Month: October 2022

Dyck, Garrison J. B.; Raj, Pema; Zieroth, Shelley; Dyck, Jason R. B.; Ezekowitz, Justin A. published the artcile< The effects of resveratrol in patients with cardiovascular disease and heart failure: a narrative review>, Application In Synthesis of 501-36-0 , the main research area is review resveratrol cardioprotectant cardiovascular disease heart failure; CVD; heart failure; resveratrol.

A review. Cardiovascular disease (CVD) is the main cause of death globally and responsible for the second highest number of deaths in Canada. Medical advancements in the treatment of CVD have led to patients living longer with CVD but often progressing to another condition called heart failure (HF). As a result, HF has emerged in the last decade as a major medical concern. Fortunately, various “”traditional”” pharmacotherapies for HF exist and have shown success in reducing HF-associated mortality. However, to augment the treatment of patients with CVD and/or HF, alternative pharmacotherapies using nutraceuticals have also shown promise in the prevention and treatment of these two conditions. One of these natural compounds considered to potentially help treat HF and CVD and prevent their development is resveratrol. Herein, we review the clin. findings of resveratrol’s ability to be used as an effective treatment to potentially help treat HF and CVD. This will allow us to gain a more fulsome appreciation for the effects of resveratrol in the health outcomes of specific patient populations who have various disorders that constitute CVD.

International Journal of Molecular Sciences published new progress about Cardioprotective agents. 501-36-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C14H12O3, Application In Synthesis of 501-36-0 .

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Lu, Hongyuan; Yu, Shiqin; Qin, Fengyu; Ning, Wenbo; Ma, Xiaoqiang; Tian, Kaiyuan; Li, Zhi; Zhou, Kang published the artcile< A secretion-based dual fluorescence assay for high-throughput screening of alcohol dehydrogenases>, Related Products of 403-41-8, the main research area is alc dehydrogenase secretion dual fluorescence assay high throughput screening; alcohol dehydrogenase; cascade reaction; directed protein evolution; fluorescence assay; protein secretion.

Alc. dehydrogenases (ADHs) play key roles in the production of various chem. precursors that are essential in pharmaceutical and fine chem. industries. To achieve a practical application of ADHs in industrial processes, tailoring enzyme properties through rational design or directed evolution is often required. Here, we developed a secretion-based dual fluorescence assay (SDFA) for high-throughput screening of ADHs. In SDFA, an ADH of interest is fused to a mutated superfolder green fluorescent protein (MsfGFP), which could result in the secretion of the fusion protein to culture broth. After a simple centrifugation step to remove the cells, the supernatant can be directly used to measure the activity of ADH based on a red fluorescence signal, whose increase is coupled to the formation of NADH (a redox cofactor of ADHs) in the reaction. SDFA allows easy quantification of ADH concentration based on the green fluorescence signal of MsfGFP. This feature is useful in determining specific activity and may improve screening accuracy. Out of five ADHs we have tested with SDFA, four ADHs can be secreted and characterized. We successfully screened a combinatorial library of an ADH from Pichia finlandica and identified a variant with a 197-fold higher kcat/km value toward (S)-2-octanol compared to its wild type.

Biotechnology and Bioengineering published new progress about Catalysis. 403-41-8 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H9FO, Related Products of 403-41-8.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Zahim, Sara; Delacroix, Kenny; Carlier, Agathe; Berranger, Thierry; Bergraser, Julie; Echeverria, Pierre-Georges; Petit, Laurent published the artcile< Tetrahydro-4H-pyran-4-one: From the Laboratory Scale to Pilot Plant Manufacture>, Related Products of 627-27-0, the main research area is tetrahydropyranone preparation.

This study describes recent efforts to find an efficient and scalable route to tetrahydro-4H-pyran-4-one using the com. available starting materials. The route scouting work and the full development of an efficient access to the target are described. This work culminated in the preparation of above 20 kg of the title compound in our pilot plant facility.

Organic Process Research & Development published new progress about Oxidation. 627-27-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C4H8O, Related Products of 627-27-0.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Wang, Chengliang; Zhang, Xu; Zhao, Wei; Liu, Xin; Wang, Qingfu; Sun, Jingjiang published the artcile< Synthesis of Aliphatic Hyperbranched Polycarbonates via Organo-Catalyzed ""A1+B2""-Ring-Opening Polymerization>, Category: alcohols-buliding-blocks, the main research area is aliphatic hyperbranched polycarbonate organo catalyzed ring opening polymerization.

Hyperbranched aliphatic polycarbonates (HBPCs) have attracted significant attention in the field of biomedical application owing to their abundant end groups, biocompatibility, and nontoxic degradation products. However, their practical application is hampered by tedious synthesis procedures. The present work described a novel organo-catalyzed “”A1+B2″”-ring-opening polymerization (ROP) using a monofunctional primary alc. (A1) as an initiator and a bicyclic carbonate monomer (B2) for the straightforward synthesis of HBPCs under mild conditions. No gelation was observed up to 90% conversion of the cyclic carbonate ring. HBPCs with molar masses in the range from 7 to 20 kg/mol were obtained. Based on the “”A1+B2″”-ROP, HBPCs bearing a variety of functionalities including alkene, alkyne, aldehyde, furan, azide, and mPEG groups, which are of great significance in the field of click chem., have been successfully prepared by using functional alc. initiators. This polymerization strategy allowed for precise control over the HBPC structure: (1) the hyperbranched polymer (HBP) backbone can be adjusted by design of a bicyclic carbonate monomer with various linkages; (2) the use of an appropriate initiator leads to the introduction of functional end groups. Overall, the “”A1+B2″”-ROP provides an efficient method for preparing a variety of HBPs like hyperbranched polyester, polyether, polyphosphate, and poly(amino acid) with complex architectures in a single step.

Macromolecules (Washington, DC, United States) published new progress about Biocompatible materials. 627-27-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C4H8O, Category: alcohols-buliding-blocks.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Park, Simon S.; Gervay-Hague, Jacquelyn published the artcile< Step-economy synthesis of β-steryl sialosides using a sialyl iodide donor>, Reference of 4064-06-6, the main research area is crystal structure conformation sialic acid preparation steroid glycoside; steryl sialoside synthesis sialyl iodide neuraminic acid glycosylation.

Steryl glycosides are prevalent in nature and have unique biol. activities dictated by sterol structure, sugar composition, and the stereochem. attachment of the aglycon. A single configurational switch can have profound biol. consequences meriting the systematic study of structure and function relationships. Steryl congeners of N-acetyl neuraminic acid (NANA) impact neurobiol. processes and may also mediate host/microbe interactions. In order to study these processes, a platform for the synthesis of β-steryl sialosides has been established. Promoter-free glycosidations using a novel α-linked sialyl iodide donor efficiently provide unique amphiphilic sialoglycoconjugates for examining bioactivities in various systems.

Journal of Antibiotics published new progress about Amphiphiles. 4064-06-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C12H20O6, Reference of 4064-06-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Schulz, Patrick; Dueck, Benjamin; Mourot, Alexandre; Hatahet, Lina; Fendler, Klaus published the artcile< Measuring ion channels on solid supported membranes>, Reference of 35564-86-4, the main research area is measurement ion channel solid supported membrane.

Application of solid supported membranes (SSMs) for the functional investigation of ion channels is presented. SSM-based electrophysiol., which has been introduced previously for the investigation of active transport systems, is expanded for the anal. of ion channels. Membranes or liposomes containing ion channels are adsorbed to an SSM and a concentration gradient of a permeant ion is applied. Transient currents representing ion channel transport activity are recorded via capacitive coupling. The authors demonstrate the application of the technique to liposomes reconstituted with the peptide cation channel gramicidin, vesicles from native tissue containing the nicotinic acetylcholine receptor, and membranes from a recombinant cell line expressing the ionotropic P2X2 receptor. It is shown that stable ion gradients, both inside as well as outside directed, can be applied and currents are recorded with an excellent signal/noise ratio. For the nicotinic acetylcholine receptor and the P2X2 receptor excellent assay quality factors of Z’ = 0.55 and Z’ = 0.67, resp., are obtained. This technique opens up new possibilities in cases where conventional electrophysiol. fails like the functional characterization of ion channels from intracellular compartments. It also allows for robust fully automatic assays for drug screening.

Biophysical Journal published new progress about Adsorption. 35564-86-4 belongs to class alcohols-buliding-blocks, and the molecular formula is C7H18ClNO5, Reference of 35564-86-4.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Beleggia, Romina; Omranian, Nooshin; Holtz, Yan; Gioia, Tania; Fiorani, Fabio; Nigro, Franca M.; Pecchioni, Nicola; De Vita, Pasquale; Schurr, Ulrich; David, Jacques L.; Nikoloski, Zoran; Papa, Roberto published the artcile< Comparative analysis based on transcriptomics and metabolomics data reveal differences between emmer and durum wheat in response to nitrogen starvation>, COA of Formula: C6H10O8, the main research area is transcriptomics metabolomics emmer durum wheat nitrogen starvation comparative analysis; GABA; Triticum turgidum; glutamate; metabolomics; plant nutrition; stress; transcriptomics.

Mounting evidence indicates the key role of nitrogen (N) on diverse processes in plant, including development and defense. Using a combined transcriptomics and metabolomics approach, we studied the response of seedlings to N starvation of two different tetraploid wheat genotypes from the two main domesticated subspecies: emmer and durum wheat. We found that durum wheat exhibits broader and stronger response in comparison to emmer as seen from the expression pattern of both genes and metabolites and gene enrichment anal. They showed major differences in the responses to N starvation for transcription factor families, emmer showed differential reduction in the levels of primary metabolites while durum wheat exhibited increased levels of most of them to N starvation. The correlation-based networks, including the differentially expressed genes and metabolites, revealed tighter regulation of metabolism in durum wheat in comparison to emmer. We also found that glutamate and γ-aminobutyric acid (GABA) had highest values of centrality in the metabolic correlation network, suggesting their critical role in the genotype-specific response to N starvation of emmer and durum wheat, resp. Moreover, this finding indicates that there might be contrasting strategies associated to GABA and glutamate signaling modulating shoot vs. root growth in the two different wheat subspecies.

International Journal of Molecular Sciences published new progress about ATP-binding cassette transporter ABCA6 Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 87-73-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H10O8, COA of Formula: C6H10O8.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Kang, Taeho; Kim, Nana; Cheng, Peter T.; Zhang, Hao; Foo, Klement; Engle, Keary M. published the artcile< Nickel-Catalyzed 1,2-Carboamination of Alkenyl Alcohols>, Name: But-3-en-1-ol, the main research area is tertiary amine preparation regioselective; alkenyl alc boronic ester amine carboamination nickel catalyst.

An alc.-directed, nickel-catalyzed three-component umpolung carboamination of unactivated alkenes with aryl/alkenylboronic esters and electrophilic aminating reagents was reported. This transformation was enabled by specifically tailored O-(2,6-dimethoxybenzoyl)hydroxylamine electrophiles that suppressed competitive processes, including undesired β-hydride elimination and transesterification between the alc. substrate and electrophile. The reaction delivered the desired 1,2-carboaminated products with generally high regio- and syn-diastereoselectivity and exhibited a broad scope of coupling partners and alkenes, including complex natural products. Various mechanistic experiments and anal. of the stereochem. outcome with a cyclic alkene substrate, as confirmed by X-ray crystallog. anal., support alc.-directed syn-insertion of an organonickel(I) species.

Journal of the American Chemical Society published new progress about Alkenyl alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 627-27-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C4H8O, Name: But-3-en-1-ol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Duchow, Elizabeth G.; Sibilska-Kaminski, Izabela K.; Plum, Lori A.; DeLuca, Hector F. published the artcile< Vitamin D esters are the major form of vitamin D produced by UV irradiation in mice>, Reference of 434-16-2, the main research area is vitamin D ester UV irradiation; 7-Dehydrocholesterol; Skin; Ultraviolet light B; Vitamin D; Vitamin D esters; Vitamin D-binding protein.

The primary source of vitamin D3 for humans is that produced in skin by UV irradiation UV B (UVB, 280-310 nm) light causes the isomerization of 7-dehydrocholesterol (7-DHC) to pre-vitamin D3 that is thermally isomerized to vitamin D3. In addition to free vitamin D3, it has been previously reported that esterified vitamin D3 is also found in the skin of rats irradiated with UVB. We found that a large fraction of the vitamin D3 precursor, 7-dehydrocholesterol is in the esterified form. Following UVB irradiation, vitamin D3 esters represent the majority of tissue vitamin D3, comprising approx. 80% in mice. Examination of vitamin D3 ester transport from skin in DBP-/- mice demonstrated that skin vitamin D3 ester content decreased only in the presence of DBP. No significant binding of vitamin D3 esters by serum was observed and no vitamin D3 esters were detectable in mouse serum after UVB treatment, indicating that the esters are hydrolyzed prior to transport into the circulation. The significance of vitamin D3 esters and their hydrolysis is the subject of current investigation.

Photochemical & Photobiological Sciences published new progress about Blood serum. 434-16-2 belongs to class alcohols-buliding-blocks, and the molecular formula is C27H44O, Reference of 434-16-2.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Prathima, A.; Karthikeyan, S.; Radhi Devi, K.; Usha, K.; Shanthi, M. published the artcile< Environmental effect of lubricity additives through dielectric molecular parameters>, Synthetic Route of 104-76-7, the main research area is caprylic valeric acid additive lubricity.

Lubricant additives are chems., nearly always-organic or organometallic, that are added to oils in quantities of a few weight percent to improve the lubricating capacity and durability of the oil. Specific purposes of lubricant additives are improving the wear and friction characteristics by provision for adsorption and extreme pressure lubrication, improving the oxidation resistance, control of corrosion, control of contamination by reaction products, wear a and other debris, reducing excessive decrease of lubricant viscosity at high temperatures, enhancing lubricant characteristics by reducing the pour point and inhibiting the generation of foam. These properties depend upon the mol. interactions between the chem. additives. So that, this study target on investigating the mol. interactions through the dielec. parameters such as Kirkwood correlation factor, Excess permittivity, Bruggemann factor and Dipolar excess free energy in the lubricative binary mixtures,(1) caprylic acid + 2-ethyl-1-hexanol and (2) valeric acid + 2-ethyl-1-hexanol. The above dielec. parameters have been calculated from the exptl. measured values of capacitance and refractive index of mixtures, at temperatures 303 K, 313 K and 323 K. In the above studied systems, existence of short and long range, homo and hetero interactions are identified. The hetero interaction results in the formation linear as well as closed multimers in the mixture Due to the existing interactions, structural changes are found to take place.

Materials Today: Proceedings published new progress about Helmholtz free energy. 104-76-7 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H18O, Synthetic Route of 104-76-7.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts