Month: October 2022

In 2011,Krishna Reddy, V. V. R. M.; Udaykiran, D.; Chintamani, U. S.; Mahesh Reddy, E.; Kameswararao, Ch.; Madhusudhan, G. published 《Development of an optimized process for the preparation of 1-Benzylazetidin-3-ol: an industrially important intermediate for substituted azetidine》.Organic Process Research & Development published the findings.Name: Azetidin-3-ol hydrochloride The information in the text is summarized as follows:

A thoroughly optimized and robust process for the synthesis of 1-benzylazetidin-3-ol has been emphasized. 1-Benzylazetidin-3-ol I, has been utilized as a starting material in the com. synthesis of azetidin-3-ol hydrochloride. Synthesis of azetidin-3-ol hydrochloride involves the usage of very low cost and com. available starting material (benzylamine) and with reduced formation of di(3-chloro-2-hydroxypropyl) benzylamine significantly resulting in an economical process that allows the effective production of 1-benzyl azetidin-3-ol as well as azetidin-3-ol hydrochloride. In the experiment, the researchers used Azetidin-3-ol hydrochloride(cas: 18621-18-6Name: Azetidin-3-ol hydrochloride)

Azetidin-3-ol hydrochloride(cas:18621-18-6) is one of azetidine.Azetidines (azacyclobutanes) constitute a well-known class of heterocyclic compounds. Azetidine scaffold has been discovered in several natural products.Name: Azetidin-3-ol hydrochloride Several pharmacologically important synthetic compounds also contain azetidine ring. Because of inherent ring strain, the synthesis of azetidines is a challenging endeavor.

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In 2017,Jagadeesh, Rajenahally V.; Murugesan, Kathiravan; Alshammari, Ahmad S.; Neumann, Helfried; Pohl, Marga-Martina; Radnik, Joerg; Beller, Matthias published 《MOF-derived cobalt nanoparticles catalyze a general synthesis of amines》.Science (Washington, DC, United States) published the findings.Application In Synthesis of trans-4-Aminocyclohexanol The information in the text is summarized as follows:

The development of base metal catalysts for the synthesis of pharmaceutically relevant compounds remains an important goal of chem. research. Here, we report that cobalt nanoparticles encapsulated by a graphitic shell are broadly effective reductive amination catalysts. Their convenient and practical preparation entailed template assembly of cobalt-diamine-dicarboxylic acid metal organic frameworks on carbon and subsequent pyrolysis under inert atm. The resulting stable and reusable catalysts were active for synthesis of primary, secondary, tertiary, and N-methylamines (more than 140 examples). The reaction couples easily accessible carbonyl compounds (aldehydes and ketones) with ammonia, amines, or nitro compounds, and mol. hydrogen under industrially viable and scalable conditions, offering cost-effective access to numerous amines, amino acid derivatives, and more complex drug targets. The experimental part of the paper was very detailed, including the reaction process of trans-4-Aminocyclohexanol(cas: 27489-62-9Application In Synthesis of trans-4-Aminocyclohexanol)

trans-4-Aminocyclohexanol(cas: 27489-62-9) belongs to anime. Examples of direct uses of amines and their salts are as corrosion inhibitors in boilers and in lubricating oils (morpholine), as antioxidants for rubber and roofing asphalt (diarylamines), as stabilizers for cellulose nitrate explosives (diphenylamine), as protectants against damage from gamma radiation (diarylamines), as developers in photography (aromatic diamines), as flotation agents in mining, as anticling and waterproofing agents for textiles, as fabric softeners, in paper coating, and for solubilizing herbicides.Application In Synthesis of trans-4-Aminocyclohexanol

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《Synthesis and characterization of Cu-N, N’-Dicyclohexylcarbodiimide supported on CMK-3 as a novel, efficient and recoverable nanocatalyst for synthesis of tetrazole, polyhydroquinoline, and sulfoxide derivatives》 was published in Reaction Kinetics, Mechanisms and Catalysis in 2020. These research results belong to Ghafouri-Nejad, Raziyeh; Hajjami, Maryam. SDS of cas: 100-83-4 The article mentions the following:

Mesoporous carbon CMK-3 was prepared using SBA-15 silica mesoporous as a hard template. Then, Cu-N, N’-Dicyclohexylcarbodiimide was supported on CMK-3 as a reusable and highly efficient nanocatalyst for the synthesis of tetrazole, polyhydroquinoline, and sulfoxide derivatives This new catalyst was characterized by FT-IR spectroscopy, XRD, SEM, BET, TGA, EDX, and ICP-OES techniques. After completing reactions, the catalyst was easily separated from the reaction mixture using centrifuge and reusable five times without significant loss of their catalytic efficiency.3-Hydroxybenzaldehyde(cas: 100-83-4SDS of cas: 100-83-4) was used in this study.

3-Hydroxybenzaldehyde(cas: 100-83-4) can be used as a reactant along with ethyl acetoacetate and thiourea in the synthesis of corresponding dihydropyrimidine-2-thione (monastrol), using Yb(OTf)3 as a catalyst by Biginelli cyclocondensation reaction.SDS of cas: 100-83-4

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《Phoenix dactylifera fruit extract ameliorates altered biochemical parameters in streptozotocin-induced diabetes mellitus albino rats》 was written by Ogo, A. O.; Abah, S. F.; Inalegwu, B.; Eru, U. E.. Safety of 2-Aminopropane-1,3-diol And the article was included in International Journal of Current Pharmaceutical Research in 2020. The article conveys some information:

Objective: Consistent projections have indicated a steady increase in the global burden of diabetes mellitus. Given the increased cost in conventional management of the condition in addition to reported side effects and cost of orthodox management, attention is shifting to the use of alternative methods such as plants materials with dual benefits as food and medicine. Thus, this study was designed to investigate the effect of date palm fruit on some biochem. parameters in streptozotocin-induced wistar rats. Methods: Animals were divided into 5 groups of 6 rats each (I as normal control, II as diabetic control and 3-5 as extract-treated groups) maintained for 14 d. At the end of the treatment, the animals were fasted overnight, then sacrificed and blood samples collected for anal. of biochem. parameters (including blood glucose, blood lipids and enzymes). Results: The results show that treatment of diabetic animals with extract of date palm fruit show a significant (P<0.05) reduction in glucose levels in groups II-V compared to group I. Similar pos. effects were observed in the levels of lipids and enzymes in treated groups compared to diabetic control group II. A GC-MS anal. of the fraction of the fruit extract revealed some bioactive compounds that may be responsible for the effects exhibited in the study. Conclusion: These findings which demonstrate the ameliorative effect on hyperglycemia and hyperlipidemia, further support the use of date palm fruit as a nutraceutical agent. The experimental part of the paper was very detailed, including the reaction process of 2-Aminopropane-1,3-diol(cas: 534-03-2Safety of 2-Aminopropane-1,3-diol)

2-Aminopropane-1,3-diol(cas: 534-03-2) belongs to anime. Nitrous acid converts secondary amines (aliphatic or aromatic) to N-nitroso compounds (nitrosamines): R2NH + HNO2 → R2N―NO. Some nitrosamines are potent cancer-inducing substances, and their possible formation is a serious consideration when nitrites, which are salts of nitrous acid, are present in foods or pharmaceutical preparations. Tertiary amines give rise to nitrosamines more slowly; an alkyl group is eliminated as an aldehyde or ketone, along with nitrous oxide, N2O.Safety of 2-Aminopropane-1,3-diol

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《Enantioselective [3+2] annulation of isatin-derived MBH-carbonates and 3-nitroindoles enabled by a bifunctional DMAP-thiourea》 was written by Mei, Ming-Shun; Wang, Yu-Hui; Hu, Qing; Li, Qing-Hua; Shi, Da-Yu; Gao, Dingding; Ge, Guangbo; Lin, Guo-Qiang; Tian, Ping. Category: alcohols-buliding-blocks And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2020. The article conveys some information:

A highly enantioselective [3+2] annulation of isatin-derived Morita-Baylis-Hillman (MBH) carbonates I (R = Me, Bn, prop-2-en-1-yl, (tert-butoxy)carbonyl; R1 = methoxycarbonyl, ethoxycarbonyl, cyano; R2 = H, Me, Cl, F, etc; R3 = H, Br; R4 = H, Me, F, Br) and 3-nitroindoles II (R5 = (4-tert-butylphenyl)carbonyl, Bz, Ts, (naphthalen-1-yl)carbonyl, etc; X = CH, N) was enabled by a chiral DMAP-thiourea bifunctional catalyst III, affording the corresponding polycyclic spirooxindoles IV bearing three consecutive stereocenters with good to excellent yields and enantioselectivities. Transformations of the annulation product were subsequently elaborated and the preliminary biol. assays demonstrated that these artificial spirooxindoles potentially inhibited pancreatic lipase in a dose-dependent manner. In the experimental materials used by the author, we found Oxetan-3-ol(cas: 7748-36-9Category: alcohols-buliding-blocks)

Oxetan-3-ol(cas: 7748-36-9) is used as a reagent in the synthesis of 5-fluoro-4,6-dialkoxypyrimidine GPR119 agonists. It is also used as a reagent in the synthesis of cyclic sulfone hydroxyethylamines as potent and selective β-site APP-cleaving enzyme 1 (BACE1) inhibitors.Category: alcohols-buliding-blocks

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Wei, Yupeng; Zhu, Junzhi; Xie, Yan; Zhao, Feiyun; Jiang, Jianzhuang; Jiang, Tiantian; Li, Linqi; Hu, Yang; Zhang, Junwei; Peng, Yong published their research in Journal of Materials Science: Materials in Electronics in 2021. The article was titled 《Achieving C/CuO microfiber composites with efficient microwave absorbing performance at low thickness》.Electric Literature of C4H12KNaO10 The article contains the following contents:

The carbon fibers with low d. still face significant microwave absorbing application issues due to their high dielec. constant Herein, C/Cu core-shell microfiber composites are prepared by electroless plating. The Cu coating of C/Cu core-shell microfiber composites is oxidized to CuO at 300°C and 400°C temperature The morphol., microstructure, and electromagnetic characteristics of C/CuO microfiber composites were analyzed. The diameter of all the fiber composites was about 7-8μm. The CuO coating thickness formed at 300°C and 400°C temperature is 30-90 nm and 300-900 nm, resp. The annealing process tunes the electromagnetic characteristics and optimizes impedance matching. The min. reflection loss (RL) value of C/CuO core-shell microfiber composites annealed at 300°C temperature remarkably reaches – 46.0 dB at 1.06 mm thickness and 3.6 GHz effective absorption bandwidth (RL ≤ – 10 dB). The C/CuO microfiber composites can be the ideal absorbing materials at a lower thickness. The results came from multiple reactions, including the reaction of Potassium sodium (2R,3R)-2,3-dihydroxysuccinate tetrahydrate(cas: 6381-59-5Electric Literature of C4H12KNaO10)

Potassium sodium (2R,3R)-2,3-dihydroxysuccinate tetrahydrate(cas: 6381-59-5) is a ferroelectric crystal with a high piezoelectric effect and electromechanical coupling coefficient. Electric Literature of C4H12KNaO10 It is utilized to break up emulsion in organic synthesis as well as a common precipitant in protein crystallography.

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In 2022,Wang, Chenfei; Huang, Xiaobei; Sun, Litao; Li, Qiuxia; Li, Zhili; Yong, Haiyang; Che, Delu; Yan, Cong; Geng, Songmei; Wang, Wenxin; Zhou, Dezhong published an article in Chemical Communications (Cambridge, United Kingdom). The title of the article was 《Cyclic poly(β-amino ester)s with enhanced gene transfection activity synthesized through intra-molecular cyclization》.COA of Formula: C4H11NO The author mentioned the following in the article:

Topol. structure plays a critical role in gene delivery of cationic polymers. Cyclic poly(β-amino ester)s (CPAEs) are successfully synthesized via sequential Michael addition and free radical initiating ring-closure reaction. The CPAEs exhibit superior gene transfection efficiency and safety profile compared to their linear counterparts. In the part of experimental materials, we found many familiar compounds, such as 4-Aminobutan-1-ol(cas: 13325-10-5COA of Formula: C4H11NO)

4-Aminobutan-1-ol(cas: 13325-10-5) is used in the synthesis of NSAIDs with anti-inflammatory properties. Also used in the synthesis of polyamine transport ligands with specificity against human cancers allowing easy access to specific cancer cells.COA of Formula: C4H11NO

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Recommanded Product: Bis[(pinacolato)boryl]methaneIn 2017 ,《Base-promoted, deborylative secondary alkylation of N-heteroaromatic N-oxides with internal gem-bis[(pinacolato)boryl]alkanes: a facile derivatization of 2,2′-bipyridyl analogues》 appeared in Chemical Communications (Cambridge, United Kingdom). The author of the article were Hwang, Chiwon; Jo, Woohyun; Cho, Seung Hwan. The article conveys some information:

A base-promoted, secondary alkylation of N-heteroaromatic N-oxides, e.g., I using internal gem-bis[(pinacolato)boryl]alkanes R1R2C(Bpin)2 [R1 = H, CH3, (CH2)5CH3; R2 = CH3, CH2C6H5, CH2HC=CH2, etc.] as alkylation reagents is reported. The reaction exhibits a broad scope, providing deoxygenated secondary alkylated N-heteroaromatic compounds, e.g., II with high efficiency. The usefulness of the developed protocol is evidenced by the sequential direct alkylation of 2,2′-bipyridine-N-oxide. In the experimental materials used by the author, we found Bis[(pinacolato)boryl]methane(cas: 78782-17-9Recommanded Product: Bis[(pinacolato)boryl]methane)

Bis[(pinacolato)boryl]methane(cas: 78782-17-9) belongs to organoboron compounds. Organoboron compounds have been a cornerstone of synthetic transformations for decades. Areas such as boron-containing catalysts, metalate chemistry, photoredox methods, and boryl anions have brought significant new developments in understanding and provided new reactivity upon.Recommanded Product: Bis[(pinacolato)boryl]methane

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Related Products of 126456-43-7In 2020 ,《Pyridine- and Quinoline-Based Gold(III) Complexes: Synthesis, Characterization, and Application》 appeared in European Journal of Organic Chemistry. The author of the article were Reiersolmoen, Ann Christin; Fiksdahl, Anne. The article conveys some information:

Studies on gold(III) coordination of a series of prepared polydentate pyridine and quinoline based ligands are reported. Characterization (1H, 13C, 15N NMR, and XRD) of the novel gold(III) complexes, prepared in 31-98% yield, revealed different coordination ability of the pyridine and quinoline nitrogen atoms. Testing of catalytic activity in cyclopropanation of propargyl ester and styrene demonstrated that all the new ligated gold(III) complexes were catalytically active and outperformed KAuCl4. The superior activity of the particular Au(III)-pyridine-oxazole complexes may indicate de-coordination of the pyridine-N ligand as a crucial step for efficient generation of catalytic activity. In the experimental materials used by the author, we found (1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol(cas: 126456-43-7Related Products of 126456-43-7)

(1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol(cas: 126456-43-7) belongs to anime. In organic chemistry, amines are compounds and functional groups that contain a basic nitrogen atom with a lone pair. Amines are formally derivatives of ammonia (NH3), wherein one or more hydrogen atoms have been replaced by a substituent such as an alkyl or aryl group (these may respectively be called alkylamines and arylamines; amines in which both types of substituent are attached to one nitrogen atom may be called alkylarylamines).Related Products of 126456-43-7

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Computed Properties of C3H7BrOIn 2019 ,《Single Chain Cationic Polymer Dot as a Fluorescent Probe for Cell Imaging and Selective Determination of Hepatocellular Carcinoma Cells》 was published in Analytical Chemistry (Washington, DC, United States). The article was written by Ozenler, Sezer; Yucel, Muge; Tuncel, Ozge; Kaya, Hakan; Ozcelik, Serdar; Yildiz, Umit Hakan. The article contains the following contents:

This letter describes formation of single chain cationic polymer dots (Pdots) made of poly[1,4-dimethyl-1-(3-((2,4,5-trimethylthiophen-3-yl)oxy)propyl)piperazin-1-ium bromide] conjugated polyelectrolyte (CPE). The single chain Pdot formation relies on a simple process which is a rapid nanophase separation between CPE solution of ethylene glycol and water. Pdots show narrow monodisperse size distribution with a 3.6 nm in diameter exhibiting high brightness and excellent colloidal and optical stability. It has been demonstrated that photoluminescent Pdots provide selective nuclear translocation to hepatocellular carcinoma cells as compared to healthy liver cells. The Pdot labeling effectively discriminates cancer cells in the coculture media. Pdots hold great promise as a luminescent probe to diagnose cancer cells in histol. and may guide surgeons during operations to precisely sep. out cancerous tissue due to augmented fluorescence brightness. In the experiment, the researchers used many compounds, for example, 3-Bromopropan-1-ol(cas: 627-18-9Computed Properties of C3H7BrO)

3-Bromopropan-1-ol(cas: 627-18-9) is used in the synthesis of fluorescent halide-sensitive quinolinium dyes, chiral, quaternary prolines through cyclization of quaternary amino acids and molten salt-polymers. It is utilized for the study of micellar media and in microemulsions based on cationic or a nonionic surfactant by reacting with phenols.Computed Properties of C3H7BrO

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