Month: October 2022

Cai, Aijie; Yan, Wenhao; Wang, Chao; Liu, Wei published the artcile< Copper-Catalyzed Difluoromethylation of Alkyl Iodides Enabled by Aryl Radical Activation of Carbon-Iodine Bonds>, Quality Control of 167938-56-9, the main research area is alkyl iodide copper catalyst difluoromethylation; alkyldifluoromethane preparation; copper; cross-coupling; difluoromethylation; radicals; reaction mechanisms.

A novel strategy that leveraged the halogen abstraction ability of aryl radicals, thereby engaging a diverse range of alkyl iodides in copper-catalyzed Negishi-type cross-coupling reactions at room temperature Specifically, aryl radicals generated via copper catalysis efficiently initiate the cleavage of the carbon-iodide bonds of alkyl iodides. The alkyl radicals thus generated enter the copper catalytic cycles to couple with a difluoromethyl zinc reagent, thus furnished the alkyl difluoromethane products. This unprecedented Negishi-type difluoromethylation approach was applied to the late-stage modification of densely functionalized pharmaceutical agents and natural products.

Angewandte Chemie, International Edition published new progress about Aralkyl halides, iodides Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 167938-56-9 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H17NO3, Quality Control of 167938-56-9.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Ballesteros-Soberanas, Jordi; Hernandez-Garrido, Juan Carlos; Ceron-Carrasco, Jose Pedro; Leyva-Perez, Antonio published the artcile< Selective semi-hydrogenation of internal alkynes catalyzed by Pd-CaCO3 clusters>, COA of Formula: C4H8O, the main research area is alkene preparation; internal alkyne selective semi hydrogenation palladium catalyst.

The de-novo synthesis of soluble or solid-supported Pd-(CaCO3)n clusters (n = 2-13) and their high catalytic activity for the semi-hydrogenation of internal alkynes compared to terminal alkynes, was presented. Mechanistic studies showed that this reactivity, i.e. internal alkynes more reactive than terminal alkynes, came from the higher electrophilicity of the Pd-(CaCO3)n cluster compared to the nanoparticulated Lindlar catalyst, which unveils the advantages of isolating the min. catalytic unit of a solid catalyst. Translating solid active sites into soluble catalysts turns around the classical approach and constitutes a paradigmatic shift in catalyst design.

Journal of Catalysis published new progress about Alkenes Role: SPN (Synthetic Preparation), PREP (Preparation). 627-27-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C4H8O, COA of Formula: C4H8O.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Liu, Hui; Zhou, Si-Yu; Wen, Guo-En; Liu, Xu-Xue; Liu, De-Yong; Zhang, Qing-Ju; Schmidt, Richard R.; Sun, Jian-Song published the artcile< The 2,2-Dimethyl-2-(ortho-nitrophenyl)acetyl (DMNPA) Group: A Novel Protecting Group in Carbohydrate Chemistry>, Product Details of C12H20O6, the main research area is dimethyl nitrophenyl acetyl protecting group carbohydrate chem.

The 2,2-dimethyl-2-(ortho-nitrophenyl)acetyl (DMNPA) group was introduced to synthetic carbohydrate chem. as a protecting group (PG) for the first time. Benefiting from a unique chem. structure and novel deprotection conditions, the DMNPA group can be cleaved rapidly and mutually orthogonal to other PGs. Orchestrated application of the DMNPA group with other PGs led to the highly efficient synthesis of the glycan of thornasterside A.

Organic Letters published new progress about Glycosides Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation) (protected). 4064-06-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C12H20O6, Product Details of C12H20O6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Yeh, Nai-Hua; Krueger, Ruby; Moeller, Kevin D. published the artcile< Microelectrode Arrays, Dihydroxylation, and the Development of an Orthogonal Safety-Catch Linker>, Recommanded Product: But-3-en-1-ol, the main research area is microelectrode array dihydroxylation orthogonal safety catch linker.

Construction of larger mol. libraries on an addressable microelectrode array requires a method for recovering and characterizing mols. from the surface of any electrode in the array. This method must be orthogonal to the synthetic strategies needed to build the array. The authors report here a method for achieving this goal that employs the site-selective dihydroxylation reaction of a simple olefin.

Organic Letters published new progress about Alkenes Role: PEP (Physical, Engineering or Chemical Process), RCT (Reactant), PROC (Process), RACT (Reactant or Reagent). 627-27-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C4H8O, Recommanded Product: But-3-en-1-ol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Maneikyte, Juste; Bausys, Augustinas; Leber, Bettina; Feldbacher, Nicole; Hoefler, Gerald; Kolb-Lenz, Dagmar; Strupas, Kestutis; Stiegler, Philipp; Schemmer, Peter published the artcile< Dietary glycine prevents FOLFOXchemotherapy-induced heart injury: a colorectal cancer liver metastasis treatment model in rats>, Computed Properties of 1492-18-8, the main research area is colorectal cancer heart injury glycine collagen type I Hb; FOLFOX; cardiotoxicity; colorectal cancer; glycine.

This study tested the hypothesis of glycine being cardioprotective in a rat model of FOLFOX in combination with CRLM. Materials and Methods: The effect of glycine was tested in vitro on human cardiac myocytes (HCMs). To test glycine in vivo Wag/Rij rats with induced CRLM were treated with FOLFOX ±5% dietary glycine. Left ventricle ejection fraction (LVEF), myocardial fibrosis, and apoptosis, also heart fatty acid binding protein (h-FABP) and brain natriuretic peptide levels were monitored. PCR anal. for Collagen type I, II, and brain natriuretic peptide (BNP) in the heart muscle was performed. Results: In vitro glycine had no effect on HCM cell viability. Treatment with FOLFOX resulted in a significant increase of h-FABP levels, increased myocardial fibrosis, and apoptosis as well as increased expression of type I Collagen. Furthermore, FOLFOX caused a decrease of LVEF by 10% (p = 0.028). Dietary glycine prevented FOLFOX-induced myocardial injury by preserving the LVEF and reducing the levels of fibrosis (p = 0.012) and apoptosis (p = 0.015) in vivo. Conclusions: Data presented here demonstrate for the first time that dietary glycine protects the heart against FOLFOX-induced injury during treatment for CRLM.

Nutrients published new progress about Apoptosis. 1492-18-8 belongs to class alcohols-buliding-blocks, and the molecular formula is C20H21CaN7O7, Computed Properties of 1492-18-8.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Chakraborty, Gargi; Sikari, Rina; Mondal, Rakesh; Mandal, Sutanuva; Paul, Nanda D. published the artcile< Nickel-Catalyzed Synthesis of Pyrimidines via Dehydrogenative Functionalization of Alcohols>, Application of C8H9FO, the main research area is pyrimidine preparation; alc amidine multicomponent dehydrogenative coupling nickel catalyst.

Herein, a comparative study of nickel-catalyzed syntheses of pyrimidines via dehydrogenative multi-component coupling of alcs. and amidines using two different classes of nickel catalysts differing with respect to their mode of action during catalysis is reported. The catalysts are either two tetracoordinate Ni(II)-complexes containing two apparently redox-inactive tetraaza macrocyclic ligands or square planar Ni(II)-complexes featuring redox-active diiminosemiquinonato type scaffolds. Tetracoordinate Ni(II) catalysts dehydrogenate alcs. via a two-electron hydride transfer pathway involving energetically demanding nickel-centered redox events while in the presence of square planar Ni(II)-complexes dehydrogenation of alcs. proceeds via a one-electron hydrogen atom transfer (HAT) pathway via synergistic participation of metal and ligand centered redox processes avoiding high energy nickel centered redox events. Detailed substrate screening and control experiments were performed to unveil the reaction sequence and understand the advantages/disadvantages of these two pathways.

Asian Journal of Organic Chemistry published new progress about Amidines Role: RCT (Reactant), RACT (Reactant or Reagent). 403-41-8 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H9FO, Application of C8H9FO.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Cheng, Zhaoyang; Guo, Jun; Sun, Yufeng; Zheng, Yushan; Zhou, Zhehong; Lu, Zhan published the artcile< Regio-controllable Cobalt-Catalyzed Sequential Hydrosilylation/Hydroboration of Arylacetylenes>, Product Details of C9H8O, the main research area is arylacetylene pinacolborane diphenylailane cobalt catalyst regioselective tandem hydrosilylation hydroboration; aryl diphenylsilylboronate preparation; alkynes; cobalt catalysis; hydroboration; hydrosilylation; regiodivergent synthesis.

A regio-controllable cobalt-catalyzed sequential hydrosilylation/hydroboration of arylacetylenes, delivering all the possible regio-outcomes with high regioselectivities (up to >20/1 rr for all the cases). Each regioisomer of value-added silylboronates were efficiently and regioselectively obtained from the same materials. The adjustment of the ligands of cobalt catalysts combined with dual catalysis relay strategy was the key to achieve regio-chem. control. This regio-controllable research inspired the exploration of the diversity-oriented synthesis that involved multiple additions and provided full sets of regioisomers of other synthetic useful mols.

Angewandte Chemie, International Edition published new progress about Alkanes Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 10602-04-7 belongs to class alcohols-buliding-blocks, and the molecular formula is C9H8O, Product Details of C9H8O.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Ghlissi, Zohra; Kallel, Rim; Krichen, Fatma; Hakim, Ahmed; Zeghal, Khaled; Boudawara, Tahiya; Bougatef, Ali; Sahnoun, Zouheir published the artcile< Polysaccharide from Pimpinella anisum seeds: Structural characterization, anti-inflammatory and laser burn wound healing in mice>, Name: (2S,3R,4S,5S,6R)-6-(Hydroxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetraol, the main research area is Staphylococcus Pimpinella laser burn wound healing seed polysaccharide antiinflammatory; Anti-inflammatory activity; Laser burn; Pimpinella anisum; Polysaccharide; Wound healing.

The polysaccharide preparation from Pimpinella anisum seeds (PAP) was isolated and characterized to evaluate its laser burn wound-healing and anti-inflammatory activities in mice. The structure characterization of PAP by Infra-red spectrometry (IR), NMR (NMR), Gas chromatogram-Mass spectrometer (GC-MS) and colorimetric methods revealed an optimum yield of 8.84%, a high quantity of carbohydrate (64.75%) and low levels of lipids, protein and sulfate. Galactose (33.47%), β-D-Glucose (26.71%) and a-D-Mannose (18.21%) were the major monosaccharides components presenting in PAP, and a smaller amounts of β-D-Galactose, D-Fructose, a-D-Glucose, a-L-Galactose and arabinose were detected. PAP showed noticeable antioxidant and antibacterial properties. The anti-inflammatory activity of PAP in the carrageenan-induced paw edema model in mice, demonstrated by reduced edema and cellular infiltration, and oxidative stress markers in muscle tissue. A beneficial wound healing effect was also revealed. The topical application of PAP based gel on laser burn lesions accelerates wound contraction, the re-epithelization and remodeling phases after seven days of treatment. The results demonstrated that PAP is a novel promising source of natural wound healing and anti-inflammatory drugs. The high content and varied PAP monosaccharides seem to be responsible for the observed biol. activities.

International Journal of Biological Macromolecules published new progress about Anti-inflammatory agents. 492-62-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H12O6, Name: (2S,3R,4S,5S,6R)-6-(Hydroxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetraol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Takale, Balaram S.; Feng, Xiujuan; Lu, Ye; Bao, Ming; Jin, Tienan; Minato, Taketoshi; Yamamoto, Yoshinori published the artcile< Unsupported Nanoporous Gold Catalyst for Chemoselective Hydrogenation Reactions under Low Pressure: Effect of Residual Silver on the Reaction>, COA of Formula: C6H9NO, the main research area is carbonyl gold silver nanoporous chemoselective hydrogenation catalyst; alc preparation; alkyne gold silver nanoporous chemoselective hydrogenation catalyst; alkene stereoselective preparation.

For the first time, H-H dissociation on an unsupported nanoporous gold (AuNPore) surface is reported for chemoselective hydrogenation of CC, C=C, C=N, and C=O bonds under mild conditions (8 atm H2 pressure, 90 °C). Silver doping in AuNPore, which was inevitable for its preparation through a process of dealloying of Au-Ag alloy, exhibited a remarkable difference in catalytic activity between two catalysts, Au>99Ag1NPore and Au90Ag10NPore.The former was more active and the latter less active in H2 hydrogenation, while the reverse tendency was observed for O2 oxidation This marked contrast between H2 reduction and O2 oxidation is discussed. Further, Au>99Ag1NPore showed a high chemoselectivity toward reduction of terminal alkynes in the presence of internal alkynes which was not achieved using supported gold nanoparticle catalysts and other previously known methods. Reductive amination, which has great significance in synthesis of amines due to its atom-economical nature, was also realized using Au>99Ag1NPore, and the Au>99Ag1NPore/H2 system showed a preference for the reduction of aldehydes in the presence of imines. In addition to this high chemoselectivity, easy recovery and high reusability of AuNPore make it a promising heterogeneous catalyst for hydrogenation reactions.

Journal of the American Chemical Society published new progress about Alcohols Role: SPN (Synthetic Preparation), PREP (Preparation). 52160-51-7 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H9NO, COA of Formula: C6H9NO.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Wang, Jianfei; Huang, Jiaqi; Guo, Huanyu; Jiang, Shaoming; Zhang, Jing; Ning, Yuchen; Fang, Mudannan; Liu, Shijie published the artcile< Optimization of immobilization conditions for Lactobacillus penntosus cells>, Product Details of C6H12O6, the main research area is immobilization lactic acid fermentation Lactobacillus penntosus; Fermentation; Immobilization; Lactic acid; Lactobacillus pentosus.

Abstract: In this study, the immobilization technol. was used to improve the LA yield and shorten the fermentation time. The optimum conditions to immobilize Lactobacillus pentosus ATCC 8041 cell were determined by Taguchi design L16 (45). The immobilized L. pentosus ATCC 8041 cells prepared by 2% sodium alginate (SA) and 6% polyvinyl alc. (PVA) with the immobilization process by 0.10 M calcium chloride (CaCl2) and 2.5% boric acid (H3BO3) had the best performance of LA yield at the temperature of 35°C, which is significantly higher than that of L. pentosus ATCC 8041 free cells. These cells maintained the stable and efficient performance in 15 repeated batch fermentation, and they also have excellent mech. strength to keep from breakage caused by cell growth and agitation.

Bioprocess and Biosystems Engineering published new progress about Fermentation. 492-62-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H12O6, Product Details of C6H12O6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts