Month: October 2022

Itoga, Moeko; Yamanishi, Masako; Udagawa, Taro; Kobayashi, Ayane; Maekawa, Keiko; Takemoto, Yoshiji; Naka, Hiroshi published the artcile< Iridium-catalyzed α-selective deuteration of alcohols>, Electric Literature of 10602-04-7, the main research area is iridium bipyridonate complex preparation DFT; deuterated alc chemoselective preparation; alc deuteration iridium bipyridonate complex catalyst.

The α-selective, iridium(III)-bipyridonate-catalyzed hydrogen(H)/deuterium(D) isotope exchange of alcs. using deuterium oxide (D2O) as the primary deuterium source to afford deuterated alcs. RCD2OH [R = Ph, 2-MeC6H4, 4-FC6H4, etc.], R1DCOHR2 [R1 = Ph, 4-ClC6H4, 4-BrC6H4, etc.; R2 = Me, cyclopropyl, Ph] was reported. This method enabled the direct, chemoselective deuteration of primary and secondary alcs. under basic or neutral conditions without being affected by coordinative functional groups such as imidazole and tetrazole. Successful substrates for deuterium labeling include the pharmaceuticals losartan potassium, rapidosept, guaifenesin and diprophylline. The deuterated losartan potassium showedhigher stability toward the metabolism by CYP2C9 than the protiated analog. Kinetic and DFT studies indicated that the direct deuteration proceeded through dehydrogenation of alc. to the carbonyl intermediate, conversion of [IrIII-H] to [IrIII-D] with D2O, and deuteration of the carbonyl intermediate to give the α-deuterated products.

Chemical Science published new progress about Alcohols Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 10602-04-7 belongs to class alcohols-buliding-blocks, and the molecular formula is C9H8O, Electric Literature of 10602-04-7.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Zhang, Huan; Yin, Dazhen; You, Shijun; Zheng, Wandong; Wei, Shen published the artcile< Experimental investigation of heat and mass transfer in a LiBr-H2O solution falling film absorber on horizontal tubes: Comprehensive effects of tube types and surfactants>, Computed Properties of 104-76-7, the main research area is surfactant lithium bromide water solution falling film absorber tube.

This paper studied the effects of various surface geometries and surfactants on the LiBr-H2O solution falling film absorption, and the heat and mass transfer during the absorption process. Three different tubes (plain tube, floral tube and floral finned tube) were tested for the LiBr-H2O solution with two different surfactants (2-Ethyl-1-hexanol and 1-Octanol). The results indicate that the heat and mass transfer coefficients of each tube gradually decrease with solution falling down the tube bundle. It is also showed that the effect of surfactant on heat and mass transfer is obviously greater than that of tube surface geometry. Furthermore, with 2-Ethyl-1-hexanol as the surfactant, the heat and mass transfer can be improved by 400% and 350%, resp. The results of comparative study show that the heat and mass transfer performance of floral tubes with 2-Ethyl-1-hexanol is more stable and reliable than others.

Applied Thermal Engineering published new progress about Heat transfer. 104-76-7 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H18O, Computed Properties of 104-76-7.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Vestergaard, Martin; Ingmer, Hanne published the artcile< Antibacterial and antifungal properties of resveratrol>, Name: (E)-5-(4-Hydroxystyryl)benzene-1,3-diol, the main research area is review resveratrol antibacterial antifungal property; ATP synthase inhibition; Antimicrobial; Antivirulence; Combination therapy; Resveratrol.

A review. Resveratrol is a naturally occurring polyphenolic antioxidant that has received massive attention for its potential health benefits, including anticarcinogenesis, anti-aging, and antimicrobial properties. The compound is well tolerated by humans and in recent years has been widely used as a nutraceutical. Its common use makes it interesting to investigate with respect to antimicrobial properties both as a single agent and in combination with conventional antibiotics. Resveratrol displays antimicrobial activity against a surprisingly wide range of bacterial, viral, and fungal species. At subinhibitory concentrations, resveratrol can alter bacterial expression of virulence traits leading to reduced toxin production, inhibition of biofilm formation, reduced motility, and interference with quorum sensing. In combination with conventional antibiotics, resveratrol enhances the activity of aminoglycosides against Staphylococcus aureus, whereas it antagonizes the lethal activity of fluoroquinolones against S. aureus and Escherichia coli. While the antimicrobial properties of the compound have been extensively studied in vitro, little is known about its efficacy in vivo. Nonetheless, following topical application resveratrol has alleviated acne lesions caused by the bacterium Propionibacterium acnes. There are currently no in vivo studies addressing its effect in combination with antibiotics, but recent research suggests that there may be a potential for enhancing the antimicrobial efficacy of certain existing antibiotic classes in combination with resveratrol. Given the difficulties associated with introducing new antimicrobial agents to the market, nutraceuticals such as resveratrol may prove to be interesting candidates when searching for solutions for the growing problem of antimicrobial resistance.

International Journal of Antimicrobial Agents published new progress about Antibacterial agents. 501-36-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C14H12O3, Name: (E)-5-(4-Hydroxystyryl)benzene-1,3-diol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Ahmed, Kabirun; Saikia, Gangutri; Begum, Pakiza; Gogoi, Sandhya Rani; Sharma, Mitu; Talukdar, Hiya; Islam, Nashreen S. published the artcile< Selective and Green Sulfoxidation in Water using a New Chitosan Supported Mo(VI) Complex as Heterogeneous Catalyst>, Application of C8H10OS, the main research area is chitosan molybdenum complex heterogeneous catalyst water selective green sulfoxidation.

Immobilization of oxo-peroxo molybdenum(VI) species on natural biopolymer, chitosan led to the development of a new heterogeneous catalyst which displayed excellent activity, stability and chemoselectivity for the oxidation of a wide variety of sulfides to the resp. sulfoxides by H2O2 in water, at ambient temperature The catalyst has been comprehensively characterized by elemental anal., spectral studies (FTIR, Raman, solid-state 13C NMR and diffuse reflectance UV-Vis), PXRD, Brunauer-Emmett-Teller (BET), SEM, EDX and TGA-DTG anal. The d. functional theory (DFT) method has been employed to study the structure of the synthesized chitosan peroxomolybdenum complex (PMoCh). In addition to water, the catalyst is also highly compatible with a variety of safer organic solvents like methanol and acetonitrile. Apart from being high yielding and operationally simple, the developed catalytic protocol is environmentally clean and safe as it is absolutely free from halogenated organic solvent. Other significant green attributes of the methodol. include its ready scalability, high H2O2 efficiency and easy recyclability of the catalyst for several catalytic cycles with consistent activity/selectivity profile.

ChemistrySelect published new progress about Chemoselectivity. 699-12-7 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H10OS, Application of C8H10OS.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Xu, Qi; Zhou, Xiaoxuan; Zhang, Si; Pan, Ling; Liu, Qun; Li, Yifei published the artcile< Visible-Light-Induced Sulfur-Alkenylation of Alkenes>, Application In Synthesis of 627-27-0, the main research area is dialkyl butenedithiol preparation diastereoselective regioselective; alkene ketene dithioacetal sulfur alkenylation trimethylphenylacridinium perchlorate photoredox catalyst.

A visible-light-induced intermol. sulfur-alkenylation of alkenes RCH=CR1R2 (R = H, Me, ethyl; R1 = H, Me, ethyl; R2 = Et, Ph, 2-naphthyl, acetyloxy, etc.; R1R2 = -(CH2)4-, -(CH2)5-; RR2 = -(CH2)3-, -(CH2)4-, -(CH2)2CH=CH-, etc.), 6,6-dimethyl-2-methylene-bicyclo[3.1.1]heptane including both activated and unactivated alkenes, mols. even induced by sunlight under ambient conditions is described. This sulfur-alkenylation reaction proceed in a highly regio- and stereospecific manner involving the visible-light-induced conversion of a ketene dithioacetal to the thiavinyl 1,3-dipole intermediate, followed by a formal [3+2] cycloaddition and C-S bond cleavage. Furthermore, it is also an efficient approach for the late-stage functionalization of natural products and complex mols., even being induced by sunlight under ambient conditions.

Organic Letters published new progress about [3+2] Cycloaddition reaction catalysts (stereo-, regioselective). 627-27-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C4H8O, Application In Synthesis of 627-27-0.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Wang, Zichao; Zhao, Xiaoxiao; Liu, Xiaoying; Lu, Wenbo; Jia, Shutong; Hong, Tingting; Li, Ruifang; Zhang, Huiru; Peng, Lin; Zhan, Xiaobei published the artcile< Anti-diabetic activity evaluation of a polysaccharide extracted from Gynostemma pentaphyllum>, Quality Control of 3458-28-4, the main research area is Gynostemma polysaccharide antidiabetic; Anti-diabetic activity; Gynostemma pentaphyllum; Polysaccharide.

In current study, a polysaccharide (GPP) was successfully extracted from Gynostemma pentaphyllum herb. Monosaccharide composition of GPP was rhamnose, arabinose, galactose, glucose, xylose, mannose, galacturonic acid and glucuronic acid in a molar ratio of 4.11: 7.34: 13.31: 20.99: 1.07: 0.91: 4.75: 0.36. Mol. weight and polydispersity (Mw/Mn) of GPP were 4.070 × 104 Da and 1.037, resp. Primary structure features of GPP were determined to be a polysaccharide by FT-IR and NMR. Fasting blood sugar of diabetic mice decreased from 17.56 mmol/L to 7.42 mmol/L by orally administration of 0.5 mL GPP (1 mg/mL) for 30 days. GPP exhibited a dose-dependent inhibition effect on a-glucosidase activity. Moreover, GPP could inhibit the glucose absorption and affect the protein expression of GLUT2, but not the protein expression of SGLT1. These results indicated GPP could be used as an effective ingredient to prevent and cure diabetes.

International Journal of Biological Macromolecules published new progress about Animal gene, SGLT1 Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 3458-28-4 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H12O6, Quality Control of 3458-28-4.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Walko, Martin; Hewitt, Eric; Radford, Sheena E.; Wilson, Andrew J. published the artcile< Design and synthesis of cysteine-specific labels for photo-crosslinking studies>, Electric Literature of 25055-82-7, the main research area is diazirine photocrosslinking reagent crosslinking mass spectrometry.

Chem. crosslinking mass-spectrometry (XL-MS) represents a powerful methodol. to map ligand/biomacromol. interactions, particularly where conventional methods such as X-ray crystallog., NMR (NMR) spectroscopy or cryo-electron microscopy (EM) are not feasible. In this manuscript, we describe the design and synthesis of two new photo-crosslinking reagents that can be used to specifically label free thiols through either maleimido or methanethiosulfonate groups and facilitate PXL-MS workflows. Both crosslinkers are based on light sensitive diazirines – precursors of highly reactive carbenes which offer addnl. advantages over alternative crosslinking groups such as benzophenones and aryl nitrenes given the controlled rapid and more indiscriminate reactivity.

RSC Advances published new progress about Biomacromolecular compounds Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 25055-82-7 belongs to class alcohols-buliding-blocks, and the molecular formula is C4H8N2O, Electric Literature of 25055-82-7.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Chevella, Durgaiah; Macharla, Arun Kumar; Kodumuri, Srujana; Banothu, Rammurthy; Gajula, Krishna Sai; Amrutham, Vasu; Gennadievna, Grigor’eva Nellya; Nama, Narender published the artcile< Synthesis of internal olefins by direct coupling of alcohols and olefins over Moβ zeolite>, Formula: C8H9FO, the main research area is reusable molybdenum zeolite preparation thermal stability crystallinity; olefin aryl alc reusable zeolite catalyst dehydrative cross coupling; internal olefin diastereoselective regioselective preparation green chem.

An efficient and novel Moβ zeolite catalyzed sp2-sp3 C-C bond development reaction over the direct coupling of alcs. and alkenes was performed in solvent free environment. The current method gave an attractive access to a wide variety of polysubstituted alkenes in good to excellent yields. The Moβ zeolite was effectively reused for up to 5 successive cycles.

Catalysis Communications published new progress about Acidity. 403-41-8 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H9FO, Formula: C8H9FO.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Guo, Xiangyang; Ho, Chi-Tang; Wan, Xiaochun; Zhu, Hui; Liu, Qiong; Wen, Zhen published the artcile< Changes of volatile compounds and odor profiles in Wuyi rock tea during processing>, Computed Properties of 78-70-6, the main research area is Wuyi rock tea Odor profile favor Odor activity value; Sensory evaluation Tea processing; Odor activity value (OAV); Odor profile; Rock flavor; Sensory evaluation; Tea processing; Wuyi rock tea.

Wuyi rock tea (WRT), is one kind of oolong tea and widely appreciated for its typical ′rock flavor′. The odor characteristics of WRT during processing were comprehensive investigated by gas chromatog.-mass spectrometry, sensory evaluation and odor activity value (OAV). Alcs., alkenes and esters were the main volatiles formed during tea processes, but the WRT contained more heterocyclic compounds, among which 15 N-containing volatiles were newly identified in this study, accounting for 60.52% of total amounts of volatiles in WRT. In response, the original green and chem. odors converted to roasted and woody odors, and full fire processing was effective to enhance roasted, floral and woody odors, weaken chem. odor. 2-Ethyl-3,5-dimethylpyrazine (OAV 4.71) was confirmed as the aroma-active compound of WRT with roasted odor by aroma recombination experiment In addition, strong roasted, floral and moderate woody odors were perceived as the outline of ′rock flavor′ in WRT aroma. These results provide theor. basis for processing and quality control of WRT.

Food Chemistry published new progress about Lactones Role: ANT (Analyte), PRP (Properties), ANST (Analytical Study). 78-70-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C10H18O, Computed Properties of 78-70-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Shrivastava, Sandeep; Paila, Yamuna Devi; Kombrabail, Mamata; Krishnamoorthy, G.; Chattopadhyay, Amitabha published the artcile< Role of Cholesterol and Its Immediate Biosynthetic Precursors in Membrane Dynamics and Heterogeneity: Implications for Health and Disease>, Application In Synthesis of 434-16-2, the main research area is cholesterol precursor membrane dynamics.

Cholesterol is an indispensible component of cellular membranes in higher eukaryotes and plays a vital role in many cellular functions. 7-Dehydrocholesterol (7-DHC) and desmosterol represent two immediate biosynthetic precursors of cholesterol in the Kandutsch-Russell and Bloch pathways of cholesterol biosynthesis, resp. Although 7-DHC and desmosterol differ from cholesterol merely by a double bond, accumulation of these two immediate biosynthetic precursors due to defective cholesterol biosynthesis leads to severe developmental and neurol. disorders. In this context, the authors explored the role of cholesterol and its immediate biosynthetic precursors (7-DHC and desmosterol) on the dynamics and heterogeneity of fluid phase POPC (1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine) and gel phase DPPC (1,2-dipalmitoyl-sn-glycero-3-phosphocholine) membranes, using fluorescence lifetime distribution anal. of Nile Red (9-diethylamino-5H-benzo[α]phenoxazine-5-one) using the maximum entropy method (MEM). The authors show here that the membrane interfacial dynamic heterogeneity, manifested as the width of the fluorescence lifetime distribution of Nile Red, exhibited by 7-DHC and desmosterol vastly differ from that displayed by cholesterol, particularly in fluid phase membranes. A subtle alteration in sterol structure could considerably alter dynamic membrane heterogeneity, which could have implications in pathogenicity associated with defective cholesterol biosynthesis.

Journal of Physical Chemistry B published new progress about Membrane, biological. 434-16-2 belongs to class alcohols-buliding-blocks, and the molecular formula is C27H44O, Application In Synthesis of 434-16-2.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts