Month: October 2022

Imperio, Daniela; Muz, Barbara; Azab, Abdel Kareem; Fallarini, Silvia; Lombardi, Grazia; Panza, Luigi published the artcile< A Short and Convenient Synthesis of closo-Dodecaborate Sugar Conjugates>, Application of C12H20O6, the main research area is boron neutron capture therapy dodecaborate sugar conjugate.

Dodecaborate anions represent a suitable boron source for boron neutron capture therapy (BNCT). Sugar derivatives of dodecaborate have been prepared through the ring-opening reaction of cyclic oxonium ions by alkoxide nucleophiles. According to this general approach, a convenient and short synthesis of three derivatives of dodecaborate-sugar conjugates is herein reported. Glucose, galactose and fructose have been chosen for their expected preferential uptake by tumor cells compared to healthy cells. The free hydroxyl group of isopropylidene protected sugars was exploited as nucleophile to open a dodecaborate cyclic oxonium salt, giving products containing a spacer between the sugar and the boron cluster. Deprotection of the sugar moiety in acidic conditions gave the desired compounds in excellent yield.

European Journal of Organic Chemistry published new progress about Antitumor agents. 4064-06-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C12H20O6, Application of C12H20O6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Wang, Zheng; Liu, Yahuan; Han, Mingyang; Ma, Ning; Lyu, Quanming; Liu, Qingbin; Sun, Wen-Hua published the artcile< Efficient transfer hydrogenation of ketones using molybdenum complexes by comprehensively verifying the auxiliary ligands>, SDS of cas: 403-41-8, the main research area is ketone hydrogenation molybdenum complex catalyst.

Molybdenum complexes ligated with N1,N1-dialkyl-N2-(5,6,7,8-tetrahydroquinolin-8-yl)ethane-1,2-diamines and auxiliary ligands, providing various structural features, were developed: [NNH/NNHN]Mo(CO)4/3, [NNHN]Mo(CO)2Br, [NNH]Mo(CO)(η3-C3H5)Br and [NNHN/S]Mo(CO)(PPh3)2. All the complexes were highly active in the transfer hydrogenation (TH) of a model substrate (acetophenone), providing excellent yields of 1-phenylethanol. The structural variation in the ligand framework had a modest effect on the catalyst performance as compared to the changes in the auxiliary ligands Br, PPh3 and CO. This structural evolution provided the complex [Mo(NNH)(η3-C3H5)(CO)2Br] as the most effective catalyst not only for the transfer hydrogenation of acetophenone but also for a wide range of diverse ketones (up to 43 examples). Moreover, easy purification of the products by only removing the acetone byproduct is another noteworthy feature of this environmentally friendly route.

Dalton Transactions published new progress about Alcohols Role: SPN (Synthetic Preparation), PREP (Preparation). 403-41-8 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H9FO, SDS of cas: 403-41-8.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Molaei, Somayeh; Moeini, Nazanin; Ghadermazi, Mohammad published the artcile< Synthesis of CoFe2O4 @Amino glycol/Gd nanocomposite as a high-efficiency and reusable nanocatalyst for green oxidation of sulfides and synthesis of 5-substituted 1H-tetrazoles>, Category: alcohols-buliding-blocks, the main research area is cobalt spinel ferrite magnetite nanoparticles immobilized covalently amino glycol; gadolinium nanocomposite preparation; nickel ferrate magnetite nanoparticles supported on silica immobilized covalently; amino glycol gadolinium nanocomposite preparation; sulfinyl green preparation; tetrazole green preparation.

In this study, a novel gadolinium 2-amino-2-methyl-1,3-propanediol (amino glycol) complex immobilized covalently on CoFe2O4 magnetite nanoparticles was synthesized. The nanocatalyst was characterized thoroughly using thermogravimetric analyzes (TGA), FT-IR spectroscopy, SEM (SEM), energy dispersive X-ray (EDX), inductively coupled plasma optical emission spectroscopy (ICP-OES), vibrational sample magnetometry (VSM), and powder X-ray diffraction (PXRD). CoFe2O4 @amino glycol/Gd was found to be efficient for the oxidation of sulfides to sulfinyl R1S(O)R2 [R1 = Et, Ph, Bn, etc.; R2 = Me, Et, Ph, etc.] and synthesis of 5-substituted 1H-tetrazoles I [R3 = Ph, Bn, 4-HOC6H4, etc.] at mild reaction conditions in the green medium. The influences of reaction temperature, solvent, and the amount of catalysts were studied. The best results were obtained in water and without organic solvent condition for 5-substituted 1H-tetrazoles and oxidation of sulfides, resp. The catalyst was easily collected via an external magnetic field and further reused at least 6 times without a significant decrease in catalytic activity. The wide applicability of the catalyst, ease of catalyst separation, its reusability capacity, and importantly reaction operation in a green medium and elimination of hazardous organic solvents were the advantages of this catalyst.

Journal of Organometallic Chemistry published new progress about Functional groups, sulfinyl group. 699-12-7 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H10OS, Category: alcohols-buliding-blocks.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Ganguli, Kasturi; Shee, Sujan; Panja, Dibyajyoti; Kundu, Sabuj published the artcile< Cooperative Mn(I)-complex catalyzed transfer hydrogenation of ketones and imines>, Formula: C8H9FO, the main research area is alc preparation chemoselective; ketone transfer hydrogenation manganese catalyst; aryl aldehyde transfer hydrogenation manganese catalyst; imine transfer hydrogenation manganese catalyst.

The synthesis and reactivity of Mn(I) complexes bearing bifunctional ligands comprising both the amine N-H and benzimidazole fragments I and II (R = H, Me; R1 = H, Me, phenyl; R2 = H, Me) are reported. Among the various ligands, the N-((1H-benzimidazol-2-yl)methyl)aniline ligand containing Mn(I) complex II (R = R2 = H; R1 = Ph) presented higher reactivity in the transfer hydrogenation (TH) of ketones R3C(O)R4 (R3 = Ph, thiophen-2-yl, cyclopropyl, etc.; R4 = Me, propan-2-yl, tert-Bu, etc.; R3R4 = 9H-fluoren-9-yl, 1,2,3,4-tetrahydronaphthalen-1-yl, cyclohexyl) in 2-propanol. Exptl., it was established that both the benzimidazole and amine N-H proton played a vital role in the enhancement of the catalytic activity. Utilizing this system, a wide range of ketones R3C(O)R4 and aldehydes R5CHO (R5 = 4-CH3C6H4, thiophen-2-yl, pentyl, etc.) was reduced efficiently. Notably, the TH of several imines R6R7C=NR8 (R6 = 4-OCH3C6H4, thiophen-2-yl, naphthalen-2-yl, etc.; R7 = H, Me, Et; R8 = C6H5, 4-OCH3C6H4, CH3(CH2)3, etc.), as well as chemoselective reduction of unsaturated ketones, was achieved in the presence of this catalyst. DFT calculations were carried out to understand the plausible reaction mechanism which disclosed that the transfer hydrogenation reaction followed a concerted outer-sphere mechanism.

Dalton Transactions published new progress about Alcohols Role: SPN (Synthetic Preparation), PREP (Preparation). 403-41-8 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H9FO, Formula: C8H9FO.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Jing, Tingting; Zhang, Na; Gao, Ting; Zhao, Mingyue; Jin, Jieyang; Chen, Yongxian; Xu, Miaojing; Wan, Xiaochun; Schwab, Wilfried; Song, Chuankui published the artcile< Glucosylation of (Z)-3-hexenol informs intraspecies interactions in plants: A case study in Camellia sinensis>, HPLC of Formula: 78-70-6, the main research area is Camellia UGT Z hexenol pest control; airborne (Z)-3-hexenol; glucosyltransferase; overexpression; site-directed mutagenesis; tea plant.

Plants emit a variety of volatiles in response to herbivore attack, and (Z)-3-hexenol and its glycosides have been shown to function as defense compounds Although the ability to incorporate and convert (Z)-3-hexenol to glycosides is widely conserved in plants, the enzymes responsible for the glycosylation of (Z)-3-hexenol remained unknown until today. In this study, uridine-diphosphate-dependent glycosyltransferase (UGT) candidate genes were selected by correlation anal. and their response to airborne (Z)-3-hexenol, which has been shown to be taken up by the tea plant. The allelic proteins UGT85A53-1 and UGT85A53-2 showed the highest activity towards (Z)-3-hexenol and are distinct from UGT85A53-3, which displayed a similar catalytic efficiency for (Z)-3-hexenol and nerol. A single amino acid exchange E59D enhanced the activity towards (Z)-3-hexenol, whereas a L445M mutation reduced the catalytic activity towards all substrates tested. Transient overexpression of CsUGT85A53-1 in tobacco significantly increased the level of (Z)-3-hexenyl glucoside. The functional characterization of CsUGT85A53 as a (Z)-3-hexenol UGT not only provides the foundation for the biotechnol. production of (Z)-3-hexenyl glucoside but also delivers insights for the development of novel insect pest control strategies in tea plant and might be generally applicable to other plants.

Plant, Cell & Environment published new progress about Camellia sinensis. 78-70-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C10H18O, HPLC of Formula: 78-70-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Wang, Feifei; Kong, Hao; Meng, Xiangfeng; Tian, Xiao; Wang, Changjiang; Xu, Lei; Zhang, Xiang; Wang, Lei; Xie, Ran published the artcile< A light-initiated chemical reporter strategy for spatiotemporal labeling of biomolecules>, Electric Literature of 5505-63-5, the main research area is biomol spatiotemporal labeling light initiated chem reporter strategy.

The emergence of optochem. approaches has had a diverse impact over a broad range of biol. research due to spatiotemporal regulation. Herein, we integrate this feature into the bioorthogonal chem. reporter strategy, which enables visible light-controlled spatiotemporal labeling of cell-surface glycans, lipids, and proteins. The metabolic precursors were first incorporated into live cells, and next the bioorthogonal reaction converted the azide/alkyne into a photo-active functional group, which allowed for subsequent photo-click reaction. We demonstrated this strategy by specifically labeling sialome, mucin-type O-glycome, phospholipids and newly-synthesized membrane proteins, resp. The sequential photoirradiation-orthogonal reporter tagging (SPORT) should facilitate the probing of biomols. in complex biol. systems with high spatiotemporal precision.

RSC Chemical Biology published new progress about Affinity labeling. 5505-63-5 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H14ClNO5, Electric Literature of 5505-63-5.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Axelrod, Kevin; Samburova, Vera; Khlystov, Andrey Y. published the artcile< Relative abundance of saccharides, free amino acids, and other compounds in specific pollen species for source profiling of atmospheric aerosol>, Computed Properties of 492-62-6, the main research area is abundance saccharide free amino acid pollen species source profiling; atm aerosol; Amino acid; Anhydrosugar; Atmospheric aerosol; Bioaerosol; Pollen; Resin acid; Saccharide.

Though studies in bioaerosols are being conducted with increasing frequency over the past decade, the total breadth of knowledge on bioaerosols and their role in atm. processes is still minimal. In order to better characterize the chem. composition of fresh biol. aerosol for purposes of source apportionment and tracing in the atm., several plant pollen species were selected for detailed chem. analyses. For this purpose, different pollen species were purchased and collected around Reno, Nevada, USA, for further extraction and detailed chem. anal. These species included aspen, corn, pecan, ragweed, eastern cottonwood, paper mulberry, rabbitbrush, bitterbrush, lodgepole pine, and Jeffrey pine. Saccharides, free amino acids, and various other polar compounds (e.g., anhydrosugars and resin acids) were quant. analyzed using gas chromatog. and ultra-high performance liquid chromatog. coupled with mass spectrometry techniques (GC-MS and UPLC-MS), with the purpose to identify differences and nuances in chem. composition of specific pollen species. The saccharides β-D-fructose, α-D-glucose, and β-D-glucose were ubiquitously found across all pollen samples (10), and sucrose was found in five samples. D-galactose was also found in pine species. Total saccharides were 4.0 to 29% of total dry weight across all samples. Total free amino acids were 0.29% to 15% of total dry weight across all samples, with the most common amino acid being proline. Chem. profiles (including both saccharides and amino acids) of surface-deposited aerosol in the Lake Tahoe area correlated most closely with pine pollen than other analyzed pollen species, indicating that chem. profiles of pollen can be used to infer its contribution to local aerosols.

Science of the Total Environment published new progress about Adenostoma fasciculatum. 492-62-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H12O6, Computed Properties of 492-62-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Zou, Yuchen; Duan, Hanying; Li, Li; Chen, Xuju; Wang, Chao published the artcile< Quantification of polyglutamyl 5-methyltetrahydrofolate, monoglutamyl folate vitamers, and total folates in different berries and berry juice by UHPLC-MS/MS>, Formula: C20H21CaN7O7, the main research area is polyglutamyl methyltetrahydrofolate berry juice; 10-Formyldihydrofolate (PubChem CID: 168809); 10-Formylfolic acid (PubChem CID: 3080544); 10-Formyltetrahydrofolate (PubChem CID: 10); 5,10-Methenyltetrahydrofolate (PubChem CID: 439237); 5-Formyltetrahydrofolate (PubChem CID: 149436); 5-Methyltetrahydrofolate (PubChem CID: 439234); Berry; Deglutamylation; Folate vitamers; Folic acid (PubChem CID: 6037); Polyglutamyl 5-CH(3)THF; Recombinant γ-glutamyl hydrolase; Tetrahydrofolate (PubChem CID: 1129); Total folates.

Edible berries are good sources of several phytochems. However, the native folate levels in berries are not well known. The structure of native folates contains polyglutamyl chains, which reportedly jeopardize the bioavailability of native folates; further γ-glutamyl hydrolase (GGH) can deglutamylate polyglutamyl chains. In this study we use a validated ultra-high performance liquid chromatog.-tandem mass spectrometry (UHPLC-MS/MS) method to determine the distribution of polyglutamyl 5-methyltetrahydrofolate (5-CH3THF-Glun), folate vitamers, and total folates in different berries and to monitor changes in their concentration during processing of berries into juice. The pre-boiling treatment was optimized during extraction to stabilize the native polyglutamyl folates profile and facilitate folate extraction, which can replace the traditional di-enzyme treatment process. Addnl., the efficiency of com. available human recombinant GGH was tested and it was found that a 10 μg GGH/mL extract at a pH of 6 could completely deconjugate polyglutamyl folates into monoglutamyl folates when incubated for 30 min. Pure human recombinant GGH with a higher catalytic efficiency and stable enzymic properties was better than traditional folate conjugase for this purpose. From exptl. anal., it could be inferred that strawberries and blackberries contained the highest amount of total folates (93-118 μg/100 g), while the total folate contents in blueberries were the lowest. Most of the investigated berries are good to excellent folate sources. This study is the first time that 5-CH3THF-Glun and distribution of folate vitamers in various berries are quantitated. Further, this is the first study to show the application of recombinant pure GGH for the deconjugation of polyglutamyl folates for folate vitamers and total folates anal.

Food Chemistry published new progress about Berry juice. 1492-18-8 belongs to class alcohols-buliding-blocks, and the molecular formula is C20H21CaN7O7, Formula: C20H21CaN7O7.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Yu, Fei; Dickson, Jalen L.; Loka, Ravi S.; Xu, Hengfu; Schaugaard, Richard N.; Schlegel, H. Bernhard; Luo, Long; Nguyen, Hien M. published the artcile< Diastereoselective sp3 C-O Bond Formation via Visible Light-Induced, Copper-Catalyzed Cross-Couplings of Glycosyl Bromides with Aliphatic Alcohols>, Application of C12H20O6, the main research area is LED copper catalyzed diastereoselective coupling bromoglycoside aliphatic alc; C(sp3)–O bond; copper catalysis; cross-coupling; stereoselective; visible light.

Copper-catalyzed cross-coupling reactions have become one of the most powerful methods for generating carbon-heteroatom bonds, an important framework of many organic mols. However, copper-catalyzed C(sp3)-O cross-coupling of alkyl halides with alkyl alcs. remains elusive because of the sluggish nature of oxidative addition to copper. To address this challenge, we have developed a catalytic copper system, which overcomes the copper oxidative addition barrier with the aid of visible light and effectively facilitates the cross-couplings of glycosyl bromides with aliphatic alcs. to afford C(sp3)-O bonds with high levels of diastereoselectivity. Importantly, this catalytic system leads to a mild and efficient method for stereoselective construction of α-1,2-cis glycosides, which are of paramount importance, but challenging. In general, stereochem. outcomes in α-1,2-cis glycosidic C-O bond-forming processes are unpredictable and dependent on the steric and electronic nature of protecting groups bound to carbohydrate coupling partners. Currently, the most reliable approaches rely on the use of a chiral auxiliary or hydrogen-bond directing group at the C2- and C4-position of carbohydrate electrophiles to control α-1,2-cis selectivity. In our approach, earth-abundant copper not only acts as a photocatalyst and a bond-forming catalyst, but also enforces the stereocontrolled formation of anomeric C-O bonds. This cross-coupling protocol enables highly diastereoselective access to a wide variety of α-1,2-cis-glycosides and biol. relevant α-glycan oligosaccharides. Our work provides a foundation for developing new methods for the stereoselective construction of natural and unnatural anomeric carbon(sp3)-heteroatom bonds.

ACS Catalysis published new progress about Alcohols Role: RCT (Reactant), RACT (Reactant or Reagent) (glycoside). 4064-06-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C12H20O6, Application of C12H20O6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Lee, Jeong Hwan; Hong, Suk Bong published the artcile< Dehydration of 1,3-butanediol to butadiene over medium-pore zeolites: Another example of reaction intermediate shape selectivity>, Electric Literature of 627-27-0, the main research area is butanediol butadiene dehydration pore zeolite intermediate shape selectivity.

Here we compare the catalytic properties of the proton form of 11 medium-pore zeolites, with different framework topologies and/or compositions for the dehydration of biomass-derived 1,3-butanediol at 300°C under excess water conditions (H2O/1,3-butanediol = 45). It was found that high-silica H-ferrierite (Si/Al = 130) with intersecting 10- and 8-ring channels exhibits the highest butadiene yield, together with the best durability, among the zeolites tested. Due to its highly inactive nature, however, 3-buten-1-ol, one of the butenol reaction intermediates in 1,3-butanediol dehydration, also remained a major byproduct. IR spectroscopy with adsorbed 3-buten-1-ol shows that intramolecularly hydrogen-bonded 3-buten-1-ol exists predominantly in H-ZSM-5 with two intersecting 10-ring channels, while the one with no intramol. hydrogen bonding is another species found not only in H-ferrierite but also in the one-dimensional 10-ring zeolite H-ZSM-22. By combining both exptl. and theor. results, we conclude that 1,3-butanediol dehydration over medium-pore zeolites may constitute another example of reaction intermediate shape selectivity.

Applied Catalysis, B: Environmental published new progress about Acidity. 627-27-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C4H8O, Electric Literature of 627-27-0.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts