Month: October 2022

Jia, Rui-Bo; Wu, Juan; Li, Zhao-Rong; Ou, Zhi-Rong; Zhu, Qiyuan; Sun, Baoguo; Lin, Lianzhu; Zhao, Mouming published the artcile< Comparison of physicochemical properties and antidiabetic effects of polysaccharides extracted from three seaweed species>, Electric Literature of 3458-28-4, the main research area is Ascophyllum Fucus Undaria diabetes polysaccharide physicochem property antidiabetic; Algal polysaccharides; Antidiabetic effects; Structural characterization.

Three algae polysaccharides (APs) extracted from Ascophyllum nodosum (ANP), Fucus vesiculosus (FVP) and Undaria Pinnatifida (USP) significantly differed in the zeta potential, water and oil holding capacity, monosaccharide composition, organic element composition, mol. weight distribution, microstructure and rheol. properties. Antidiabetic effects of APs were compared by oral intervention at the dose of 400 mg/kg·body weight/day in high sugar and fat diets and streptozotocin injection induced type 2 diabetic rats. The anal. of body weight, water intake, fasting blood glucose, insulin, oral glucose tolerance, blood lipid indicators (including total cholesterol (TC), triglyceride (TG), low d. lipoprotein cholesterol (LDL-C) and free fatty acid (FFA)), liver function indexes (involving alanine aminotransferase (ALT) and aspartate aminotransferase (AST)) and renal function profiles (comprising uric acid (UA) and urea nitrogen (BUN)) showed that APs possessed obvious antidiabetic activities, and FVP showed better effects in controlling the levels of FFA, AST, ALT, UA and BUN. Intervention of FVP reduced the total bile acid (TBA) level and elevated high d. lipoprotein cholesterol (HDL-C) level of diabetic rats. Histomorphol. observation further demonstrated that APs, especially FVP, could attenuate liver and kidney damage caused by diabetes. This study concluded that the antidiabetic effects of ANP, FVP and USP were distinctly different, which might be attributed to their different chem. structures. Therefore, the structure-activity relationship and antidiabetic mechanism of APs will be our future research direction.

International Journal of Biological Macromolecules published new progress about Antidiabetic agents. 3458-28-4 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H12O6, Electric Literature of 3458-28-4.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Mohamed, Maged E.; Abduldaium, Yamen S.; Younis, Nancy S. published the artcile< Ameliorative effect of linalool in cisplatin-induced nephrotoxicity: the role of HMGB1/TLR4/NF-κB and Nrf2/HO1 pathways>, Safety of 3,7-Dimethylocta-1,6-dien-3-ol, the main research area is linalool cisplatin induced nephrotoxicity ameliorative effect; apoptosis; essential oil; human cell line cytotoxicity; monoterpenes; oxidative stress; toll-like receptors.

The monoterpene linalool is a well-known essential oil component produced by several aromatic plants. Cisplatin is a widely used anticancer drug that produces many side effects, particularly nephrotoxicity. Here, we aimed to inspect linalool′s protective activity against cisplatin-induced nephrotoxicity and explore part of the underlying mechanisms. Male Wistar rats were given linalool (50 and 100 mg/kg/day orally) for 15 days; then challenged with cisplatin (8 mg/kg) on the 12th day. Renal function parameters, oxidative stress, inflammatory and apoptotic markers, and toll-like receptor pathway gene, and protein expressions were investigated. Histopathol., immunohistochem., and cell-line mediated cytotoxicity assays were conducted. Linalool ameliorated kidney function after cisplatin challenge and managed all oxidation system parameters including GSH, SOD, CAT, MDA, NADPH, and particularly the Nrf2-mediated pathway markers. Linalool decreased TLR4, MYD88 and TRIF gene and protein expressions; diminished related inflammatory mediators such as TNF-α, IL-1β, IL-6, and NF-κB; and down-regulated HMBG1. Linalool mitigated cisplatin-induced apoptotic markers such as caspase 3, caspase 9, and Bax expression, and boosted the anti-apoptotic Bcl2 expression. Linalool potentiated the cytotoxic effect of cisplatin when investigated on HeLa and PC3 human cancer cell lines. Linalool could protect against cisplatin-induced kidney function and tissue damage.

Biomolecules published new progress about Animal gene Role: BSU (Biological Study, Unclassified), PRP (Properties), BIOL (Biological Study) (Bax). 78-70-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C10H18O, Safety of 3,7-Dimethylocta-1,6-dien-3-ol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Liu, Jianguo; Lin, Shanshan; Sun, Jiangming; Ma, Longlong published the artcile< In-situ facile synthesis novel N-doped thin graphene layer encapsulated Pd@N/C catalyst for semi-hydrogenation of alkynes>, Electric Literature of 10602-04-7, the main research area is doped graphene encapsulated palladium carbon nitrogen catalyst preparation; semi hydrogenation alkyne graphene palladium carbon catalyst.

Transition metal-catalyzed semi-hydrogenation of alkynes has become one of the most popular methods for alkene synthesis. Specifically, the noble metal Pd, Rh, and Ru-based heterogeneous catalysts have been widely studied and utilized in both academia and industry. But the supported noble metal catalysts are generally suffering from leaching or aggregation during harsh reaction conditions, which resulting low catalytic reactivity and stability. Herein, we reported the facile synthesis of nitrogen doped graphene encapsulated Pd catalyst and its application in the chemo-selective semi-hydrogenation of alkynes. The graphene layer served as “”bulletproof”” over the active Pd Nano metal species, which was confirmed by X-ray and TEM anal., enhanced the catalytic stability during the reaction conditions. The optimized prepared Pd@N/C catalyst showed excellent efficiency in semi-hydrogenation of phenylacetylene and other types of alkynes with un-functionalized or functionalized substituents, including the hydrogenation sensitive functional groups (NO2, ester, and halogen).

Journal of Catalysis published new progress about Alkenes Role: SPN (Synthetic Preparation), PREP (Preparation). 10602-04-7 belongs to class alcohols-buliding-blocks, and the molecular formula is C9H8O, Electric Literature of 10602-04-7.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Nikitas, Nikolaos F.; Tzaras, Dimitrios Ioannis; Triandafillidi, Ierasia; Kokotos, Christoforos G. published the artcile< Photochemical oxidation of benzylic primary and secondary alcohols utilizing air as the oxidant>, Formula: C8H9FO, the main research area is photochem oxidation benzylic secondary alc air oxidant; aldehyde ketone preparation.

A mild and green photochem. protocol for the oxidation of alcs. to aldehydes and ketones was developed. Using thioxanthenone as the photocatalyst, mol. oxygen from air as the oxidant and cheap household lamps or sunlight as the light source, a variety of primary and secondary alcs. were converted into the corresponding aldehydes or ketones in low to excellent yields. The reaction mechanism was extensively studied.

Green Chemistry published new progress about Aldehydes Role: SPN (Synthetic Preparation), PREP (Preparation). 403-41-8 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H9FO, Formula: C8H9FO.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Krishnan, Saravanan; Patel, Paresh N.; Balasubramanian, Kalpattu K.; Chadha, Anju published the artcile< Yeast supported gold nanoparticles: an efficient catalyst for the synthesis of commercially important aryl amines>, SDS of cas: 5344-90-1, the main research area is nitroarene Candida parapsilosis support gold catalyst reduction green chem; aryl amine preparation.

Candida parapsilosis ATCC 7330 supported gold nanoparticles (CpGNP), prepared by a simple and green method was selectively reduce nitroarenes and substituted nitroarenes with different functional groups like halides (-F, -Cl, -Br), olefins, esters and nitriles using sodium borohydride. The product aryl amines which were useful for the preparation of pharmaceuticals, polymers and agrochems. were obtained in good yields (up to >95%) using CpGNP catalyst under mild conditions. The catalyst showed high recyclability (≥10 cycles) and was a robust free flowing powder, stored and used after eight months without any loss in catalytic activity.

New Journal of Chemistry published new progress about Aromatic amines Role: SPN (Synthetic Preparation), PREP (Preparation). 5344-90-1 belongs to class alcohols-buliding-blocks, and the molecular formula is C7H9NO, SDS of cas: 5344-90-1.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Matsuda, Asami; Matsumura, Yoshitaka; Yamada, Yasuhiro; Sato, Satoshi published the artcile< Vapor-phase dehydration of 1,4-butanediol to 1,3-butadiene over Y2Zr2O7 catalyst>, Product Details of C4H8O, the main research area is vapor dehydration butanediol butadiene Y2Zr2O7 catalyst.

Vapor-phase catalytic dehydration of 1,4-butanediol (1,4-BDO) was investigated over Y2O3-ZrO2 catalysts. In the dehydration, 1,3-butadiene (BD) together with 3-buten-1-ol (3B1OL), THF, and propylene was produced depending on the reaction conditions. In the dehydration over Y2O3-ZrO2 catalysts with different Y contents at 325°C, Y2Zr2O7 with an equimolar ratio of Y/Zr showed high selectivity to 3B1OL, an intermediate to BD. In the dehydration at 360°C, a BD yield higher than 90% was achieved over the Y2Zr2O7 calcined at 700°C throughout 10 h. In the dehydration of 3B1OL over Y2Zr2O7, however, the catalytic activity affected by the calcination temperature is roughly proportional to the sp. surface area of the sample. The highest activity of Y2Zr2O7 calcined at 700°C for the BD formation from 1,4-BDO is explained by the trade-off relation in the activities for the first-step dehydration of 1,4-BDO to 3B1OL and for the second-step dehydration of 3B1OL to BD. The higher reactivity of 3B1OL than saturated alcs. such as 1-butanol and 2-butanol suggests that the C=C double bond of 3B1OL induces an attractive interaction to anchor the catalyst surface and promotes the dehydration. A probable mechanism for the one-step dehydration of 1,4-BDO to BD was discussed.

Molecular Catalysis published new progress about Adsorption. 627-27-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C4H8O, Product Details of C4H8O.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Boekman, C. Fredrik; Zettersten, Camilla; Sjoeberg, Per J. R.; Nyholm, Leif published the artcile< A setup for the coupling of a thin-layer electrochemical flow cell to electrospray mass spectrometry>, Name: Sodium 5,5′-(diazene-1,2-diyl)bis(2-hydroxybenzoate), the main research area is thin layer electrochem flow cell electrospray mass spectrometer coupling; Olsalazine hexanethiol electrochem oxidation electrospray mass spectrometry.

A novel setup for the coupling of a com. available thin-layer cell to electrospray mass spectrometry (ESI-MS) which allows the electrochem. reactions at the counter electrode to be straightforwardly separated from the flow into the mass spectrometer was developed. In this way, interferences from reaction products formed at the counter electrode can be minimized. This reduces the risk of changes in the mass spectra as a result of electrochem. reactions in the solution The described setup also enables the working electrode to be positioned close to the electrospray (ESI) emitter without the need for a grounding point or a long transfer line between the electrochem. cell and the electrospray emitter. By decoupling the electrochem. reactions in the flow cell and those in the electrospray emitter, improved facilities for studies of electrochem. reactions were obtained through a better control of the potential of the working electrode. The setup was used to study the oxidation of a drug (Olsalazine), which previously was found to involve chem. follow-up reactions. Also uncharged thiols can be detected in ESI-MS after spontaneous adsorption on a gold working electrode, followed by oxidative desorption to yield sulfinates or sulfonates. This adsorption and potential-controlled desorption was used for the preconcentration of micromolar concentrations of 1-hexanethiol as well as for desalting of solutions containing micromolar concentrations of thiols. The present online coupling of an electrochem. cell to ESI-MS provides promising possibilities for sample preconcentration, matrix exchange (including desalting), and ionization of neutral compounds, such as thiols.

Analytical Chemistry published new progress about Electrochemical oxidation. 6054-98-4 belongs to class alcohols-buliding-blocks, and the molecular formula is C14H8N2Na2O6, Name: Sodium 5,5′-(diazene-1,2-diyl)bis(2-hydroxybenzoate).

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Rohan, Rupesh; Hung, Miao-Ken; Yang, Yi-Fei; Hsu, Chia-Wei; Yeh, Cheng-Kuang; Chang, Yu-Lung; Lee, Jyh-Tsung published the artcile< Enhancement of the High-Rate Performance of an Organic Radical Thin-Film Battery by Decreasing the Grafting Density of Polymer Brushes>, Reference of 627-27-0, the main research area is enhancement High Rate performance organic radical Thin Film battery.

A high-rate performance enhancement of a poly(2,2,6,6-tetramethylpiperidin-1-oxy-4-yl methacrylate) (PTMA) brush as a thin-film organic radical cathode is achieved by grafting d. reduction n-Octyltrichlorosilane as a capping agent diluted the surface initiator d. on the indium tin oxide (ITO) substrate. Surface initiator-modified ITO substrates (1% and 100%) were grafted with PTMA to yield low (LD) and high (HD) grafting d. PTMA brushes (0.11 and 0.26 chains nm-2, resp.). The cyclic voltammetry and AC impedance results showed that the LD PTMA brush has a lower impedance than the HD PTMA brush electrode. The in situ electrochem. at. force microscopy detected a larger thickness change in the LD PTMA brush during the redox reactions than in the HD PTMA brush. This difference is attributed to the loose packing of the polymer chains in the LD PTMA brush that enhances polymer chain mobility and transportation of ClO4- anions. Furthermore, the thin-film organic radical battery cell with the LD PTMA brush electrode exhibited outstanding high-rate performance (>50% retention at 1500 C) and a good cycle-life performance of 89% retention at 20 C over 400 cycles.

ACS Applied Polymer Materials published new progress about Atomic force microscopy. 627-27-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C4H8O, Reference of 627-27-0.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Hatzfeld, Jana; Skowaisa, Steffen; Jackel, Elisabeth; Kaufmann, Julia; Haak, Edgar published the artcile< Triaminocyclopentadienyl Ruthenium Complexes - New Catalysts for Cascade Conversions of Propargyl Alcohols>, Related Products of 4396-13-8, the main research area is triaminocyclopentadienyl ruthenium complex preparation catalyst cascade conversion propargyl alc; cycloaddition catalyst triaminocyclopentadienyl ruthenium complex preparation ketolactone phloroglucinol; cyclopentadienyl ligands; heterocycles; homogeneous catalysis; ruthenium; terpenoids.

Various triaminocyclopentadienyl ruthenium complexes have been synthesized from Ru3(CO)12. The new complexes were tested for their ability to catalyze cascade conversions of propargyl alcs. Their associated catalytic activities complement the activities of known diaminocyclopentadienone ruthenium complexes. In particular, the substrate scope of catalytic cycloadditions with 3-ketolactones or phloroglucinol derivatives is extended to terpenoid-derived propargyl alcs. containing an internal alkyne moiety. A wide range of cyclic terpenoid and phloroglucinol adducts are obtained by complementary application of both types of catalysts.

Chemistry – A European Journal published new progress about Alcohols, propargyl Role: RCT (Reactant), RACT (Reactant or Reagent). 4396-13-8 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H6O5, Related Products of 4396-13-8.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Anderson, Allison; Genaro-Mattos, Thiago C.; Allen, Luke B.; Koczok, Katalin; Korade, Zeljka; Mirnics, Karoly published the artcile< Interaction of maternal immune activation and genetic interneuronal inhibition>, Product Details of C27H44O, the main research area is Gad1 neuropeptide Y maternal immune activation genetic interneuronal inhibition; Acylcarnitines; Interneuron; Maternal immune activation; Neuroinflammation; Schizophrenia; Sterol profile.

Genes and environment interact during intrauterine life, and potentially alter the developmental trajectory of the brain. This can result in life-long consequences on brain function. We have previously developed two transgenic mouse lines that suppress Gad1 expression in parvalbumin (PVALB) and neuropeptide Y (NPY) expressing interneuron populations using a bacterial artificial chromosome (BAC)-driven miRNA-based silencing technol. We were interested to assess if maternal immune activation (MIA), genetic interneuronal inhibition, and the combination of these two factors disrupt and result in long-term changes in neuroinflammatory gene expression, sterol biosynthesis, and acylcarnitine levels in the brain of maternally exposed offspring. Pregnant female WT mice were given a single i.p. injection of saline or polyinosinic-polycytidilic acid [poly(I:C)] at E12.5. Brains of offspring were analyzed at postnatal day 90. We identified complex and persistent neuroinflammatory gene expression changes in the hippocampi of MIA-exposed offspring, as well in the hippocampi of Npy/Gad1 and Pvalb/Gad1 mice. In addition, both MIA and genetic inhibition altered the post-lanosterol sterol biosynthesis in the neocortex and disrupted the typical acylcarnitine profile. In conclusion, our findings suggest that both MIA and inhibition of interneuronal function have long-term consequences on critical homeostatic mechanisms of the brain, including immune function, sterol levels, and energy metabolism

Brain Research published new progress about Acylcarnitines Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 434-16-2 belongs to class alcohols-buliding-blocks, and the molecular formula is C27H44O, Product Details of C27H44O.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts