Month: October 2022

Santos, Ana Claudia; Pereira, Irina; Pereira-Silva, Miguel; Ferreira, Laura; Caldas, Mariana; Collado-Gonzalez, Mar; Magalhaes, Mariana; Figueiras, Ana; Ribeiro, Antonio J.; Veiga, Francisco published the artcile< Nanotechnology-based formulations for resveratrol delivery: Effects on resveratrol in vivo bioavailability and bioactivity>, Computed Properties of 501-36-0 , the main research area is review resveratrol nanoformulation bioavailability nanocarrier; Bioactivity; Bioavailability; In vivo; Nanocarriers; Nanoencapsulation; Nanoformulations; Nanoparticles; Nanotechnology; Resveratrol.

A review. Resveratrol (RES), also known as 3,5,4′-trihydroxystilbene, is a polyphenolic phytoalexin that has been widely researched in the past decade due to its recognized numerous biol. activities. Despite the potential benefits of RES, its effective use is limited due to its poor solubility, photosensitivity and rapid metabolism, which strongly undermine RES bioavailability and bioactivity. Thereby, recently, nanotechnol. appeared as a potential strategy to circumvent RES physicochem. and pharmacokinetics constrains. However, only few studies have addressed the crucial in vivo suitability of the developed delivery systems to improve RES efficacy. Facing this scenario, in the present review, it is intended to present and discuss the in vivo resveratrol bioavailability and bioactivity, following its encapsulation or conjugation in nanotechnol.-based carriers, contemplating their pharmacokinetics effectiveness.

Colloids and Surfaces, B: Biointerfaces published new progress about Drug bioavailability. 501-36-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C14H12O3, Computed Properties of 501-36-0 .

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Zhang, Zhenguo; Liu, Xiaoxiao; Ji, Liang; Zhang, Ting; Jia, Zhenhua; Loh, Teck-Peng published the artcile< Metal-Free Access to (Spirocyclic)Tetrahydro-β-carbolines in Water Using an Ion-Pair as a Superacidic Precatalyst>, HPLC of Formula: 4064-06-6, the main research area is tetrahydro carboline preparation; aryl aldehyde tryptamine Pictet Spengler triarylcarbonium ion pair catalyst; spirocyclic tetrahydro carboline preparation; cyclic ketone tryptamine Pictet Spengler triarylcarbonium ion pair catalyst.

The unprecedented triarylcarbonium ion-pair-catalyzed Pictet-Spengler reaction of tryptamines with aromatic aldehydes and cyclic ketones in water was disclosed. Under metal-free conditions, diverse tetrahydro-β-carbolines/spirocyclic tetrahydro-β-carbolines I [R1 = H, Me, Cl, etc.; R2 = H; R3 = Ph, 4-MeC6H4, 2-naphthyl, etc.; R2R3 = (CH2)5, CH2CH2CH(Me)CH2CH2, CH2CH2N(Boc)CH2CH2, etc.] were obtained in good yields with excellent functional group tolerance, including late-stage modification of natural products and small mol. drugs. The practicability of this protocol was also characterized in the gram-scale synthesis of komavine and several other functional compounds Preliminary mechanistic studies indicated that in aqueous media the in situ-generated superacidic species from the carbonium ion pair with water was crucial to promote the Pictet-Spengler reaction.

ACS Catalysis published new progress about Aryl aldehydes Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 4064-06-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C12H20O6, HPLC of Formula: 4064-06-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Malaguarnera, Lucia published the artcile< Influence of resveratrol on the immune response>, Synthetic Route of 501-36-0, the main research area is review resveratrol immune response; B lymphocytes; T lymphocytes; immune response; macrophages; natural killer; resveratrol.

A review. Resveratrol is the most well-known polyphenolic stilbenoid, present in grapes, mulberries, peanuts, rhubarb, and in several other plants. Resveratrol can play a beneficial role in the prevention and in the progression of chronic diseases related to inflammation such as diabetes, obesity, cardiovascular diseases, neurodegeneration, and cancers among other conditions. Moreover, resveratrol regulates immunity by interfering with immune cell regulation, proinflammatory cytokines’ synthesis, and gene expression. At the mol. level, it targets sirtuin, adenosine monophosphate kinase, nuclear factor- κB, inflammatory cytokines, anti-oxidant enzymes along with cellular processes such as gluconeogenesis, lipid metabolism, mitochondrial biogenesis, angiogenesis, and apoptosis. Resveratrol can suppress the toll-like receptor (TLR) and pro-inflammatory genes’ expression. The antioxidant activity of resveratrol and the ability to inhibit enzymes involved in the production of eicosanoids contribute to its anti-inflammation properties. The effects of this biol. active compound on the immune system are associated with widespread health benefits for different autoimmune and chronic inflammatory diseases. This review offers a systematic understanding of how resveratrol targets multiple inflammatory components and exerts immune-regulatory effects on immune cells.

Nutrients published new progress about B cell. 501-36-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C14H12O3, Synthetic Route of 501-36-0.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Seki, Tomohiro; Mashimo, Takaki; Ito, Hajime published the artcile< Anisotropic strain release in a thermosalient crystal: correlation between the microscopic orientation of molecular rearrangements and the macroscopic mechanical motion>, COA of Formula: C19H16O, the main research area is anisotropic strain thermosalient crystal structure microscopic orientation.

The salient effect, which refers to a jumping phenomenon of org and organometallic mol. crystals typically triggered by phase transitions in response to external stimuli, has been investigated intensively in the last five years. A challenging topic in this research area is the question of how to characterize the release of microscopic strain accumulated during phase transitions, which generates macroscopic mech. motion. Herein, we describe the thermosalient effect of the triphenylethenyl gold 4-chlorophenyl isocyanide complex 1, which jumps reversibly at approx -100°C upon cooling at 50°C min-1 and heating at 30°C min-1. Single-crystal X-ray diffraction measurements and differential scanning calorimetric analyses of 1 suggest the occurrence of a thermal phase transition at this temperature Detailed structural analyses indicate that anisotropic changes to the mol arrangement occur in 1, whereby the crystallog a axis contracts upon cooling while the b axis expands. Simultaneously, macroscopic changes of the crystal dimensions occur. This is observed as bending, i.e., as an inclination of the crystal edges, and in the form of splitting, which occurs in a perpendicular direction to the major crystal axis. This study thus bridges the gap between macroscopic mech responses that are observed in high-speed photog images and microscopic changes of the crystal structure, which are evaluated by X-ray diffraction measurements with face indexing.

Chemical Science published new progress about Bending. 76-84-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C19H16O, COA of Formula: C19H16O.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Zhang, Shanshan; Wang, Zheng; Cao, Qianrong; Yue, Erlin; Liu, Qingbin; Ma, Yanping; Liang, Tongling; Sun, Wen-Hua published the artcile< Aza-crown compounds synthesised by the self-condensation of 2-amino-benzyl alcohol over a pincer ruthenium catalyst and applied in the transfer hydrogenation of ketones>, HPLC of Formula: 403-41-8, the main research area is aminobenzyl alc pincer ruthenium catalyst self condensation; aza crown compound preparation; alkyl aryl ketone transfer hydrogenation iron catalyst; aralkyl alc preparation.

A well-defined PNN-Ru catalyst was revisited to self-condense 2-aminobenzyl alc. formed a series of novel aza-crown compounds All aza-crown compounds were separated and determined by NMR, IR, and ESI-MS spectroscopy as well as X-ray crystallog., indicated the saddle structure of aza-12-crown-3 and the twisted 1,3-alternate conformation structure of aza-20-crown-5. These aza-crown compounds was explored to study ferric initiation of transfer hydrogenation (TH) of ketones into their corresponding secondary alcs. in the presence of 2-propanol with a basic t-BuOK solution, achieving a high conversion (up to 95%) by a ferric complex with aza-16-crown-4 in a low loading (0.05 mol%).

Dalton Transactions published new progress about Alkyl aryl ketones Role: RCT (Reactant), RACT (Reactant or Reagent). 403-41-8 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H9FO, HPLC of Formula: 403-41-8.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Wang, Haijing; Feng, Zhuolei; Han, Xue; Xing, Yue; Zhang, Xiaomei published the artcile< Downregulation of acylglycerol kinase suppresses high-glucose-induced endothelial-mesenchymal transition in human retinal microvascular endothelial cells through regulating the LPAR1/TGF-β/Notch signaling pathway>, Recommanded Product: (2S,3R,4S,5S,6R)-6-(Hydroxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetraol, the main research area is acylglycerolkinase glucose endothelialmesenchymal retinal microvascular endothelialcell LPAR1 TGFb Notch; acide lysophosphatidique; acylglycerol kinase; acylglycérol kinase; cellule endothéliale des microvaisseaux rétiniens; endothelial-mesenchymal transition; high glucose; hyperglycémie; lysophosphatidic acid; retinal microvascular endothelial cell; transition de l’endothélium au mésenchyme.

The endothelial-mesenchymal transition (EndMT) participates in the progression of diabetic retinopathy (DR), but cell-intrinsic factors modulating this process remain elusive. In this study, we explored the role of lysophosphatidic acid (LPA) – producing enzyme, acylglycerol kinase (AGK), in the EndMT of human retinal microvascular endothelial cells (HRECs) under high-glucose (HG) conditions. We found that AGK was significantly elevated in HG-treated cells. In addition, AGK knockdown reversed the HG-induced EndMT in HRECs, which was evidenced by the increased endothelial markers (CD31 and VE-cadherin) and decreased mesenchymal markers (FSP1 and β-SMA). Furthermore, downregulation of AGK inhibited the HG-induced activation of transforming growth factor β (TGF-β)/Notch pathways, whereas exogenous TGF-β1 (10 ng/mL) impeded the inhibitory effects of AGK knockdown on HG-induced EndMT in HRECs. Addnl., the silencing of AGK abolished the HG-induced upregulation of LPA and its receptor, LPA receptor 1 (LPAR1), and overexpression of LPAR1 further rescued the AGK knockdown-mediated inhibition of the EndMT process. In conclusion, we demonstrate that downregulation of AGK suppresses HG-induced EndMT in HRECs through regulating the LPAR1/TGF-β/Notch signaling pathway, indicating that AGK might be a potential therapeutic target for the treatment of DR.

Canadian Journal of Physiology and Pharmacology published new progress about Adhesion G protein-coupled receptor E2 Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 492-62-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H12O6, Recommanded Product: (2S,3R,4S,5S,6R)-6-(Hydroxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetraol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Monticelli, Serena; Urban, Ernst; Langer, Thierry; Holzer, Wolfgang; Pace, Vittorio published the artcile< A Straightforward Homologation of Carbon Dioxide with Magnesium Carbenoids en Route to α-Halocarboxylic Acids>, Reference of 699-12-7, the main research area is halo carboxylic acid preparation green chem diastereoselective chemoselective; magnesium carbenoid chloro sulfoxide carbon dioxide nucleophilic addition; dihalo carboxylic acid preparation green chem chemoselective; dihalomethane magnesium carbenoid carbon dioxide nucleophilic addition.

The homologation of carbon dioxide with stable, (enantiopure) magnesium carbenoids constitutes a valuable method for preparing α-halo acid derivatives RR1C(COOH)Cl (R = H, Et, 2,6-dimethylbenzyl, thiophen-2-ylmethyl, etc.; RR1 = -(CH2)2-; X = Cl, Br, I), 2-chloroacrylic acid and α, α-dihalo carboxylic acids XCH(Y)COOH (X = Cl, Br, I; Y = Cl, Br, I). The tactic features a high level of chemocontrol, thus enabling the synthesis of variously functionalized analogs. such as 1-chloro-2-(methoxycarbonyl)-2-methylcyclopropanecarboxylic acid and 1-chloro-2-methyl-1,2-cyclopropanedicarboxylic acid. The flexibility to generate magnesium carbenoids through sulfoxide-, halogen- or proton- Mg exchange accounts for the wide scope of the reaction.

Advanced Synthesis & Catalysis published new progress about Chemoselectivity. 699-12-7 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H10OS, Reference of 699-12-7.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Ayyash, Mutamed; Abu-Jdayil, Basim; Itsaranuwat, Pariyaporn; Galiwango, Emmanuel; Tamiello-Rosa, Camila; Abdullah, Hassan; Esposito, Gennaro; Hunashal, Yamanappa; Obaid, Reyad S.; Hamed, Fathalla published the artcile< Characterization, bioactivities, and rheological properties of exopolysaccharide produced by novel probiotic Lactobacillus plantarum C70 isolated from camel milk>, Recommanded Product: (2S,3S,4R,5R)-2,3,4,5,6-Pentahydroxyhexanal, the main research area is exopolysaccharide probiotic Lactobacillus plantarum camel milk characterization rheol property; Anticancer; Antidiabetic; Exopolysaccharides; L. plantarum; Rheological properties.

Various industries highly regard the functionalities and bioactivities of bacterial polysaccharides. We aimed to characterize the exopolysaccharide (EPS) produced by novel probiotic Lactobacillus plantarum C70 (accession number KX881779) isolated from camel milk and to investigate its bioactivities and rheol. properties. EPS-C70 had a weight-average mol. weight (Mw) of 3.8 × 105 Da. Arabinose (13.3%), mannose (7.1%), glucose (74.6%), and galactose (5.0%) were the major monosaccharides constituents. EPS-C70 had two endothermic peaks at 76.95°C and 158.76°C corresponding to glass transition (Tg) and m.p. (Tm), resp. Zeta potential and particle size of EPS-C70 were -330.71 mV and 525.5 nm, resp. DPPH and ABTS of EPS-C70 were 75.91% and 49.42% at 10 mg/mL concentration, resp. The cytotoxic activities against colon cancer and breast cancer lines were 88.1% and 73.1% at concentration 10 mg/mL, resp. EPS-C70 exhibited shear-thinning behavior. Salts and pH values had a significant impact on the rheol. properties of EPS-C70.

International Journal of Biological Macromolecules published new progress about Antidiabetic agents. 3458-28-4 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H12O6, Recommanded Product: (2S,3S,4R,5R)-2,3,4,5,6-Pentahydroxyhexanal.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Wu, Kegang; Lin, Yahui; Chai, Xianghua; Duan, Xuejuan; Zhao, Xinxin; Chun, Chen published the artcile< Mechanisms of vapor-phase antibacterial action of essential oil from Cinnamomum camphora var. linaloofera Fujita against Escherichia coli>, Reference of 78-70-6, the main research area is Cinnamomum camphora essential oil vapor phase antibacterial agent Escherichia; antibacterial mechanism; essential oil; linaloofera fujita; vapor‐phase antimicrobial activity.

The purpose of this study was to investigate antibacterial activity of essential oil from Cinnamomum camphora var. linaloofera Fujita (EOL) at vapor phase and its mechanism of bactericidal action against Escherichia coli. Results showed that the vapor-phase EOL had significant antibacterial activity with a min. inhibitory concentration (MIC) and min. bactericidal concentration (MBC) of 200μl/L. Further analyses showed that treatment of E. coli with vapor-phase EOL resulted in partial degradation of cell membrane, increased membrane permeability, leakage of cytoplasm materials, and prominent distortion and shrinkage of bacterial cells. FTIR showed that EOL altered bacterial protein secondary and tertiary structures. GC/MS anal. showed that the components of vapor-phase EOL included linalool (69.94%), camphor (10.90%), nerolidol (10.92%), and safrole (8.24%), of which linalool had bactericidal activity. Quantum chem. anal. suggested that the antibacterial reactive center of linalool was oxygen atom (O10) which transferred electrons during antibacterial action by the donation of electrons.

Food Science & Nutrition (Hoboken, NJ, United States) published new progress about Antibacterial agents. 78-70-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C10H18O, Reference of 78-70-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Vezina, Ben; Judd, Louise M.; McDougall, Fiona K.; Boardman, Wayne S. J.; Power, Michelle L.; Hawkey, Jane; Brisse, Sylvain; Monk, Jonathan M.; Holt, Kathryn E.; Wyres, Kelly L. published the artcile< Transmission of Klebsiella strains and plasmids within and between grey-headed flying fox colonies>, Related Products of 87-73-0, the main research area is plasmid transmission Klebsiella Pteropus.

The gray-headed flying fox (Pteropus poliocephalus) is an endemic Australian fruit bat, known to carry zoonotic pathogens. We recently showed they harbor bacterial pathogen Klebsiella pneumoniae and closely related species in the K. pneumoniae species complex (KpSC); however, the dynamics of KpSC transmission and gene flow within flying fox colonies are poorly understood. High-resolution genome comparisons of 39 KpSC isolates from gray-headed flying foxes identified five putative strain transmission clusters (four intra- and one inter-colony). The instance of inter-colony strain transmission of K. africana was found between two flying fox populations within flying distance, indicating either direct or indirect transmission through a common food/water source. All 11 plasmids identified within the KpSC isolates showed 73% coverage (mean) and ≥95% identity to human-associated KpSC plasmids, indicating gene flow between human clin. and gray-headed flying fox isolates. Along with strain transmission, inter-species horizontal plasmid transmission between K. pneumoniae and Klebsiella africana was also identified within a flying fox colony. Finally, genome-scale metabolic models were generated to predict and compare substrate usage to previously published KpSC models, from human and environmental sources. These models indicated no distinction on the basis of metabolic capabilities. Instead, metabolic capabilities were consistent with population structure and ST/lineage.

Environmental Microbiology published new progress about Food. 87-73-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H10O8, Related Products of 87-73-0.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts