionic CM with the antiplatelet agent clopidogrel. MATERIALS AND METHODS. Carotid thrombosis was induced in rats by extravascular application of a filter paper soaked in FeCl (35% vol/wt), proximal to an ultrasonic flow probe. (1) The antithrombotic potential of low-osmolar ionic (ioxaglate Na/meglumine) or nonionic contrast media (iohexol and iodixanol) (all 1600 mg iodine/kg, IV) was assessed by measuring the time to occlusion (TTO) of the carotid artery and the thrombus weight (TW). (2) Isotonic saline and iso-osmolar (280 mOsm/kg) and hyperosmolar (560 mOsm/kg) solutions of meglumine hydrochloride, meglumine ioxaglate (560 mOsm/kg), sodium ioxaglate (600 mOsm/kg) and sodium and meglumine ioxaglate (com. solution) were tested under similar conditions. (3) Interaction with clopidogrel was tested by injecting lower dose of CM (960 mg iodine/kg) 2 h after clopidogrel (2 mg/kg per os). RESULTS: (1) Ioxaglate prolonged TTO when compared with saline (30.0 ± 1.1 min vs. 19.6 ± 2.4 min, <0.001), whereas iohexol had no effect (21.3 ± 1.3 min). Ioxaglate's effect was associated with a reduction in TW with ioxaglate vs. saline (2.6 ± 0.4 mg and 4.7 ± 0.7 mg, resp., <0.05) whereas TW remained unchanged in the iohexol group (4.2 ± 0.4 mg). The nonionic dimer iodixanol induced a direct vasoconstrictor effect on the carotid artery and was consequently excluded from the study. (2) Neither iso-osmolar nor hyperosmolar solutions of meglumine had any effect on TTO whereas both sodium and meglumine salts of ioxaglic acid prolonged TTO, suggesting that the antithrombotic effect of ioxaglate is mediated by the ioxaglic acid moiety alone as neither meglumine, osmolality or sodium played a significant role. (3) A synergistic effect on TTO was found when ioxaglate was associated with clopidogrel whereas no such effect was observed with iohexol. CONCLUSIONS: These data show a greater in vivo antithrombotic potential for the ionic contrast medium ioxaglate than for the non-ionic contrast medium iohexol and, for the first time, a synergistic effect between a contrast medium and a platelet antiaggregant drug in vivo. Investigative Radiology published new progress about Anticoagulants. 35564-86-4 belongs to class alcohols-buliding-blocks, and the molecular formula is C7H18ClNO5, Synthetic Route of 35564-86-4.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Pandey, Akanksha M.; Mondal, Shankhajit; Gnanaprakasam, Boopathy published the artcile< Continuous Flow Direct Azidation of Alcohols and Peroxides for the Synthesis of Quinoxalinones, Benzooxazinone and Triazole Derivatives>, Recommanded Product: Triphenylmethanol, the main research area is aryl azide preparation; aromatic alc azidation continuous flow; azide benzoxazinone preparation; peroxide indole ring expansion azidation continuous flow; quinoxalinone azide preparation; indole azide ring expansion skeletal rearrangement continuous flow.

The continuous flow direct azidation of various alcs. by using TMSN3 as an azide transfer reagent in the presence of Amberlyst-15 as a recyclable catalyst was reported. Numerous 3-hydroxy-2-oxindoles e.g., diphenylmethanol effectively undergo azide transfer reaction to afford azide functionalized quaternary stereocenter e.g., [azido(phenyl)methyl]benzene under continuous flow module. Interestingly, peroxyoxindole undergoes sequential skeletal rearrangement to generate carbocation and followed by nucleophilic azidation to afford a library of substituted-2-azido-2H-benzo[b][1,4]oxazin-3(4H)-one derivatives I (R = 4-methoxyphenyl, Me, Bn, etc.; R1 = H, Me, Bn) under continuous flow. Furthermore, a continuous-flow Cu-catalyzed Click reaction afforded triazole functionalized derivatives II (R2 = Me, Ph). Next, reduction of azide in the presence of PPh3 results the amine derivatives in good yield. The continuous-flow application was extended further for the thermolytic skeletal rearrangement of 3-azide-2-oxindole for the synthesis of biol. important quinoxalin-2(1H)-ones III (R3 = Me, Bn, 4-MeC6H4, etc.) under reagentless condition. Furthermore, this continuous-flow direct azidation reaction is scaled up to 6.144 g of azides with TON = 9.24 under safer condition.

Journal of Organic Chemistry published new progress about Aromatic alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 76-84-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C19H16O, Recommanded Product: Triphenylmethanol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Safaiee, Maliheh; Moeinimehr, Mahtab; Zolfigol, Mohammad Ali published the artcile< Pyridiniumporphyrazinato oxo-vanadium tribromomethanide as a new source of Br+ catalyst for the chemo and homoselective oxidation of sulfides and benzylic alcohols>, SDS of cas: 699-12-7, the main research area is pyridiniumporphyrazinato oxo vanadium tribromomethanide preparation catalyst chemoselective homoselective oxidation; sulfide benzylic alc oxidation catalyst pyridiniumporphyrazinato oxo vanadium tribromomethanide; sulfoxide benzaldehyde preparation.

The present study describes the design and synthesis of novel nano N-bromo porphyrazin (N-bromo tetra-2,3-pyridiniumporphyrazinato oxo-vanadium tribromomethanide [VO(TPPABr)] CBr3) as an efficient, recyclable and thermal stable heterogeneous catalyst for chemo and homoselective oxidation of sulfides to sulfoxides and benzyl alcs. to benzaldehydes. This ecofriendly heterogeneous catalyst was fully characterized by FT-IR spectra, UV-Vis spectra, x-ray diffraction (XRD), SEM (SEM), transmission electron microscopy (TEM), and thermal gravimetric anal. (TGA), energy-dispersive x-ray spectroscopy (EDX) and elemental anal. (CHN). The synthesized catalyst exhibited a high-performance and considerable reusability.

Polyhedron published new progress about Aralkyl alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 699-12-7 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H10OS, SDS of cas: 699-12-7.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Hollander, Amit; Yaron, Sima published the artcile< Pore-forming treatments induce aggregation of Salmonella Senftenberg through protein leakage>, Computed Properties of 78-70-6, the main research area is Salmonella senftenberg protein pore treatment aggregation; Aggregation; Antimicrobials; Food safety; Membrane damage; Salmonella.

Fresh herbs are not commonly associated with foodborne pathogens, due to the production of essential oils with antimicrobial activity. Recalls of contaminated basil, and basil outbreaks caused by Salmonella motivated studies aimed to comprehend the antimicrobial activity of basil essential oils, and to explore the mechanisms in which Salmonella can overcome them. Linalool, a major constituent of basil oil, increases the permeability of Salmonella Senftenberg cells by damaging their membrane. Linalool also induces bacterial aggregation. We hypothesized that the membrane perforation effect triggers cell aggregation through leakage of intracellular substances from live and dead cells. By exposing S. Senftenberg to addnl. phys. (sonication) or chem. (eugenol, Triton-X-100) treatments, we showed that the aggregation is caused by various membrane-targeted treatments. Enzymic degradation of leaked proteins restricted the bacterial aggregation, and disassembled existing aggregates. Moreover, supplemented proteins such as bacterial intracellular proteins or BSA also caused aggregation, further supporting the hypothesis that non-specific proteins trigger the bacterial aggregation. This study provides a novel understanding of the role of protein leakage in promoting bacterial aggregation. Since aggregation has significant roles in food safety and microbial ecol., this finding may establish future studies about microbial resistance via formation of clusters similar to biofilm development.

Food Microbiology published new progress about Aggregation. 78-70-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C10H18O, Computed Properties of 78-70-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Zakany, Florina; Pap, Pal; Papp, Ferenc; Kovacs, Tamas; Nagy, Peter; Peter, Maria; Szente, Lajos; Panyi, Gyorgy; Varga, Zoltan published the artcile< Determining the target of membrane sterols on voltage-gated potassium channels>, Electric Literature of 434-16-2, the main research area is sterol voltage gated potassium channel intracellular domain transmembrane helix; Cholesterol; Ion channel gating; K(V)1.3; K(V)10.1; Pore domain; Voltage-sensor.

Cholesterol, an essential lipid component of cellular plasma membranes, regulates fluidity, mech.integrity, raft structure and may specifically interact with membrane proteins. Numerous effects on ion channels by cholesterol, including changes in current amplitude, voltage dependence and gating kinetics, have been reported. We have previously described such changes in the voltage-gated potassium channel Kv1.3 of lymphocytes by cholesterol and its analog 7-dehydrocholesterol (7DHC). In voltage-gated channels membrane depolarization induces movement of the voltage sensor domains (VSD), which is transmitted by a coupling mechanism to the pore domain (PD) to open the channel. Here, we investigated whether cholesterol effects were mediated by the VSD to the pore or the PD was the direct target. Specificity was tested by comparing Kv1.3 and Kv10.1 channels having different VSD-PD coupling mechanisms. Current recordings were performed with two-electrode voltage-clamp fluorometry, where movement of the VSDs was monitored by attaching fluorophores to external cysteine residues introduced in the channel sequence. Loading the membrane with cholesterol or 7DHC using methyl-β-cyclodextrin induced changes in the steady-state and kinetic parameters of the ionic currents while leaving fluorescence parameters mostly unaffected in both channels. Non-stationary noise anal.revealed that reductionof single channel conductance rather than that of open probability caused the observedcurrent decrease. Furthermore, confocal laser scanning and stimulated emission depletion microscopy demonstrated significant changes in the distribution of these ion channels in response to sterol loading. Our results indicate that sterol-induced effects on ion channel gating directly target the pore and do not act via the VSD.

Biochimica et Biophysica Acta, Molecular and Cell Biology of Lipids published new progress about Antibodies and Immunoglobulins Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 434-16-2 belongs to class alcohols-buliding-blocks, and the molecular formula is C27H44O, Electric Literature of 434-16-2.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Su, Yue; Li, Liang published the artcile< Structural characterization and antioxidant activity of polysaccharide from four auriculariales>, Electric Literature of 3458-28-4, the main research area is Auricularia natural antioxidant fucose mannose galactose polysaccharide; Antioxidant activity; Auricularia polysaccharides; Structural characterization.

The structural characterization and antioxidant activity of four Auricularia polysaccharides (A. cornea (ACP), A. auricula (AAP), A. polytricha (APP) and M.fungus (MFP)) were studied in this paper. The results shown: polysaccharides of four Auricularia were mainly composed of mannose and galactose, all polysaccharides contained uronic acid and pyran ring structure with spectroscopy and NMR anal. There was a significant difference in the total antioxidant capacity and APP was significantly higher than the other polysaccharides. The ability of APP to scavenge DPPH radicals and hydroxyl radicals was significantly higher than that of other polysaccharides, resp. The mol. weight was significantly pos. correlated with DPPH radicals, superoxide anion radicals and hydroxyl radicals. Total antioxidant capacity was significantly neg. correlated with fucose and galactose. The result indicated that fucose and galactose jointly determine total antioxidant capacity. The polysaccharide from four Auricularia had good oxidation resistance and could be used as natural antioxidants.

Carbohydrate Polymers published new progress about Auricularia auricula-judae. 3458-28-4 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H12O6, Electric Literature of 3458-28-4.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts