Month: October 2022

In 2019,Chemical Engineering Journal (Amsterdam, Netherlands) included an article by Liu, Lu; Meng, Wei-Kun; Zhou, Yan-Sheng; Wang, Xia; Xu, Gui-Ju; Wang, Ming-Lin; Lin, Jin-Ming; Zhao, Ru-Song. Synthetic Route of C9H6O6. The article was titled 《β-Ketoenamine-linked covalent organic framework coating for ultra-high-performance solid-phase microextraction of polybrominated diphenyl ethers from environmental samples》. The information in the text is summarized as follows:

Covalent organic frameworks (COFs) via Schiff base-type linkages (1,3,5-triformylphloroglucinol-paraphenylenediamine, TpPa-1), as an ideal coating, possesses significant potential for solid-phase microextraction (SPME) due to their fascinating properties, such as outstanding thermal and chem. stabilities, inherent porosity, and high crystallinity. A novel SPME device was fabricated based on TpPa-1 as an enrichment coating for capturing trace polybrominated di-Ph ethers (PBDEs). This TpPa-1 coating exhibited a superior enrichment capacity in “”catching”” PBDEs over com. SPME fibers. Such performance is attributed to multiple factors, including the coating’s hydrophobic nature, π-π stacked architectures, large sp. surface area, high thermal stability, and size-matching effect. High enhancement factors of 2035-6859, low detection limits of 0.0058-0.022 ng L-1, satisfactory linear range of 0.01-100 ng L-1, good repeatability of 4.86%-9.33%, and excellent reproducibility of 5.62%-9.85% were achieved. Finally, as expected, as the most sensitive SMPE technique for detecting PBDEs, to the best of our knowledge, the developed SPME procedure in combination with gas chromatog.-neg. chem. ion-mass spectrometry anal. was proven to be ultrasensitive, dependable, and practical in analyzing PBDE species in real water. These exceptional results signify that the proposed method offers a fresh prospect to extend the potential applications of COFs to pick up pollutants at ultra-low levels from environmental samples. In addition to this study using 2,4,6-Trihydroxybenzene-1,3,5-tricarbaldehyde, there are many other studies that have used 2,4,6-Trihydroxybenzene-1,3,5-tricarbaldehyde(cas: 34374-88-4Synthetic Route of C9H6O6) was used in this study.

2,4,6-Trihydroxybenzene-1,3,5-tricarbaldehyde(cas: 34374-88-4) is a member of phloroglucinol derivatives.Synthetic Route of C9H6O6Phloroglucinols are known for their broad-spectrum antiviral, antibacterial, antifungal, antihelminthic, and phytotoxic activities.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

In 2019,Angewandte Chemie, International Edition included an article by Silva, Siguara B. L.; Oberhaensli, Francois; Tribalat, Marie-Aude; Genta-Jouve, Gregory; Teyssie, Jean-Louis; Dechraoui-Bottein, Marie-Yasmine; Gallard, Jean-Francois; Evanno, Laurent; Poupon, Erwan; Thomas, Olivier P.. Product Details of 13325-10-5. The article was titled 《Insights into the Biosynthesis of Cyclic Guanidine Alkaloids from Crambeidae Marine Sponges》. The information in the text is summarized as follows:

Among the outstanding chem. diversity found in marine sponges, cyclic guanidine alkaloids, present in species of the family Crambeidae, are particularly attractive, not only because of their unique chem. features, but also due to a broad range of biol. activities. Despite a growing interest in these natural products as therapeutic agents, their metabolic pathway has not been exptl. investigated. Ex situ feeding experiments using radiolabeled precursors performed on the Mediterranean sponge Crambe crambe suggest arginine and fatty acids as precursors in the metabolic pathway of crambescins. A subsequent bio-inspired approach supported the change of paradigm in the metabolic pathway of cyclic guanidine alkaloids. A large part of the chem. diversity of this family would therefore originate from a tethered Biginelli-like reaction between C-2/C-3 activated fatty acids and a central guanidinylated pyrrolinium. In the experiment, the researchers used 4-Aminobutan-1-ol(cas: 13325-10-5Product Details of 13325-10-5)

4-Aminobutan-1-ol(cas: 13325-10-5) is used in the synthesis of NSAIDs with anti-inflammatory properties. Also used in the synthesis of polyamine transport ligands with specificity against human cancers allowing easy access to specific cancer cells.Product Details of 13325-10-5

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

The author of 《Synthesis and characterization of spinel FeAl2O4 (hercynite) magnetic nanoparticles and their application in multicomponent reactions》 were Ghorbani-Choghamarani, Arash; Mohammadi, Masoud; Shiri, Lotfi; Taherinia, Zahra. And the article was published in Research on Chemical Intermediates in 2019. Application of 100-83-4 The author mentioned the following in the article:

The spinel ferrite FeAl2O4 (hercynite) MNPs (magnetic nanoparticles) were applied as a reusable catalytic system for the one-pot synthesis of benzo[a]pyrano[2,3-c] phenazine and polyhydroquinoline derivatives via a multicomponent reaction under green reaction conditions. The structure of the prepared nanocatalyst has been characterized by XRD, FTIR, SEM, EDS, BET, and VSM techniques. The FeAl2O4 MNPs act as Lewis acids and offer several advantages such as high yields of products, short reaction times, and easy workup procedure. Moreover, the recycled nanocatalyst was used at least four times without significant loss of its activity. The results came from multiple reactions, including the reaction of 3-Hydroxybenzaldehyde(cas: 100-83-4Application of 100-83-4)

3-Hydroxybenzaldehyde(cas: 100-83-4) can be used as a reactant along with ethyl acetoacetate and thiourea in the synthesis of corresponding dihydropyrimidine-2-thione (monastrol), using Yb(OTf)3 as a catalyst by Biginelli cyclocondensation reaction.Application of 100-83-4

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《Enantioselective Synthesis of a 2,3-Benzodiazepine Intermediate of BET Inhibitor BAY 1238097 via Catalytic Asymmetric Hydrogenation》 was written by Verzijl, Gerard K. M.; Hassfeld, Jorma; de Vries, Andre H. M.; Lefort, Laurent. Product Details of 126456-43-7 And the article was included in Organic Process Research & Development in 2020. The article conveys some information:

Herein, we report the first example of the asym. hydrogenation of a prochiral benzodiazepine substrate as key transformation in a pilot-scale synthesis of BET inhibitor BAY 1238097 (I). High-throughput screening in a parallel reactor enabled us to identify an efficient catalyst based on Ir and a chiral bisphosphine. An additive screening allowed significant reduction of catalyst loading. Ultimately, the hydrogenation was performed on a kilogram scale leading to the production of 27 kg of the desired product with an enantiomeric excess of 99% after crystallization In the experiment, the researchers used (1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol(cas: 126456-43-7Product Details of 126456-43-7)

(1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol(cas: 126456-43-7) belongs to anime. Nitrous acid converts secondary amines (aliphatic or aromatic) to N-nitroso compounds (nitrosamines): R2NH + HNO2 → R2N―NO. Some nitrosamines are potent cancer-inducing substances, and their possible formation is a serious consideration when nitrites, which are salts of nitrous acid, are present in foods or pharmaceutical preparations. Tertiary amines give rise to nitrosamines more slowly; an alkyl group is eliminated as an aldehyde or ketone, along with nitrous oxide, N2O.Product Details of 126456-43-7

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

《A new FRET probe for ratiometric fluorescence detecting mitochondria-localized drug activation and imaging endogenous hydroxyl radicals in zebrafish》 was written by Deng, Tao; Wang, Xiaojuan; Wu, Shengjun; Hu, Shiyou; Liu, Wei; Chen, Tongkai; Yu, Zhiqiang; Xu, Qin; Liu, Fang. Computed Properties of C6H7BO3 And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2020. The article conveys some information:

A new FRET probe has been prepared for ratiometric fluorescence detection of hydroxyl radicals. It has been successfully used for detecting mitochondria-localized drug activation in living cells and imaging endogenous hydroxyl radicals in zebrafish gastrointestinal (GI) tracts under normal culturing conditions. The results came from multiple reactions, including the reaction of 2-Hydroxyphenylboronic acid(cas: 89466-08-0Computed Properties of C6H7BO3)

2-Hydroxyphenylboronic acid(cas: 89466-08-0) belongs to acyl phenylboronic acid. Phenylboronic acid (PBA) has been used to extract β-blockers (a class of aminoalcohol-containing drugs) from aqueous solution, rat, and human plasma. Computed Properties of C6H7BO3

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

《Visible-Light-Induced Metal-Free Trifluoromethylselenolation of Electron-Rich Heteroarenes Using the Nucleophilic [Me4N][SeCF3] Reagent》 was written by De Zordo-Banliat, Arnaud; Barthelemy, Lucas; Bourdreux, Flavien; Tuccio, Beatrice; Dagousset, Guillaume; Pegot, Bruce; Magnier, Emmanuel. Name: Oxetan-3-ol And the article was included in European Journal of Organic Chemistry in 2020. The article conveys some information:

A metal-free visible-light-promoted regioselective trifluoromethylselenolation of electron-rich heteroarenes was developed using C-H functionalization. This eco-friendly, atom-economical, and easy-to-operate protocol provides direct access to a wide range of functionalized SeCF3-containing heteroarenes in high yields, and is amenable to continuous flow techniques. A radical mechanism was supported by EPR experiments In the part of experimental materials, we found many familiar compounds, such as Oxetan-3-ol(cas: 7748-36-9Name: Oxetan-3-ol)

Oxetan-3-ol(cas: 7748-36-9) is used as a reagent in the synthesis of 5-fluoro-4,6-dialkoxypyrimidine GPR119 agonists. It is also used as a reagent in the synthesis of cyclic sulfone hydroxyethylamines as potent and selective β-site APP-cleaving enzyme 1 (BACE1) inhibitors.Name: Oxetan-3-ol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

《Rational Design of an Iron-Based Catalyst for Suzuki-Miyaura Cross-Couplings Involving Heteroaromatic Boronic Esters and Tertiary Alkyl Electrophiles》 was written by Crockett, Michael P.; Wong, Alexander S.; Li, Bo; Byers, Jeffery A.. Electric Literature of C12H17BO2 And the article was included in Angewandte Chemie, International Edition in 2020. The article conveys some information:

Suzuki-Miyaura cross-coupling reactions between a variety of alkyl halides and unactivated aryl boronic esters using a rationally designed iron-based catalyst supported by β-diketiminate ligands are described. High catalyst activity resulted in a broad substrate scope that included tertiary alkyl halides and heteroaromatic boronic esters. Mechanistic experiments revealed that the iron-based catalyst benefited from the propensity for β-diketiminate ligands to support low-coordinate and highly reducing iron amide intermediates, which are very efficient for effecting the transmetalation step required for the Suzuki-Miyaura cross-coupling reaction. In the part of experimental materials, we found many familiar compounds, such as 4,4,5,5-Tetramethyl-2-phenyl-1,3,2-dioxaborolane(cas: 24388-23-6Electric Literature of C12H17BO2)

4,4,5,5-Tetramethyl-2-phenyl-1,3,2-dioxaborolane(cas: 24388-23-6) can be used to prepare sulfinamide derivatives by reacting with diethylaminosulfur trifluoride (DAST) and potassium phenyltrifluoroborate.Electric Literature of C12H17BO2

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

《Novel Biodegradable Laminarin Microparticles for Biomedical Applications》 was written by Castanheira, Edgar J.; Correia, Tiago R.; Rodrigues, Joao M. M.; Mano, Joao F.. Recommanded Product: 3-Bromopropan-1-ol And the article was included in Bulletin of the Chemical Society of Japan in 2020. The article conveys some information:

Fabrication of biocompatible polymeric carriers for sustained/controlled drug-delivery have been extensively explored over the years. Furthermore, systems based on polymers from natural origins exceed conventional polymers in biocompatibility, biodegradability and cost efficiency. Polysaccharides are one of the most common biopolymers found in nature and they can achieve a high degree of complexity and fine biol. properties. Herein, is proposed a biodegradable and biocompatible microcarrier synthesized from laminarin, a low Mw marine polysaccharide based on glucose units with great biol. activity, such as immune modulation and antimicrobial properties. Within this work, controlled size microparticles were obtained from novel modifications of laminarin. Microparticles showed 40% release of fluorescein isothiocyanate-dextran (70 kDa) after 24 h and full degradability after 11 days, when in physiol. conditions. When incubated with human adipose stem and L929 cell lines (up to a microparticle concentration of 100 μg/mL) no cytotoxicity was perceived, and neither membrane or nucleus disturbance. Thus, microparticles synthesized from laminarin, proved to be a cost efficient, biocompatible and biodegradable system. After reading the article, we found that the author used 3-Bromopropan-1-ol(cas: 627-18-9Recommanded Product: 3-Bromopropan-1-ol)

3-Bromopropan-1-ol(cas: 627-18-9) is used in the synthesis of fluorescent halide-sensitive quinolinium dyes, chiral, quaternary prolines through cyclization of quaternary amino acids and molten salt-polymers. It is utilized for the study of micellar media and in microemulsions based on cationic or a nonionic surfactant by reacting with phenols.Recommanded Product: 3-Bromopropan-1-ol

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Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

《Identification of tetracyclic lactams as NMDA receptor antagonists with potential application in neurological disorders》 was written by Espadinha, Margarida; Viejo, Lucia; Lopes, Ricardo M. R. M.; Herrera-Arozamena, Clara; Molins, Elies; dos Santos, Daniel J. V. A.; Goncalves, Lidia; Rodriguez-Franco, Maria Isabel; de los Rios, Cristobal; Santos, Maria M. M.. Product Details of 126456-43-7 And the article was included in European Journal of Medicinal Chemistry in 2020. The article conveys some information:

The synthesis and pharmacol. evaluation of a new scaffold with antagonistic activity for NMDAR was reported. Specifically, a chem. library of eighteen 1-aminoindan-2-ol tetracyclic lactams was synthesized and screened as NMDAR antagonists. The compounds were obtained by chiral pool synthesis using enantiomerically pure 1-aminoindan-2-ols as chiral inductors, and their stereochem. was proven by X-ray crystallog. anal. of two target compounds Most compounds reveal NMDAR antagonism, and eleven compounds display IC50 values in a Ca2+ entry-sensitive fluo-4 assay in the same order of magnitude of memantine, a clin. approved NMDAR antagonist. Docking studies suggest that the novel compounds can act as NMDAR channel blockers since there is a compatible conformation with MK-801 co-crystallized with NMDAR channel. In addition, we show that the tetracyclic 1-aminoindan-2-ol derivatives are brain permeable and non-toxic, and we identify promising hits for further optimization as modulators of the NMDAR function. In the part of experimental materials, we found many familiar compounds, such as (1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol(cas: 126456-43-7Product Details of 126456-43-7)

(1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol(cas: 126456-43-7) belongs to anime. Amines have a free lone pair with which they can coordinate to metal centers. Amine–metal bonds are weaker because amines are incapable of backbonding, but they are still important for sensing applications.While stronger than hydrogen bonds, amine–metal bonds are still weaker than both covalent and ionic bonds.Product Details of 126456-43-7

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Jana, Akash; Kumar, Amol; Maji, Biplab published their research in Chemical Communications (Cambridge, United Kingdom) in 2021. The article was titled 《Manganese catalyzed C-alkylation of methyl N-heteroarenes with primary alcohols》.Reference of 3-Pyridinemethanol The article contains the following contents:

C-Alkylations of nine different classes of methyl-substituted N-heteroarenes including quinolines, quinoxalines, benzimidazoles, benzoxazoles, pyrazines, pyrimidines, pyridazines, pyridines, and triazines were disclosed. A bench stable earth-abundant Mn(I)-complex catalyzed the chemoselective hydrogen-transfer reaction utilizing a diverse range of primary alcs. as the non-fossil fuel-derived carbon source. The diversified N-heteroarenes were isolated in high yields and selectivities. Water was produced as the sole byproduct, making the protocol environmentally benign. After reading the article, we found that the author used 3-Pyridinemethanol(cas: 100-55-0Reference of 3-Pyridinemethanol)

3-Pyridinemethanol(cas: 100-55-0) belongs to pyridine. Pyridine is widely used in the precursor to agrochemicals and pharmaceuticals. Also, it is used as an important reagent and organic solvent.Reference of 3-Pyridinemethanol

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Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts