Month: October 2022

The author of 《Formulation and in-vitro characterization of ambroxol hydrochloride sustained-release matrix tablets》 were Jaya, S.; Srilaxmi, G.. And the article was published in International Journal of Pharmaceutical Sciences and Research in 2019. Computed Properties of C13H19Br2ClN2O The author mentioned the following in the article:

The present study involves the formulation and in-vitro characterization of sustained release matrix tablets of Ambroxol hydrochloride, a potent mucolytic agent used in the treatment of respiratory disorders. FTIR anal. confirmed the absence of drug-polymer interactions. Sustained release matrix tablets containing 75 mg were formulated employing HPMCK15 and xanthan gum as release retarding polymer and dicalcium phosphate and microcrystalline cellulose as diluents. The powder blend was evaluated for micromeritic properties. The matrix tablets were prepared by direct compression technique. The prepared tablets were evaluated for uniformity of weight, hardness, friability, and uniformity of content. All the formulations showed compliance with pharmacopoeial standards The in-vitro drug release studies were carried out for a period of 12 h using USP type II dissolution apparatus at 50 rpm by taking 900 mL of 0.1 N HCl (pH 1.2) as dissolution medium for first 2 h and later replacing it with 900 mL pH 6.8 phosphate buffer solution for a period of 10 h at 37 ± 0.5°C. Among the different combinations of polymers in different ratios studied, the desired in-vitro drug release (97.65% for 12 h) was found with the combination of HPMC K15M and xanthan gum with the drug in the ratio of 1: 0.75 (F7). The drug release from the F7 formulation followed zero order kinetics and mechanism was found to be erosion. In the experimental materials used by the author, we found trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride(cas: 23828-92-4Computed Properties of C13H19Br2ClN2O)

trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride(cas: 23828-92-4) is a mucolytic expectorant and a metabolite of bromhexine.Computed Properties of C13H19Br2ClN2O It is used in the treatment of respiratory disorders characterized by viscous or excessive mucus.

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The author of 《Photochemical synthesis and properties of axially chiral naphthylpyridines》 were Wessig, Pablo; Pick, Charlotte. And the article was published in Journal of Photochemistry and Photobiology, A: Chemistry in 2011. Electric Literature of C8H7NO The author mentioned the following in the article:

Five alkynyl pyridines were prepared and cyclized to naphthylpyridines as the main products in the course of a Photo-Dehydro-Diels-Alder reaction. Four of the final products (I,II,III,IV) are axially chiral and the determination of the rotational barrier by DFT calculations, dynamic NMR and HPLC experiments is demonstrated. In addition to this study using 3-(4-Pyridyl)-2-propyn-1-ol, there are many other studies that have used 3-(4-Pyridyl)-2-propyn-1-ol(cas: 93524-95-9Electric Literature of C8H7NO) was used in this study.

3-(4-Pyridyl)-2-propyn-1-ol(cas: 93524-95-9) belongs to pyridine. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. As ligands, solvents, and catalysts they facilitate reactions; thus descriptions of these new ligands and their applications abound each year.Electric Literature of C8H7NO

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In 2013,Kjartansdottir, Cecilia Kristin; Nielsen, Lars Pleth; Moeller, Per published 《Development of durable and efficient electrodes for large-scale alkaline water electrolysis》.International Journal of Hydrogen Energy published the findings.Name: Potassium sodium (2R,3R)-2,3-dihydroxysuccinate tetrahydrate The information in the text is summarized as follows:

A new type of electrodes for alk. water electrolysis is produced by phys. vapor depositing (PVD) of aluminum onto a nickel substrate. The PVD Al/Ni is heat-treated to facilitate alloy formation followed by a selective aluminum alk. leaching. The obtained porous Ni surface is uniform and characterized by a unique interlayer adhesion, which is critical for industrial application. IR-compensated polarization curves prepared in a half-cell setup with 1 M KOH electrolyte at room temperature reveals that at least 400 mV less potential is needed to decompose water into hydrogen and oxygen with the developed porous PVD Al/Ni electrodes as compared to solid nickel electrodes. High-resolution scanning electron microscope (HR-SEM) micrographs reveal Ni-electrode surfaces characterized by a large surface area with pores down to a few nanometer sizes. Durability tests were carried out in a com. produced bipolar electrolyzer stack. The developed electrodes showed stable behavior under intermittent operation for over 9000 h indicating no serious deactivation in the d. of active sites. The experimental process involved the reaction of Potassium sodium (2R,3R)-2,3-dihydroxysuccinate tetrahydrate(cas: 6381-59-5Name: Potassium sodium (2R,3R)-2,3-dihydroxysuccinate tetrahydrate)

Potassium sodium (2R,3R)-2,3-dihydroxysuccinate tetrahydrate(cas: 6381-59-5) is a ferroelectric crystal with a high piezoelectric effect and electromechanical coupling coefficient. Name: Potassium sodium (2R,3R)-2,3-dihydroxysuccinate tetrahydrate As a Biuret reagent, it is used to measure the protein concentration. Furthermore, it is used as laxative and is also used in food industry.

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In 2017,Maxwell, Brad D. published 《The syntheses of [13C6] and [phenyl-14C(U)]BMS-816336, an inhibitor of 11β-hydroxysteroid dehydrogenase type 1, for type 2 diabetes》.Journal of Labelled Compounds and Radiopharmaceuticals published the findings.HPLC of Formula: 18621-18-6 The information in the text is summarized as follows:

Type 2 diabetes is a significant worldwide health problem. To support the development of BMS-816336 as an inhibitor of 11β-hydroxysteroid dehydrogenase type 1 for type 2 diabetes, the synthesis of carbon-14 labeled material was required for use in metabolic profiling. [Phenyl-14C(U)]BMS-816336 (A) was synthesized in 8 steps and 22% radiochem. yield from com. available [14C(U)]bromobenzene. The radiochem. purity of A was 100% having a specific activity of 84.4 μCi/mg or 28.8 mCi/mmol for a total of 8.9 mCi. It was also necessary to synthesize [13C6]BMS-816336 (B) for use as a liquid chromatog./mass spectrometry standard B was also prepared in 8 labeled steps in 26% yield from [13C6]bromobenzene. In the experiment, the researchers used many compounds, for example, Azetidin-3-ol hydrochloride(cas: 18621-18-6HPLC of Formula: 18621-18-6)

Azetidin-3-ol hydrochloride(cas:18621-18-6) is one of azetidine.Azetidines (azacyclobutanes) constitute a well-known class of heterocyclic compounds. Azetidine scaffold has been discovered in several natural products.HPLC of Formula: 18621-18-6 Several pharmacologically important synthetic compounds also contain azetidine ring. Because of inherent ring strain, the synthesis of azetidines is a challenging endeavor.

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《Pyridinium salts of dithiophosphoric acids on the basis of nicotinic acids and their isomers, 3-hydroxypyridine, and 3-pyridinemethanol》 was published in Phosphorus, Sulfur and Silicon and the Related Elements in 2020. These research results belong to Nizamov, Ilyas S.; Salikhov, Ramazan Z.; Timushev, Ildus D.; Nikitin, Yevgeniy N.; Nizamov, Ilnar D.; Yakimov, Vladimir Yu.; Shulaeva, Marina P.; Pozdeev, Oscar K.; Batyeva, Elvira S.; Cherkasov, Rafael A.; Ponomareva, Anna S.. Quality Control of 3-Pyridinemethanol The article mentions the following:

A new series of chiral carboxypyridinium dithiophosphates I (R = pyridin-2-yl, pyridin-3-yl, pyridin-4-yl) was synthesized by the reactions of acids RC(O)OH with dithiophosphoric acid on the basis (1S)-endo-(-)-borneol in benzene or ethanol. The compound 5,5-dimethyl-2-mercapto-2-thiono-1,3,2-dioxaphosphorinane reacted with 3-hydroxypyridine or 3-pyridinemethanol in EtOH to afford the 3-hydroxypyridinium/3-hydroxymethylpyridinium 5,5-dimethyl-2-mercapto-2-thiono-1,3,2-dioxaphosphorinane which possessed antifungal activity against Candida albicans. The results came from multiple reactions, including the reaction of 3-Pyridinemethanol(cas: 100-55-0Quality Control of 3-Pyridinemethanol)

3-Pyridinemethanol(cas: 100-55-0) belongs to pyridine. Pyridines are often used as catalysts or reagents; particular notice has been paid recently to how pyridine coordinates to metal centers enabling a wide range of valuable reactions. Quality Control of 3-Pyridinemethanol

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In 2015,Chemical Communications (Cambridge, United Kingdom) included an article by Furukawa, Takayuki; Tobisu, Mamoru; Chatani, Naoto. Safety of 2-(3,4-Dimethylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane. The article was titled 《Nickel-catalyzed borylation of arenes and indoles via C-H bond cleavage》. The information in the text is summarized as follows:

The 1st Ni-catalyzed method for the borylation of C-H bonds in arenes and indoles is described. The use of an N-heterocyclic carbene ligand is essential for an efficient reaction, with an N-cyclohexyl-substituted derivative being optimal. This method is readily applied to the gram scale synthesis of 2-borylindole. In the experiment, the researchers used many compounds, for example, 2-(3,4-Dimethylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane(cas: 401797-00-0Safety of 2-(3,4-Dimethylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane)

2-(3,4-Dimethylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane(cas: 401797-00-0) belongs to hydroxy-containing compounds. Hydroxy groups participate in the dehydration reactions that link simple biological molecules into long chains. The creation of a peptide bond to link two amino acids to make a protein removes the −OH from the carboxy group of one amino acid.Safety of 2-(3,4-Dimethylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

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The author of 《New adsorption indicators for argentometric titrations of halides and thiocyanates》 were Aliotta, Guillermo; Casal, Alberto R.. And the article was published in Anales de la Asociacion Quimica Argentina (1921-2001) in 1964. Related Products of 2525-05-5 The author mentioned the following in the article:

Bromochlorophenol blue (I), bromophenol red (II), o-cresol red (III), and m-cresol purple (IV) are proposed as new adsorption indicators for application in Cl-, Br-, I-, and SCN- argentometric titrations at different pH values. In some tests it was found necessary to adjust the pH for satisfactory results. I can be employed for all anions, II for Br-, I-, and SCN-, while III and IV only for I- and SCN- determinations The reproducibility and accuracy obtained by using these indicators are discussed. 16 references. In the part of experimental materials, we found many familiar compounds, such as 4-Butylbenzene-1,2-diol(cas: 2525-05-5Related Products of 2525-05-5)

4-Butylbenzene-1,2-diol(cas: 2525-05-5) belongs to organoboron compounds. Organoboron compounds are versatile intermediates and as such are some of the most important classes of reagents in modern organic chemistry. Organoboron compounds are less toxic than organostannane reagents, and unlike alkynylzinc and magnesium, many organoboron compounds possess remarkable oxidative and thermal stabilities. Related Products of 2525-05-5

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Singh, Ekta; Matada, Gurubasavaraja Swamy Purawarga published their research in International Journal of Pharmacy and Pharmaceutical Research in 2021. The article was titled 《Chemical features responsible for the antioxidant property in 7-azaindoles and related compounds》.Formula: C3H6O2 The article contains the following contents:

The pro-oxidant mols. are reactive towards the cell organelles due to instability in their electronic composition Thus, pro-oxidants interact with and cause damages to cell organelles. This damage can be prevented by antioxidant mols. as they neutralize the pro-oxidants and render them harmless. The ability of mols. to act as an antioxidant is exhibited by its chem. feature. Alpha tocopherol and its analogs are well established antioxidants. The antioxidants can be designed based on the structure of alpha tocopherol. Some research articles have compared the antioxidant properties of alpha tocopherol and small mols. with different heterocylic rings. In continuation to the development of small antioxidant mols. azaindole analogs have also been compared with alpha tocopherol. Azaindoles are a novel class of compounds that can be developed as antioxidant mols. based on their similarity with heterocyclic rings present in reported antioxidants. In the current research we have studied some azaindole related compounds and their antioxidant properties. The objective of this study is to study some 7-azaindole related compounds as antioxidants. In this research work, small substituted azaindoles and related structures have been studied for their antioxidant properties by DPPH assay method. The structure with Ketone and double bond functional group show antioxidant property in DPPHA assay. The presence of chlorine on aromatic ring increases the antioxidant property of azaindoles. Azaindole scaffold can be used to design and develop novel antioxidant mols. After reading the article, we found that the author used Oxetan-3-ol(cas: 7748-36-9Formula: C3H6O2)

Oxetan-3-ol(cas: 7748-36-9) is used as a reagent in the synthesis of 5-fluoro-4,6-dialkoxypyrimidine GPR119 agonists. It is also used as a reagent in the synthesis of cyclic sulfone hydroxyethylamines as potent and selective β-site APP-cleaving enzyme 1 (BACE1) inhibitors.Formula: C3H6O2

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In 2022,Hassan, Ahmed H. E.; Kim, Hyeon Jeong; Gee, Min Sung; Park, Jong-Hyun; Jeon, Hye Rim; Lee, Cheol Jung; Choi, Yeonwoo; Moon, Suyeon; Lee, Danbi; Lee, Jong Kil; Park, Ki Duk; Lee, Yong Sup published an article in Journal of Enzyme Inhibition and Medicinal Chemistry. The title of the article was 《Positional scanning of natural product hispidol′s ring-b: discovery of human monoamine oxidase-b inhibitor downregulating neuroinflammation for neurodegenerative diseases》.HPLC of Formula: 26153-38-8 The author mentioned the following in the article:

Multifunctional mols. might offer better treatment of complex multifactorial neurol. diseases. Monoaminergic pathways dysregulation and neuroinflammation are common convergence points in diverse neurodegenerative and neuropsychiatric disorders. Aiming to target these diseases, polypharmacol. agents modulating both monoaminergic pathways and neuroinflammatory were addressed. A library of analogs of the natural product hispidol was prepared and evaluated for inhibition of monoamine oxidases (MAOs) isoforms. Several mols. emerged as selective potential MAO B inhibitors. The most promising compounds were further evaluated in vitro for their impact on microglia viability, induced production of proinflammatory mediators and MAO-B inhibition mechanism. Amongst tested compounds, was a safe potent competitive reversible MAO-B inhibitor and inhibitor of microglial production of neuroinflammatory mediators; NO and PGE2. In-silico study provided insights into mol. basis of the observed selective MAO B inhibition. This study presents compound as a promising lead compound for management of neurodegenerative disease. The results came from multiple reactions, including the reaction of 3,5-Dihydroxybenzaldehyde(cas: 26153-38-8HPLC of Formula: 26153-38-8)

3,5-Dihydroxybenzaldehyde(cas: 26153-38-8) is used as a building block in the synthesis of more complex structures. It is also used in the synthesis of terbutaline, which is an important bronchodilator.HPLC of Formula: 26153-38-8

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Formula: C3H9NOIn 2021 ,《Ice Recrystallization Inhibition Activity of Protein Mimetic Peptoids》 appeared in Journal of Inorganic and Organometallic Polymers and Materials. The author of the article were Hua, Weiwen; Wang, Yuanguang; Guo, Cun-Yue; Wang, Jianjun; Li, Songjun; Guo, Li. The article conveys some information:

Natural antifreeze proteins are known for their excellent control of ice formation and growth, while synthetic mols. seldom have the similar effects. Here we report a series of protein mimetic peptoids with different side chains exhibiting significant ice recrystallization inhibition activity, and their structure-property relationships are also studied. The presence of peptoid can clearly slow down ice growth and decrease ice crystal grain size, but shows no thermal hysteresis, which make peptoids great antifreeze agent candidates in cryopreservation. Peptoids with Me, Et and amino groups on side chains can modulate ice crystal shape, while peptoids bearing hydroxyl and Et groups decrease ice growth rate the most. All peptoids can reduce ice crystal grain size and the one with hydroxyl groups give the smallest grain size. This study reveals peptoid structure effects on ice growth and points to the design rules for biomimetic antifreeze agents. The results came from multiple reactions, including the reaction of 3-Aminopropan-1-ol(cas: 156-87-6Formula: C3H9NO)

3-Aminopropan-1-ol(cas: 156-87-6) belongs to anime. Many important products require amines as part of their syntheses. Methylamine is utilized in the production of the analgesic meperidine (trade name Demerol) and the photographic developer Metol (trademark), and dimethylamine is used in the synthesis of the antihistamine diphenhydramine (trade name Benadryl), the solvent dimethylformamide (DMF), and the rocket propellant 1,1-dimethylhydrazine. The synthesis of the insect repellent N,N-diethyl-m-toluamide (DEET) incorporates diethylamine while that of the synthetic fibre Kevlar requires aromatic amines.Formula: C3H9NO

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