Month: October 2022

Chen, Zewei; Lv, Kang; Yuan, Taoyue; Zhang, Xuguang; Yao, Weiwei; Ma, Mengtao published the artcile< Electrochemical hydroboration of carbonyl compounds>, Computed Properties of 403-41-8, the main research area is aryl alkyl alc preparation; boronic ester preparation regioselective green chem hydrolysis; carbonyl compound tetramethyl dioxaborolane electrochem hydroboration.

A green and sustainable electrochem. hydroboration of carbonyl compounds RC(O)R1 (R = Bu, Ph, cyclohexyl, pyridin-4-yl, etc.; R1 = H, Me, Ph, i-Pr, 2-fluorophenyl) with HBpin has been reported for the first time. Under catalyst-free and additive-free mild reaction conditions the corresponding boronic esters RR1CHOBpin were obtained in excellent yields via the simple electrochem. hydroboration of various aldehydes and ketones with HBpin at room temperature The scale-up reaction demonstrated potential practical applications. A plausible reaction mechanism was proposed based on the corresponding deuterium-labeling, radical inhibition and cyclic voltammetry experiments

Dalton Transactions published new progress about Aldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 403-41-8 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H9FO, Computed Properties of 403-41-8.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Yun, Xue-Jing; Zhu, Jing-Wei; Jin, Yan; Deng, Wei; Yao, Zi-Jian published the artcile< Half-Sandwich Ruthenium Complexes for One-Pot Synthesis of Quinolines and Tetrahydroquinolines: Diverse Catalytic Activity in the Coupled Cyclization and Hydrogenation Process>, Application In Synthesis of 5344-90-1, the main research area is ruthenium half sandwich cyclometalated complex preparation hydrogenation catalyst; amine ketone hydrogenation catalyst ruthenium half sandwich cyclometalated complex.

Four types of half-sandwich ruthenium complexes with an N,O-coordinate mode based on hydroxyindanone-imine ligands have been prepared in good yields. These stable ruthenium complexes exhibited high activity in the catalytic synthesis of quinolines from the reactions of amino alcs. with different types of ketones or secondary alcs. under very mild conditions. Moreover, the methodol. for the direct one-pot synthesis of tetrahydroquinoline derivatives from amino alcs. and ketones has been also developed on the basis of the continuous catalytic activity of this ruthenium catalyst in the selective hydrogenation of the obtained quinoline derivatives with a low catalyst loading. The corresponding products, quinolines and tetrahydroquinoline derivatives, were afforded in good to excellent yields. The efficient and diverse catalytic activity of these ruthenium complexes suggested their potential large-scale application. All of the ruthenium complexes were characterized by various spectroscopies to confirm their structures. Half-sandwich ruthenium complexes based on hydroxyindanone-imine ligands exhibited high activity in the catalytic synthesis of quinoline derivatives starting from amino alcs. and ketones as well as secondary alcs. under very mild conditions. One-pot synthesis of tetrahydroquinoline has been also developed on the basis of the continuous catalytic activity of these ruthenium catalysts in selective hydrogenation.

Inorganic Chemistry published new progress about Aralkyl amines Role: RCT (Reactant), RACT (Reactant or Reagent). 5344-90-1 belongs to class alcohols-buliding-blocks, and the molecular formula is C7H9NO, Application In Synthesis of 5344-90-1.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Sarkar, Parijat; Kumar, G. Aditya; Shrivastava, Sandeep; Chattopadhyay, Amitabha published the artcile< Chronic cholesterol depletion increases F-actin levels and induces cytoskeletal reorganization via a dual mechanism>, Formula: C27H44O, the main research area is chronic cholesterol depletion Factin cytoskeletal reorganization dual mechanism; F-actin; MβCD; Rho GTPase; actin polymerization; cholesterol; confocal microscopy; methyl-β-cyclodextrin; phosphatidylinositol; plasma membrane; statins.

Previous work from us and others has suggested that cholesterol is an important lipid in the context of the organization of the actin cytoskeleton. However, reorganization of the actin cytoskeleton upon modulation of membrane cholesterol is rarely addressed in the literature. In this work, we explored the signaling crosstalk between cholesterol and the actin cytoskeleton by using a high-resolution confocal microscopic approach to quant. measure changes in F-actin content upon cholesterol depletion. Our results show that F-actin content significantly increases upon chronic cholesterol depletion, but not during acute cholesterol depletion. In addition, utilizing inhibitors targeting the cholesterol biosynthetic pathway at different steps, we show that reorganization of the actin cytoskeleton could occur due to the synergistic effect of multiple pathways, including prenylated Rho GTPases and availability of membrane phosphatidylinositol 4,5-bisphosphate. These results constitute one of the first comprehensive dissections of the mechanistic basis underlying the interplay between cellular actin levels and cholesterol biosynthesis. We envision these results will be relevant for future understating of the remodeling of the actin cytoskeleton in pathol. conditions with altered cholesterol.

Journal of Lipid Research published new progress about Apoptosis. 434-16-2 belongs to class alcohols-buliding-blocks, and the molecular formula is C27H44O, Formula: C27H44O.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Yavuz, Ulas; Alaylioglu, Merve; Sengul, Busra; Karras, Spyridon N.; Gezen-Ak, Duygu; Dursun, Erdinc published the artcile< Protein disulfide isomerase A3 might be involved in the regulation of 24-dehydrocholesterol reductase via vitamin D equilibrium in primary cortical neurons>, Recommanded Product: (3S,9S,10R,13R,14R,17R)-10,13-Dimethyl-17-((R)-6-methylheptan-2-yl)-2,3,4,9,10,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-ol, the main research area is cortical neuron protein disulfide isomerase vitamin D treatment; 24-dehydrocholesterol reductase; Neurodegeneration; Primary neuronal culture; Protein disulfide isomerase A3; Vitamin D.

Vitamin D is a secosteroid hormone mediating its functions via vitamin D receptor (VDR) and an endoplasmic reticulum chaperone, protein disulfide isomerase A3 (PDIA3). From a physiol. perspective, there is also a well-established association of cholesterol and vitamin D synthesis, since both share a common metabolic substrate, 7 dehydrocholesterol (7-DHC). Yet, the potential basic pathways, of the biol. interplay of DHCR24 and vitamin D equilibrium, on neuronal level, are yet to be determined In this study, we aimed to investigate the relation between vitamin D pathways and DHCR24 in primary cortical neuron cultures. The neocortex of Sprague-Dawley rat embryos (E16) was used for the preparation of primary cortical neuron cultures. DHCR24 mRNA and protein expression levels were determined by qRT-PCR, Western blotting, and immunofluorescent labeling in 1,25-dihydroxyvitamin D3-treated or VDR/PDIA3-silenced primary cortical neurons. The mRNA expression of DHCR24 was significantly decreased in the cortical neurons treated with 10-8M 1,25-dihydroxyvitamin D3 (p<0.001). In parallel with the mRNA results, DHCR24 protein expression in cortical neurons treated with 10-8M 1,25-dihydroxyvitamin D3 was also significantly lower than untreated neurons (p<0.05). These data were also confirmed with immunofluorescent labeling and fluorescence intensity measurements of DHCR24 (p<0.001). Finally, DHCR24 mRNA expression level was significantly increased in PDIA3 siRNA-treated neurons (p<0.05). Similar to the mRNA results, the DHCR24 protein expression of PDIA3 siRNA-treated neurons was also statistically higher than the other groups (p<0.05). Results of this mechanistic exptl. basic study demonstrate that DHCR24 mRNA expression and protein concentrations attenuated in response to vitamin D treatment. Furthermore, we observed that PDIA3 might be involved in this modulatory effect. Our findings indicate a complex interaction of DHCR24 and vitamin D equilibrium, through the involvement of PDIA3 and vitamin D in the modulation of cholesterol metabolism in neuronal cells, requiring future studies on the field. In Vitro Cellular & Developmental Biology: Animal published new progress about Cerebral neocortex. 434-16-2 belongs to class alcohols-buliding-blocks, and the molecular formula is C27H44O, Recommanded Product: (3S,9S,10R,13R,14R,17R)-10,13-Dimethyl-17-((R)-6-methylheptan-2-yl)-2,3,4,9,10,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-ol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Wu, Haifan; Saltzberg, Daniel J.; Kratochvil, Huong T.; Jo, Hyunil; Sali, Andrej; DeGrado, William F. published the artcile< Glutamine Side Chain 13C=18O as a Nonperturbative IR Probe of Amyloid Fibril Hydration and Assembly>, Synthetic Route of 76-84-6, the main research area is glutamine carbon oxygen isotope amyloid fibril IR spectroscopy.

IR spectroscopy has provided considerable insight into the structures, dynamics, and formation mechanisms of amyloid fibrils. IR probes, such as main chain 13C=18O, have been widely employed to obtain site-specific structural information, yet only secondary structures and strand-to-strand arrangements can be probed. Very few nonperturbative IR probes are available to report on the side-chain conformation and environments, which are critical to determining sheet-to-sheet arrangements in steric zippers within amyloids. Polar residues, such as glutamine, contribute significantly to the stability of amyloids and thus are frequently found in core regions of amyloid peptides/proteins. Furthermore, polyglutamine (polyQ) repeats form toxic aggregates in several neurodegenerative diseases. Here the authors report the synthesis and application of a new nonperturbative IR probe-glutamine side chain 13C=18O. The authors use side chain 13C=18O labeling and isotope dilution to detect the presence of intermolecularly hydrogen-bonded arrays of glutamine side chains (Gln ladders) in amyloid-forming peptides. Moreover, the line width of the 13C=18O peak is highly sensitive to its local hydration environment. The IR data from side chain labeling allows us to unambiguously determine the sheet-to-sheet arrangement in a short amyloid-forming peptide, GNNQQNY, providing insight that was otherwise inaccessible through main chain labeling. With several different fibril samples, the authors also show the versatility of this IR probe in studying the structures and aggregation kinetics of amyloids. Finally, the authors demonstrate the capability of modeling amyloid structures with IR data using the integrative modeling platform (IMP) and the potential of integrating IR with other biophys. methods for more accurate structural modeling. Together, the authors believe that side chain 13C=18O will complement main chain isotope labeling in future IR studies of amyloids and integrative modeling using IR data will significantly expand the power of IR spectroscopy to elucidate amyloid assemblies.

Journal of the American Chemical Society published new progress about Amyloid fibril. 76-84-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C19H16O, Synthetic Route of 76-84-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Cai, Wei; Zhou, Yiming; He, Yanlin; Huang, You published the artcile< DABCO catalyzed [4+2] annulations of Morita-Baylis-Hillman carbonates with isocyanates>, COA of Formula: C7H9NO, the main research area is alkoxy oxopropenyl dihydroquinazoline carboxylate preparation; MBH carbonate preparation isocyanate DABCO catalyst chemoselective cycloaddition.

A highly concise method for 1,4-diazabicyclo[2.2.2]octane (DABCO) catalyzed [4+2] annulations of o-amino-acylation of aryl Morita-Baylis-Hillman (MBH) carbonates with isocyanates was developed. For the first time, MBH carbonates served as 1,4-dipoles, providing functionalized 3,4-dihydroquinazolinones in mild conditions with good to excellent yields. The d. functional theory calculations of the mechanism supports this hypothesis.

Chemical Communications (Cambridge, United Kingdom) published new progress about [4+2] Cycloaddition reaction (chemoselective). 5344-90-1 belongs to class alcohols-buliding-blocks, and the molecular formula is C7H9NO, COA of Formula: C7H9NO.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Karpinski, Tomasz M. published the artcile< Essential oils of lamiaceae family plants as antifungals>, Application of C10H18O, the main research area is review lamiaceae Essential oil antifungals.

A review. The incidence of fungal infections has been steadily increasing in recent years. Systemic mycoses are characterized by the highest mortality. At the same time, the frequency of infections caused by drug-resistant strains and new pathogens e.g., Candida auris increases. An alternative to medicines may be essential oils, which can have a broad antimicrobial spectrum. Rich in the essential oils are plants from the Lamiaceae family. In this review are presented antifungal activities of essential oils from 72 Lamiaceae plants. More than half of these have good activity (min. inhibitory concentrations (MICs) < 1000μg/mL) against fungi. The best activity (MICs < 100) have essential oils from some species of the genera Clinopodium, Lavandula, Mentha, Thymbra, and Thymus. In some cases were observed significant discrepancies between different studies. In the review are also shown the most important compounds of described essential oils. To the chem. components most commonly found as the main ingredients include β-caryophyllene (41 plants), linalool (27 plants), limonene (26), β-pinene (25), 1,8-cineole (22), carvacrol (21), α-pinene (21), p-cymene (20), γ-terpinene (20), and thymol (20). Biomolecules published new progress about Candida auris. 78-70-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C10H18O, Application of C10H18O.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Li, Yunfei; Liu, Jia; Chen, Xuepeng; Yuan, Xiaole; Li, Nan; He, Weihua; Feng, Yujie published the artcile< Tailoring spatial structure of electroactive biofilm for enhanced activity and direct electron transfer on iron phthalocyanine modified anode in microbial fuel cells>, Quality Control of 492-62-6, the main research area is phthalocyanine modified anode electroactive biofilm electricity electrochem property; C-type cytochromes; Electroactive biofilm; Extracellular electron transfer; Iron phthalocyanine; Microbial fuel cell; Spatial structure.

Electroactive biofilm (EAB) has been considered as the core determining electricity generation in microbial fuel cells (MFCs), and its spatial structure regulation for enhanced activity and selectivity is of great concern. In this study, iron phthalocyanine (FePc) was introduced into a carbon cloth (CC) electrode, aiming at improving the affinity between the anode and outer membrane c-type cytochromes (OM c-Cyts) and achieving a highly active EAB. The FePc modified CC anode (FePc-CC) effectively improved the viability of EAB and enriched the Geobacter species up to 44.83% (FePc-CC) from 6.97% (CC). The FePc-CC anode achieved a much higher power d. of 2419 mW m-2 than the CC (560 mW m-2) and a remarkable higher biomass loading of 2477.2 ± 84.5μg cm-2 than the CC (749.3 ± 31.3μg cm-2). As the charge transfer resistance was decreased by 58.6 times from 395.2 Ω (CC) to 6.74 Ω (FePc-CC), the interfacial reaction rate was accelerated and the direct electron transfer via OM c-Cyts was promoted. This work provides an effective method to improve the EAB activity by regulating its spatial structure, and opens the door toward the development of highly active EAB using metal phthalocyanines in MFCs.

Biosensors & Bioelectronics published new progress about Binding energy. 492-62-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H12O6, Quality Control of 492-62-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Huang, Fei; Hong, Ruiyue; Yi, Yang; Bai, Yajuan; Dong, Lihong; Jia, Xuchao; Zhang, Ruifen; Wang, Guangjin; Zhang, Mingwei; Wu, Jian published the artcile< In vitro digestion and human gut microbiota fermentation of longan pulp polysaccharides as affected by Lactobacillus fermentum fermentation>, Related Products of 3458-28-4, the main research area is Lactobacillus Dimocarpus fermentation polysaccharide gut; Digestion; Fermentation; Longan polysaccharide.

This study investigated the effect of Lactobacillus fermentum fermentation treatment on the gastrointestinal digestion and fermentation in vitro of polysaccharides from longan pulp. Polysaccharide isolated from unfermented and fermented longan pulp named LP and LP-F, resp. The mol. weight of LP-F declined from 109.62 ± 10.66 kDa to 51.46 ± 6.26 kDa while that of LP declined from 221.63 ± 2.41 kDa to 69.68 ± 2.36 kDa with gastrointestinal digestion. At same time, the reducing sugars content of LP and LP-F were both increased significantly. In addition, after 48 h gut microbiota fermentation, there were more total short chain fatty acids and acetic acid, as well as more Enterococcus, Bifidobacterium, and Clostridium in LP-F fermentation culture than those in LP fermentation culture. Moreover, LP-F fermentation culture showed lower pH value and less residual carbohydrate percentage than that of LP. These results indicated that LP-F is easier than LP to be fermented by human gut microbiota.

International Journal of Biological Macromolecules published new progress about Bifidobacterium. 3458-28-4 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H12O6, Related Products of 3458-28-4.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts