Month: October 2022

Tamoradi, Taiebeh; Taheri, Atefeh; Vahedi, Shima; Ghadermazi, Mohammad published the artcile< Gd (III) and Tb (III) immobilized tryptophan functionalized magnetic nanoparticles for eco-friendly oxidation rections>, Safety of 2-(Phenylthio)ethanol, the main research area is sulfide thiol oxidation gadolinium terbium tryptophan magnetic nanoparticle catalyst.

In this study, Gd (III) and Td (III) immobilized magnetic nanocatalysts were prepared following a simple procedure using available materials. These nanoparticles were characterized by FT-IR, XRD, TGA, EDX, and ICP-OES studies and utilized in the S-oxidation reactions. It was observed that the rate of oxidation with Tb magnetic nanocatalyst was higher than that of Gd. Significant advantages of this environmental friendly process include short reaction times, high efficiency, and convenient recovery and reusability of the catalyst for several times without any significant loss of activity.

Solid State Sciences published new progress about Magnetic nanoparticles. 699-12-7 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H10OS, Safety of 2-(Phenylthio)ethanol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Xiao, Jun; Li, Weiyun; Zheng, Xin; Qi, Linlin; Wang, Hui; Zhang, Chi; Wan, Xiaopeng; Zheng, Yuxiao; Zhong, Ruiyue; Zhou, Xin; Lu, Yao; Li, Zhiqi; Qiu, Ying; Liu, Chang; Zhang, Fang; Zhang, Yanbo; Xu, Xiaoyan; Yang, Zhongzhou; Chen, Hualan; Zhai, Qiwei; Wei, Bin; Wang, Hongyan published the artcile< Targeting 7-Dehydrocholesterol Reductase Integrates Cholesterol Metabolism and IRF3 Activation to Eliminate Infection>, Application of C27H44O, the main research area is viral infection DHCR7 IRF3 TBK1 tamoxifen cholesterol metabolism; 7-DHC; AKT3; DHCR7; IRF3; cholesterol metabolism; infection; macrophage; type I IFN.

Recent work suggests that cholesterol metabolism impacts innate immune responses against infection. However, the key enzymes or the natural products and mechanisms involved are not well elucidated. Here, we have shown that upon DNA and RNA viral infection, macrophages reduced 7-dehydrocholesterol reductase (DHCR7) expression. DHCR7 deficiency or treatment with the natural product 7-dehydrocholesterol (7-DHC) could specifically promote phosphorylation of IRF3 (not TBK1) and enhance type I interferon (IFN-I) production in macrophages. We further elucidated that viral infection or 7-DHC treatment enhanced AKT3 expression and activation. AKT3 directly bound and phosphorylated IRF3 at Ser385, together with TBK1-induced phosphorylation of IRF3 Ser386, to achieve IRF3 dimerization. Deletion of DHCR7 and the DHCR7 inhibitors including AY9944 and the chemotherapy drug tamoxifen promoted clearance of Zika virus and multiple viruses in vitro or in vivo. Taken together, we propose that the DHCR7 inhibitors and 7-DHC are potential therapeutics against emerging or highly pathogenic viruses.

Immunity published new progress about Cell membrane. 434-16-2 belongs to class alcohols-buliding-blocks, and the molecular formula is C27H44O, Application of C27H44O.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Xu, Zhixiang; Xu, Xiangxiang; O’Laoi, Ruadhan; Ma, Haikuo; Zheng, Jiyue; Chen, Shuaishuai; Luo, Lusong; Hu, Zhilin; He, Sudan; Li, Jiajun; Zhang, Hongjian; Zhang, Xiaohu published the artcile< Design, synthesis, and evaluation of novel porcupine inhibitors featuring a fused 3-ring system based on the 'reversed' amide scaffold>, Formula: C12H18BNO2, the main research area is Wnt3A inhibitor amide scaffold; Antagonist; Cancer therapy; Porcupine; Scaffold hybridization; Wnt signaling pathway.

The Wnt signaling pathway is an essential signal transduction pathway which leads to the regulation of cellular processes such as proliferation, differentiation and migration. Aberrant Wnt signaling is known to have an association with multiple cancers. Porcupine is an enzyme that catalyzes the addition of palmitoleate to a serine residue in Wnt proteins, a process which is required for the secretion of Wnt proteins. Here the authors report the synthesis and structure-activity-relationship of the novel porcupine inhibitors based on a ‘reversed’ amide scaffold. The leading compound I was as potent as the clin. compound LGK974 in a cell based STF reporter gene assay. Compound I potently inhibited the secretion of Wnt3A, therefore was confirmed to be a porcupine inhibitor. Furthermore, compound I showed excellent chem. and plasma stabilities. However, the clearance of compound I in liver microsomal tests was moderate to high, and the solubility of compound I was suboptimal. Collective efforts toward further optimization of this novel tricyclic template to develop better porcupine inhibitors will be subsequently undertaken and reported in due course.

Bioorganic & Medicinal Chemistry published new progress about Homo sapiens. 660867-80-1 belongs to class alcohols-buliding-blocks, and the molecular formula is C12H18BNO2, Formula: C12H18BNO2.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Aumala, Ville; Mollerup, Filip; Jurak, Edita; Blume, Fabian; Karppi, Johanna; Koistinen, Antti E.; Schuiten, Eva; Voss, Moritz; Bornscheuer, Uwe; Deska, Jan; Master, Emma R. published the artcile< Biocatalytic production of amino carbohydrates through oxidoreductase and transaminase cascades>, Recommanded Product: ((3aR,5R,5aS,8aS,8bR)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-5-yl)methanol, the main research area is amino carboxydrate production biocatalysis oxidoreductase transaminase enzyme cascade; amination; biocatalysis; carbohydrates; domino reactions; enzymes.

Plant-derived carbohydrates are an abundant renewable resource. Transformation of carbohydrates into new products, including amine-functionalized building blocks for biomaterials applications, can lower reliance on fossil resources. Herein, biocatalytic production routes to amino carbohydrates, including oligosaccharides, are demonstrated. In each case, two-step biocatalysis was performed to functionalize D-galactose-containing carbohydrates by employing the galactose oxidase from Fusarium graminearum or a pyranose dehydrogenase from Agaricus bisporus followed by the ω-transaminase from Chromobacterium violaceum (Cvi-ω-TA). Formation of 6-amino-6-deoxy-D-galactose, 2-amino-2-deoxy-D-galactose, and 2-amino-2-deoxy-6-aldo-D-galactose was confirmed by mass spectrometry. The activity of Cvi-ω-TA was highest towards 6-aldo-D-galactose, for which the highest yield of 6-amino-6-deoxy-D-galactose (67%) was achieved in reactions permitting simultaneous oxidation of D-galactose and transamination of the resulting 6-aldo-D-galactose.

ChemSusChem published new progress about Agaricus bisporus (pyranose dehydrogenase from). 4064-06-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C12H20O6, Recommanded Product: ((3aR,5R,5aS,8aS,8bR)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-5-yl)methanol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Kutyna, Dariusz R.; Onetto, Cristobal A.; Williams, Thomas C.; Goold, Hugh D.; Paulsen, Ian T.; Pretorius, Isak S.; Johnson, Daniel L.; Borneman, Anthony R. published the artcile< Construction of a synthetic Saccharomyces cerevisiae pan-genome neo-chromosome>, Name: D-Glucosaccharic acid, the main research area is Saccharomyces pan genome neo chromosome genetic diversity phenotypic plasticity.

The Synthetic Yeast Genome Project (Sc2.0) represents the first foray into eukaryotic genome engineering and a framework for designing and building the next generation of industrial microbes. However, the laboratory strain S288c used lacks many of the genes that provide phenotypic diversity to industrial and environmental isolates. To address this shortcoming, we have designed and constructed a neo-chromosome that contains many of these diverse pan-genomic elements and which is compatible with the Sc2.0 design and test framework. The presence of this neo-chromosome provides phenotypic plasticity to the Sc2.0 parent strain, including expanding the range of utilizable carbon sources. We also demonstrate that the induction of programmable structural variation (SCRaMbLE) provides genetic diversity on which further adaptive gains could be selected. The presence of this neo-chromosome within the Sc2.0 backbone may therefore provide the means to adapt synthetic strains to a wider variety of environments, a process which will be vital to transitioning Sc2.0 from the laboratory into industrial applications.

Nature Communications published new progress about Biofuels. 87-73-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H10O8, Name: D-Glucosaccharic acid.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Gunda, Venugopal; Genaro-Mattos, Thiago C.; Kaushal, Jyoti B.; Chirravuri-Venkata, Ramakanth; Natarajan, Gopalakrishnan; Mallya, Kavita; Grandgenett, Paul M.; Mirnics, Karoly; Batra, Surinder K.; Korade, Zeljka; Rachagani, Satyanarayana published the artcile< Ubiquitous Aberration in Cholesterol Metabolism across Pancreatic Ductal Adenocarcinoma>, Application In Synthesis of 434-16-2, the main research area is cholesterol metabolism pancreatic ductal adenocarcinoma; Dhcr24; Dhcr7; PDAC (pancreatic ductal adenocarcinoma); free cholesterol; sterol analysis.

Pancreatic cancer (PC) is characterized by metabolic deregulations that often manifest as deviations in metabolite levels and aberrations in their corresponding metabolic genes across the clin. specimens and preclin. PC models. Cholesterol is one of the critical metabolites supporting PC, synthesized or acquired by PC cells. Nevertheless, the significance of the de novo cholesterol synthesis pathway has been controversial in PC, indicating the need to reassess this pathway in PC. We utilized preclin. models and clin. specimens of PC patients and cell lines and utilized mass spectrometry-based sterol anal. Further, we also performed in silico anal. to corroborate the significance of de novo cholesterol synthesis pathway in PC. Our results demonstrated alteration in free sterol levels, including free cholesterol, across in vitro, in vivo, and clin. specimens of PC. Especially, our sterol analyses established consistent alterations in free cholesterol across the different PC models. Overall, this study demonstrates the significance and consistency in deviation of cholesterol synthesis pathway in PC while showing the aberrations in sterol metabolite intermediates and the related genes using preclin. models, in silico platforms, and the clin. specimens.

Metabolites published new progress about Animal gene Role: BSU (Biological Study, Unclassified), PRP (Properties), BIOL (Biological Study) (DHCR24). 434-16-2 belongs to class alcohols-buliding-blocks, and the molecular formula is C27H44O, Application In Synthesis of 434-16-2.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Ghorbani-Choghamarani, Arash; Seydyosefi, Zeinab; Tahmasbi, Bahman published the artcile< Tribromide ion supported on boehmite nanoparticles as a reusable catalyst for organic reactions>, Reference of 699-12-7, the main research area is sulfoxide preparation chemoselective; sulfide sulfoxidation tribromide ion nanocatalyst; dihydroquinazolinone preparation; benzaldehyde anthranilamide condensation tribromide ion nanocatalyst; polyhydroquinoline preparation; dimedone benzaldehyde ethyl acetoacetate ammonium acetate condensation tribromide ion.

Boehmite nanoparticles are not air or moisture sensitive; therefore, they were prepared in water at room temperature using inexpensive materials, without inert atm., by a very simple and inexpensive procedure. When the surface of boehmite nanoparticles was modified by N,N,N’,N’-tetraethyldiethylenetriamine (TEDETA), tribromide ions became immobilized on modified boehmite nanoparticles (Br3-TEDETA@Boehmite). These materials were characterized by Fourier transform IR spectroscopy, thermogravimetric anal., Brunauer-Emmett-Teller, X-ray diffraction, energy-dispersive X-ray spectroscopy, and SEM techniques. Finally, the catalytic activity of Br3-TEDETA@Boehmite was examined in the selective oxidation of sulfides R1SR2 [R1 = Ph, Me, (CH2)2CH3, etc.; R1R2 = -(CH2)4-; R2 = Me, benzyl, (CH2)2OH, etc.] to sulfoxides R1S(O)R2. Besides, the catalytic activity of Br3-TEDETA@Boehmite was extended to the synthesis of organic heterocyclic compounds, such as 2,3-dihydroquinazolin-4(1H)-one I [R3 = 4-Cl, 4-NO2, 3,4-(OMe)2, etc.] and polyhydroquinoline derivatives II [R4 = 2,3-(Cl)2, 3-NO2, 4-OEt, etc.]. This catalyst was reused several times without significant loss of its catalytic efficiency.

Comptes Rendus Chimie published new progress about Benzaldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 699-12-7 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H10OS, Reference of 699-12-7.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Natsch, Andreas; Nagelin, Marco; Leijs, Hans; van Strien, Michel; Gimenez-Arnau, Elena; Vey, Matthias; Gonzalez, Cecile published the artcile< Exposure source for skin sensitizing hydroperoxides of limonene and linalool remains elusive: An analytical market surveillance>, Computed Properties of 78-70-6, the main research area is Consumer products; Market surveillance; Quantification; Skin allergy; Terpene hydroperoxides.

Pos. patch test reactions of dermatol. patients to oxidized samples of linalool and limonene are frequently reported. The sensitizing ingredients in the oxidation mixtures are hydroperoxides (HP). It is not clear whether fragranced consumer products are a relevant exposure source for HP. Anal. methodologies had been validated, allowing quantification of HP in different consumer products. The anal. approach was used to analyze 104 consumer products. Samples included aged and new samples from the same brand, products suspected by patients to elicit their symptoms and products containing essential oils. Only four samples contained >50 μg/g of at least one of the HP by the screening method. Confirmatory anal. by LC-MS methods indicated that levels are even below those observed by the conservative screening method. The samples retrieved from patch-test pos. patients were below detection limit for all target analytes. This market surveillance indicates that concentrations of HP in consumer products and patient products are orders of magnitude below sensitizing doses in animal tests. No evidence for hydroperoxide accumulation in aged products or products used by patients was found. The nature and source of the inducing agent responsible for the frequent pos. patch test reactions to oxidized terpenes remains elusive.

Food and Chemical Toxicology published new progress about 78-70-6. 78-70-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C10H18O, Computed Properties of 78-70-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Zhao, Yajun; Zhu, Shuaishuai; Liao, Can; Wang, Yong; Lam, Jacky W. Y.; Zhou, Xingping; Wang, Xianhong; Xie, Xiaolin; Tang, Ben Zhong published the artcile< Cobalt-Mediated Switchable Catalysis for the One-Pot Synthesis of Cyclic Polymers>, Safety of But-3-en-1-ol, the main research area is cyclic polymer cobalt mediated switchable catalysis; biodegradable polymers; cyclic polymers; photo-induced radical closure; ring-opening copolymerization; switchable catalysis.

A cobalt salen pentenoate complex [salen = (R,R)-N,N’-bis(3,5-di-tertbutylsalicylidene)-1,2-cyclohexanediamine] is rationally designed as the catalyst for the ring-opening copolymerization (ROCOP) of epoxides/anhydrides/CO2. Via migratory insertion of carbon monoxide (CO) into the Co-O bonds, the ROCOP-active species α-alkene-ω-O-CoIII(salen) can be rapidly and quant. transformed into α-alkene-ω-O2C-CoIII(salen) telechelic linear precursors. Upon dilution of reaction mixtures, the homolytic cleavage of Co-C bonds induced by visible light generates α-alkene acyl radicals that spontaneously undergo intramol. radical addition to afford organocobalt-functionalized cyclic polyesters and CO2-based polycarbonates with excellent regioselectivity. The cyclic products can either react with radical scavengers to generate metal-free cyclic polymers or serve as photo-initiators for organometallic-mediated radical polymerization (OMRP) to produce tadpole-shaped copolymers.

Angewandte Chemie, International Edition published new progress about Cyclization. 627-27-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C4H8O, Safety of But-3-en-1-ol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Shi, Yinyin; Wang, Yue; Huang, Zhefan; Zhang, Fangjun; Shao, Yinlin published the artcile< tBuOLi-Promoted Hydroboration of Esters and Epoxides>, SDS of cas: 10602-04-7, the main research area is ester lactone epoxide hydroboration chemoselective lithium tertbutoxide catalyst; alc preparation.

Com. available and inexpensive lithium tert-butoxide (tBuOLi) acts as a good precatalyst for the hydroboration of esters, lactones, and epoxides using pinacolborane as a borylation agent. Functional groups such as cyano-, nitro-, amino-, vinyl, and alkynyl are unaffected under the presented hydroboration process, representing high chemoselectivity. This transformation has also been effectively applied to the synthesis of key intermediates of Erlotinib and Cinacalcet. Preliminary investigations of the mechanism show that the hydroboration proceeds through the in situ formed BH3 species.

ACS Omega published new progress about Alcohols Role: SPN (Synthetic Preparation), PREP (Preparation). 10602-04-7 belongs to class alcohols-buliding-blocks, and the molecular formula is C9H8O, SDS of cas: 10602-04-7.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts