Month: October 2022

Gallegos, Felipe E.; Meneses, Lorena M.; Cuesta, Sebastian A.; Santos, Juan C.; Arias, Josefa; Carrillo, Pamela; Pilaquinga, Fernanda published the artcile< Computational Modeling of the Interaction of Silver Clusters with Carbohydrates>, Product Details of C6H12O6, the main research area is computational modeling interaction silver cluster carbohydrate.

Silver nanoparticles are recognized for their numerous phys., biol., and pharmaceutical applications. In the present study, the interaction of silver clusters with monosaccharide mols. is examined to identify which mol. works better as a reducing agent in the application of a green synthesis approach. Geometry optimization of clusters containing one, three, and five silver atoms is performed along with the optimization of α-D-glucose, α-D-ribose, D-erythrose, and glyceraldehyde using d. functional theory. Optimized geometries allow identifying the interaction formed in the silver cluster and monosaccharide complexes. An electron localization function anal. is performed to further analyze the interaction found and explain the reduction process in the formation of silver nanoparticles. The overall results indicate that glyceraldehyde presents the best characteristics to serve as the most efficient reducing agent.

ACS Omega published new progress about Complexation. 492-62-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H12O6, Product Details of C6H12O6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Molaei, Somayeh; Ghadermazi, Mohammad published the artcile< Selective and efficient oxidation of sulfides and thiols to their corresponding sulfoxides and disulfides catalyzed with praseodymium (III) and dysprosium (III) isonicotinamide (INA) complexes grafted onto modified mesoporous MCM-41>, Formula: C8H10OS, the main research area is sulfide thiol oxidation praseodymium dysprosium isonicotinamide complex.

Praseodymium (III) and dysprosium (III) isonicotinamide (INA) complexes grafted onto modified mesoporous MCM-41 with 3-chloropropyltriethoxysilane (CPTES), as two novel catalysts, were synthesized. The catalysts were determined using SEM, Mapping, EDX, FT-IR, TGA, XRD, ICP, and BET anal. The catalysts (MCM-41-INA-Pr and MCM-41-INA-Dy) were further studied for the oxidation reaction of sulfur-containing compounds Catalytic results displayed that the MCM-41-INA-Pr and MCM-41-INA-Dy show high effectiveness for promoting the oxidation reaction of sulfur-containing compounds The catalysts could be recycled for seven runs with negligible destruction of catalytic performance.

Solid State Sciences published new progress about Adsorption. 699-12-7 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H10OS, Formula: C8H10OS.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Heindel, Daniel W.; Koppolu, Sujeethraj; Zhang, Yue; Kasper, Brian; Meche, Lawrence; Vaiana, Christopher A.; Bissel, Stephanie J.; Carter, Chalise E.; Kelvin, Alyson A.; Elaish, Mohamed; Lopez-Orozco, Joaquin; Zhang, Bin; Zhou, Bin; Chou, Tsui-Wen; Lashua, Lauren; Hobman, Tom C.; Ross, Ted M.; Ghedin, Elodie; Mahal, Lara K. published the artcile< Glycomic analysis of host response reveals high mannose as a key mediator of influenza severity>, Reference of 3458-28-4, the main research area is mannose lectin MBL2 Influenza virus infection glycomic; MBL2; lectin array; lectin microarray; mannan binding lectin; mannose binding lectin.

Influenza virus infections cause a wide variety of outcomes, from mild disease to 3 to 5 million cases of severe illness and ∼290,000 to 645,000 deaths annually worldwide. The mol. mechanisms underlying these disparate outcomes are currently unknown. Glycosylation within the human host plays a critical role in influenza virus biol. However, the impact these modifications have on the severity of influenza disease has not been examined Herein, we profile the glycomic host responses to influenza virus infection as a function of disease severity using a ferret model and our lectin microarray technol. We identify the glycan epitope high mannose as a marker of influenza virus-induced pathogenesis and severity of disease outcome. Induction of high mannose is dependent upon the unfolded protein response (UPR) pathway, a pathway previously shown to associate with lung damage and severity of influenza virus infection. Also, the mannan-binding lectin (MBL2), an innate immune lectin that neg. impacts influenza outcomes, recognizes influenza virus-infected cells in a high mannose-dependent manner. Together, our data argue that the high mannose motif is an infection-associated mol. pattern on host cells that may guide immune responses leading to the concomitant damage associated with severity.

Proceedings of the National Academy of Sciences of the United States of America published new progress about Epitopes (glycan). 3458-28-4 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H12O6, Reference of 3458-28-4.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Dahatonde, Dipak J.; Ghosh, Aritra; Batra, Sanjay published the artcile< Metal-Free Synthesis of Alkenylazaarenes and 2-Aminoquinolines through Base-Mediated Aerobic Oxidative Dehydrogenation of Benzyl Alcohols>, Electric Literature of 5344-90-1, the main research area is alkyl azaarene arylmethanol base promoter diastereoselective dehydrogenative olefination; alkenyl azaarene preparation; aminobenzyl alc arylacetonitrile base promoter dehydrogenative cyclocondensation; aminoquinoline preparation.

A metal-free, base-mediated, and atom-efficient oxidative dehydrogenative coupling of substituted phenylmethanols (benzyl alcs.) with Me azaarenes or phenylacetonitriles to afford substituted alkenylazaarenes or 2-aminoquinolines, resp. was described. CsOH. H2O was discovered to be the base of choice for obtaining optimal yields of the title compounds, although the reaction proceeded with KOH as well. The protocol that worked efficiently in the presence of air was amenable over broad range of substrates.

European Journal of Organic Chemistry published new progress about Acetonitriles Role: RCT (Reactant), RACT (Reactant or Reagent). 5344-90-1 belongs to class alcohols-buliding-blocks, and the molecular formula is C7H9NO, Electric Literature of 5344-90-1.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Jantunen, Niklas; Virolainen, Sami; Latostenmaa, Petri; Salminen, Justin; Haapalainen, Mika; Sainio, Tuomo published the artcile< Removal and recovery of arsenic from concentrated sulfuric acid by solvent extraction>, Name: 2-Ethylhexan-1-ol, the main research area is arsenic sulfuric acid tributyl phosphate phase equilibrium solvent extraction.

Arsenic-contaminated sulfuric acid solutions are produced in large quantities as byproduct during pyrometallurgical processing of sulfide minerals. Options for re-using such acid solutions are increased if the arsenic is removed and recovered as a product. The performances of tri-Bu phosphate and a mixture of 6 wt-% 1,2-octanediol in 2-ethylhexanol were studied in liquid-liquid extraction of arsenic from an industrial solution containing 10.4 M H2SO4. It was found that, due to the complex phase equilibrium, a process design based on conventional batch equilibrium data did not describe the countercurrent processes accurately. A countercurrent flowsheet utilizing undiluted tri-Bu phosphate was investigated by pseudo-countercurrent extractions 83.7% extraction of arsenic and 31.4% coextn. of H2SO4 was obtained in three-stage countercurrent extraction operated at a solvent-to-feed ratio of 0.79. Two-stage countercurrent scrubbing with pure water at O/A = 4.03 back-extracted 83.6% of H2SO4 and 24.9% of arsenic. 100% and 89.7% back-extraction was achieved in four-stage stripping at O/A = 2.01 for H2SO4 and arsenic, resp. The effects of varying the flowsheet and operating parameters on separation efficiency are discussed.

Hydrometallurgy published new progress about Phase equilibrium Role: PEP (Physical, Engineering or Chemical Process), PRP (Properties), PROC (Process). 104-76-7 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H18O, Name: 2-Ethylhexan-1-ol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Luo, Yitao; Liu, Zhengyuan; Zeng, Yujie; Zhang, Yuxiao; Luan, Yujing; Ma, Li; Chen, Li; Zou, Lin; Yang, Jingmin; Huang, Zhibin; Rao, Yulan; Zhang, Chengqiang published the artcile< A reliable tool for detecting 7-dehydrocholesterol and cholesterol in human plasma and its use in diagnosis of Smith-Lemli-Opitz syndrome>, Product Details of C27H44O, the main research area is Smith-Lemli-Opitz syndrome; antioxidants; biomarkers; inborn errors of metabolism; microwave-assisted derivatization.

Background : Smith-Lemli-Opitz syndrome is a birth defect caused by the deficiency of 7-dehydrocholesterol reductase in cholesterol biosynthesis pathway, which leads to accumulation of 7-dehydrocholesterol and reduction of cholesterol in body fluids. To effectively diagnose Smith-Lemli-Opitz syndrome and monitor therapy, a reliable method for simultaneous detection of 7-dehydrocholesterol and cholesterol is needed. Methods : In the presence of antioxidants (2,6-ditert-butyl-4-methylphenol and triphenylphosphine), 50 μL of human plasma were hydrolyzed at 70°C for 40 min with 1 M potassium hydroxide in 90% ethanol, and then 7-dehydrocholesterol and cholesterol were extracted by 600 μL of n-hexane for three times. After microwave-assisted derivatization with 70 μL of N,O-bis(trimethylsilyl)trifluoroacetamide at 460 W for 3 min, the analytes were measured by gas chromatog.-mass spectrometry. Results : The limits of detection were 100 ng/mL for 7-dehydrocholesterol and 300 ng/mL for cholesterol. Good linearity was obtained in the range of 1-600 μg/mL for 7-dehydrocholesterol and 10-600 μg/mL for cholesterol, which completely covered the biochem. levels of Smith-Lemli-Opitz syndrome patients that have been reported. Conclusion : A time-saving and accurate gas chromatog. with mass spectrometry based method was developed for the determination of 7-dehydrocholesterol and cholesterol in human plasma, which also serves as a useful tool for Smith-Lemli-Opitz syndrome diagnosis, treatment, and research.

Journal of Separation Science published new progress about 434-16-2. 434-16-2 belongs to class alcohols-buliding-blocks, and the molecular formula is C27H44O, Product Details of C27H44O.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Gianchecchi, Elena; Fierabracci, Alessandra published the artcile< Insights on the effects of resveratrol and some of its derivatives in cancer and autoimmunity: a molecule with a dual activity>, COA of Formula: C14H12O3, the main research area is review cancer autoimmunity type 1 diabetes resveratrol; autoimmunity; cancer; resveratrol.

A review. In recent years, the interest in natural compounds exerting immunoregulatory effects has enormously increased. Among these, the polyphenol resveratrol, found in a variety of foods and beverages, including red grapes and red wine, has been demonstrated to exert both in vitro and in vivo biol. activities. More specifically, it has antiaging, cardioprotective, antioxidant, immunomodulatory, anti-inflammatory and chemopreventive activities. Due to its anti-proliferative, pro-apoptotic and immunoregulatory effects, resveratrol has gained substantial attention for the treatment of cancer or autoimmunity, which represent frequently diagnosed diseases with important consequences for the health of the patients affected. The aim of the present review is to focus on the role of resveratrol in the modulation of cancer as well as of several organ-specific or systemic autoimmune diseases, including autoimmune hepatitis, type 1 diabetes mellitus, inflammatory bowel disease, rheumatoid arthritis, systemic lupus erythematosus and multiple sclerosis.

Antioxidants published new progress about Anti-aging agents. 501-36-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C14H12O3, COA of Formula: C14H12O3.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Gas-Pascual, Elisabet; Ichikawa, Hiroshi Travis; Sheikh, Mohammed Osman; Serji, Mariam Isabella; Deng, Bowen; Mandalasi, Msano; Bandini, Giulia; Samuelson, John; Wells, Lance; West, Christopher M. published the artcile< CRISPR/Cas9 and glycomics tools for toxoplasma glycobiology>, Safety of (2S,3S,4R,5R)-2,3,4,5,6-Pentahydroxyhexanal, the main research area is genome editing CRISPR Cas9 glycome Toxoplasma human infection; CRISPR/Cas; Toxoplasma gondii; glycan; glycobiology; glycogene; glycomics; glycosyltransferase; mass spectrometry (MS); parasitology; protein glycosylation.

Infection with the protozoan parasite Toxoplasma gondii is a major health risk owing to birth defects, its chronic nature, ability to reactivate to cause blindness and encephalitis, and high prevalence in human populations. Unlike most eukaryotes, Toxoplasma propagates in intracellular parasitophorous vacuoles, but like nearly all other eukaryotes, Toxoplasma glycosylates many cellular proteins and lipids and assembles polysaccharides. Toxoplasma glycans resemble those of other eukaryotes, but species-specific variations have prohibited deeper investigations into their roles in parasite biol. and virulence. The Toxoplasma genome encodes a suite of likely glycogenes expected to assemble N-glycans, O-glycans, a C-glycan, GPI-anchors, and polysaccharides, along with their precursors and membrane transporters. To investigate the roles of specific glycans in Toxoplasma, here we coupled genetic and glycomics approaches to map the connections between 67 glycogenes, their enzyme products, the glycans to which they contribute, and cellular functions. We applied a double-CRISPR/Cas9 strategy, in which two guide RNAs promote replacement of a candidate gene with a resistance gene; adapted MS-based glycomics workflows to test for effects on glycan formation; and infected fibroblast monolayers to assess cellular effects. By editing 17 glycogenes, we discovered novel Glc0-2-Man6-GlcNAc2-type N-glycans, a novel HexNAc-GalNAc-mucin-type O-glycan, and Tn-antigen; identified the glycosyltransferases for assembling novel nuclear O-Fuc-type and cell surface Glc-Fuc-type O-glycans; and showed that they are important for in vitro growth. The guide sequences, editing constructs, and mutant strains are freely available to researchers to investigate the roles of glycans in their favorite biol. processes.

Journal of Biological Chemistry published new progress about Amplicon Role: BUU (Biological Use, Unclassified), BIOL (Biological Study), USES (Uses) (DHFR). 3458-28-4 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H12O6, Safety of (2S,3S,4R,5R)-2,3,4,5,6-Pentahydroxyhexanal.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Zhu, Fengxiao; Zhu, Changyin; Zhou, Dongmei; Gao, Juan published the artcile< Fate of di (2-ethylhexyl) phthalate and its impact on soil bacterial community under aerobic and anaerobic conditions>, Safety of 2-Ethylhexan-1-ol, the main research area is di 2ethylhexylphthalate Clostridiales Bacillus Actinobacteria Proteobacteria Gemmatimonadaceae soil pollution; Bacterial community; High-throughput sequencing; Metabolite; Oxygen; Phthalate ester.

In this study, we examined the influence of oxygen on the degradation of di (2-ethylhexyl) phthalate (DEHP), the accumulation of its monoester metabolite mono (2-ethylhexyl) phthalate (MEHP) and their impact on soil bacterial communities. Soil microcosms artificially contaminated with DEHP (0, 100 and 1000 mg kg-1) were incubated under aerobic and anaerobic flooded conditions, and sacrificed after 0, 21 and 42 days. The results indicated that DEHP degradation proceeded at similar rates in aerobic and anaerobic flooded soils, but accumulation of metabolite MEHP was more likely to occur in anaerobic soils. Moreover, MEHP generated from DEHP degradation seemed to be readily released into the water phase, which may arouse health concerns. Illumina Miseq sequencing showed that MEHP had a greater impact on soil bacterial community than DEHP at the same dosage, and a wide range of bacterial phylotypes were inhibited by MEHP under anaerobic conditions. High DEHP contamination (1000 mg kg-1) significantly reduced bacterial diversity and altered bacterial community structure under anaerobic conditions, but not under aerobic conditions. Firmicutes was constantly inhibited by DEHP under both aerobic (Bacillus) and anaerobic (unclassified Clostridiales Family_XVIII) conditions. On the other hand, bacterial phylotypes belonging to Actinobacteria, β-Proteobacteria and Gemmatimonadaceae were constantly enriched by DEHP in anaerobic soils, however no such a clear pattern existed in aerobic soils. This work greatly expanded our understanding of the fate of DEHP and its modifying effect on bacterial communities under different environmental conditions.

Chemosphere published new progress about Actinobacteria. 104-76-7 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H18O, Safety of 2-Ethylhexan-1-ol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Liu, Yaxu; He, Shaopo; Quan, Ziyi; Cai, Huizhuo; Zhao, Yang; Wang, Bo published the artcile< Mild palladium-catalysed highly efficient hydrogenation of CN, C-NO2, and C=O bonds using H2 of 1 atm in H2O>, COA of Formula: C8H9FO, the main research area is amine preparation green chem; nitro compound hydrogenation palladium nanocatalyst; nitrile hydrogenation palladium nanocatalyst; alc preparation green chem; aldehyde hydrogenation palladium nanocatalyst; ketone hydrogenation palladium nanocatalyst.

The first example of a mild and high-efficiency protocol enabling a process in water using 1 atm of H2 for the efficient and selective hydrogenation of nitriles RCN [R = CH3(CH2)2, 4-FC6H4, naphthalen-1-yl, etc.], nitro compounds 4-R1C6H4NO2 (R1 = H, F, Cl, Br, OH, Me, MeO, NH2), ketones R2C(O)R3 [R2 = CH3(CH2)2, 3-FC6H4, 2-H3CC6H4, etc.; R3 = Me, CF3] and aldehydes R4CHO [R4 = 4-(H3C)2CHC6H4, 3,4,5-(H3CO)3C6H2, naphthalen-1-yl, etc.], to yield primary amines RCH2NH2, 4-R1C6H4NH2 and alcs. R2CH(OH)CH3, R4CH2OH with satisfactory yields of up to >99% has been presented. Several palladium-based nanoparticle catalysts were prepared from K2PdCl4 and ligands, and one of them was found to be the best and most suitable for the hydrogenation of CN, C-NO2 and C=O bonds. In addition, the catalyst Pd-NPs can be easily recycled and reused without losing their activity and selectivity. A plausible mechanism for the hydrogenation of a CN bond was also proposed, representing the first example that possesses great potential for sustainable industrial purposes.

Green Chemistry published new progress about Alcohols Role: SPN (Synthetic Preparation), PREP (Preparation). 403-41-8 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H9FO, COA of Formula: C8H9FO.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts