Month: October 2022

Xiong, Jiu-Qiang; Zhao, Chen-Yu; Qin, Jing-Yu; Cui, Pengfei; Zhong, Qiu-Lian; Ru, Shaoguo published the artcile< Metabolic perturbations of Lolium perenne L. by enrofloxacin: Bioaccumulation and multistage defense system>, Synthetic Route of 492-62-6, the main research area is glycolysis tricarboxylic acid metabolic perturbation bioaccumulation Lolium perenne; Defense systems; Ecotoxicological risks; Energy metabolism; Pasture grass; Pharmaceutical contaminants; Reclaimed water.

Plants are readily exposed to the antibiotics residues in reclaimed water indicating an urgent need to comprehensively analyze their ecotoxicol. effects and fate of these emerging contaminants. Here, we unraveled the dissemination of enrofloxacin (ENR) in a pasture grass, Lolium perenne L., and identified multistage defense systems as its adaptation mechanism. Uptaken concentrations of ENR ranged from 1.28 to 246.60μg g-1 with bioconcentration factors (BCF) upto 15.13, and translocation factors (TF) upto 0.332. The antioxidant enzymic activities such as superoxide dismutase, peroxidase, and catalase were increased by upto 115%. Further transcriptomics demonstrated that differentially expressed genes (DEGs) involved in glycolysis, tricarboxylic acid (TCA) cycle, oxidative phosphorylation, and glutathione metabolism were significantly up-regulated by 1.56-5.93, 3-7 and 1.04-6.42 times, resp.; while, the DEGs in nitrogen and sulfur metabolism pathways were significantly up-regulated by 1.06-5.64 and 2.64-3.54 folds. These processes can supply energy, signaling mols., and antioxidants for detoxification of ENR in ryegrass. Such results provide understanding into fasting grass adaptability to antibiotics by enhancing the key protective pathways under organic pollutant stresses in environments.

Journal of Hazardous Materials published new progress about Antibiotics. 492-62-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H12O6, Synthetic Route of 492-62-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Bhanja, Piyali; Das, Sabuj K.; Bhunia, Kousik; Pradhan, Debabrata; Hayashi, Taku; Hijikata, Yuh; Irle, Stephan; Bhaumik, Asim published the artcile< A New Porous Polymer for Highly Efficient Capacitive Energy Storage>, Application In Synthesis of 4396-13-8, the main research area is porous polymer supercapacitor electrode capacitance triazine isophthalaldehyde.

The new porous polymer TPDA-1 has been synthesized via solvothermal Schiff base condensation reaction between two organic monomers, i.e., 2,4,6-trihydroxyisophthalaldehyde and 1,3,5-tris(4-aminophenyl)triazine. The TPDA-1 material showed a very high specific capacitance of 469.4 F g-1, at 2 mV s-1 scan rate, together with a high sp. surface area of 545 m2 g-1. It also exhibited excellent cyclic stability with 95% retention of its initial specific capacitance after 1000 cycles at 5 A g-1, suggesting its potential as a high performance supercapacitor. Extended π-conjugation and ion conduction inside the micropores throughout the whole polymeric matrix and high BET surface area could be responsible for this high supercapacitor performance in energy storage device. TPDA-1 has been characterized thoroughly by various electrochem. techniques such as cyclic voltammetry, galvanic charge-discharge, and electrochem. impedance spectroscopy. Our exptl. results suggested a high potential of this porous polymer in energy storage devices for future generation.

ACS Sustainable Chemistry & Engineering published new progress about Aminoplasts Role: PRP (Properties), SPN (Synthetic Preparation), TEM (Technical or Engineered Material Use), PREP (Preparation), USES (Uses). 4396-13-8 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H6O5, Application In Synthesis of 4396-13-8.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Tavakoli, Ghazal; Prechtl, Martin H. G. published the artcile< The reductive deaminative conversion of nitriles to alcohols using para-formaldehyde in aqueous solution>, Recommanded Product: (2-Aminophenyl)methanol, the main research area is benzylic alkyl primary alc chemoselective preparation; ruthenium catalyst chemoselective reduction nitrile paraformaldehyde water; mechanism reductive deamination nitrile paraformaldehyde water ruthenium catalyst.

In the presence of [Ru(p-cymene)Cl2]2, paraformaldehyde in H2O/toluene acted as a reductant for the chemoselective reductive deamination of alkyl and aryl nitriles to yield alkyl or benzylic primary alcs. The mechanism of the reaction is studied using the characterization of reaction intermediates by mass spectrometry; dimeric ruthenium complexes are necessary to generate reduced ruthenium complexes from paraformaldehyde, while nitrile coordination generates monomeric complexes of ruthenium which reduce the nitriles to alcs.

Catalysis Science & Technology published new progress about Aralkyl alcohols Role: SPN (Synthetic Preparation), PREP (Preparation). 5344-90-1 belongs to class alcohols-buliding-blocks, and the molecular formula is C7H9NO, Recommanded Product: (2-Aminophenyl)methanol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Genaro-Mattos, Thiago C.; Klingelsmith, Korinne B.; Allen, Luke B.; Anderson, Allison; Tallman, Keri A.; Porter, Ned A.; Korade, Zeljka; Mirnics, Karoly published the artcile< Sterol Biosynthesis Inhibition in Pregnant Women Taking Prescription Medications>, Category: alcohols-buliding-blocks, the main research area is cholesterol DHCR7 7DHC pregnancy combinations neurodevelopment synergistic effect.

Sterol biosynthesis is a critical homeostatic mechanism of the body. Sterol biosynthesis begins during early embryonic life and continues throughout life. Many commonly used medications, prescribed >200 million times in the United States annually, have a sterol biosynthesis inhibition side effect. Using our high-throughput LC-MS/MS method, we assessed the levels of post-lanosterol sterol intermediates (lanosterol, desmosterol, and 7-dehydrocholesterol (7-DHC)) and cholesterol in 1312 deidentified serum samples from pregnant women. 302 samples showing elevated 7-DHC were analyzed for the presence of 14 medications known to inhibit the 7-dehydrocholesterol reductase enzyme (DHCR7) and increase 7-DHC. Of the 302 samples showing 7-DHC elevation, 43 had detectable levels of prescription medications with a DHCR7-inhibiting side effect. Taking more than one 7-DHC-elevating medication in specific combinations (polypharmacy) might exacerbate the effect on 7-DHC levels in pregnant women, suggesting a potentially additive or synergistic effect. As 7-DHC and 7-DHC-derived oxysterols are toxic, and as DHCR7-inhibiting medications are considered teratogens, our findings raise potential concerns regarding the use of prescription medication with a DHCR7-inhibiting side effect during pregnancy. The use of prescription medications during pregnancy is sometimes unavoidable, but choosing a medication without a DHCR7-inhibiting side effect might lead to a healthier pregnancy and prevent putatively adverse outcomes for the developing offspring.

ACS Pharmacology & Translational Science published new progress about Aging, animal. 434-16-2 belongs to class alcohols-buliding-blocks, and the molecular formula is C27H44O, Category: alcohols-buliding-blocks.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Li, Guangtao; Wang, Qing; Kakuda, Shinako; London, Erwin published the artcile< Nanodomains can persist at physiologic temperature in plasma membrane vesicles and be modulated by altering cell lipids>, Recommanded Product: (3S,9S,10R,13R,14R,17R)-10,13-Dimethyl-17-((R)-6-methylheptan-2-yl)-2,3,4,9,10,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-ol, the main research area is nanodomain physiol temperature plasma membrane vesicle cell lipid; giant vesicles; lipid substitution; phase separation.

The formation and properties of liquid-ordered lipid domains (rafts) in plasma membrane are still poorly understood. This limits our ability to manipulate ordered lipid domain-dependent biol. functions. Giant plasma membrane vesicles (GPMVs) undergo large-scale phase separations into coexisting Lo and liquid-disordered lipid domains. However, large-scale phase separation in GPMVs detected by light microscopy is observed only at low temperatures The persistence of nanodomains at higher temperatures is consistent with previously reported theor. calculations To investigate the sensitivity of nanodomains to lipid composition, GPMVs were prepared from mammalian cells in which sterol, phospholipid, or sphingolipid composition in the plasma membrane outer leaflet had been altered by cyclodextrin-catalyzed lipid exchange. Lipid substitutions that stabilize or destabilize ordered domain formation in artificial lipid vesicles had a similar effect on the thermal stability of nanodomains and large-scale phase separation in GPMVs, with nanodomains persisting at higher temperatures than large-scale phases for a wide range of lipid compositions This indicates that it is likely that plasma membrane nanodomains can form under physiol. conditions more readily than large-scale phase separation We also conclude that membrane lipid substitutions carried out in intact cells are able to modulate the propensity of plasma membranes to form ordered domains. This implies lipid substitutions can be used to alter biol. processes dependent upon ordered domains.

Journal of Lipid Research published new progress about Cell membrane. 434-16-2 belongs to class alcohols-buliding-blocks, and the molecular formula is C27H44O, Recommanded Product: (3S,9S,10R,13R,14R,17R)-10,13-Dimethyl-17-((R)-6-methylheptan-2-yl)-2,3,4,9,10,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-ol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Ahmed, Kabirun; Saikia, Gangutri; Paul, Sivangi; Baruah, Satyajit Dey; Talukdar, Hiya; Sharma, Mitu; Islam, Nashreen S. published the artcile< Water-soluble polymer anchored peroxotitanates as environmentally clean and recyclable catalysts for mild and selective oxidation of sulfides with H2O2 in water>, Application In Synthesis of 699-12-7, the main research area is sulfoxide sulfone green preparation peroxotitanate polymer recyclable catalyst; sulfide selective oxidation.

Anchoring of peroxotitanium (pTi) species to linear water-soluble acrylic acid based polymers, poly(sodium acrylate) (PA) and poly(sodium methacrylate) (PMA) led to the successful synthesis of a pair of new, water-tolerant and recyclable catalysts of the type [Ti2(O2)2O2(OH)2]4–L (L = PA or PMA), highly effective in chemoselective sulfoxidation of organic sulfides I (R = C6H5, Me, 4-MeC6H4, etc.; R’ = Me, C6H5, Bn, etc.) with 30% H2O2 in aqueous medium at ambient temperature The catalytic protocol is high yielding (TOF up to 11,280 h-1), operationally simple as well as environmentally clean and safe, being free from halide, or any other toxic auxiliaries. The catalysts are sufficiently stable to afford easy recyclability for at least 10 consecutive reaction cycles of sulfoxidation with consistent activity selectivity profile. Oxidation of dibenzothiophene (DBT) to resp. high purity sulfoxide or sulfone could also be accomplished using the same catalysts by variation of reaction conditions.

Tetrahedron published new progress about Green chemistry. 699-12-7 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H10OS, Application In Synthesis of 699-12-7.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Su, Min; Jing, Ya-Nan; Bao, Hongli; Wan, Wen-Ming published the artcile< Triarylmethanolation as a versatile strategy for the conversion of PAHs into amorphization-induced emission luminogens for extremely sensitive explosive detection and fabrication of artificial light-harvesting systems>, Application In Synthesis of 76-84-6, the main research area is triarylmethanolation.

Current synthetic strategies involving π-system coupling reactions for the mol. design of luminescent materials suffer from the challenging precise synthesis on the desired reactive site and also difficulty in solubility derived from the rigid structures of π-systems. Herein, a novel and versatile triarylmethanolation strategy for the mol. design of luminescent materials with facile synthesis and good solubility is reported. The prepared luminescent materials exhibit unique amorphization-induced emission (AmIE) behaviors, which represent an entropy-favored and ubiquitous type of aggregation-induced emission that is currently famous and is contrary to crystallization-induced emission. Due to the outstanding AmIE behaviors, the luminescent materials exhibit applications in the fields of rewritable display and storage, extremely sensitive explosive detection at the ppb level, and high-efficiency artificial light-harvesting system with an antenna effect up to 21.3. This work therefore expands the methodol., structure, and functionality libraries of luminescent materials with outstanding properties in the application fields of explosive detection, energy transfer, and artificial light-harvesting systems.

Materials Chemistry Frontiers published new progress about Crystal structure. 76-84-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C19H16O, Application In Synthesis of 76-84-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Fraga, Cesar G.; Croft, Kevin D.; Kennedy, David O.; Tomas-Barberan, Francisco A. published the artcile< The effects of polyphenols and other bioactives on human health>, Product Details of C14H12O3, the main research area is review polyphenols quercetin cerebral blood flow.

A review. Although deficiencies in polyphenol intake do not result in specific deficiency diseases, adequate intake of polyphenols could confer health benefits, especially with regard to chronic diseases. Tea, cocoa, fruits, and berries, as well as vegetables, are rich in polyphenols. Flavan-3-ols from cocoa have been found to be associated with a reduced risk of stroke, myocardial infarction, and diabetes, as well as improvements in lipids, endothelial-dependent blood flow and blood pressure, insulin resistance, and systemic inflammation. The flavonoid quercetin and the stilbene resveratrol have also been associated with cardiometabolic health. Although polyphenols have been associated with improved cerebral blood flow, evidence of an impact on cognition is more limited. The ability of dietary polyphenols to produce clin. effects may be due, at least in part, to a bi-directional relationship with the gut microbiota. Polyphenols can impact the composition of the gut microbiota (which are independently associated with health benefits), and gut bacteria metabolize polyphenols into bioactive compounds that produce clin. benefits. Another critical interaction is that of polyphenols with other phytochems., which could be relevant to interpreting the health parameter effects of polyphenols assayed as purified extracts, whole foods, or whole food extracts

Food & Function published new progress about Blood pressure Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 501-36-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C14H12O3, Product Details of C14H12O3.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Wang, Z. Yan; Pergande, Melissa R.; Ragsdale, Clifton W.; Cologna, Stephanie M. published the artcile< Steroid hormones of the octopus self-destruct system>, Quality Control of 434-16-2, the main research area is Octopus self destruct system steroid hormone; bile acids; cephalopod; dafachronic acids; longevity; maternal care; neuroendocrinology; neuroethology; progesterone; reproduction; senescence.

Among all invertebrates, soft-bodied cephalopods have the largest central nervous systems and the greatest brain-to-body mass ratios, yet unlike other big-brained animals, cephalopods are unusually short lived. Primates and corvids survive for many decades, but shallow-water octopuses, such as the California two-spot octopus (Octopus bimaculoides), typically live for only 1 yr. Lifespan and reproduction are controlled by the principal neuroendocrine center of the octopus: the optic glands, which are functional analogs to the vertebrate pituitary gland. After mating, females steadfastly brood their eggs, begin fasting, and undergo rapid physiol. decline, featuring repeated self-injury and leading to death. Removal of the optic glands completely reverses this life history trajectory, but the signaling factors underlying this major life transition are unknown. Here, we characterize the major secretions and steroidogenic pathways of the female optic gland using mass spectrometry techniques. We find that at least three pathways are mobilized to increase synthesis of select sterol hormones after reproduction One pathway generates pregnane steroids, known in other animals to support reproduction Two other pathways produce 7-dehydrocholesterol and bile acid intermediates, neither of which were previously known to be involved in semelparity. Our results provide insight into invertebrate cholesterol pathways and confirm a remarkable unity of steroid hormone biol. in life history processes across Bilateria.

Current Biology published new progress about Animal gene Role: BSU (Biological Study, Unclassified), BIOL (Biological Study) (DAF36). 434-16-2 belongs to class alcohols-buliding-blocks, and the molecular formula is C27H44O, Quality Control of 434-16-2.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Dambri, Oussama Abderrahmane; Cherkaoui, Soumaya published the artcile< Performance Enhancement of Diffusion-Based Molecular Communication.>, Application of C27H44O, the main research area is .

Inter-Symbol Interference (ISI) is one of the challenges of bio-inspired diffusion-based molecular communication. The degradation of the remaining molecules from a previous transmission is the solution that biological systems use to mitigate this ISI. While most prior work has proposed the use of enzymes to catalyze the molecules degradation, enzymes also degrade the molecules carrying the information, which drastically decreases the signal strength. In this paper, we propose the use of photolysis reactions, which use the light to instantly transform the emitted molecules so they no longer be recognized after their detection. The light will be emitted in an optimal time, allowing the receiver to detect as many molecules as possible, which increases both the signal strength and ISI mitigation. A lower bound expression on the expectation of the observed molecules number at the receiver is derived. Bit error probability expression is also formulated, and both expressions are validated with simulation results, which show a visible enhancement when using photolysis reactions. The performance of the proposed method is evaluated using Interference-to-Total-Received molecules metric (ITR) and the derived bit error probability.

IEEE transactions on nanobioscience published new progress about 434-16-2. 434-16-2 belongs to class alcohols-buliding-blocks, and the molecular formula is C27H44O, Application of C27H44O.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts