Month: October 2022

Sudhakaran, Swetha; Siddiki, S. M. A. Hakim; Kitiyanan, Boonyarach; Nomura, Kotohiro published the artcile< CaO Catalyzed Transesterification of Ethyl 10-Undecenoate as a Model Reaction for Efficient Conversion of Plant Oils and Their Application to Depolymerization of Aliphatic Polyesters>, Quality Control of 627-27-0, the main research area is CaO transesterification ethyl undecenoate plant oil depolymerization polyester.

Transesterification of Et 10-undecenoate (derived from castor oil) with cyclohexanemethanol over a CaO catalyst (prebaked at 300 °C) gave undec-10-enoate exclusively (yield 92%, selectivity 95-98%) at 100 °C, and the activity increased at 120 °C with maintaining the high selectivity (97-98%). The transesterification with other alcs., especially primary alcs. (2-ethyl-1-butanol, 1-hexanol, 3-buten-1-ol, and 10-undecen-1-ol), afforded the corresponding esters with high selectivity, indicating the possibility for application of efficient conversion of plant oils to various fine chems. including the monomer for the synthesis of polyesters. Efficient acid-, base-free depolymerization of aliphatic polyesters, poly(ethylene adipate) and poly(butylene adipate), has been demonstrated in this catalysis by transesterification with ethanol and cyclohexanemethanol, affording corresponding adipates and ethylene glycol or butylene glycol exclusively: the reusability of a CaO catalyst has also been demonstrated.

ACS Sustainable Chemistry & Engineering published new progress about Polyesters, aliphatic Role: RCT (Reactant), RACT (Reactant or Reagent). 627-27-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C4H8O, Quality Control of 627-27-0.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Khazan, Negar; Kim, Kyu Kwang; Hansen, Jeanne N.; Singh, Niloy A.; Moore, Taylor; Snyder, Cameron W. A.; Pandita, Ravina; Strawderman, Myla; Fujihara, Michiko; Takamura, Yuta; Jian, Ye; Battaglia, Nicholas; Yano, Naohiro; Teramoto, Yuki; Arnold, Leggy A.; Hopson, Russell; Kishor, Keshav; Nayak, Sneha; Ojha, Debasmita; Sharon, Ashoke; Ashton, John M.; Wang, Jian; Milano, Michael T.; Miyamoto, Hiroshi; Linehan, David C.; Gerber, Scott A.; Kawar, Nada; Singh, Ajay P.; Tabdanov, Erdem D.; Dokholyan, Nikolay V.; Kakuta, Hiroki; Jurutka, Peter W.; Schor, Nina F.; Rowswell-Turner, Rachael B.; Singh, Rakesh K.; Moore, Richard G. published the artcile< Identification of a Vitamin-D Receptor Antagonist, MeTC7, which Inhibits the Growth of Xenograft and Transgenic Tumors In Vivo>, Formula: C27H44O, the main research area is vitamin D receptor antagonist MeTC7 antitumor.

Vitamin-D receptor (VDR) mRNA is overexpressed in neuroblastoma and carcinomas of lung, pancreas, and ovaries and predicts poor prognoses. VDR antagonists may be able to inhibit tumors that overexpress VDR. However, the current antagonists are arduous to synthesize and are only partial antagonists, limiting their use. Here, we show that the VDR antagonist MeTC7 (5)(I), which can be synthesized from 7-dehydrocholesterol (6) in two steps, inhibits VDR selectively, suppresses the viability of cancer cell-lines, and reduces the growth of the spontaneous transgenic TH-MYCN neuroblastoma and xenografts in vivo. The VDR selectivity of 5 against RXRα and PPAR-γ was confirmed, and docking studies using VDR-LBD indicated that 5 induces major changes in the binding motifs, which potentially result in VDR antagonistic effects. These data highlight the therapeutic benefits of targeting VDR for the treatment of malignancies and demonstrate the creation of selective VDR antagonists that are easy to synthesize.

Journal of Medicinal Chemistry published new progress about Antitumor agents. 434-16-2 belongs to class alcohols-buliding-blocks, and the molecular formula is C27H44O, Formula: C27H44O.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Ugawa, Tohru; Kurihara, Kenzo published the artcile< Enhancement of canine taste responses to umami substances by salts>, Category: alcohols-buliding-blocks, the main research area is taste umami substance dog salt type; MSG taste dog salt type; GMP taste dog salt type.

The effects of salts on canine taste responses to umami substances were examined by recording the activity of the chorda tympani nerve. The responses to monosodium glutamate (MSG), disodium 5′-guanylate (GMP), and that induced by the synergism between MSG and GMP were enhanced by the presence of various salts. The effective salts were those carrying inorganic cations such as Na, K, and Mg, while CaCl2 had no enhancing effect. Salts carrying organic cations such as tris(hydroxymethyl)aminomethane (Tris), choline, N-methyl-D-glucamine, and 1,3-bis[tris(hydroxymethyl)methylamino]propane also produced pos. results. The dependence of the umami responses on NaCl and MgCl2 concentrations showed a bell-shaped response curve with the maximal enhancing effect being seen at 100 mM NaCl and 3-10 mM MgCl2. The degree of the enhancement depended not only on the species of the cation, but also on that of anion. For example, 100 mM NaCl showed a much larger enhancing effect than Na phosphate, Na2SO4, and Na4Fe(CN)6 at equimolar Na. The enhancing effects of salts on the responses to the umami substances could not be simply explained in terms of the permeability of cation and anion of salts. It was speculated that the binding of both cations and anions to the receptor membranes leads to changes in the interaction of the umami substances with the receptor proteins.

American Journal of Physiology published new progress about Canis familiaris. 35564-86-4 belongs to class alcohols-buliding-blocks, and the molecular formula is C7H18ClNO5, Category: alcohols-buliding-blocks.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Talik, Agnieszka; Tarnacka, Magdalena; Geppert-Rybczynska, Monika; Hachula, Barbara; Bernat, Roksana; Chrzanowska, Agnieszka; Kaminski, Kamil; Paluch, Marian published the artcile< Are hydrogen supramolecular structures being suppressed upon nanoscale confinement? The case of monohydroxy alcohols>, Recommanded Product: 2-Ethylhexan-1-ol, the main research area is monohydroxy alc silica alumina nanopore nanoconfinement; Confinement; Dielectric spectroscopy; Hydrogen bonds; Infrared spectroscopy; Interfacial energy; Monohydroxy alcohols; Self-assembly; Surface effects; Surface tension.

In this paper, the mol. dynamics, H-bonding pattern and wettability of the primary and secondary monohydroxyalcs., 2-ethyl-1-hexanol (2E1H), 2-ethyl-1-butanol (2E1B) and 5-methyl-3-heptanol (5M3H) infiltrated into native and functionalized silica and alumina pores having pore diameters, d = 4 nm and d = 10 nm, have been studied with the use of Broadband Dielec. (BDS) and Fourier Transform IR (FTIR) spectroscopies, as well as contact angle measurements. We found significant differences in the behavior of alcs. forming chain- (2E1H, 2E1B) or micelle-like (5M3H) supramol. structures despite of their similarities in the wettability and interfacial energy. It turned out that nanoassocs. as well as H-bonds are more or less affected by the confinement dependently on the chem. structure and alc. order. Moreover, a peculiar behavior of the self-assemblies at the interface was noted in the latter material (5M3H). Finally, it was found that irresp. to the sample, type of pores, functionalization, the temperature evolution of Debye relaxation times, τD, of the confined systems deviates from the bulk behavior always at similar τD due to vitrification of the interfacial layer. This finding is a clear indication that unexpectedly dynamics (mobility) of the supramol. structures close to the hydrophilic and hydrophobic surfaces is similar in each system.

Journal of Colloid and Interface Science published new progress about Contact angle. 104-76-7 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H18O, Recommanded Product: 2-Ethylhexan-1-ol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Mou, Xue-Qing; Ren, Liang-Chen; Zhang, Mei; Wang, Min; Jin, Yu-Fan; Guan, Qing-Xin; Cai, Ang; Zhang, Shi-Min; Ren, Hai; Zhang, Yun; Chen, Yong-Zheng published the artcile< Complementary Copper-Catalyzed and Electrochemical Aminosulfonylation of O-Homoallyl Benzimidates and N-Alkenyl Amidines with Sodium Sulfinates>, HPLC of Formula: 627-27-0, the main research area is alkylsulfonyl oxazine preparation; benzimidate sodium sulfinate copper catalyst aminosulfonylation; alkyl sulfonyl tetrahydropyrimidine preparation; alkenyl amidine sodium sulfinate copper catalyst aminosulfonylation; sulfonyl oxazepine preparation; sodium sulfinate benzimidate trichloroacetimidate copper electrochem aminosulfonylation cyclization regioselective.

A complementary copper-catalyzed and electrochem. aminosulfonylation of O-homoallyl benzimidates/N-alkenyl amidines with sodium sulfinates were developed. The terminal alkene substrate produced Sulfone-containing 1,3-oxazines and tetrahydropyrimidines in the presence of Cu(OAc)2, Ag2CO3 and DPP, and under similar reaction conditions, sulfonylated tetrahydro-1,3-oxazepines were prepared from 1-aryl-substituted O-homoallyl benzimidates in moderate to good yields. For certain electron-rich 1,1- diaryl-substituted alkene substrate, corresponding tetrahydro-1,3-oxazepines was also be obtained in similar or even higher yield via a green electrochem. technique.

Organic Letters published new progress about Alkenes Role: PRP (Properties), RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 627-27-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C4H8O, HPLC of Formula: 627-27-0.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Couto, Hyrla Grazielle Silva de Araujo; Blank, Arie Fitzgerald; de Oliveira e Silva, Ana Mara; Nogueira, Paulo Cesar de Lima; Arrigoni-Blank, Maria de Fatima; Nizio, Daniela Aparecida de Castro; Pinto, Jessika Andreza de Oliveira published the artcile< Essential oils of basil chemotypes: Major compounds, binary mixtures, and antioxidant activity>, Reference of 78-70-6, the main research area is essential oil basil genotype antioxidant eugenol; 1,8 cineole (PubChem CID: 2758); Antagonism; Eugenol; Eugenol (PubChem CID: 3314); Geranial (PubChem CID: 638011); Linalool (PubChem CID: 6549); Methyl chavicol (PubChem CID: 8815); Methyl cinnamate (PubChem CID: 637520); Neral (PubChem CID: 643779); Ocimum; Synergism; Volatile oil.

The antioxidant potential of the essential oils (EO) of 24 basil genotypes was assessed by 4 distinct in vitro evaluation methods. Different combinations of the major compounds found in the EO were also tested to identify those combinations responsible for the antioxidant activity of the volatile oils and verify the occurrence of synergism or antagonism between them. Results indicate that 9 EO exhibited promising antioxidant potential, with at least 52.68% of inhibition of the linoleic acid peroxidation at 10 μL/mL and 76.34% of inhibition of the DPPH· radical at 1 μL/mL. The major compound eugenol had the highest antioxidant activity. The antioxidant activity of these EO cannot be explained solely by the presence of the major compounds Despite the influence of eugenol, the antioxidant activity is also related to the synergism between other minor compounds found in the EO. This fact confers a potent antioxidant activity to some basil EO.

Food Chemistry published new progress about Antioxidants. 78-70-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C10H18O, Reference of 78-70-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Zeynizadeh, Behzad; Mohammad Aminzadeh, Farkhondeh; Mousavi, Hossein published the artcile< Chemoselective reduction of nitroarenes, N-acetylation of arylamines, and one-pot reductive acetylation of nitroarenes using carbon-supported palladium catalytic system in water>, SDS of cas: 5344-90-1, the main research area is aryl amine preparation chemoselective; nitroarene reduction palladium catalyst; acyl aryl amine preparation chemoselective; arylamine acetylation palladium catalyst; reductive acetylation nitroarene palladium catalyst.

In this paper, convenient, green and efficient approaches for the chemoselective reduction of nitroarenes, N-acetylation of arylamines and one-pot reductive acetylation of nitroarenes in the presence of the recoverable heterogeneous carbon-supported palladium (Pd/C) catalytic system in water was developed. The utilize of the simple, effective and recoverable catalyst and also using of water as an entirely green solvent along with relatively short reaction times and good-to-excellent yields of the desired products were some of the noticeable features of the presented synthetic protocols.

Research on Chemical Intermediates published new progress about Acetylation. 5344-90-1 belongs to class alcohols-buliding-blocks, and the molecular formula is C7H9NO, SDS of cas: 5344-90-1.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Wu, Han; Li, Rui-Ting; Dong, Jun-Feng; Jiang, Nan-Ji; Huang, Ling-Qiao; Wang, Chen-Zhu published the artcile< An odorant receptor and glomerulus responding to farnesene in Helicoverpa assulta (Lepidoptera: Noctuidae)>, Category: alcohols-buliding-blocks, the main research area is Helicoverpa larva glomerulus odorant receptor farnesene oviposition index; Farnesene; Glomeruli; Labeled-line; Odorant receptor.

Terpenoids emitted from herbivore-damaged plants were found to play an important role in regulating tritrophic interactions. How herbivores and their natural enemies perceive terpenoids has not been thoroughly elucidated to date. Using in vivo calcium imaging, we found in this study that farnesene activates one glomerulus in the antennal lobe of female Helicoverpa assulta. The response induced by a mixture of farnesene isomers is stronger than that elicited by E-β-farnesene alone. In the Xenopus oocyte expression system, HassOR23/ORco is narrowly tuned to farnesene isomers and compounds with similar structures. Finally, the behavioral studies showed that the farnesene isomers have an inhibitory effect on oviposition of female H. assulta, but have an attractive effect on host searching of Campoletis chlorideae, the key endoparasitoid of H. assulta larvae. These results demonstrate that farnesene isomers are encoded by a labeled-line mode in the olfactory system of female H. assulta, suggesting that farnesene as a chem. signal from plants has important behavioral relevance and evolutionary implications in the tritrophic context.

Insect Biochemistry and Molecular Biology published new progress about Antennal lobe. 78-70-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C10H18O, Category: alcohols-buliding-blocks.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Zhu, Han; Cao, Chujin; Wu, Zhongcai; Zhang, Heping; Sun, Zhihong; Wang, Meng; Xu, Huzi; Zhao, Zhi; Wang, Yuxi; Pei, Guangchang; Yang, Qian; Zhu, Fengming; Yang, Juan; Deng, Xuan; Hong, Yu; Li, Yinzheng; Sun, Jie; Zhu, Fan; Shi, Mengxia; Qian, Kun; Ye, Ting; Zuo, Xuezhi; Zhao, Fenfei; Guo, Jing; Xu, Gang; Yao, Ying; Zeng, Rui published the artcile< The probiotic L. casei Zhang slows the progression of acute and chronic kidney disease>, Quality Control of 87-73-0, the main research area is Lactobacillus casei acute chronic kidney disease progression; Lactobacillus casei Zhang; acute kidney injury; chronic kidney disease; gut microbiota; nicotinamide; short-chain fatty acids.

The relationship between gut microbial dysbiosis and acute or chronic kidney disease (CKD) is still unclear. Here, we show that oral administration of the probiotic Lactobacillus casei Zhang (L. casei Zhang) corrected bilateral renal ischemia-reperfusion (I/R)-induced gut microbial dysbiosis, alleviated kidney injury, and delayed its progression to CKD in mice. L. casei Zhang elevated the levels of short-chain fatty acids (SCFAs) and nicotinamide in the serum and kidney, resulting in reduced renal inflammation and damage to renal tubular epithelial cells. We also performed a 1-yr phase 1 placebo-controlled study of oral L. casei Zhang use (Chinese clin. trial registry, ChiCTR-INR-17013952), which was well tolerated and slowed the decline of kidney function in individuals with stage 3-5 CKD. These results show that oral administration of L. casei Zhang, by altering SCFAs and nicotinamide metabolism, is a potential therapy to mitigate kidney injury and slow the progression of renal decline.

Cell Metabolism published new progress about 16S rRNA Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 87-73-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H10O8, Quality Control of 87-73-0.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Hong, Yawen; Ying, Tiejin published the artcile< Isolation, molecular characterization and antioxidant activity of a water-soluble polysaccharide extracted from the fruiting body of Termitornyces albuminosus (Berk.) Heim>, Category: alcohols-buliding-blocks, the main research area is Termitomyces fruiting body water soluble polysaccharide antioxidant activty; Antioxidant activity; Polysaccharide; Structure analysis; Termitornyces albuminosus.

A water-soluble polysaccharide WSP1 was extracted from the fruiting body of Termitornyces albuminosus. Its mol. weight, monosaccharide composition and mol. structure were determined by GPC, GC-MS, UV spectroscopy, FT-IR spectroscopy, methylation anal., NMR (1D and 2D) and AFM. Moreover, the antioxidant activity of WSP1 was evaluated in vitro by the tests of reducing power, scavenging ability on DPPH radical and hydroxyl radical, and chelating ability on ferrous ion. The results indicated that the mol. weight of WSP1 was 9 kDa, and it was mainly composed of fucose and galactose in a molar ratio of 1:3.09. Based on monosaccharide composition, methylation anal. and NMR, the possible repeating unit of WSP1 was presented as follows:→2-α-L-Fucp-1→ (6-α-D-Galp-1)3→. The antioxidant assay revealed that, in the concentration range tested in this experiment, WSP1 had strong scavenging ability on DPPH radical, suggesting that WSP1 could be potentially used as a powerful radical scavenger.

International Journal of Biological Macromolecules published new progress about Antioxidants. 3458-28-4 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H12O6, Category: alcohols-buliding-blocks.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts