Month: October 2022

Safety of Octadecan-9-olOn March 31, 2002, Ohrui, Hiroshi; Terashima, Hanae; Imaizumi, Keiichiro; Akasaka, Kazuaki published an article in Proceedings of the Japan Academy, Series B: Physical and Biological Sciences. The article was 《A solution of the “”intrinsic problem”” of diastereomer method in chiral discrimination: Development of a method for highly efficient and sensitive discrimination of chiral alcohols》. The article mentions the following:

Very potent fluorescent chiral labeling reagents for alcs., (R,R)- and (S,S)-2-(anthracene-2,3-dicarboximido)cyclohexanecarboxylic acids, were developed. By labeling with them, the enantiomeric discriminations of primary alcs. having a Me branching at the carbon from 2 to 9 by 1H-NMR and from 2 to 16 by HPLC were achieved. Further, HPLC separations of all four optical isomers of Me branched secondary alcs. and enantiomers of 9-nonadecanol were also achieved. The experimental process involved the reaction of Octadecan-9-ol(cas: 591-70-8Safety of Octadecan-9-ol)

Octadecan-9-ol(cas: 591-70-8) belongs to hydroxy-containing compounds. Hydroxy-containing compounds engage in intermolecular hydrogen bonding increasing the electrostatic attraction between molecules and thus to higher boiling and melting points than found for compounds that lack this functional group. Organic compounds, which are often poorly soluble in water, become water-soluble when they contain two or more hydroxy groups, as illustrated by sugars and amino acid.Safety of Octadecan-9-ol

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Alcohol – Wikipedia,
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《Spectroscopic characterization and antimicrobial activity of nanoparticle doped cyclodextrin polyurethane bionanosponge》 was published in Materials Science & Engineering, C: Materials for Biological Applications in 2020. These research results belong to Leudjo Taka, Anny; Doyle, Bryan P.; Carleschi, Emanuela; Youmbi Fonkui, Thierry; Erasmus, Rudolph; Fosso-Kankeu, Elvis; Pillay, Kriveshini; Mbianda, Xavier Y.. Application In Synthesis of 6-Aminohexan-1-ol The article mentions the following:

This study reports on the spectroscopic characterization and antimicrobial potency of polyurethane cyclodextrin co-polymerized phosphorylated multiwalled carbon nanotube-doped Ag-TiO2 nanoparticle (pMWCNT-CD/Ag-TiO2) bionanosponge nanocomposite. The synthesis of pMWCNT-CD/Ag-TiO2 bionanosponge nanocomposite was carried out through the combined processes of amidation and polymerization reactions as well as the sol-gel method. The native nanosponge cyclodextrin and phosphorylated multiwalled carbon nanotube-nanosponge CD (pMWCNT-CD) polyurethanes were also prepared, and their antimicrobial activities carried out for comparison purposes. The potency tests of the synthesized compounds were carried out against three bacterial strains Escherichia coli, Bacillus subtilis, Staphylococcus aureus, and two fungal representatives Aspergillus ochraceus and Aspergillus fumigatus, using the disk diffusion method. Micro dilution and agar plating were used to determine the min. bactericidal concentration (MBC) and min. fungicidal concentration (MFC), resp. The results obtained revealed that pMWCNT-CD/Ag-TiO2 exhibits superior antibacterial and antifungal activities when compared to the other bionanosponge polymers tested. Thus, the bionanosponge polyurethane pMWCNT-CD/Ag-TiO2 nanocomposite can be considered as an active antimicrobial compound (AMC). In addition to this study using 6-Aminohexan-1-ol, there are many other studies that have used 6-Aminohexan-1-ol(cas: 4048-33-3Application In Synthesis of 6-Aminohexan-1-ol) was used in this study.

6-Aminohexan-1-ol(cas: 4048-33-3) may be used along with glutaric acid to generate poly(ester amide)s with excellent film- and fiber forming properties. It can undergo cyclization over copper supported on γ-alumina and magnesia to form hexahydro-1H-azepine.Application In Synthesis of 6-Aminohexan-1-ol

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《Research on the selection of a certain content of “”Ambronat”” juice syrup》 was published in International Journal of Pharmacy and Pharmaceutical Research in 2021. These research results belong to Mannanovna, Yunusova Kholida; Hikmatullaevna, Abdijalilova Zilola. Computed Properties of C13H19Br2ClN2O The article mentions the following:

This article presents several experiments on the selection of a specific composition of Ambronat syrup. These selected several excipients in the selection of the sweetness and consistency and consistency of the syrup, based on which the ingredients were considered, and the result was the result of the selection of a moderate content. In addition to this study using trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride, there are many other studies that have used trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride(cas: 23828-92-4Computed Properties of C13H19Br2ClN2O) was used in this study.

trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride(cas: 23828-92-4) enhances pulmonary surfactant production and stimulates ciliary activity.Computed Properties of C13H19Br2ClN2O It promotes mucus clearance, facilitates expectoration and eases productive cough, allowing patients to breathe.

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Alcohol – Wikipedia,
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《Mechanism of the Electrical Conductivity of a Film Consisting of Dielectric Nanoparticles with Surface Donor Centers》 was published in Journal of Surface Investigation: X-Ray, Synchrotron and Neutron Techniques in 2020. These research results belong to Kharlamov, V. F.. Electric Literature of C4H12KNaO10 The article mentions the following:

Abstract-: Restrictions imposed on the characteristics of a semiconductor by the condition that ohmic losses in it are zero are established using equations of the thermodn. of irreversible processes. A consequence of the neg. value of the static permittivity of a semiconductor consisting of nanogranules or microgranules is that the intensity E of the external elec. field in its volume is zero. Because of the action of thermodn. forces, the ohmic losses in the semiconductor are zero (jE = 0, where E = 0) or nonzero depending on the direction of the constant elec. current in a closed circuit. Theor. explanation of the exptl. data for the elec. conductivity of films consisting of Al2O3 and/ or NiO nanoparticles with chemisorbed hydrogen atoms is obtained.Potassium sodium (2R,3R)-2,3-dihydroxysuccinate tetrahydrate(cas: 6381-59-5Electric Literature of C4H12KNaO10) was used in this study.

Potassium sodium (2R,3R)-2,3-dihydroxysuccinate tetrahydrate(cas: 6381-59-5) is a ferroelectric crystal with a high piezoelectric effect and electromechanical coupling coefficient. Electric Literature of C4H12KNaO10 Potassium sodium tartrate tetrahydrate has been used in the preparation of Lowry reagent for the determination of microsomal protein concentration in rat hepatic microsomes by Lowry method.

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Alcohol – Wikipedia,
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The author of 《Preclinical candidate for the treatment of visceral leishmaniasis that acts through proteasome inhibition》 were Wyllie, Susan; Brand, Stephen; Thomas, Michael; De Rycker, Manu; Chung, Chun-wa; Pena, Imanol; Bingham, Ryan P.; Bueren-Calabuig, Juan A.; Cantizani, Juan; Cebrian, David; Craggs, Peter D.; Ferguson, Liam; Goswami, Panchali; Hobrath, Judith; Howe, Jonathan; Jeacock, Laura; Ko, Eun-Jung; Korczynska, Justyna; MacLean, Lorna; Manthri, Sujatha; Martinez, Maria S.; Mata-Cantero, Lydia; Moniz, Sonia; NA1/4hs, Andrea; Osuna-Cabello, Maria; Pinto, Erika; Riley, Jennifer; Robinson, Sharon; Rowland, Paul; Simeons, Frederick R. C.; Shishikura, Yoko; Spinks, Daniel; Stojanovski, Laste; Thomas, John; Thompson, Stephen; Gaza, Elisabet Viayna; Wall, Richard J.; Zuccotto, Fabio; Horn, David; Ferguson, Michael A. J.; Fairlamb, Alan H.; Fiandor, Jose M.; Martin, Julio; Gray, David W.; Miles, Timothy J.; Gilbert, Ian H.; Read, Kevin D.; Marco, Maria; Wyatt, Paul G.. And the article was published in Proceedings of the National Academy of Sciences of the United States of America in 2019. Synthetic Route of C12H17BO2 The author mentioned the following in the article:

Visceral leishmaniasis (VL), caused by the protozoan parasites Leishmania donovani and Leishmania infantum, is one of the major parasitic diseases worldwide. There is an urgent need for new drugs to treat VL, because current therapies are unfit for purpose in a resource-poor setting. Here, we describe the development of a preclin. drug candidate, GSK3494245/DDD01305143/compound 8, with potential to treat this neglected tropical disease. The compound series was discovered by repurposing hits from a screen against the related parasite Trypanosoma cruzi. Subsequent optimization of the chem. series resulted in the development of a potent cidal compound with activity against a range of clin. relevant L. donovani and L. infantum isolates. Compound 8 demonstrates promising pharmacokinetic properties and impressive in vivo efficacy in our mouse model of infection comparable with those of the current oral antileishmanial miltefosine. Detailed mode of action studies confirm that this compound acts principally by inhibition of the chymotrypsin-like activity catalyzed by the β5 subunit of the L. donovani proteasome. High-resolution cryo-EM structures of apo and compound 8-bound Leishmania tarentolae 20S proteasome reveal a previously undiscovered inhibitor site that lies between the β4 and β5 proteasome subunits. This induced pocket exploits β4 residues that are divergent between humans and kinetoplastid parasites and is consistent with all of our exptl. and mutagenesis data. As a result of these comprehensive studies and due to a favorable developability and safety profile, compound 8 is being advanced toward human clin. trials. In the experiment, the researchers used 4,4,5,5-Tetramethyl-2-phenyl-1,3,2-dioxaborolane(cas: 24388-23-6Synthetic Route of C12H17BO2)

4,4,5,5-Tetramethyl-2-phenyl-1,3,2-dioxaborolane(cas: 24388-23-6) can be used to prepare sulfinamide derivatives by reacting with diethylaminosulfur trifluoride (DAST) and potassium phenyltrifluoroborate.Synthetic Route of C12H17BO2

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Alcohol – Wikipedia,
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《Effectiveness of surgical approach of insertion ventilation tubes (Tympanostomy) and adenoidectomy in comparison with non-surgical approach (Watchful Waiting Approach) in children at the age between 1 and 6 and who suffer from otitis media with effusion (OME) in 12-month period of observation-the retrospective analysis》 was published in International Journal of Environmental Research and Public Health in 2021. These research results belong to Skarzynska, Magdalena Beata; Gos, Elzbieta; Czajka, Natalia; Sanfis, Milaine Dominici; Skarzynski, Piotr Henryk. Synthetic Route of C13H19Br2ClN2O The article mentions the following:

Otitis media with effusion (OME) is one of the most common diseases in childhood. The objective was to assess clin. the effectiveness of the surgical approach (tube insertion with adenoidectomy) in comparison with the non-surgical approach (watchful waiting) during a 12-mo observation period. This study was retrospective and obtained approval from the bioethics committee. The criteria of inclusion in the first group (surgical approach) were: (1) a diagnosis of chronic otitis media with effusion in children aged between 1 and 6 years; (2) their medical history showed that they had undergone adenoidectomy and tympanostomy with the insertion of ventilation tubes (VTs). The criteria for inclusion in the second group (non-surgery) were similar to the first group except that their medical history showed they had not undergone adenoidectomy or tympanostomy with the insertion of VTs. There were 422 children included in the surgical group and 50 children in the non-surgical group, and the period of observation was 12 mo. For the entire surgical group, the number of healthy days ranged from 20 to 365, with a mean of 328.0 days (SD = 91.4).In the non-surgical group, the number of healthy days ranged from 13 to 365, with a mean of 169.2 days (SD = 127.3). The difference in the number of healthy days was statistically significant (p < 0.001). The certainty of treatment in the first group was higher than in the second group, and the number of days without recurrence was significantly higher than in the second group. In the first group, there were 71 recurrences from 422 children (16.8%), and, in the second subgroup, there were 40 recurrences of acute otitis media (AOM) from 50 children (80%). The RR was 0.21. The surgical approach in children aged 1-6 years who have been diagnosed with otitis media with effusion is reasonable and beneficial for the child. In the experiment, the researchers used many compounds, for example, trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride(cas: 23828-92-4Synthetic Route of C13H19Br2ClN2O)

trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride(cas: 23828-92-4) enhances pulmonary surfactant production and stimulates ciliary activity.Synthetic Route of C13H19Br2ClN2O It promotes mucus clearance, facilitates expectoration and eases productive cough, allowing patients to breathe.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

The author of 《Reverse phase-UPLC method of analysis for simultaneous estimation of Levosalbutamol sulphate, Guaiphenesin and Ambroxol hydrochloride in pharmaceutical cough, cold liquid dosage forms》 were Kiran Kumar, A.; Balakrishnan, M.; Bannoth, Chandrasekhar Kothapalli. And the article was published in International Journal of Research in Pharmaceutical Sciences (Madurai, India) in 2019. Safety of trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride The author mentioned the following in the article:

The three most drug combinations for cough, cold are widely used worldwide now a day. The purpose of the study was to build up an innovative RP-UPLC technique for simultaneous estimation of Levosalbutamol Sulfate (LEV), Guaiphenesin (GUA) and Ambroxol Hydrochloride (AMB) in liquid dosage forms. Chromatog. was carried out on UHPLC (WATERS)⊕MMETRY C18 4.6mm × 1000mm, 3.5μm, (Agilent – Zorbax Eclipse Plus C18 – Rapid Resolution) with an isocratic mobile phase with pH 3.0 composed of buffer, methanol and Acetonitrile (60:20:20) with a flow rate of 0.8mL/min. The detection was carried out with column temperature at 25°C using a UV detector at 276nm. Validation parameters like linearity, specificity, precision, accuracy, limit of detection (LOD), limit of quantification (LOQ), system suitability, Solutions stability and robustness were considered as affirmed in the ICH guidelines. Retention times for LEV, GUA & AMB were 1.07 min, 1.99 min & 3.55 min resp. The assay of syrups with the relative standard deviation found to be less than 2%. The parameters values were found, and the method was found to be satisfactory. This validated UHPLC method is cost-effective, receptive and precise than other chromatog. methods. The experimental process involved the reaction of trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride(cas: 23828-92-4Safety of trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride)

trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride(cas: 23828-92-4) is a mucolytic expectorant and a metabolite of bromhexine.Safety of trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride It is used in the treatment of respiratory disorders characterized by viscous or excessive mucus.

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Alcohol – Wikipedia,
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Application of 6381-59-5In 2021 ,《Study of ferroelectric phenomena and other related properties in NaKC4H4O6·4H2O crystal》 appeared in European Physical Journal D: Atomic, Molecular, Optical and Plasma Physics. The author of the article were Khan, Muzaffar Iqbal; Upadhyay, Trilok Chandra. The article conveys some information:

We calculated ferroelec. and elec. permittivity properties of H-bonded-type NaKC4H4O6·4H2O crystal within modified two sublattice pseudospin lattice coupled mode model Hamiltonian extended by the phonon anharmonic interactions terms, indirect spin-lattice coupling and direct spin-spin coupling interaction terms along with external elec. field terms. The model Hamiltonian is developed by the modification of the semi-microscopic Mitsui’s mode model. With the help of double thermal Green’s function method and sym. decoupling scheme, we obtain the theor. expressions of shift, width, normal mode frequency, Curie temperatures, dielec. permittivity, tangent loss and spontaneous polarization for NaKC4H4O6·4H2O (RS) crystal. The numerical calculation has been obtained by setting different model parameters in derived expressions. The thermal dependence of the above properties has been calculated and theor. results are well agreed with the exptl. results of Ismailzade et al., Jona and Shirane. A comprehensive investigation of thermal variation on phase transitions of ferroelec. normal mode frequency, elec. permittivity, dielec. loss and spontaneous polarization properties of NaKC4H4O6·4H2O (RS) crystal has been obtained. After reading the article, we found that the author used Potassium sodium (2R,3R)-2,3-dihydroxysuccinate tetrahydrate(cas: 6381-59-5Application of 6381-59-5)

Potassium sodium (2R,3R)-2,3-dihydroxysuccinate tetrahydrate(cas: 6381-59-5) is a ferroelectric crystal with a high piezoelectric effect and electromechanical coupling coefficient. Application of 6381-59-5 As a Biuret reagent, it is used to measure the protein concentration. Furthermore, it is used as laxative and is also used in food industry.

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Alcohol – Wikipedia,
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Liang, Dongjun; Wu, Kane; Tei, Reika; Bumpus, Timothy W.; Ye, Johnny; Baskin, Jeremy M. published an article in Proceedings of the National Academy of Sciences of the United States of America. The title of the article was 《A real-time, click chemistry imaging approach reveals stimulus-specific subcellular locations of phospholipase D activity》.Name: (R)-Oxiran-2-ylmethanol The author mentioned the following in the article:

The fidelity of signal transduction requires spatiotemporal control of the production of signaling agents. Phosphatidic acid (PA) is a pleiotropic lipid second messenger whose modes of action differ based on upstream stimulus, biosynthetic source, and site of production How cells regulate the local production of PA to effect diverse signaling outcomes remains elusive. Unlike other second messengers, sites of PA biosynthesis cannot be accurately visualized with subcellular precision. Here, we describe a rapid, chemoenzymic approach for imaging physiol. PA production by phospholipase D (PLD) enzymes. Our method capitalizes on the remarkable discovery that bulky, hydrophilic trans-cyclooctene-containing primary alcs. can supplant water as the nucleophile in the PLD active site in a transphosphatidylation reaction of PLD’s lipid substrate, phosphatidylcholine. The resultant trans-cyclooctene-containing lipids are tagged with a fluorogenic tetrazine reagent via a no-rinse, inverse electron-demand Diels-Alder (IEDDA) reaction, enabling their immediate visualization by confocal microscopy in real time. Strikingly, the fluorescent reporter lipids initially produced at the plasma membrane (PM) induced by phorbol ester stimulation of PLD were rapidly internalized via apparent nonvesicular pathways rather than endocytosis, suggesting applications of this activity-based imaging toolset for probing mechanisms of intracellular phospholipid transport. By instead focusing on the initial 10 s of the IEDDA reaction, we precisely pinpointed the subcellular locations of endogenous PLD activity as elicited by physiol. agonists of G protein-coupled receptor and receptor tyrosine kinase signaling. These tools hold promise to shed light on both lipid trafficking pathways and physiol. and pathol. effects of localized PLD signaling.(R)-Oxiran-2-ylmethanol(cas: 57044-25-4Name: (R)-Oxiran-2-ylmethanol) was used in this study.

(R)-Oxiran-2-ylmethanol(cas: 57044-25-4) is a chiral building block used to construct an epoxyvinyl iodide intermediate in a synthesis of a furanocembrane, a marine natural product.Name: (R)-Oxiran-2-ylmethanol

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Barton, Lisa M.; Chen, Longrui; Blackmond, Donna G.; Baran, Phil S. published their research in Proceedings of the National Academy of Sciences of the United States of America in 2021. The article was titled 《Electrochemical borylation of carboxylic acids》.Electric Literature of C13H26B2O4 The article contains the following contents:

A simple electrochem. mediated method for the conversion of alkyl carboxylic acids to their borylated congeners is presented. This protocol features an undivided cell setup with inexpensive carbon-based electrodes and exhibits a broad substrate scope and scalability in both flow and batch reactors. The use of this method in challenging contexts is exemplified with a modular formal synthesis of jawsamycin, a natural product harboring five cyclopropane rings. After reading the article, we found that the author used Bis[(pinacolato)boryl]methane(cas: 78782-17-9Electric Literature of C13H26B2O4)

Bis[(pinacolato)boryl]methane(cas: 78782-17-9) belongs to organoboron compounds.Electric Literature of C13H26B2O4 Organoboron compounds are versatile intermediates and as such are some of the most important classes of reagents in modern organic chemistry. This stems from their ease of preparation combined with their ability to undergo a broad range of chemical transformations.

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Alcohol – Wikipedia,
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