Month: October 2022

Cox, Lydia; Zhu, Yuxiang; Smith, Philip J.; Christensen, Kirsten E.; Sidera Portela, Mireia; Donohoe, Timothy J. published the artcile< Alcohols as Alkylating Agents in the Cation-Induced Formation of Nitrogen Heterocycles>, Synthetic Route of 627-27-0, the main research area is pyrrolidine substituted piperidine diastereoselective regioselective preparation; homoallylic amine alc endo trig cyclization titanium isopropoxide catalyst; Azacycles; Carboamination; Carbocations; Hexafluoroisopropanol; Lewis Acid Catalysis.

A Ti(Oi-Pr)4 promoted 5- or 6-endo-trig cyclization to make nitrogen heterocycles was presented. The utilization of HFIP as a key solvent enabled stereoselective preparation of di- tri-substituted pyrrolidines, e.g. I and piperidines, e.g. II while forming a new C-C bond at same time. The process was triggered by a cationic intermediate generated from an allylic or benzylic alc. and led to simultaneous generation of both a C-C and a C-N bond in a single step. Notably, either 2,3-trans- or 2,3-cis-substituted heterocycles could be obtained by using a nucleophilic amine bearing different substituents. Lastly, stereoselective synthesis of enantiopure products was achieved by using readily available enantiopure acyclic starting materials.

Angewandte Chemie, International Edition published new progress about Allylic alcohols Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 627-27-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C4H8O, Synthetic Route of 627-27-0.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Wang, Yun; Wang, Shengxuan; Song, Rongzhen; Cai, Jingjing; Xu, Jingjing; Tang, Xiaozhen; Li, Ningyang published the artcile< Ginger polysaccharides induced cell cycle arrest and apoptosis in human hepatocellular carcinoma HepG2 cells>, Safety of (2S,3S,4R,5R)-2,3,4,5,6-Pentahydroxyhexanal, the main research area is hepatocellular carcinoma cell cycle arrest apoptosis polysaccharide; Apoptosis; Cell cycle arrest; Ginger polysaccharide.

In this study, ginger polysaccharide (GP) was obtained from ginger by enzymic method, its chem. properties and antitumor activity were investigated. The results indicated that the composition and proportion of GP were L-rhamnose, D-arabinose, D-mannose, D-glucose and D-galactose in a molar ratio of 3.64:5.37:3.04:61.03:26.91, GP had the characteristic absorption peak of polysaccharide. Congo red experiment showed that GP had a triple helix structure, which could have anti-tumor effect. Furthermore, MTT assay, cell morphol. observation, nuclear morphol. observation and reactive oxygen species observation demonstrated that GP had significant antitumor effect. Flow cytometry suggested that GP could promote apoptosis and arrest cells in G0-G1 phase. Real-time fluorescence quantification and Western blot revealed that GP could up-regulate the expression of Bax, Fas, FasL, caspase-3, p21 and p53, and down-regulate the expression of Bcl-2. These studies suggested that GP would be used as an antitumor drug in foods to promote the development of functional foods.

International Journal of Biological Macromolecules published new progress about Absorption. 3458-28-4 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H12O6, Safety of (2S,3S,4R,5R)-2,3,4,5,6-Pentahydroxyhexanal.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Tabasi, Nihal S.; Genc, Sertac; Gulcemal, Derya published the artcile< Tuning the selectivity in iridium-catalyzed acceptorless dehydrogenative coupling of primary alcohols>, HPLC of Formula: 5344-90-1, the main research area is carboxylic acid ester alkali carboxylate preparation iridium catalyst; primary alc dehydrogenation; alc preparation homo cross alkylation.

An acceptorless dehydrogenative coupling of primary alcs. to carboxylic acids/carboxylates, esters, and Guerbet alcs. (via both homo- and cross-β-alkylation of the alcs.) in the presence of an N-heterocyclic carbene iridium(I) catalyst was developed under aerobic conditions. The product selectivity can be easily tuned among the products with a single catalyst through simple modification of the reaction conditions, such as the catalyst and base amounts, the choice of base, and the reaction temperature

Organic & Biomolecular Chemistry published new progress about Alkylation. 5344-90-1 belongs to class alcohols-buliding-blocks, and the molecular formula is C7H9NO, HPLC of Formula: 5344-90-1.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Liu, Zhongcheng; Bisoyi, Hari Krishna; Huang, Yinliang; Wang, Meng; Yang, Hong; Li, Quan published the artcile< Thermo- and Mechanochromic Camouflage and Self-Healing in Biomimetic Soft Actuators Based on Liquid Crystal Elastomers>, Recommanded Product: But-3-en-1-ol, the main research area is thermo mechanochromic camouflage selfhealing biomimetic actuator liquid crystal elastomer; Biomimetic actuator; Camouflage; Chromophore; Liquid crystal elastomer; Self-healing.

In nature, many mysterious creatures capable of deformation camouflage, color camouflage, and self-healing have inspired scientists to develop various biomimetic soft robots. However, the systematic integration of all the above functionalities into a single soft actuator system still remains a challenge. Here we chem. introduce a multi-stimuli-responsive tetraarylsuccinonitrile (TASN) chromophore into a liquid crystal elastomer (LCE) network through a facile thiol-ene photoaddn. method. The obtained TASN-LCE soft actuators not only exhibit reversible shape-morphing and reversible color-changing behavior in response to heat and mech. compression, but also show excellent self-healing, reprogramming and recycling characteristics. We hope that such a TASN-LCE actuator system endowed with dynamic distortion, thermo- and mechano-chromic camouflage, and self-healing functionalities would pave the way for further development of multifunctional biomimetic soft robotic devices.

Angewandte Chemie, International Edition published new progress about Actuators (photoresponsive). 627-27-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C4H8O, Recommanded Product: But-3-en-1-ol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Yuan, Yiqiong; Li, Chuan; Zheng, Qianwen; Wu, Jixiang; Zhu, Kexue; Shen, Xuanri; Cao, Jun published the artcile< Effect of simulated gastrointestinal digestion in vitro on the antioxidant activity, molecular weight and microstructure of polysaccharides from a tropical sea cucumber (Holothuria leucospilota)>, Related Products of 3458-28-4, the main research area is Holothuria simulated gastrointestinal digestion polysaccharide antioxidant microstructure.

The physicochem. properties of Holothuria leucospilota polysaccharides (HLP) were measured, and the changes of mol. weight (Mw), antioxidant activity and microstructure in vitro were studied. The Mw of HLP was approx. 52.80 kDa, and the monosaccharide composition was primarily fucose, rhamnose and glucuronic acid. HLP showed good antioxidant activity at high concentration (≥2 mg/mL), and the DPPH (1,1-Diphenyl-2-picryl-hydrazil) free radical scavenging rate reached approx. 84%. It was observed that saliva did not have an effect on the Mw and antioxidant capability of HLP. Gastric and intestinal digestion significantly reduced the Mw of HLP (from 52.80 kDa to 14.67 kDa and 12.01 kDa) and maintained high antioxidant activity. In addition, the structure and surface morphol. were markedly altered. After simulated gastric digestion, the HLP changed from a smooth, irregular, and angular structure to a layered honeycomb with a large volume This result demonstrated that the decrease of Mw after gastric digestion was caused by the destruction of aggregates. Due to the decomposition of glycosidic bonds after digestion in intestine, HLP showed loose, small and blocky structures. Thus, HLP had antioxidant activity, and this activity was improved after gastric and intestinal digestion.

Food Hydrocolloids published new progress about Digestive juice. 3458-28-4 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H12O6, Related Products of 3458-28-4.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Cai, Zhiquan; Xie, Tao; Xu, Jin published the artcile< Source-sink manipulations differentially affect carbon and nitrogen dynamics, fruit metabolites and yield of Sacha Inchi plants>, Electric Literature of 87-73-0, the main research area is carbon source sink manipulation defoliation seed yield fruit Plukenetia; Fruitlet metabolites; Growth; Physiological traits; Plukenetia volubilis; Reproductive trait; Source–sink regulations.

Being a promising tropical woody oilseed crop, the evergreen and recurrent plants of Sacha Inchi (Plukenetia volubilis L.) has complex phenol. and source-sink interactions. Carbon source-sink manipulations with control and two treatments (reduce source, ca. 10% mature leaf pruning; reduce sink, 10% fruitlet thinning) were conducted on 2.5-yr-old field-grown P. volubilis plantation during the early-wet season in a seasonal tropical area. Leaf photosynthetic rate and specific leaf area largely remained unchanged in response to defoliation or defloration. Compared with control, higher N contents on average were observed in both remaining leaves and branches of the defoliated plants, suggesting that N-mobilization was mainly due to the enhanced N uptake from soil. Carbon, but not N, is a source-driven growth process of P. volubilis plants, as defoliation reduced the contents of non-structural carbohydrates (especially sugar) in branches, although temporally, whereas defloration increased available C reserve. The seasonal dynamic pattern of fruit ripening was altered by source-sink regulations. Total seed yield throughout the growing season, which depends on fruit set and retention (i.e., number of matured fruit) rather than individual fruit development (size), was slightly increased by defloration but was significantly decreased by defoliation. Compared with control, defloration did not enrich the KEGG pathway, but defoliation downregulated the TCA cycle and carbohydrate and lipid metabolisms in fruitlets after 24 days of the applications of source-sink manipulation. Carbohydrate reserves serve to buffer sink-source imbalances that may result from temporary adjustment in demand for assimilates (e.g., defloration) or shortfalls in carbon assimilation (e.g., defoliation). Defoliation is disadvantageous for the yield and also for carbohydrate and lipid accumulation in fruits of P. volubilis plants. Although more studies are needed, these results provide new insights to the further improvement in seed yield of the strong source-limited P. volubilis plants by source/sink manipulations.

BMC Plant Biology published new progress about Bioaccumulation. 87-73-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H10O8, Electric Literature of 87-73-0.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Alrafas, Haider Rasheed; Busbee, Philip B.; Nagarkatti, Mitzi; Nagarkatti, Prakash S. published the artcile< Resveratrol modulates the gut microbiota to prevent murine colitis development through induction of Tregs and suppression of Th17 cells>, Application of C14H12O3, the main research area is resveratrol regulatory T cell immune response gut microbiota colitis; 2,4,6-trinitrobenzenesulfonic acid; T helper cells; butyrate; fecal transfer; inflammation; short-chain fatty acid.

In the current study, we investigated if resveratrol, a polyphenol found in a variety of foods and beverages, would reverse microbial dysbiosis induced during colitis. Administration of resveratrol attenuated colonic inflammation and clin. symptoms in the murine model of 2,4,6-trinitrobenzenesulfonic acid (TNBS)-induced colitis. Resveratrol treatment in mice with colitis led to an increase in CD4+FOXP3+ and CD4+IL-10+ T cells, and a decrease in CD4+IFN-γ+ and CD4+IL-17+ T cells. Anal. of cecal flush revealed that TNBS administration led to an increase in species such as Bacteroides acidifaciens, but decrease in species such as Ruminococcus gnavus and Akkermansia mucinphilia, as well as a decrease in SCFA i-butyric acid. Fecal transfer experiments confirmed the protective role of resveratrol-induced microbiota against colitis inasmuch as such recipient mice were more resistant to TNBS-colitis and exhibited polarization toward CD4+FOXP3+ T cells and decreases in CD4+IFN-γ+ and CD4+IL-17+ T cells. Collectively, these data demonstrate that resveratrol-mediated attenuation of colitis results from reversal of microbial dysbiosis induced during colitis and such microbiota protect the host from colonic inflammation by inducing Tregs while suppressing inflammatory Th1/Th17 cells.

Journal of Leukocyte Biology published new progress about 16S rRNA Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 501-36-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C14H12O3, Application of C14H12O3.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Nakajima, Isami; Shimizu, Minori; Okuda, Yuta; Akiyama, Ryo; Tadano, Ryu; Nagaoka, Masahiro; Uemura, Naohiro; Yoshida, Yasushi; Mino, Takashi; Shinozaki, Hiraku; Yamamoto, Tetsuya published the artcile< Synthesis and Catalysis of NHC Coordinated Cyclometalated Palladium(II) Complexes with Bridging Hydroxide Ligands>, Category: alcohols-buliding-blocks, the main research area is hydroxide palladium NHC addition catalyst boronic ester aldehyde ketone; crystal structure mol dipalladium hydroxide bridged heterocyclic carbene complex; palladium hydroxide bridged NHC cyclometalated dimer complex preparation.

1,2-Addition reactions using organoboron compounds are one of the useful syntheses of various functionalized alcs., but they generally require a large quantity of bases. In this study, we attempted to solve this problem by synthesizing unsym. 1,3-diarylimidazoline-type N-heterocyclic carbene (NHC)-coordinated CĈ* cyclometalated palladium(II) complexes with bridging hydroxide ligands (CYPOHs) in two steps and one pot from the corresponding Cl bridged dimer and using them as catalysts. 2,6-Di(pentan-3-yl)aniline (IPent)-based NHC coordinated PhS-IPent-CYPOH acted as a highly efficient catalyst for the 1,2-addition of (hetero)arylboronates to a large number of aldehydes and ketones, including unactivated ketones, under base-free conditions.

Advanced Synthesis & Catalysis published new progress about 1,2-Addition reaction. 76-84-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C19H16O, Category: alcohols-buliding-blocks.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Genc, Sertac; Arslan, Burcu; Gulcemal, Suleyman; Gunnaz, Salih; Cetinkaya, Bekir; Gulcemal, Derya published the artcile< Iridium(I)-Catalyzed C-C and C-N Bond Formation Reactions via the Borrowing Hydrogen Strategy>, Computed Properties of 5344-90-1, the main research area is secondary aminobenzyl alc alkylation cyclization iridium catalyst.

Iridium(I) complexes having an imidazol-2-ylidene ligand with benzylic wingtips efficiently catalyzed the β-alkylation of secondary alcs. with primary alcs. and acceptorless dehydrogenative cyclization of 2-aminobenzyl alc. with ketones through a borrowing hydrogen pathway. The β-alkylated alcs., including cholesterol derivatives, and substituted quinolines were obtained in good yields by using a minute amount of the catalyst with a catalytic amount of NaOH or KOH under the air atm., liberating water (and H2 in the case of quinoline synthesis) as the sole byproduct. Notably, this system demonstrated turnover numbers of 940,000 (for β-alkylation of secondary alcs. with primary alcs. by using down to 0.0001 mol % = 1 ppm of the catalyst) and 9200 (acceptorless dehydrogenative cyclization of 2-aminobenzyl alc. with ketones).

Journal of Organic Chemistry published new progress about Alkylation (β-, of secondary alcs. with primary alcs.). 5344-90-1 belongs to class alcohols-buliding-blocks, and the molecular formula is C7H9NO, Computed Properties of 5344-90-1.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Ji, Hai-yu; Chen, Pei; Yu, Juan; Feng, Ying-ying; Liu, An-jun published the artcile< Effects of Heat Treatment on the Structural Characteristics and Antitumor Activity of Polysaccharides from Grifola frondosa>, Recommanded Product: (2S,3S,4R,5R)-2,3,4,5,6-Pentahydroxyhexanal, the main research area is Grifola polysaccharide antitumor agent heat treatment hepatocellular carcinoma; Antitumor; Heat treatment; Polysaccharides from Grifola frondosa; Structure.

This study investigated the effects of heat treatment on structural characteristics and in vitro antitumor activity of polysaccharides from Grifola frondosa. GFP-4 (extracted at 4°C), GFP-4-80 (80°C treatment on GFP-4) and GFP-80 (extracted at 80°C) were prepared, and the chem. composition anal. showed that their total sugar contents were all higher than 90%, high-performance gel-permeation chromatog. (HPGPC), ion chromatog. (IC) and Fourier-transform IR spectroscopy (FTIR) results demonstrated that GFP-4 were degraded and denatured after 80°C heat treatment, MTT and JC-1 results showed that GFP-4 exhibited higher inhibitory effects on HepG2 cells in vitro than GFP-4-80 and GFP-80. Our study suggested that heat treatment at 80°C on polysaccharides from Grifola frondosa would destroy their structure and attenuate their antitumor effects.

Applied Biochemistry and Biotechnology published new progress about Antitumor agents. 3458-28-4 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H12O6, Recommanded Product: (2S,3S,4R,5R)-2,3,4,5,6-Pentahydroxyhexanal.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts