Month: October 2022

In 2018,Sao, Soumik; Naskar, Sumit; Mukhopadhyay, Narottam; Das, Mousumi; Chaudhuri, Debangshu published 《Assisted π-stacking: a strong synergy between weak interactions》.Chemical Communications (Cambridge, United Kingdom) published the findings.Related Products of 1195-59-1 The information in the text is summarized as follows:

Synergy between a pair of weak non-covalent interactions can predispose a mol. self-assembly towards a specific pathway. We report assisted π-stacking, a synergy between aromatic π-stacking and n → π* interactions that exhibits an unprecedented strength and thermal stability. Natural bond orbital anal. reveals the non-additive nature of the interaction.2,6-Pyridinedimethanol(cas: 1195-59-1Related Products of 1195-59-1) was used in this study.

2,6-Pyridinedimethanol(cas: 1195-59-1) belongs to pyridine. Pyridines form stable salts with strong acids. Pyridine itself is often used to neutralize acid formed in a reaction and as a basic solvent. Related Products of 1195-59-1

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

In 2019,Transition Metal Chemistry (Dordrecht, Netherlands) included an article by Qin, Yutian; Wang, Bowei; Li, Jiayi; Wu, Xingchun; Chen, Ligong. Quality Control of 2,6-Pyridinedimethanol. The article was titled 《Cobalt imine-pyridine-carbonyl complex functionalized metal-organic frameworks as catalysts for alkene epoxidation》. The information in the text is summarized as follows:

Aerobic epoxidation of alkene is a green and economical route to produce epoxides. For such reaction, transition metal complexes exhibit favorable catalytic activity. In this work, NH2-MIL-101, a stable metal-organic framework (MOF) material with large surface area and high pore volume, was functionalized with pyridine-2,6-dicarbaldehyde and Co(NO3)2, to realize the immobilization of Co(II) via imine-pyridine-carbonyl (N,N,O) tridentate ligands bonding to MOF skeleton. The modified materials were applied as heterogeneous catalysts for the aerobic epoxidation of cyclohexene at ambient temperature, and multiple factors were studied to explore their influences on catalytic effects. Under the optimal reaction conditions, satisfactory substrate conversion and epoxide selectivity were reached. In addition, this catalytic system is suitable for a variety of alkene substrates. Furthermore, recycle experiments and IR spectroscopy characterization illustrated that the coordination surroundings of Co are altering smoothly during the reaction process, thus having an impact on the performance of catalyst. In the part of experimental materials, we found many familiar compounds, such as 2,6-Pyridinedimethanol(cas: 1195-59-1Quality Control of 2,6-Pyridinedimethanol)

2,6-Pyridinedimethanol(cas: 1195-59-1) belongs to pyridine. Pyridines are often used as catalysts or reagents; particular notice has been paid recently to how pyridine coordinates to metal centers enabling a wide range of valuable reactions. Quality Control of 2,6-Pyridinedimethanol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

In 2019,International Journal of Biological Macromolecules included an article by Valiey, Ehsan; Dekamin, Mohammad G.; Alirezvani, Zahra. Name: 3-Hydroxybenzaldehyde. The article was titled 《Melamine-modified chitosan materials: An efficient and recyclable bifunctional organocatalyst for green synthesis of densely functionalized bioactive dihydropyrano[2,3-c]pyrazole and benzylpyrazolyl coumarin derivatives》. The information in the text is summarized as follows:

An environmentally benign protocol for diversity-oriented synthesis of functionalized bioactive dihydropyrano[2,3-c]pyrazole and benzylpyrazolyl coumarin derivatives has been investigated by the reaction of aryl aldehydes, Et acetoacetate, hydrazine derivatives, malononitrile and 4-hydroxycoumarin in the presence of melamine-modified chitosan (Cs-Pr-Me) materials as a reusable bifunctional organocatalyst. The Cs-Pr-Me materials were properly characterized by the Fourier transform IR (FTIR) spectroscopy, CHN elemental anal., thermal gravimetric (TGA) and derivative thermogravimetric (DTG) anal., field emission SEM (FESEM) and energy-dispersive X-ray (EDX) spectroscopy. The remarkable advantages of this green protocol are high to quant. yields of the desired products, short reaction times, wide scope, simple work-up procedure and low loading of a transition metal-free catalyst. An addnl. advantage of this bio-based organocatalyst is the ability to sep. and recycle it easily from the reaction mixture with minimal effort in subsequent runs without significant loss of its catalytic activity. In the experiment, the researchers used many compounds, for example, 3-Hydroxybenzaldehyde(cas: 100-83-4Name: 3-Hydroxybenzaldehyde)

3-Hydroxybenzaldehyde(cas: 100-83-4) can be used as a reactant along with ethyl acetoacetate and thiourea in the synthesis of corresponding dihydropyrimidine-2-thione (monastrol), using Yb(OTf)3 as a catalyst by Biginelli cyclocondensation reaction.Name: 3-Hydroxybenzaldehyde

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

The author of 《A colorimetric and fluorescent lighting-up sensor based on ICT coupled with PET for rapid, specific and sensitive detection of nitrite in food》 were Wu, Juanjuan; Jiang, Lirong; Verwilst, Peter; An, Jusung; Zeng, Hongyan; Zeng, Lintao; Niu, Guangle; Kim, Jong Seung. And the article was published in Chemical Communications (Cambridge, United Kingdom) in 2019. Recommanded Product: 3-Aminopropan-1-ol The author mentioned the following in the article:

An anthracene carboxyimide derivative was synthesized as a colorimetric and fluorogenic sensor to determine NO2- with a rapid response (<4 min), excellent selectivity and a low detection limit (84 nM). Paper strips containing the sensor were applied to visually determine the NO2- content in food. The results came from multiple reactions, including the reaction of 3-Aminopropan-1-ol(cas: 156-87-6Recommanded Product: 3-Aminopropan-1-ol)

3-Aminopropan-1-ol(cas: 156-87-6) belongs to anime. Milder oxidation, using reagents such as NaOCl, can remove four hydrogen atoms from primary amines of the type RCH2NH2 to form nitriles (R―C≡N), and oxidation with reagents such as MnO2 can remove two hydrogen atoms from secondary amines (R2CH―NHR′) to form imines (R2C=NR′). Tertiary amines can be oxidized to enamines (R2C=CHNR2) by a variety of reagents.Recommanded Product: 3-Aminopropan-1-ol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

The author of 《Synthesis and identification of 1,3-oxazepine derivatives by reaction of Schiff bases with anhydride derivative of cycloheptatriene》 were Mohammad, Ham J.; Alsamarrai, Abdulmajeed S. H.; Mahmood, Rabeah T.. And the article was published in Journal of Pharmaceutical Sciences and Research in 2019. Recommanded Product: 3-Hydroxybenzaldehyde The author mentioned the following in the article:

In this work, 1,3-oxazepine derivatives I [R = H, OH, Cl, Br; R’ = H] and I [R = H, R’ = OH; R = OH, R’ = OMe] were synthesized from reaction of Schiff bases with anhydride derivative of cycloheptatriene. Schiff bases C6H5N=C(4-R,3-R’C6H3) were prepared by the reaction of aniline with benzaldehydes at room temperature Anhydride derivative of cycloheptatriene also prepared from reaction of maleic anhydride with cycloheptatriene without using any solvent. In the part of experimental materials, we found many familiar compounds, such as 3-Hydroxybenzaldehyde(cas: 100-83-4Recommanded Product: 3-Hydroxybenzaldehyde)

3-Hydroxybenzaldehyde(cas: 100-83-4) is used as an ionophore, during the development of an highly selective and sensitive PVC membrane sensor, which can be used as a Tb3+ ion selective electrode.Recommanded Product: 3-Hydroxybenzaldehyde

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

《Microbial production of 4-amino-1-butanol, a four-carbon amino alcohol》 was written by Prabowo, Cindy Pricilia Surya; Shin, Jae Ho; Cho, Jae Sung; Chae, Tong Un; Lee, Sang Yup. Formula: C4H11NO And the article was included in Biotechnology and Bioengineering in 2020. The article conveys some information:

4-Amino-1-butanol (4AB) serves as an important intermediate compound for drugs and a precursor of biodegradable polymers used for gene delivery. Here, we report for the first time the fermentative production of 4AB from glucose by metabolically engineered Corynebacterium glutamicum harboring a newly designed pathway comprising a putrescine (PUT) aminotransferase(encoded by ygjG) and an aldehyde dehydrogenase (encoded by yqhD) from Escherichia coli, which convert PUT to 4AB. Application of several metabolic engineering strategies such as fine-tuning the expression levels of ygjG and yqhD, eliminating competing pathways, and optimizing culture condition further improved 4AB production Fed-batch culture of the final metabolically engineered C. glutamicum strain produced 24.7 g/L of 4AB. The strategies reported here should be useful for the microbial production of primary amino alcs. from renewable resources. After reading the article, we found that the author used 4-Aminobutan-1-ol(cas: 13325-10-5Formula: C4H11NO)

4-Aminobutan-1-ol(cas: 13325-10-5) is used in the synthesis of NSAIDs with anti-inflammatory properties. Also used in the synthesis of polyamine transport ligands with specificity against human cancers allowing easy access to specific cancer cells.Formula: C4H11NO

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

《An activatable near-infrared fluorescent probe for methylglyoxal imaging in Alzheimer’s disease mice》 was written by Dang, Yijing; Wang, Fengyang; Li, Lingling; Lai, Yi; Xu, Zhiai; Xiong, Zhi; Zhang, Ao; Tian, Yang; Ding, Chunyong; Zhang, Wen. Category: alcohols-buliding-blocks And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2020. The article conveys some information:

Visual detection of the methylglyoxal (MGO) level in the brain is critical for understanding its role in the onset and progression of AD. Herein, the authors disclosed a NIR fluorescent probe, DBTPP, for detecting MGO by using a thiadiazole-fused o-phenylenediamine moiety as a MGO-specific sensing unit. DBTPP exhibits a series of distinct advantages, such as NIR emission, high selectivity and sensitivity, excellent acid-stability, and a huge off-on ratio. The probe could accurately monitor both exogenous and endogenous MGO variations in SH-SY5Y cells. Besides, it was able to image the endogenous MGO in a transgenic AD mouse model successfully, suggesting the great potential of MGO as a biomarker for early AD diagnosis. In the part of experimental materials, we found many familiar compounds, such as 3-Bromopropan-1-ol(cas: 627-18-9Category: alcohols-buliding-blocks)

3-Bromopropan-1-ol(cas: 627-18-9) is used in the synthesis of fluorescent halide-sensitive quinolinium dyes, chiral, quaternary prolines through cyclization of quaternary amino acids and molten salt-polymers. It is utilized for the study of micellar media and in microemulsions based on cationic or a nonionic surfactant by reacting with phenols.Category: alcohols-buliding-blocks

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

《Simplistic perylene-related compounds as inhibitors of tick-borne encephalitis virus reproduction》 was written by Slesarchuk, Nikita A.; Khvatov, Evgeny V.; Chistov, Alexey A.; Proskurin, Gleb V.; Nikitin, Timofei D.; Lazarevich, Anastasiya I.; Ulanovskaya, Angelina A.; Ulashchik, Egor A.; Orlov, Alexey A.; Jegorov, Artjom V.; Ustinov, Alexey V.; Tyurin, Anton P.; Shmanai, Vadim V.; Ishmukhametov, Aydar A.; Korshun, Vladimir A.; Osolodkin, Dmitry I.; Kozlovskaya, Liubov I.; Aralov, Andrey V.. HPLC of Formula: 13325-10-5 And the article was included in Bioorganic & Medicinal Chemistry Letters in 2020. The article conveys some information:

Rigid amphipathic fusion inhibitors are potent broad-spectrum antivirals based on the perylene scaffold, usually decorated with a hydrophilic group linked via ethynyl or triazole. We have sequentially simplified these structures by removing sugar moiety, then converting uridine to aniline, then moving to perylenylthiophenecarboxylic acids and to perylenylcarboxylic acid. All these polyaromatic compounds, as well as antibiotic heliomycin, still showed pronounced activity against tick-borne encephalitis virus (TBEV) with limited toxicity in porcine embryo kidney (PEK) cell line. 5-(Perylen-3-yl)-2-thiophenecarboxylic acid (5a) showed the highest antiviral activity with 50% effective concentration of approx. 1.6 nM. In the part of experimental materials, we found many familiar compounds, such as 4-Aminobutan-1-ol(cas: 13325-10-5HPLC of Formula: 13325-10-5)

4-Aminobutan-1-ol(cas: 13325-10-5) is used in the synthesis of NSAIDs with anti-inflammatory properties. Also used in the synthesis of polyamine transport ligands with specificity against human cancers allowing easy access to specific cancer cells.HPLC of Formula: 13325-10-5

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Singh, Nidhi; Pandey, Jaya published their research in Current Research in Green and Sustainable Chemistry in 2021. The article was titled 《DABCO catalyzed, green and efficient, one-pot multicomponent synthesis of 5-aminopyrazole-4-carbonitrile》.Name: 3-Hydroxybenzaldehyde The article contains the following contents:

This work describes an unaccustomed DABCO catalyzed synthetic approach for the synthesis of 5-Aminopyrazole-4-carbonitriles I [R1 = H, 3-OH, 4-OH, 4-Br, 4-Cl, 4-OMe; R2 = H, 3,5-(NO2)2]. A series of substituted derivatives of 5-Aminopyrazole-4-carbonitrile I was synthesized deploying this facile and efficient catalyst in green aqueous media. The reaction involves condensation of malononitrile, benzaldehydes R1C6H4CHO and phenylhydrazines such as phenylhydrazine and 3,5-dinitrophenylhydrazine, generating one-pot pyrazole products. The mechanistic chem. of synthesis encompasses Knoevenagel condensation followed by amination and superseded by intra-mol. cyclization. The synthetic route is a lucid and effective route involving green solvent and less hazardous reaction conditions. Besides this, min. reaction period, easy work-up and elimination of byproducts during synthesis, make this reaction a model reaction for pyrazole synthesis. In the experiment, the researchers used many compounds, for example, 3-Hydroxybenzaldehyde(cas: 100-83-4Name: 3-Hydroxybenzaldehyde)

3-Hydroxybenzaldehyde(cas: 100-83-4) can be used as a reactant along with ethyl acetoacetate and thiourea in the synthesis of corresponding dihydropyrimidine-2-thione (monastrol), using Yb(OTf)3 as a catalyst by Biginelli cyclocondensation reaction.Name: 3-Hydroxybenzaldehyde

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Kim, Joseph Byung-Kyu; Mackeyev, Yuri; Raghuram, Subhiksha; Cho, Sang Hyun; Krishnan, Sunil published an article in 2021. The article was titled 《Synthesis and characterization of gadolinium-decorated [60]fullerene for tumor imaging and radiation sensitization》, and you may find the article in International Journal of Radiation Biology.Product Details of 534-03-2 The information in the text is summarized as follows:

The excellent contrast of high at. number (Z) elements compared to soft tissues has advanced their use as contrast agents for computed tomog. imaging and as potential radiation sensitizers. We evaluated whether gadolinium (Gd) could serve as such a theranostic agent for high-resolution magnetic resonance imaging (MRI) due to its paramagnetic properties and radiosensitization due to its high Z. To improve the relaxivity of Gd, we coupled it to [60]fullerene, an elemental carbon allotropic nanoparticle that seamlessly traverses physiol. barriers . By adding serinol, an aliphatic alc. derived from amino acid serine, we turned [60]fullerene, which is otherwise insoluble in water, into a highly water-soluble derivative and decorated it externally with a payload of chelated gadolinium ions. When [60]fullerene was functionalized in this manner with two gadolinium ions (Gd2C60), it displayed considerably higher T1 relaxivity at 4.7 T than the com. used MRI contrast agent, Magnevist, (18.2 mM-1s-1 vs. 4.7 mM-1s-1). Attempts to increase this even further via decoration of [60]fullerene with 12 gadolinium ions was unsuccessful due to a poor water solubility However, the current formulation of Gd2C60 did not result in any appreciable radiosensitization. Our results show a successful generation of a novel contrast agent via decoration of fullerene with two chelated Gd ions. Though this formulation was not successful in generating radiosensitization, other chem. modifications can be further explored to increase radiosensitization potential. In the experimental materials used by the author, we found 2-Aminopropane-1,3-diol(cas: 534-03-2Product Details of 534-03-2)

2-Aminopropane-1,3-diol(cas: 534-03-2) belongs to anime. Hydrogen peroxide (H2O2) and peroxy acids generally add an oxygen atom to the nitrogen of amines. With primary amines, this step is normally followed by further oxidation, leading to nitroso compounds, RNO, or nitro compounds, RNO2. Secondary amines are converted to hydroxylamines, R2NOH, and tertiary amines to amine oxides, R3NO.Product Details of 534-03-2

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts