Month: October 2022

Jia, Hao; Haering, Andreas P.; Berger, Florian; Zhang, Li; Ritter, Tobias published the artcile< Trifluoromethyl Thianthrenium Triflate: A Readily Available Trifluoromethylating Reagent with Formal CF3+, CF3• and CF3- Reactivity>, Reference of 627-27-0, the main research area is trifluoromethyl thianthrenium triflate preparation application trifluoromethylation.

Here, the synthesis and application of trifluoromethyl thianthrenium triflate (TT-CF3+OTf-) as a novel trifluoromethylating reagent, which was conveniently accessible in a single step from thianthrene and triflic anhydride was reported. The use of TT-CF3+OTf- in electrophilic, radical, and nucleophilic trifluoromethylation reactions was demonstrated.

Journal of the American Chemical Society published new progress about Alkenes Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 627-27-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C4H8O, Reference of 627-27-0.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Guo, Bin; Yu, Tian-Qi; Li, Hong-Xi; Zhang, Shi-Qi; Braunstein, Pierre; Young, David J.; Li, Hai-Yan; Lang, Jian-Ping published the artcile< Phosphine Ligand-Free Ruthenium Complexes as Efficient Catalysts for the Synthesis of Quinolines and Pyridines by Acceptorless Dehydrogenative Coupling Reactions>, Name: 1-(4-Fluorophenyl)ethyl Alcohol, the main research area is quinoline preparation green chem; aminobenzyl secondary alc dehydrogenative coupling ruthenium complex catalyst; pyridine preparation green chem; amino secondary alc dehydrogenative coupling ruthenium complex catalyst.

A series of phosphine-free Ru(III)/Ru(II) complexes of NH functionalized N N N pincer ligands exhibit excellent activity for acceptorless dehydrogenative coupling (ADC) of secondary alcs. RCH(OH)CH2R1 [R = Ph, thiophen-2-yl, Et, etc.; R1 = H, Me, Et, n-Pr; RR1 = -(CH2)4-] and bicyclo[2.2.1]heptan-2-ol with 2-aminobenzyl 2-NH2-R3C6H3CH(R2)OH [R2 = H, Me; R3 = H, 5-Me, 4-Cl] or γ-amino alcs. R4CH(NH2)(CH2)2OH (R4 = Ph, Me) to quinolines I (R5 = H, 6-Me, 7-Cl), 1,2,3,4-tetrahydro-1,4-methanoacridine and pyridines II. Ru(III) complexes [LRuCl3] III (R6 = R7 = R8 = H, R9 = Cl; R6 = H, R7 = R8 = Me, R9 = Cl; R6 = R7 = H, R8 = Ph, R9 = Cl, etc.) were obtained by refluxing RuCl3.xH2O with the corresponding ligand in EtOH. Five Ru(II) complexes [LRu(DMSO-κS)Cl2] III [R9 = S(CH3)2(O)] were formed by reducing the corresponding Ru(III) complex in refluxing EtOH. The latter complexes could also be prepared directly by refluxing Ru(DMSO)4Cl2 with the corresponding ligand in EtOH. These Ru(III) and Ru(II) complexes, especially III exhibited high catalytic efficiency and broad functional group tolerance in ADC reactions of secondary alcs. with 2-aminobenzyl or γ-amino alcs. to quinolines I and pyridines II. A detail mechanistic study indicated that the Ru(III) complex III (R9 = Cl) was reduced into the Ru(II) species III (R9 = S(CH3)2(O)), which was the active catalytic center for ADC via a Ru-H/N-H bifunctional outer-sphere mechanism. This protocol provides a reliable, atom-economical and environmentally benign procedure for C-N and C-C bond formation.

ChemCatChem published new progress about Amino alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 403-41-8 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H9FO, Name: 1-(4-Fluorophenyl)ethyl Alcohol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Nishiyama, Yutaka; Xu, Shijie; Hanatani, Yuuki; Tsuda, Susumu; Umeda, Rui published the artcile< Rhenium complex-catalyzed deoxygenation and silylation of alcohols with hydrosilane>, Reference of 76-84-6, the main research area is alc rhenium catalyst reduction; hydrocarbon preparation; hydrosilane alc rhenium catalyst silylation; silyl ether preparation.

The reduction of benzylic, tertiary, and allylic alcs. with hydrosilane was efficiently catalyzed by the rhenium complex, such as ReBr(CO)5, to give the corresponding deoxygenarated products, alkanes, in moderate to good yields. In the case of aliphatic secondary alc., the alkane was formed along with the formation of dehydrated products. On the other hand, in the case of primary and cyclic alcs., silylation of alcs. proceeded to form the corresponding silyl ethers.

Tetrahedron Letters published new progress about Alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 76-84-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C19H16O, Reference of 76-84-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Sharma, Ashwani; Kumar, G. Aditya; Chattopadhyay, Amitabha published the artcile< Late endosomal/lysosomal accumulation of a neurotransmitter receptor in a cellular model of Smith-Lemli-Opitz syndrome>, Electric Literature of 434-16-2, the main research area is Smith Lemli Opitz syndrome neurotransmitter receptor; 7-DHC; AY 9944; SLOS; altered trafficking; cholesterol; serotonin1A receptor.

Smith-Lemli-Opitz syndrome (SLOS) is a congenital and developmental malformation syndrome associated with defective cholesterol biosynthesis. It is characterized by accumulation of 7-dehydrocholesterol (the immediate biosynthetic precursor of cholesterol in the Kandutsch-Russell pathway) and an altered cholesterol to total sterol ratio. Because SLOS is associated with neurol. malfunction, exploring the function and trafficking of neuronal receptors and their interaction with membrane lipids under these conditions assume significance. In this work, we generated a cellular model of SLOS in HEK-293 cells stably expressing the human serotonin1A receptor (an important neurotransmitter G-protein coupled receptor) using AY 9944, an inhibitor for the enzyme 3β-hydroxy-steroid-Δ7-reductase (7-DHCR). Using a quant. flow cytometry based assay, we show that the plasma membrane population of serotonin1A receptors was considerably reduced under these conditions without any change in total cellular expression of the receptor. Interestingly, the receptors were trafficked to sterol-enriched LysoTracker pos. compartments, which accumulated under these conditions. To the best of our knowledge, our results constitute one of the first reports demonstrating intracellular accumulation and misregulated traffic of a neurotransmitter GPCR in SLOS-like conditions. We believe these results assume relevance in our overall understanding of the mol. basis underlying the functional relevance of neurotransmitter receptors in SLOS.

Traffic (Oxford, United Kingdom) published new progress about 5-HT1A receptors Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 434-16-2 belongs to class alcohols-buliding-blocks, and the molecular formula is C27H44O, Electric Literature of 434-16-2.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Rubel Mozumder, N. H. M.; Lee, Yeong-Ran; Hwang, Kyeong Hwan; Lee, Min-Seuk; Kim, Eun-Hee; Hong, Young-Shick published the artcile< Characterization of tea leaf metabolites dependent on tea (Camellia sinensis) plant age through 1H NMR-based metabolomics>, Electric Literature of 492-62-6, the main research area is Camellia sinensis tea leaf metabolite.

Abstract: The chem. or metabolic compositions of tea (Camellia sinensis) varies according to numerous factors, such as geog. origin, cultivar, climate, plucking position, and horticultural practices. However, how the age of tea plants affects the metabolite compositions of tea leaves has not been reported yet. Therefore, we extended the metabolomic approach to the investigation of the age-related differences of tea leaf metabolites in the fresh leaves collected from tea plants aged 8 and 25 years. Multivariate statistical anal. with comprehensive metabolite profiles analyzed by 1H NMR spectroscopy showed the clear metabolic differentiation between the fresh tea leaves from different ages of the tea plants. Of the various tea leaf metabolites varied according to the age of the tea plants, theanine, glutamine, catechin, and gallocatechin were uniquely dependent on the age of tea plants, demonstrating a difference of theanine metabolism between young and old tea plants. These results suggest that leaves from 25-yr-old tea plants would still be worthy as a functional ingredient for the production in the food or cosmetic industry rather than quality-enhanced tea infusions for human consumption.

Applied Biological Chemistry published new progress about Camellia sinensis. 492-62-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H12O6, Electric Literature of 492-62-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Li, Huige; Xia, Ning; Hasselwander, Solveig; Daiber, Andreas published the artcile< Resveratrol and vascular function>, Quality Control of 501-36-0, the main research area is review resveratrol blood pressure vascular function; cardiovascular disease; endothelial nitic oxide synthase; endothelium; resveratrol; sirtuin 1; vascular function.

A review. Resveratrol increases the production of nitric oxide (NO) in endothelial cells by upregulating the expression of endothelial NO synthase (eNOS), stimulating eNOS enzymic activity, and preventing eNOS uncoupling. At the same time, resveratrol inhibits the synthesis of endothelin-1 and reduces oxidative stress in both endothelial cells and smooth muscle cells. Pathol. stimuli-induced smooth muscle cell proliferation, vascular remodeling, and arterial stiffness can be ameliorated by resveratrol as well. In addition, resveratrol also modulates immune cell function, inhibition of immune cell infiltration into the vascular wall, and improves the function of perivascular adipose tissue. All these mechanisms contribute to the protective effects of resveratrol on vascular function and blood pressure in vivo. Sirtuin 1, AMP-activated protein kinase, and estrogen receptors represent the major mols. mediating the vascular effects of resveratrol.

International Journal of Molecular Sciences published new progress about Adipose tissue. 501-36-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C14H12O3, Quality Control of 501-36-0.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Li, Tan; Miao, Kai; Zhao, Zhigang; Li, Yuqing; Wang, Huiyuan; Watanabe, Atsushi; Teramae, Norio; Wang, Kaige published the artcile< Understanding cellulose pyrolysis under hydrogen atmosphere>, Electric Literature of 627-27-0, the main research area is cellulose pyrolysis hydropyrolysis mechanism.

The product distributions of cellulose pyrolysis under different pressures, temperatures, and atmospheres were investigated using a high-pressure micropyrolyzer to clarify the pyrolysis reaction mechanism of cellulose decomposition with hydrogen. EGA-MS results shows that the increase in hydrogen pressure prolonged the second stage of cellulose pyrolysis, which was dominated by decarboxylation. Pyrolysis products of cellulose under helium mainly included levoglucosan, furfural, and acids, while cellulose hydropyrolysis mainly produced C5-C7 ketones, besides small amount of alcs., aromatics and aliphatic hydrocarbons, and even small amount of phenolics. Carbon yield of ketones was as high as 27.2% from cellulose hydropyrolysis under 2.5 MPa hydrogen and 500°. The yield of liquid products and non-condensable hydrocarbons increased with elevated hydrogen pressure. The formation mechanisms of aromatics, phenolics, aliphatic hydrocarbons, aldehydes, ketones, and alcs. under hydrogen atm. were discussed. Acetaldehyde was produced by acids through a HDO reaction. C5-C7 chain ketones and cyclic ketones were generated by furfural through HDO and hydrocracking reactions. The Diels-Alder reaction to generate aromatics was enhanced by increasing pyrolysis temperature under hydrogen atm. The reaction network of cellulose hydropyrolysis was also proposed.

Energy Conversion and Management published new progress about Chars. 627-27-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C4H8O, Electric Literature of 627-27-0.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Lan, Xiao-Bing; Ye, Zongren; Liu, Jiahao; Huang, Ming; Shao, Youxiang; Cai, Xiang; Liu, Yan; Ke, Zhuofeng published the artcile< Sustainable and Selective Alkylation of Deactivated Secondary Alcohols to Ketones by Non-bifunctional Pincer N-heterocyclic Carbene Manganese>, Electric Literature of 403-41-8, the main research area is ketone preparation green chem; primary secondary alc alkylation heterocyclic carbene manganese catalyst; N-heterocyclic carbene; alkylation; borrowing hydrogen; manganese; pincer.

A sustainable and green route to access diverse functionalized ketones RC(O)CH2CH2R1 (R = Ph, thiophen-2-yl, 4-bromophenyl, etc.; R1 = Ph, naphthalen-2-yl, pyridin-3-yl, etc.) via dehydrogenative-dehydrative cross-coupling of primary R1CH2OH and secondary alcs. RCH(OH)CH3 is demonstrated. This borrowing hydrogen approach employing a pincer N-heterocyclic carbene Mn complex I•Br- (R2 = Me, iPr, Ph) displays high activity and selectivity. A variety of primary and secondary alcs. is well tolerant and results in satisfactory isolated yields. Mechanistic studies suggest that this reaction proceeds via a direct outer-sphere mechanism and the dehydrogenation of the secondary alc. substrates plays a vital role in the rate-limiting step.

ChemSusChem published new progress about Alkylation. 403-41-8 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H9FO, Electric Literature of 403-41-8.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Zeng, Fanke; Chen, Wenbo; He, Ping; Zhan, Qiping; Wang, Qian; Wu, Hui; Zhang, Mengmeng published the artcile< Structural characterization of polysaccharides with potential antioxidant and immunomodulatory activities from chinese water chestnut peels>, Product Details of C6H12O6, the main research area is Eleocharis polysaccharide antioxidant immunomodulation; Antioxidant activity; Chinese water chestnut peels; Immunomodulatory activity; Polysaccharides; Structural features.

Chinese water chestnut peels are a kind of vegetable processing waste containing many active components such as polysaccharides, the structure of which remains unknown. To elucidate the structure of polysaccharides from Chinese water chestnut peels, two polysaccharides named WVP-1 and WVP-2 were isolated. WVP-1 (3.16 kDa) consisted of mannose (1.75%), glucose (84.69%), galactose (6.32%), and arabinose (7.24%), while WVP-2 (56.97 kDa) was composed of mannose (3.18%), rhamnose (1.52%), glucuronic acid (1.42%), galacturonic acid (4.83%), glucose (11.51%), galactose (36.02%), and arabinose (41.53%). Linkage and NMR data indicated that WVP-1 was composed mainly of →4)-α-D-Glcp(1→ and a certain proportion of →3)-β-D-Glcp-(1→, including linear and branched polysaccharides simultaneously. WVP-2 was a pectin-like polysaccharide with →4)-α-D-GalpA6Me-(1→ units and the branch points of →3,4)-α-L-Arap-(1→, →3,6)-β-D-Galp-(1→. WVP-2 exhibited stronger potential antioxidant and immunomodulatory activities than WVP-1 in vitro. These results provide a foundation for the further study of polysaccharides from Chinese water chestnut peels.

Carbohydrate Polymers published new progress about Antioxidants. 3458-28-4 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H12O6, Product Details of C6H12O6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Gholinejad, Mohammad; Naghshbandi, Zhwan; Sansano, Jose M. published the artcile< Co/Cu bimetallic ZIF as New heterogeneous catalyst for reduction of nitroarenes and dyes>, Electric Literature of 5344-90-1, the main research area is cobalt copper bimetallic ZIF catalyst reduction dye nitroarene aminoarene.

Nowadays one of the great challenges is to design new bimetallic catalysts with enhanced catalytic activity, selectivity and recycling properties. In this work, the preparation of new Co/Cu bimetallic Zeolitic Imidazolate Framework (Co-Cu/ZIF) as an efficient catalyst for the reduction of nitro compounds and organic dyes is described. Co-Cu/ZIF was characterized with different techniques such as SEM, TEM, XRD, XPS, TGA, FT-IR and UV-vis absorption indicating formation of entirely uniform cubic particles. Using this catalyst, structurally different aromatic nitro compounds were reduced efficiently to corresponding amines in excellent yields. Kinetic studies revealed that the reduction rates of nitrophenol isomers follow 3-NP > 4-NP > 2-NP order. The catalytic activity of Co-Cu/ZIF was further investigated in the reduction of organic dyes such as methyl orange (MO) and rhodamine B (RhB). This catalyst was recycled for at least ten runs in the reduction of 4-nitrophenol without a noticeable decrease in activity and reused catalyst was characterized.

Applied Organometallic Chemistry published new progress about Aromatic amines Role: SPN (Synthetic Preparation), PREP (Preparation). 5344-90-1 belongs to class alcohols-buliding-blocks, and the molecular formula is C7H9NO, Electric Literature of 5344-90-1.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts