Month: October 2022

Dong, Wei; Fang, Zhuo-Yue; Cao, Tong-Yang; Cao, Jie-Hui; Zhao, Zi-Qiang; Zhang, Linlin; Li, Wei; Qi, Lin; Wang, Li-Jing published the artcile< Copper-Catalyzed Aminosulfonylation of O-Homoallyl Benzimidates with Sodium Sulfinates to Access Sulfonylated 1,3-Oxazines>, HPLC of Formula: 627-27-0, the main research area is sulfonyl oxazine preparation; homoallyl benzimidate sodium sulfinate aminosulfonylation copper catalyst.

A facile copper-catalyzed aminosulfonylation of O-homoallyl benzimidates with sodium sulfinates in the presence of tert-Bu peroxybenzoate (TBPB) and XPhos ligand has been developed. By using this protocol, a variety of potentially bioactive 1,3-oxazines were directly synthesized. This method has the merits of a cheap catalyst, easily available and stable sulfone reagents, and simple operation.

Organic Letters published new progress about Benzimidazoles Role: RCT (Reactant), RACT (Reactant or Reagent). 627-27-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C4H8O, HPLC of Formula: 627-27-0.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Russo, E.; Montt Guevara, M.; Giannini, A.; Mannella, P.; Palla, G.; Caretto, M.; Pancetti, F.; Genazzani, A. D.; Simoncini, T. published the artcile< Cranberry, D-mannose and anti-inflammatory agents prevent lower urinary tract symptoms in women undergoing prolapse surgery>, Recommanded Product: (2S,3S,4R,5R)-2,3,4,5,6-Pentahydroxyhexanal, the main research area is mannose anti inflammatory agent human urinary tract prolapse surgery; Cystocele; lower urinary tract symptoms; nutritional supplements; pelvic organ prolapse.

We assessed the effect on lower urinary tract symptoms (LUTS) of a supplement containing cranberry, D-mannose and anti-inflammatory mols. in postmenopausal women undergoing surgery for cystocele. Forty postmenopausal women were randomized 1:1 to an active group receiving the nutritional supplement twice a day for 2 wk starting from surgery, or to a control group receiving surgery only. Primary outcomes were the effectiveness in the postoperative LUTS and urinary tract infections (UTI). LUTS were investigated by a validated questionnaire (ICIQ-FLUTS) at baseline and at week 4. Secondary outcomes were the safety and tolerability of the supplement and other perioperative outcomes. No significant differences were found in perioperative outcomes and in incidence of UTI. After surgery, women treated with the supplement experienced significantly better scores on the filling domain of the questionnaire. A non-significant decrease in voiding scores was also found. No adverse events were detected. The use of an oral supplement containing cranberry, D-mannose and anti-inflammatory mols. decreases the perception of LUTS in postmenopausal women after anterior colporraphy. Our data suggest that perioperative use of nutritional supplements may be useful in the management of postoperative LUTS.

Climacteric published new progress about Anti-inflammatory agents. 3458-28-4 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H12O6, Recommanded Product: (2S,3S,4R,5R)-2,3,4,5,6-Pentahydroxyhexanal.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Verma, Ashutosh; Hazra, Susanta; Dolui, Pritam; Elias, Anil J. published the artcile< Ruthenium-Catalyzed Synthesis of α-Alkylated Ketones and Quinolines in an Aqueous Medium via a Hydrogen-Borrowing Strategy Using Ketones and Alcohols>, Category: alcohols-buliding-blocks, the main research area is ruthenium catalyst preparation; aryl ketone alc ruthenium catalyst green alkylation; phenyl arylpropanone preparation; arylquinoline preparation.

A simple, efficient, and sustainable method for the synthesis of α-alkylated ketones and quin50556012Aolines using a hydrogen-borrowing strategy was reported, which has emerged as a greener alternative in organic transformation reactions. Synthesis of a range of α-alkylated ketones and quinoline derivatives was achieved by using the water-soluble [Ru(8-AQ)Cl(p-cym.)]+Cl- [Ru]-1 (AQ=aminoquinoline) catalyst with water as the reaction medium. By adopting this strategy, α-alkylated ketones and quinolines was synthesized using ketones or secondary alcs. as starting materials and the primary alc. as a green and naturally abundant alkylating agent.

Asian Journal of Organic Chemistry published new progress about Alkylation. 5344-90-1 belongs to class alcohols-buliding-blocks, and the molecular formula is C7H9NO, Category: alcohols-buliding-blocks.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Yu, Jiajia; Zhang, Huihui; Wu, Xinxin; Zhu, Chen published the artcile< Intermolecular radical fluoroalkylative olefination of unactivated alkenes>, Electric Literature of 627-27-0, the main research area is vinyl preparation photochem regioselective chemoselective diastereoselective; alkene intermol radical fluoroalkylative olefination.

A novel, efficient radical-mediated intermol. fluoroalkylative olefination of inactivated alkenes RCH=CH2 [R = 2-hydroxypropan-2-yl, 1-(2-oxocyclohexyl)methyl, 3-(1-benzothiophen-2-yl)-3-oxopropyl, etc.] was disclosed. The transformation proceeded through a radical docking-migration cascade, in which a portfolio of strategically designed dual-function alkenylating reagents was harnessed to afford vinylated products RC(CH=CHR1)(C(Br)(F)(R2)) [R1 = Ph, 4-MePh, naphthalen-2-yl, etc.; R2 = CN, COOEt] with exclusive E-configuration. The reaction featured mild conditions, broad functional group compatibility, and unique chemo-, regio-, and stereoselectivities. The protocol has also provided a useful approach for late-stage olefination of complex natural products and drug derivatives containing alkenyl moieties.

CCS Chemistry published new progress about Alkenes Role: PRP (Properties), RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 627-27-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C4H8O, Electric Literature of 627-27-0.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Ibrahim, Elsayed A.; Wang, Mei; Radwan, Mohamed M.; Wanas, Amira S.; Majumdar, Chandrani G.; Avula, Baharthi; Wang, Yan-Hong; Khan, Ikhlas A.; Chandra, Suman; Lata, Hemant; Hadad, Ghada M.; Abdel Salam, Randa A.; Ibrahim, Amany K.; Ahmed, Safwat A.; El Sohly, Mahmoud A. published the artcile< Analysis of Terpenes in Cannabis sativa L. Using GC/MS: Method Development, Validation, and Application>, Reference of 78-70-6, the main research area is terpene Cannabis sativa gas chromatog mass spectrometry.

Terpenes are the major components of the essential oils present in various Cannabis sativaL. varieties. These compounds are responsible for the distinctive aromas and flavors. Besides the quantification of the cannabinoids, determination of the terpenes in C. sativastrains could be of importance for the plant selection process. At the University of Mississippi, a GC-MS method has been developed and validated for the quantification of terpenes in cannabis plant material, viz., α-pinene, β-pinene, β-myrcene, limonene, terpinolene, linalool, α-terpineol, β-caryophyllene, α-humulene, and caryophyllene oxide. The method was optimized and fully validated according to AOAC (Association of Official Anal. Chemists) guidelines against reference standards of selected terpenes. Samples were prepared by extraction of the plant material with Et acetate containing n-tridecane solution (100μg/mL) as the internal standard The concentration-response relationship for all analyzed terpenes using the developed method was linear with r 2values > 0.99. The average recoveries for all terpenes in spiked indoor cultivated samples were between 95.0 – 105.7%, with the exception of terpinolene (67 – 70%). The measured repeatability and intermediate precisions (% relative standard deviation) in all varieties ranged from 0.32 to 8.47%. The limit of detection and limit of quantitation for all targeted terpenes were determined to be 0.25 and 0.75μg/mL, resp. The proposed method is highly selective, reliable, and accurate and has been applied to the simultaneous determination of these major terpenes in the C. sativabiomass produced by our facility at the University of Mississippi as well as in confiscated marijuana samples.

Planta Medica published new progress about Cannabinoids Role: ANT (Analyte), ANST (Analytical Study). 78-70-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C10H18O, Reference of 78-70-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Fuss, Werner published the artcile< Previtamin D: Z-E photoisomerization via a Hula-twist conical intersection>, Category: alcohols-buliding-blocks, the main research area is previtamin photoisomerization conical intersection rotamer CD.

On photoisomerization of previtamin D – a steroid Z-triene – produced in situ by ring opening of 7-dehydrocholesterol in a cold matrix, it was found in A.M.Muller et al. [Angew.Chem., Int.Ed., 1998, 37, 505-507] that the product (tachysterol) had rotated not only its central double bond but also an adjacent single bond. This is called a Hula twist (HT) due to the alternative description, in which it is just one central CH group that rotates. It was pointed out that the results directly support the calculated mol. structure at a conical intersection, which mediates the Z-E isomerization of polyenes. With a more sophisticated technique, Saltiel et al. (J.Phys.Chem.Lett., 2013, 4, 716-721) confirmed this tachysterol rotamer as the main product but found two addnl. conformers. They believed to have seen also three previtamin D conformers, suggested to be a result of hot-ground-state reactions from the primary rotamer, and interpreted all tachysterol products to be a result of a double-bond twist (DBT), not a HT. On the basis of published CD data and consideration of other reactions, it is here shown that under these conditions hot-ground-state reactions are unimportant or even negligible and that there is practically only a single conformer of previtamin D after ring opening. All products can be easily understood on the basis of an HT-type conical intersection, which is thus further supported. Invoking a published pretwist model even rationalizes product ratios. The two twists in HT are concerted. Furthermore HT is fully consistent with the NEER principle (nonequilibration of excited rotamers) and even offers addnl. possibilities for conformer control.

Physical Chemistry Chemical Physics published new progress about Bond angle, torsional. 434-16-2 belongs to class alcohols-buliding-blocks, and the molecular formula is C27H44O, Category: alcohols-buliding-blocks.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Ziemianowicz, Daniel S.; MacCallum, Justin L.; Schriemer, David C. published the artcile< Correlation between Labeling Yield and Surface Accessibility in Covalent Labeling Mass Spectrometry>, Synthetic Route of 25055-82-7, the main research area is surface accessibility covalent labeling mass spectrometry.

The functional properties of a protein are strongly influenced by its topog., or the solvent-facing contour map of its surface. Together with crosslinking, covalent labeling mass spectrometry (CL-MS) has the potential to contribute topog. data through the measurement of surface accessibility. However, recent efforts to correlate measures of surface accessibility with labeling yield have been met with mixed success. Most applications of CL-MS involve differential anal. of protein interactions (i.e., footprinting experiments) where such inconsistencies have limited effect. Extending CL-MS into structural anal. requires an improved evaluation of the relation between labeling and surface exposure. The authors applied recently developed diazirine reagents to obtain deep coverage of the large motor domain of Eg5 (a mitotic kinesin), and together with computational methods the authors correlated labeling yields with accessibility data in a number of ways. Correlations can indeed be seen at a local structural level, but these correlations do not extend across the structure. The lack of correlation arises from the influence of protein dynamics and chem. composition on reagent partitioning and, thus, also on labeling yield. The authors’ use of CL-MS data should be considered in light of “”chem. accessibility”” rather than “”solvent accessibility”” and suggest that CL-MS data would be a useful tool in the fundamental study of protein-solute interactions.

Journal of the American Society for Mass Spectrometry published new progress about Kinesin-like protein KIF11 Role: ANT (Analyte), BSU (Biological Study, Unclassified), ANST (Analytical Study), BIOL (Biological Study) (Eg5, ADP-bound). 25055-82-7 belongs to class alcohols-buliding-blocks, and the molecular formula is C4H8N2O, Synthetic Route of 25055-82-7.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Nikoorazm, Mohsen; Ghobadi, Massoud published the artcile< Cu-SBTU@MCM-41: As an Efficient and Reusable Nanocatalyst for Selective Oxidation of Sulfides and Oxidative Coupling of Thiols>, Application In Synthesis of 699-12-7, the main research area is copper complex mesoporous silica nanocatalyst sulfide selective oxidation sulfoxide; disulfide thiol oxidative coupling.

Cu(II) complex with S-benzylisothiourea ligand was grafted into functionalized mesoporous MCM-41 (Cu-SBTU@MCM-41) and characterized by X-ray diffraction (XRD), thermal gravimetric anal. (TGA), SEM (SEM), energy-dispersive X-ray spectroscopy (EDX), Fourier transform IR spectroscopy (FT-IR) and inductively coupled plasma (ICP-OES) techniques. After characterization of this catalyst, its application has been studied in selective oxidation of sulfides to sulfoxides and oxidative coupling of thiols to disulfides using hydrogen peroxide (H2O2) as oxidant. This catalyst was shown good recyclability and reused for several consecutive runs without significant loss of its activity.

Silicon published new progress about Disulfides, organic Role: IMF (Industrial Manufacture), PREP (Preparation). 699-12-7 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H10OS, Application In Synthesis of 699-12-7.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Berzins, Karlis; Sales, Ruth E.; Barnsley, Jonathan E.; Walker, Greg; Fraser-Miller, Sara J.; Gordon, Keith C. published the artcile< Low-wavenumber Raman spectral database of pharmaceutical excipients>, COA of Formula: C6H12O6, the main research area is pharmaceutical LWR spectroscopy amino acids esters organosulfates protein polymers.

The interest in applications of low-wavenumber Raman (LWR) spectroscopy for pharmaceutical anal. has increased rapidly over the last decade. In this study, a collection of LWR spectra are presented for 75 commonly used pharmaceutical excipients, which serve an important role in the manufacture and delivery of pharmaceutics. The excipients were divided into 10 main groups based on chem. composition: amino acids, mono- and disaccharides, polysaccharides, monomeric polyols, esters, inorganic substances, organosulfates and carboxylic acids/salts, protein, polymers and others. The spectral data is intended to serve as a reference for a number of general purposes such as qual. and quant. anal., counterfeit detection and pharmaceutical process control.

Vibrational Spectroscopy published new progress about Amino acids Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 492-62-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H12O6, COA of Formula: C6H12O6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Gasmi, Laila; Martinez-Solis, Maria; Frattini, Ada; Ye, Meng; Collado, Maria Carmen; Turlings, Ted C. J.; Erb, Matthias; Herrero, Salvador published the artcile< Can herbivore-induced volatiles protect plants by increasing the herbivores' susceptibility to natural pathogens?>, Synthetic Route of 78-70-6, the main research area is herbivore plant volatile gut microbiota pathogenicity cellular immunity; Bacillus thuringiensis; baculovirus; entomopathogen; indole; linalool; plant volatiles; plant-microbe interactions.

In response to insect herbivory, plants mobilize various defenses. Defense responses include the release of herbivore-induced plant volatiles (HIPVs) that can serve as signals to alert undamaged tissues and to attract natural enemies of the herbivores. Some HIPVs can have a direct neg. impact on herbivore survival, but it is not well understood by what mechanisms. Here, we tested the hypothesis that exposure to HIPVs renders insects more susceptible to natural pathogens. Exposure of the caterpillars of the noctuid Spodoptera exigua to indole and linalool, but not exposure to (Z)-3-hexenyl acetate, increased the susceptibility to Spodoptera exigua multiple nucleopolyhedrovirus (SeMNPV). We also found that exposure to indole, but not exposure to linalool or (Z)-3-hexenyl acetate, increased the pathogenicity of Bacillus thuringiensis. Addnl. experiments revealed significant changes in microbiota composition after forty-eight hours of larval exposure to indole. Overall, these results provide evidence that certain HIPVs can strongly enhance the susceptibility of caterpillars to pathogens, possibly through effects on the insect gut microbiota. These findings suggest a novel mechanism by which HIPVs can protect plants from herbivorous insects. Multitrophic interactions involving insect pests, their natural enemies, microorganisms, and plant hosts are increasingly being recognized as relevant factors in pest management. In response to herbivory attacks, plants activate a wide range of defenses that aim to mitigate the damage. Attacked plants release herbivore-induced plant volatiles (HIPVs), which can act as priming signals for other plants and attract natural enemies of herbivores, and which may have a direct neg. impact on herbivore survival. In the present work, we show that exposure of the insects to the induced volatiles could increase the insects’ susceptibility to the entomopathogens naturally occurring in the plant environment. These findings suggest a novel role for plant volatiles by influencing insect interactions with natural pathogens, probably mediated by alterations in the insect microbiota composition In addition,this work provides evidence for selectable plant traits (production of secondary metabolites) that can have an influence on the ecol. of the pests and could be relevant in the improvement of pest management strategies using natural entomopathogens.

Applied and Environmental Microbiology published new progress about Bacillus thuringiensis. 78-70-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C10H18O, Synthetic Route of 78-70-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts