Month: October 2022

Bheeter, Linus P.; Henrion, Mickael; Brelot, Lydia; Darcel, Christophe; Chetcuti, Michael J.; Sortais, Jean-Baptiste; Ritleng, Vincent published the artcile< Hydrosilylation of aldehydes and ketones catalyzed by an N-heterocyclic carbene-nickel hydride complex under mild conditions>, Safety of (1-Methyl-1H-pyrrol-2-yl)methanol, the main research area is nitrogen heterocyclic carbene nickel hydride preparation mol crystal structure; aldehyde hydrosilylation nitrogen heterocyclic carbene nickel hydride complex catalyst; ketone hydrosilylation nitrogen heterocyclic carbene nickel hydride complex catalyst; alc preparation.

Half-sandwich N-heterocyclic carbene (NHC)-nickel complexes of the general formula [Ni(NHC)ClCp1] (Cp1 = Cp, Cp*) efficiently catalyze the hydrosilylation of aldehydes and ketones at room temperature in the presence of a catalytic amount of sodium triethylborohydride and thus join the fairly exclusive club of well-defined nickel(II) catalyst precursors for the hydrosilylation of carbonyl functionalities. Of notable interest is the isolation of an intermediate nickel hydride complex that proved to be the real catalyst precursor.

Advanced Synthesis & Catalysis published new progress about Alcohols Role: SPN (Synthetic Preparation), PREP (Preparation). 52160-51-7 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H9NO, Safety of (1-Methyl-1H-pyrrol-2-yl)methanol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Canellas, Natalia O. A.; Olivares, Fabio L.; Canellas, Luciano P. published the artcile< Metabolite fingerprints of maize and sugarcane seedlings: searching for markers after inoculation with plant growth-promoting bacteria in humic acids>, Category: alcohols-buliding-blocks, the main research area is metabolite fingerprint biostimulant seedling Zea Saccharum.

Background: The neg. consequences of industrial agriculture greatly affect human health and the environment. Debating our dietary requirements and challenging the means of food production are necessary. In the first years of transitioning to agroecol. production, crop yields normally decrease. Humic acids and beneficial bacteria used as plant growth promoters can be helpful during this stressful time. Metabolite target identification will aid in increasing plant responses to these agents. Materials: We evaluated the metabolite fingerprints of maize and sugarcane seedlings after 5 days of treatment with like-humic acids isolated from vermicompost coupled with a combined Herbaspirillum seropedicae and Gluconacetobacter diazotrophicus application. The hydromethanolic foliar extracts were submitted for 1H NMR anal., and the data were explored using chemometrics procedures. After the preliminary screening, the extracts were analyzed by gas chromatog. coupled to time of flight mass spectrometry to identify metabolite targets. Results: The biostimulant significantly changed the metabolic fingerprints independent of the plant species. The main proton spectral regions changed by biostimulant use were from 0 to 2.5 ppm and 3.5 to 5 ppm, as revealed by a principal component anal. The main signals corresponded to amino acid, sugar and organic acid chem. shifts. Aspartic acid was the amino acid present in greatest amounts in both leaf extracts A significant change occurred in the region normally attributed to (CHn)-protons bound to electron-withdrawing groups, such as carboxyls from mucic, ribonic and saccharic acids derived from sugars and aromatic structures from shikimic acid, 4-hydroxybenzoate and 3,4-dihydroxycinnamic acid. The main organic acids altered by the biostimulant were representatives of the tricarboxylic acid cycle (citric, isocitric, aconitic, malic and fumaric acids). Linoleic and myristic acids, 1-mono palmitin and tocopherol were the major lipid components found at greater levels in the treated leaf extracts Compounds from the oxidative end products of ascorbic acid metabolism, like threonic, isothreonic and oxalic acids, are putative biomarkers of the biostimulant as are the cyclic polyol identified as quinic acid and trehalose, a disaccharide involved in plant stress responses. Conclusion: The biostimulant induced significant changes in the metabolite fingerprints of maize and sugarcane seedlings as revealed by NMR. Both primary and secondary metabolisms were affected, and 22 putative biomarkers associated with the biostimulant-treated plant phenotype were identified. This agrees with previous work indicating that the stimulation of primary and secondary metabolisms was partially responsible for biostimulant effects on non-leguminous plants. Moreover, these metabolite targets could be used to genetically manipulate metabolic pathways to aid Poaceae breeding programs in increasing biostimulative responses.

Chemical and Biological Technologies in Agriculture published new progress about Amino acids Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 87-73-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H10O8, Category: alcohols-buliding-blocks.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Chen, Lin; Zhao, Xue; Wu, Ji’en; He, Yun; Yang, Hongshun published the artcile< Metabolic analysis of salicylic acid-induced chilling tolerance of banana using NMR>, Related Products of 492-62-6, the main research area is banana salicylic acid metabolic analysis; Cold injury; Energy status; Fruit; Metabolomics; Omics; Pathway; Principal component analysis; Salicylic acid.

Banana is highly susceptible to low temperature and salicylic acid (SA) can effectively improve the chilling tolerance. The metabolic changes of SA induced chilling responses of banana were studied. Bananas normally ripened under 15°C and dramatic metabolic difference compared with other groups was recorded. Accumulation of glucose (>1.5 folds) and consumption of unsaturated fatty acids (11.0-16.5%) were observed The glycolysis was induced to compensate the decreased energy charge. Low temperature (6°C) caused chilling damage and metabolites including glutamine, serine, and glucose were related to chilled bananas. Various physiol. changes such as sugar metabolism and consumption of reducing substances occurred to adapt the cold stress. SA released the cold injury and the disaccharides were increased by 18.1-21.4%. Further anal. revealed the synthesis of unsaturated fatty acids, amino acids such as proline, and enhanced energy charge. Thus, SA increased the chilling tolerance via a number of different metabolic mechanisms.

Food Research International published new progress about Banana. 492-62-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H12O6, Related Products of 492-62-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Martinez-Ferrate, Oriol; Chatterjee, Basujit; Werle, Christophe; Leitner, Walter published the artcile< Hydrosilylation of carbonyl and carboxyl groups catalysed by Mn(I) complexes bearing triazole ligands>, Recommanded Product: 1-(4-Fluorophenyl)ethyl Alcohol, the main research area is alc preparation; ketone ester carboxyl hydrosilylation manganese triazole ligand catalyst.

Manganese(I) complexes bearing triazole ligands are reported as catalysts for the hydrosilylation of carbonyl and carboxyl compounds The desired reaction proceeds readily at 80° within 3 h at catalyst loadings as low as 0.25 to 1 mol%. Hence, good to excellent yields of alcs. could be obtained for a wide range of substrates including ketones, esters, and carboxylic acids illustrating the versatility of the metal/ligand combination.

Catalysis Science & Technology published new progress about Alcohols Role: SPN (Synthetic Preparation), PREP (Preparation). 403-41-8 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H9FO, Recommanded Product: 1-(4-Fluorophenyl)ethyl Alcohol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Vega-Rojas, Lineth Juliana; Luzardo-Ocampo, Ivan; Mosqueda, Juan; Palmerin-Carreno, Dulce Maria; Escobedo-Reyes, Antonio; Blanco-Labra, Alejandro; Escobar-Garcia, Konisgmar; Garcia-Gasca, Teresa published the artcile< Bioaccessibility and in vitro intestinal permeability of a recombinant lectin from Tepary bean (Phaseolus acutifolius) using the everted intestine assay>, SDS of cas: 492-62-6, the main research area is Phaseolus acutifolius lectin tepary bean intestinal permeability bioaccessibility; Tepary bean (Phaseolus acutifolius); apparent permeability; bioaccessibility; ex vivo everted intestine assay; in vitro and ex vivo gastrointestinal digestion; recombinant lectin.

Tepary bean (Phaseolus acutifolius) lectins exhibit differential in vitro and in vivo biol. effects, but their gastrointestinal interactions and digestion have not yet been assessed. This work aimed to evaluate the changes of a recombinant Tepary bean lectin (rTBL-1) through an in vitro and ex vivo gastrointestinal process. A polyclonal antibody was developed to selectively detect rTBL-1 by Western blot (WB) and immunohistochem. anal. Everted gut sac viability was confirmed until 60 min, where protein bioaccessibility, apparent permeability coefficient, and efflux ratio showed rTBL-1 partial digestion and absorption. Immunoblot assays suggested rTBL-1 internalization, since the lectin was detected in the digestible fraction. The immunohistochem. assay detected rTBL-1 presence at the apical side of the small intestine, potentially due to the interaction with the intestinal cell membrane. The in silico interactions between rTBL-1 and some saccharides or derivatives showed high binding affinity to sialic acid (-6.70 kcal/mol) and N-acetylglucosamine (-6.10 kcal/mol). The ultra-high-performance liquid chromatog.-electron spray ionization-quant. time-of-flight coupled to mass spectrometry (UHPLC-ESI-QTOF/MS) anal. showed rTBL-1 presence in the gastric content and the non-digestible fraction after intestinal simulation conditions. The results indicated that rTBL-1 partially resisted the digestive conditions and interacted with the intestinal membrane, whereas its digestion allowed the absorption or internalization of the protein or the derivative peptides. Further purification of digestion samples should be conducted to identify intact rTBL-1 protein and digested peptides to assess their physiol. effects.

International Journal of Molecular Sciences published new progress about Absorption. 492-62-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H12O6, SDS of cas: 492-62-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Lan, Xiao-Bing; Ye, Zongren; Huang, Ming; Liu, Jiahao; Liu, Yan; Ke, Zhuofeng published the artcile< Nonbifunctional Outer-Sphere Strategy Achieved Highly Active α-Alkylation of Ketones with Alcohols by N-Heterocyclic Carbene Manganese (NHC-Mn)>, Synthetic Route of 5344-90-1, the main research area is ketone alc NHC manganese alkylation catalyst; alkylated ketone preparation; amino benzyl alc ketone NHC manganese Friedlander annulation catalyst; quinoline preparation.

The unusual nonbifunctional outer-sphere strategy was successfully utilized in developing an easily accessible N-heterocyclic carbene manganese (NHC-Mn) system for highly active α-alkylation of ketones with alcs. This system was efficient for a wide range of ketones and alcs. under mild reaction conditions, and also for the green synthesis of quinoline derivatives The direct outer-sphere mechanism and the high activity of the present system demonstrate the potential of nonbifunctional outer-sphere strategy in catalyst design for acceptorless dehydrogenative transformations.

Organic Letters published new progress about Alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 5344-90-1 belongs to class alcohols-buliding-blocks, and the molecular formula is C7H9NO, Synthetic Route of 5344-90-1.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Wang, Huai-Wei; Wu, Jia-Xue; Huang, Xian-Qiang; Li, Da-Cheng; Wang, Su-Na; Lu, Yi; Dou, Jian-Min published the artcile< RhIII-Catalyzed C-H N-Heteroarylation and Esterification Cascade of Carboxylic Acid with Organoboron Reagents and 1,2-Dichloroethane in One-Pot Synthesis>, Application of C12H18BNO2, the main research area is aryl carboxylic acid heteroaromatic boronate heteroarylation esterification cascade rhodium.

A RhIII-catalyzed C(sp2)-H N-heteroarylation and esterification cascade of aryl carboxylic acids with N-heteroaromatic boronates and 1,2-dichloroethane in a one-pot synthesis has been disclosed. The strong coordinating ability of ortho- and meta-substituted pyridine boronates and pyrazoles as well as unsubstituted pyrimidine allows them to serve as the coupling partners. This protocol allows late-stage modification of the key precursor of roflumilast and compounds of pharmaceutical interest, which highlights the potential application of this synthetic method.

Organic Letters published new progress about Aromatic carboxylic acids Role: RCT (Reactant), RACT (Reactant or Reagent). 660867-80-1 belongs to class alcohols-buliding-blocks, and the molecular formula is C12H18BNO2, Application of C12H18BNO2.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Rozi, Parhat; Abuduwaili, Aytursun; Mutailifu, Paiheerding; Gao, Yanhua; Rakhmanberdieva, Rano; Aisa, Haji Akber; Yili, Abulimiti published the artcile< Sequential extraction, characterization and antioxidant activity of polysaccharides from Fritillaria pallidiflora Schrenk>, Safety of (2S,3S,4R,5R)-2,3,4,5,6-Pentahydroxyhexanal, the main research area is Fritillaria polysaccharide extraction antioxidant activity property; Antioxidant activity; Characterization; Fritillaria pallidiflora schrenk; Polysaccharide.

In this paper, Fritillaria pallidiflora schrenk polysaccharides were extracted with different methods and isolated by anion-exchange and gel-permeation chromatog. Physicochem. properties, structural characteristics and antioxidant activities were investigated for the first time. The polysaccharides composed of glucose, galactose, arabinose, xylose, mannose and rhamnose with different molar ratio and mol. weight Fourier transform IR spectroscopy and NMR anal. exhibited the presence of key functional groups of polysaccharides whereas SEM anal. revealed the characteristic morphol. of different fractions. The thermogravimetric anal. manifested the thermal stability of polysaccharides. The reducing power and antioxidant activities of polysaccharides were evaluated in vitro. Among them, the acidic fraction FPSP-H2-1 has a strong antioxidant effect against DPPH, hydroxyl and ABTS free radicals. The results revealed the polysaccharide’s important role as potential natural antioxidant agents during the investigation and application of bioactive polysaccharide.

International Journal of Biological Macromolecules published new progress about Anion exchange. 3458-28-4 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H12O6, Safety of (2S,3S,4R,5R)-2,3,4,5,6-Pentahydroxyhexanal.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Zhou, Lianyu; Jiao, Lu; Ju, Jiasheng; Ma, Xuelan published the artcile< Effect of Sodium Selenite on the Metabolite Profile of Epichloe sp. Mycelia from Festuca sinensis in Solid Culture>, Formula: C6H10O8, the main research area is Epichloe Festuca sinensis sodium selenite metabolite mycelia solid culture; Culture time; Epichloë sp. from Festuca sinensis; Metabolite analysis; Selenium.

Selenium (Se) is an essential micronutrient with many beneficial effects for humans and other living organisms. Numerous microorganisms in culture systems enrich and convert inorganic selenium to organic selenium. In this study, Epichloe sp. from Festuca sinensis was exposed to increasing Na2SeO3 concentrations (0, 0.1, 0.2, 0.3, and 0.4 mmol/L) in Petri dishes with potato dextrose agar (PDA) for 8 wk. Epichloe sp. mycelia were immediately collected after mycelial diameters were measured at 4, 5, 6, 7, and 8 wk of cultivation, resp. Gas chromatog.-mass spectrometer (GC-MS) anal. was performed on different groups of Epichloe sp. mycelia. Different changes were observed as Epichloe sp. was exposed to different selenite conditions and cultivation time. The colony diameter of Epichloe sp. decreased in response to increased selenite concentrations, whereas the inhibitory effects diminished over time. Seventy-two of the 203 identified metabolites did not differ significantly across selenite treatments within the same time point, while 82 compounds did not differ significantly between multiple time points of the same Se concentration However, the relative levels of 122 metabolites increased the most under selenite conditions. Specifically, between the 4th and 8th weeks, there were increases in 2-keto-isovaleric acid, uridine, and maltose in selenite treatments compared to controls. Selenium increased glutathione levels and exhibited antioxidant properties in weeks 4, 5, and 7. Addnl., we observed that different doses of selenite could promote the production of carbohydrates such as isomaltose, cellobiose, and sucrose; fatty acids such as palmitoleic acid, palmitic acid, and stearic acid; and amino acids such as lysine and tyrosine in Epichloe sp. mycelia. Therefore, Epichloe sp. exposed to selenite stress may benefit from increased levels of some metabolite compounds

Biological Trace Element Research published new progress about Amino acids Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 87-73-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H10O8, Formula: C6H10O8.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Chen, Yong; Chen, Qi; Wang, Yuyu; Zhang, Qiang; Han, Qiuxia published the artcile< Fluorocarbon-assisted surface orientation of N-halamine groups on cellulose in supercritical CO2: An effective and eco-friendly approach for developing higher biocidability>, Safety of But-3-en-1-ol, the main research area is surface orientation halamine polysiloxane cellulose supercritical carbon dioxide; biocidal halamine polysiloxane coating cotton textile antibacterial.

Preferential segregation of N-halamine structure to top surface to better contact with bacteria is demonstrated to be an effective tactic for achievement of higher biocidability. 5-Allylbarbituric acid and its fluorinated derivative, formed by sacrificing a imide hydrogen to tether a 4-perfluorohexylbutyl segment via nucleophilic substitution, were synthesized and sep. attached to (50% methylhydrosiloxane)-dimethylsiloxane block copolymer (P(MHS-DMS)) via hydrosilylation. Chlorination of N-H bonds originating from barbituric acid produced two N-halamine polysiloxanes that were interpenetrated into cellulose to form coatings with similar morphol. and thickness. Although containing ∼50% less total content of chlorine than its nonfluorinated counterpart, polysiloxane with fluorinated pendants exerted faster inactivation against Staphylococcus aureus and Escherichia coli due to the orientation of its N-halamine groups on top surface with the assistance of the low-surface-tension 4-perfluorohexylbutyl segment as verified by depth profiling using angle-dependent XPS (ADXPS). Design biocide with proper surface segregation ability therefore paves a new way for improved antibacterial efficacy. The stability and rechargeability of the biocidability of the coatings are satisfactory under washing cycles, UV irrigation, and storage.

Applied Surface Science published new progress about Antibacterial agents. 627-27-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C4H8O, Safety of But-3-en-1-ol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts