Month: October 2022

Chimento, Adele; De Amicis, Francesca; Sirianni, Rosa; Sinicropi, Maria Stefania; Puoci, Francesco; Casaburi, Ivan; Saturnino, Carmela; Pezzi, Vincenzo published the artcile< Progress to improve oral bioavailability and beneficial effects of resveratrol>, Formula: C14H12O3, the main research area is review resveratrol oral bioavailability beneficial effect; resveratrol; resveratrol bioavailability; resveratrol delivery systems; resveratrol derivatives.

A review. Resveratrol (3,5,4′-trihydroxystilbene; RSV) is a natural nonflavonoid polyphenol present in many species of plants, particularly in grapes, blueberries, and peanuts. Several in vitro and in vivo studies have shown that in addition to antioxidant, anti-inflammatory, cardioprotective and neuroprotective actions, it exhibits antitumor properties. In mammalian models, RSV is extensively metabolized and rapidly eliminated and therefore it shows a poor bioavailability, in spite it of its lipophilic nature. During the past decade, in order to improve RSV low aqueous solubility, absorption, membrane transport, and its poor bioavailability, various methodol. approaches and different synthetic derivatives have been developed. In this review, we will describe the strategies used to improve pharmacokinetic characteristics and then beneficial effects of RSV. These methodol. approaches include RSV nanoencapsulation in lipid nanocarriers or liposomes, nanoemulsions, micelles, insertion into polymeric particles, solid dispersions, and nanocrystals. Moreover, the biol. results obtained on several synthetic derivatives containing different substituents, such as methoxylic, hydroxylic groups, or halogens on the RSV aromatic rings, will be described. Results reported in the literature are encouraging but require addnl. in vivo studies, to support clin. applications.

International Journal of Molecular Sciences published new progress about Arachis hypogaea. 501-36-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C14H12O3, Formula: C14H12O3.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Huang, Fei; Hong, Ruiyue; Zhang, Ruifen; Yi, Yang; Dong, Lihong; Liu, Lei; Jia, Xuchao; Ma, Yongxuan; Zhang, Mingwei published the artcile< Physicochemical and biological properties of longan pulp polysaccharides modified by Lactobacillus fermentum fermentation>, COA of Formula: C6H12O6, the main research area is polysaccharides modified by Lactobacillus fermentum fermentation; Biological activity; Fermentation; Longan polysaccharide.

Longan polysaccharides are valuable compounds with many biol. activities. Lactobacillus fermentum was selected to ferment longan pulp and the polysaccharides from unfermented and fermented longan pulp (denoted as LP and LP-F, resp.) were isolated. Their physicochem., immunomodulatory and prebiotic activities were investigated. The results revealed that LP-F, the mol. weight of which was lower than that of LP, contained less neutral sugar, uronic acid and glucose but more arabinose, galactose, rhamnose and mannose. Compared with LP, LP-F had better solubility, lower apparent viscosity and particle size. LP-F exhibited stronger stimulation on macrophages secretion of NO and IL-6, as well as better proliferation of Leuconostoc mesenteroides and Lactobacillus casei. In summary, fermentation treatment could change the physicochem. properties and enhance the bioactivity of polysaccharides from longan pulp.

International Journal of Biological Macromolecules published new progress about Dimocarpus longan (pulp). 3458-28-4 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H12O6, COA of Formula: C6H12O6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Tressl, Roland; Wondrak, Georg T.; Krueger, Ralph-Peter; Rewicki, Dieter published the artcile< New Melanoidin-like Maillard Polymers from 2-Deoxypentoses>, Application In Synthesis of 52160-51-7, the main research area is melanoidin Maillard polymer deoxypentose oligomerization antioxidant.

In the 2-deoxy-D-ribose/methyl 4-aminobutyrate Maillard system a trapped N-substituted 2-(hydroxymethyl)pyrrole is one of the major products. However, nontrapped representatives of this type of compound were hitherto not found in other Maillard model systems, indicating their extraordinary reactivity. Model experiments with 2-deoxy-D-ribose/methylamine enabled the detection of N-methyl-2-(hydroxymethyl)pyrrole and some derived linear oligomers as minor components. Consequently, N-methyl-2-(hydroxymethyl)pyrrole was synthesized and its oligomerization was studied under very mild acidic conditions. The deformylated dimeric bis(N-methyl-2-pyrrolyl)methane and trimeric N-methyl-2,5-bis(N-methyl-2-pyrrolylmethyl)pyrrole were characterized by GC/MS and NMR. Higher regular oligomers up to 6 N-methyl-2-pyrrolylmethyl units as well as corresponding dehydro-oligomers up to 12 units were identified by MALDI-TOF-MS. A complementary experiment starting with N-methyl-2-hydroxy[13C]methylpyrrole confirmed the structure and the oligomerization pathway. The possible significance of this type of model oligomer for the melanoidin formation in Maillard reactions is discussed. The antioxidative activity of the isolated dimer and trimer was tested in Fe(III)-thiocyanate and DPPH assays.

Journal of Agricultural and Food Chemistry published new progress about Antioxidants. 52160-51-7 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H9NO, Application In Synthesis of 52160-51-7.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Kumar, Akshay; Kujur, Anupam; Singh, Prem Pratap; Prakash, Bhanu published the artcile< Nanoencapsulated plant-based bioactive formulation against food-borne molds and aflatoxin B1 contamination: Preparation, characterization and stability evaluation in the food system>, Recommanded Product: 3,7-Dimethylocta-1,6-dien-3-ol, the main research area is nanoencapsulation aflatoxin mold; Aflatoxin B(1); Antifungal; Mode of action; Nanoencapsulation; Plant-based formulation.

A novel synergistic formulation (TML) based on the combination of thymol (T), Me cinnamate (M), and linalool (L) has been prepared using the mixture design assay. Nanoencapsulation of developed formulation TML (Ne-TML) was prepared and characterised by SEM, XRD and FTIR. The Ne-TML was assessed for its antifungal and anti-aflatoxin B1 potential in vitro and in the food systems (Pennisetum glaucum L.), and also examined its effects on organoleptic properties. The Ne-TML cause complete inhibition of growth and AFB1 production at 0.3 μl/mL and 0.2 μl/mL. In-situ results revealed that Ne-TML exhibited maximum protection from fungal (75.40%) and aflatoxin B1 contamination (100%) at 0.3 μl/mL during six months of storage. The speculated antifungal mode of action of Ne-TML was related to the decrease in ergosterol content, membrane ions leakage, impairment in carbon-source utilization, mitochondrial functioning, anti-oxidative defense system (SOD, CAT, and GR) and Ver-1 gene of aflatoxin B1 biosynthesis.

Food Chemistry published new progress about Essential oils Role: BUU (Biological Use, Unclassified), BIOL (Biological Study), USES (Uses). 78-70-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C10H18O, Recommanded Product: 3,7-Dimethylocta-1,6-dien-3-ol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Mondal, Rajarshi; Herbert, David E. published the artcile< Synthesis of Pyridines, Quinolines, and Pyrimidines via Acceptorless Dehydrogenative Coupling Catalyzed by a Simple Bidentate P^N Ligand Supported Ru Complex>, Related Products of 5344-90-1, the main research area is ruthenium catalyst dehydrogenative coupling multicomponent alc mol structure mechanism; pyridine quinoline pyrimidine preparation aldehyde adduct.

A ruthenium hydrido chloride complex supported by a simple, heteroleptic bidentate PN̂ ligand (I) containing a diarylphosphine and a benzannulated phenanthridine donor arm is reported. In the presence of base, the complex catalyzes multicomponent reactions using alc. precursors to produce structurally diverse mols. including pyridines, quinolines and pyrimidines via acceptorless dehydrogenative coupling pathways. Notably, I does not bear readily (de)protonated Bronsted acidic or basic groups common to transition metal catalysts capable of these sorts of transformations, suggesting metal-ligand cooperativity does not play a significant role in the catalytic reactivity of the complex. A rare example of an η2-aldehyde adduct of ruthenium was isolated and structurally characterized, and its role in acceptorless dehydrogenative coupling reactions is discussed.

Organometallics published new progress about Amino alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 5344-90-1 belongs to class alcohols-buliding-blocks, and the molecular formula is C7H9NO, Related Products of 5344-90-1.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Zhao, Peng; El-kott, Attalla; Ahmed, Ahmed Ezzat; Khames, Ahmed; Zein, Mohamed Abdellatif published the artcile< Green synthesis of gold nanoparticles (Au NPs) using Tribulus terrestris extract: Investigation of its catalytic activity in the oxidation of sulfides to sulfoxides and study of its anti-acute leukemia activity>, Computed Properties of 699-12-7, the main research area is green preparation gold nanoparticle; XRD particle size distribution gold nanoparticle; sulfide oxidation gold nanoparticle catalyst; sulfoxide preparation catalyst gold nanoparticle; antiacute leukemia activity gold nanoparticle; antioxidant activity gold nanoparticle; cytotoxicity gold nanoparticle.

With regards to applied, facile, green chem. research, a bio-inspired approach is being reported for the synthesis of Au NPs by using Tribulus terrestris extract The innate oxygenated phytochems. facilitated the green reduction of Au3+ ions to corresponding NPs and also stabilized them by encapsulating them. This modification prevented the as-synthesized Au NPs towards agglomeration and tiny NPs were obtained in uniformly spherical in shape and at 10-15 nm dimension. Physicochem. characteristics of the green synthesized Au NPs were evaluated by advanced physicochem. techniques like UV-visible and FTIR spectroscopy, SEM, TEM, EDX and XRD study. Catalytic performance of the biomol. functionalized Au NPs was studied in the controlled and selective oxidation of sulfides to sulfoxides using hydrogen peroxide as green oxidant at room temperature Aromatic, aliphatic and heterocyclic sulfides were oxidized to their corresponding sulfoxides with high yields without formation of over oxidized sulfones. The catalyst was easily recovered and recycled for 8 successive times without noticeable decrease in catalytic activity. In addition, the biosynthesized Au NPs indicated suitable antioxidant and anti-acute leukemia properties against THP-1 cell line. Tribulus terrestris extract and the green synthesized Au NPs exhibited a maximum DPPH scavenging activity of 78% and 29.37%, resp. Again, in the anticancer studies over THP-1 cell line following MTT assay, the Au NP exhibited gradual reduced % cell viability with increase in its concentration At an Au NPs concentration of 2000μg/mL, the % toxicity became maximum suggesting efficient inhibition of cancer invasion. Based on the above results, Au NPs-Tribulus could be administered as a potential anti-leukemia drug for the treatment of acute leukemia following the clin. trial studies in humans.

Inorganic Chemistry Communications published new progress about Cytotoxicity. 699-12-7 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H10OS, Computed Properties of 699-12-7.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Wu, Tun-Hui; Su, Zih-Syuan; Sung, Robert; Sung, Kuangsen published the artcile< Aza-ortho-Quinone Methide and Its Conjugated Acid: Reactivity, Stability and Acidity>, Quality Control of 5344-90-1, the main research area is quinone methide laser flash photolysis kinetics reactivity chem stability; acidity; aza-o-quinone methide; cycloaddition; drug metabolite; reactivity.

Aza-o-quinone methides and their conjugated acids are reactive drug metabolites that might react with nucleophilic sites of DNAs and proteins to cause cancer or immune responses, and their reactivity with water is the key information to judge if these metabolites are harmful in living systems. For the first time, aza-o-quinone methide (1) and its conjugated acid (2) are observed by laser flash photolysis, and their reactivity, stability and acidity in water are determined

ChemPhysChem published new progress about Absorption spectra. 5344-90-1 belongs to class alcohols-buliding-blocks, and the molecular formula is C7H9NO, Quality Control of 5344-90-1.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Zhang, Y-J; Zhao, H; Dong, L; Zhen, Y-F; Xing, H-Y; Ma, H-J; Song, G-Y published the artcile< Resveratrol ameliorates high-fat diet-induced insulin resistance and fatty acid oxidation via ATM-AMPK axis in skeletal muscle.>, COA of Formula: C14H12O3, the main research area is .

OBJECTIVE: Resveratrol (RSV) is a polyphenolic phytoalexin that exhibits diverse pharmacological actions, including its effect on the insulin resistance. However, the mechanism through which RSV improves insulin resistance is not fully understood yet. The aim of this study was to determine the mechanism through which RSV ameliorates insulin resistance in skeletal muscle of high-fat diet (HFD)-induced mouse model, as well as palmitic acid (PA) treated L6 cells, with a specific focus on the response of RSV on fatty acid oxidation. MATERIALS AND METHODS: Male C57BL6/J mice were randomly divided into three groups: normal diet-fed mice (ND), the high-fat diet-fed mice (HFD), HFD supplemented with RSV (100 mg/kg body weight [BW]/day orally; n = 10). Fasting plasma glucose, insulin, total cholesterol, triglyceride (TG), and free fatty acid levels were determined. The intraperitoneal glucose tolerance test was used to measure blood glucose and area under the curve. The quantitative insulin sensitivity index was calculated to assess insulin resistance. Skeletal muscles were collected for histology study and protein expression measurement. L6 cells were cultured with PA and the glucose concentration in the culture medium, and the intracellular TG levels were tested. RSV, chloroquine, palmitoyltransferase and Ku-55933 were administered to differentiate L6 cells. RESULTS: The HFD fed mice showed increased BW, hyperglycemia, and hyperlipidemia. The expressions of ataxia telangiectasia mutated (ATM), 5′ adenosine monophosphate-activated protein kinase (AMPK), carnitine palmitoyltransferase 1, cytochrome oxidase subunit IV protein were significantly decreased in the skeletal muscles of HFD fed mice and PA-treated L6 cells. All these effects induced by HFD and PA were reversed by RSV treatment. CONCLUSIONS: ATM is a key factor to improve HFD-induced lipid metabolism and insulin resistance in skeletal muscles. The effects of RSV on ameliorating HFD-induced abnormal lipid metabolism and insulin resistance mediated through ATM-AMPK pathway may due to its improvement in fatty acid oxidation efficiency and sequential reduction in ROS production in skeletal muscle. These results provide important theoretical evidence for the application of RSV in the prevention and treatment of diabetes mellitus and related metabolic diseases.

European review for medical and pharmacological sciences published new progress about 501-36-0 . 501-36-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C14H12O3, COA of Formula: C14H12O3.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts