Month: October 2022

Dong, Youxian; Yuma, Madina; Mei, Yuling; Jiang, Nan; Yang, Guofang; Wang, Zhongfu; Zhang, Jianbo published the artcile< Copper-Catalyzed Stereoselective Synthesis of 2-Deoxygalactosides>, Formula: C12H20O6, the main research area is copper catalyst stereoselective glycosylation deoxygalactoside deoxygalactoside oligosaccharide glycoside disaccharide.

An efficient glycosylation method to synthesize 2-deoxy-O-galactosides based on a Cu(II)-catalyzed reaction without addnl. ligand has been developed. The glycosylation was amenable to different protected glycal donors and a wide range of acceptors including alcs., amino acids, sugars, and phenol, and proceeds with excellent yield and high α-selectivity under mild conditions. The reaction proceeds readily on a gram scale, and its versatility is exemplified in the synthesis of oligosaccharides.

Synlett published new progress about Disaccharides Role: SPN (Synthetic Preparation), PREP (Preparation). 4064-06-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C12H20O6, Formula: C12H20O6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Biswas, Manik Chandra; Bush, Bailey; Ford, Ericka published the artcile< Glucaric acid additives for the antiplasticization of fibers wet spun from cellulose acetate/acetic acid/water>, Application In Synthesis of 87-73-0, the main research area is cellulose acetate fiber glucaric acid spinning antiplasticization mech property; Antiplasticizer; Bio-based derivatives; Cellulose acetate; Glucarate salt; Glucaric acid; Spectroscopy; Strengthening; Structure-property relationship.

Cellulose acetate (CA) receives notable attention as an environmentally friendly, biodegradable polymer from renewable, low-cost resources. CA polymers are believed to have a critical role in shaping a greener and more circular textile economy. However, the mech. properties of CA fibers are among the lowest in terms of its tensile strength, poor wet strength, and low flexural strength. This study investigates the effect of biobased additives for antiplasticizing the mech. performance and structure of CA fibers. At up to 5% of CA, glucaric acid (GA) and its monoammonium salt were added to CA fibers. With 1.5% GA additive, tensile modulus improved by 155%, tensile strength by 55%, and CA flexibility according to knot to straight fiber tenacity ratios improved by 107% when compared to neat CA fibers. Based on the results, green small mol. antiplasticizers do exist, but their performance improvements are observed at low percentages of loading.

Carbohydrate Polymers published new progress about Acetate fibers Role: PEP (Physical, Engineering or Chemical Process), POF (Polymer in Formulation), PRP (Properties), PROC (Process), USES (Uses). 87-73-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H10O8, Application In Synthesis of 87-73-0.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Xu, Xiaotong; Zhang, Hanmin; Gao, Tianyu; Wang, Yuezhu; Teng, Jiaheng; Lu, Mengyang published the artcile< Customized thin and loose cake layer to mitigate membrane fouling in an electro-assisted anaerobic forward osmosis membrane bioreactor (AnOMEBR)>, Quality Control of 492-62-6, the main research area is electro assisted anaerobic forward osmosis membrane bioreactor wastewater treatment; customized thin loose cake layer mitigation membrane fouling; AnOMEBR; Electro-assisted; Electrostatic repulsion; Membrane fouling alleviation; Membrane surface charge.

An anaerobic forward osmosis (FO) membrane bioreactor (AnOMBR) is a potential wastewater treatment technol. with low energy consumption and high effluent quality; however, membrane fouling remains a considerable problem which causes water flux dwindling and shortened membrane lifetime. An electro-assisted, anaerobic forward osmosis membrane bioreactor (AnOMEBR) was developed to treat wastewater and mitigate membrane fouling, where the conductive FO membrane was used as the separation unit and cathode. Formation, development, and alleviation of membrane fouling in AnOMEBR were assessed. Results showed the soluble microbial products content and protein/polysaccharide (PN/PS) value in AnOMEBR were 26 and 15% lower than that in AnOMBR, resp. The sludge mixture absolute zeta value in AnOMEBR was 1.2 times that of AnOMBR. Increased interaction between the membrane surface and neg. charged foulants could inhibit foulant adsorption on the membrane surface in the initial membrane fouling stage. The strong interaction among foulants further affected the composition, structure, and thickness of the FO membrane surface cake layer. AnOMEBR with a shorter hydraulic retention time, higher organic loading rate, and a lower osmotic pressure difference, could still obtain a lower flux decline rate (0.063 LMH/h), 35.7% lower than AnOMBR. The AnOMEBR wastewater treatment capacity was nearly 1.5 times that of AnOMBR. Results provided an efficient strategy to mitigate membrane fouling and improve wastewater treatment capacity.

Science of the Total Environment published new progress about Biopolymers Role: OCU (Occurrence, Unclassified), RCT (Reactant), OCCU (Occurrence), RACT (Reactant or Reagent) (soluble microbial products and loose- and tightly-bound). 492-62-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H12O6, Quality Control of 492-62-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Zeng, Jing; Wang, Ruobin; Zhang, Shuxin; Fang, Jing; Liu, Shanshan; Sun, Guangfei; Xu, Bingbing; Xiao, Ying; Fu, Dengxian; Zhang, Wenqi; Hu, Yixin; Wan, Qian published the artcile< Hydrogen-Bonding-Assisted Exogenous Nucleophilic Reagent Effect for β-Selective Glycosylation of Rare 3-Amino Sugars>, Application In Synthesis of 4064-06-6, the main research area is trisaccharide synthesis synthon avidinorubicin; stereoselective glycosylation hydrogen bond amino sugar oxyphosphonium.

Challenges for stereoselective glycosylation of deoxy sugars are notorious in carbohydrate chem. We herein report a novel strategy for the construction of the less investigated β-glycosidic bonds of 3,5-trans-3-amino-2,3,6-trideoxy sugars (3,5-trans-3-ADSs), which constitute the core structure of several biol. important antibiotics. Current protocol leverages a C-3 axial sulfonamide group in 3,5-trans-3-ADSs as a hydrogen-bond (H-bond) donor and substoichiometric phosphine oxide as an exogenous nucleophilic reagent (exNu) to establish an intramol. H-bond between the former and the derived α-oxyphosphonium ion. This pivotal interaction stabilizes the α-face-covered intermediate to inhibit the formation of the more reactive β-intermediate, thereby yielding reversed β-selectivity, which is unconventional for an ex-Nu-mediated glycosylation system. A wide range of substrates was accommodated, and good to excellent β-selectivities were ensured by this H-bonding-assisted exNu effect. The robustness of the current strategy was further attested by the architectural modification of natural products and drugs containing 3,5-trans-3-ADSs, as well as the synthesis of a trisaccharide unit in avidinorubicin.

Journal of the American Chemical Society published new progress about Crystal structure. 4064-06-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C12H20O6, Application In Synthesis of 4064-06-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Feng, Zhihui; Li, Yifan; Li, Ming; Wang, Yijun; Zhang, Liang; Wan, Xiaochun; Yang, Xiaogen published the artcile< Tea aroma formation from six model manufacturing processes>, Electric Literature of 78-70-6, the main research area is tea aroma formation processing; Aroma character impact; Precursors; Quantitative SPME; Tea aroma; Tea processing; Tea types; Volatiles.

Tea aroma is determined by the nature of the plant, the production processes, and many other factors influencing its formation and release. The objective of this study was to investigate the impact of manufacturing processes on the aroma composition of tea. Fresh tea leaves from the same cultivar and growing area were selected for producing the six types of tea: green, white, yellow, oolong, black, and dark teas. Comprehensive anal. by gas chromatog. mass spectrometry (GC/MS) was performed for the volatiles of tea infusion, prepared by solid-phase microextraction (SPME), solid-phase extraction (SPE), and solvent assisted flavor evaporation (SAFE). A total of 168 volatile compounds were identified. Black tea has the highest volatile concentration of 710 μg/g, while green tea has the lowest concentration of 20 μg/g. Significantly affected by these processes, tea aroma mols. are formed mainly from four precursor groups: carotenoids, fatty acids, glycosides, and amino acids/sugars.

Food Chemistry published new progress about Odor and Odorous substances. 78-70-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C10H18O, Electric Literature of 78-70-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Malerz, Sebastian; Mudryk, Karen; Tomanik, Lukas; Stemer, Dominik; Hergenhahn, Uwe; Buttersack, Tillmann; Trinter, Florian; Seidel, Robert; Quevedo, Wilson; Goy, Claudia; Wilkinson, Iain; Thuermer, Stephan; Slavicek, Petr; Winter, Bernd published the artcile< Following in Emil Fischer's Footsteps: A Site-Selective Probe of Glucose Acid-Base Chemistry>, Reference of 492-62-6, the main research area is site selective probe glucose acid base chem.

Liquid-jet photoelectron spectroscopy was applied to determine the first acid dissociation constant (pKa) of aqueous-phase glucose while simultaneously identifying the spectroscopic signature of the resp. deprotonation site. Valence spectra from solutions at pH values below and above the first pKa reveal a change in glucose’s lowest ionization energy upon the deprotonation of neutral glucose and the subsequent emergence of its anionic counterpart. Site-specific insights into the solution-pH-dependent mol. structure changes are also shown to be accessible via C 1s photoelectron spectroscopy. The spectra reveal a considerably lower C 1s binding energy of the carbon site associated with the deprotonated hydroxyl group. The occurrence of photoelectron spectral fingerprints of cyclic and linear glucose prior to and upon deprotonation are also discussed. The exptl. data are interpreted with the aid of electronic structure calculations Our findings highlight the potential of liquid-jet photoelectron spectroscopy to act as a site-selective probe of the mol. structures that underpin the acid-base chem. of polyprotic systems with relevance to environmental chem. and biochem.

Journal of Physical Chemistry A published new progress about Acidity (pKa). 492-62-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H12O6, Reference of 492-62-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Wen, Rongxin; Hu, Yingying; Zhang, Lang; Wang, Yan; Chen, Qian; Kong, Baohua published the artcile< Effect of NaCl substitutes on lipid and protein oxidation and flavor development of Harbin dry sausage>, Electric Literature of 104-76-7, the main research area is sodium chloride dry sausage flavor lipid protein oxidation; Harbin dry sausage; Lipid oxidation; Protein oxidation; Sodium substitutes; Volatile compound analysis.

The effects of partially replacing NaCl with sodium substitutes (SS) on the lipid and protein oxidation and flavor development of Harbin dry sausage was investigated. There were three salt formulations, including a control (100% NaCl), NaCl partially substituted with KCl (SS1) (70% NaCl and 30% KCl), and NaCl partially substituted with KCl combined with other components (SS2) (70% NaCl, 20% KCl, 4% lysine, 1% alanine, 0.5% citric acid, 1% Ca-lactate and 3.5% maltodextrin). The levels of lipid and protein oxidation increased in all sausages during fermentation (P < 0.05). In addition, lower oxidation of lipids and proteins were found in the SS2 treatment (P < 0.05) due to the lower NaCl concentration The SS, especially the SS2, promoted the formation of volatile compounds originated from carbohydrate and amino acid metabolism, β-lipid oxidation and esterification; however, this substitute inhibited the formation of volatile compounds originated from lipid autoxidation (P < 0.05). Overall, SS2 could improve the flavor development of Harbin dry sausage and reduce NaCl by 30%. Meat Science published new progress about Carbohydrates Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 104-76-7 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H18O, Electric Literature of 104-76-7.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Liu, Yong; Xing, Shuya; Zhang, Jing; Liu, Wen; Xu, Yuenian; Zhang, Yan; Yang, Kefang; Yang, Lei; Jiang, Kezhi; Shao, Xinxin published the artcile< Construction of diverse C-S/C-Se bonds via nickel catalyzed reductive coupling employing thiosulfonates and a selenosulfonate under mild conditions>, Safety of But-3-en-1-ol, the main research area is organic iodide thiosulfonate nickel catalyst chemoselective reductive coupling; thioether preparation; selenosulfonate organic iodide nickel catalyst chemoselective reductive coupling; selenoether preparation.

A nickel-catalyzed reductive cross coupling between organic iodides and thiosulfonates and a selenosulfonate under mild conditions was disclosed. This practical method provides a facile access to a series of unsym. thioethers with low catalyst loading, good functional group tolerance, and excellent chemo-selectivity. Notably, the synthetic applications of the approach feature scaling-up of reactions, late-stage modification of pharmaceuticals, and preparation of various useful targeted compounds, including sulfoximine, bipyridine, and vortioxetine. Primary mechanistic studies showed that a radical pathway was involved. Moreover, diverse C-S/C-Se bond formations were achieved under mild reaction conditions.

Organic Chemistry Frontiers published new progress about Chemoselectivity. 627-27-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C4H8O, Safety of But-3-en-1-ol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Green, Scott B.; Lanier, Robert J. Jr.; Carey, Shane M.; Morgan, David R.; Gracz, Hanna; Sherman, Julian; Rodriguez, Ana; D′Antonio, Edward L. published the artcile< Synthesis, biochemical, and biological evaluation of C2 linkage derivatives of amino sugars, inhibitors of glucokinase from Trypanosoma cruzi>, Category: alcohols-buliding-blocks, the main research area is glucosamine mannosamine galactosamine inhibitor glucokinase inhibitor parasite protozoan; amino sugar inhibitor glucokinase Trypanosoma cruzi glucosamine protozoan parasite; Amino sugars; Chagas’ disease; Glucokinase; Inhibitors; Neglected tropical diseases.

Eighteen amino sugar analogs were screened against Trypanosoma cruzi glucokinase (TcGlcK), a potential drug-target of the protozoan parasite in order to assess for viable enzyme inhibition. The analogs were divided into three amino sugar scaffolds that included D-glucosamine (D-GlcN), D-mannosamine (D-ManN), and D-galactosamine (D-GalN); moreover, all but one of these compounds were novel. TcGlcK is an important metabolic enzyme that has a role in producing G6P for glycolysis and the pentose phosphate pathway (PPP). The inhibition of these pathways via glucose kinases (i.e., glucokinase and hexokinase) appears to be a strategic approach for drug discovery. Glucose kinases phosphorylate D-glucose with co-substrate ATP to yield G6P and the formed G6P enters both pathways for catabolism. The compound screen revealed five on-target confirmed inhibitors that were all from the D-GlcN series, such as compounds 1, 2, 4, 5, and 6. Four of these compounds were strong TcGlcK inhibitors (1, 2, 4, and 6) since they were found to have micromolar inhibitory constant (Ki) values around 20 μM. Three of the on-target confirmed inhibitors amino sugars, e.g. I-III, revealed notable in vitro anti-T. cruzi activity with IC50 values being less than 50 μM. Compound 1 was benzoyl glucosamine (BENZ-GlcN), a known TcGlcK inhibitor that was the starting point for the design of the compounds in this study; in addition, TcGlcK – I inhibition properties were previously determined [D′Antonio, E. L. et al. (2015) Mol. Biochem. Parasitol. 204, 64-76]. As such, compounds II-III were further evaluated biochem., where formal Ki values were determined as well as their mode of TcGlcK inhibition. The Ki values determined for compounds II-III were 107 ± 4 μM and 15.2 ± 3.3 μM, resp., and both of these compounds exhibited the competitive inhibition mode.

Bioorganic & Medicinal Chemistry Letters published new progress about Drug discovery. 5505-63-5 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H14ClNO5, Category: alcohols-buliding-blocks.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Li, Yang; Bao, Jiamin; Zhang, Yu; Peng, Xue; Yu, Weijie; Wang, Tao; Yang, Dengtao; Liu, Qun; Zhang, Qian; Fu, Junkai published the artcile< Three-component aminofluorination of alkenes with electronically rich amino sources>, Category: alcohols-buliding-blocks, the main research area is alkene bromo dialkyl amine silver fluoride regioselective aminofluorination; fluoro alkyl amine preparation.

The first intermol. three-component aminofluorination of alkenes with electronically rich amino sources was developed via an umpolung strategy. In this reaction, electrophilic N-bromodialkylamines were employed as amine electrophiles, whereas multifunctional AgF served as both a nucleophilic fluoride source and a reductive catalyst, for the first time, to initiate a single-electron transfer with N-bromodialkylamines. The addition of hexafluoroisopropanol as a cosolvent was crucial to promote protonated alkylaminyl radical formation and maintain the nucleophilicity of fluoride ion. This protocol exhibited excellent functional-group tolerance toward various aryl and unactivated alkenes, furnishing the corresponding β-fluoroamines with high regioselectivity. Mechanistic investigation revealed an aziridinium intermediate via a radical pathway. The synthetic utility of this transformation was demonstrated by the aminofluorination of several bioactive mols., including an efficient route to a Rizatriptan analog. This finding holds promise for new discoveries in medicinal chem. and the amination reactions.

Chem published new progress about Alkenes Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 627-27-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C4H8O, Category: alcohols-buliding-blocks.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts