Month: October 2022

Wan, Xiao-Min; Liu, Zi-Lin; Liu, Wan-Qing; Cao, Xiao-Niu; Zhu, Xinju; Zhao, Xue-Mei; Song, Bing; Hao, Xin-Qi; Liu, Guoji published the artcile< NNN pincer Ru(II)-catalyzed dehydrogenative coupling of 2-aminoarylmethanols with nitriles for the construction of quinazolines>, Name: (2-Aminophenyl)methanol, the main research area is aminobenzyl alc nitrile ruthenium catalyst oxidative coupling reaction; quinazoline preparation green chem.

An efficient NNN pincer Ru(II)-catalyzed preparation of quinazolines via acceptorless dehydrogenative strategy was developed. Under the optimized conditions, a broad range of substituted o-aminobenzyl alcs. and (hetero)aryl or alkyl nitriles were well tolerated to afford various 2-substituted quinazolines in high yields. Subsequently, a set of control experiments was performed to elucidate the reaction mechanism, which underwent alc. oxidation, nitrile hydration and cyclocondensation steps. This protocol was featured with several advantages, such as environmental benignity, operational simplicity, broad substrate scope (compatible with aliphatic nitriles, up to 87% yield) and short reaction time (mostly in 2 h).

Tetrahedron published new progress about Aralkyl alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 5344-90-1 belongs to class alcohols-buliding-blocks, and the molecular formula is C7H9NO, Name: (2-Aminophenyl)methanol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Ratz-Łyko, Anna; Arct, Jacek published the artcile< Resveratrol as an active ingredient for cosmetic and dermatological applications: a review.>, Application In Synthesis of 501-36-0 , the main research area is Resveratrol; anti-inflammatory activity; antiaging properties; antioxidant capacity; bioavailability and toxicity; skin-whitening activity.

Resveratrol is now being increasingly used in cosmetology and dermatology. This polyphenolic phytoalexin present in large amounts in red grapes and berries has a number of scientifically proven health-promoting properties associated with a positive effect on the cardiovascular system, lowering the concentration of low-density lipoprotein, and the ability to inhibit the cyclooxygenases activity. Additionally, it has antiproliferative, anti-angiogenic, anti-inflammatory, antioxidant, and antimicrobial properties. Its popularity in cosmetology and dermatology is primarily associated with proven ability to penetrate the skin barrier and antiaging activity. It has been shown that formulations with resveratrol can stimulate the proliferation of fibroblasts and contributing to the increase in the concentration of collagen III. Resveratrol has an affinity for the estrogen protein receptors (both ERα and ERβ), thereby contributing to the stimulation of collagen types I and II production. Moreover, resveratrol also has the antioxidant properties, thus can protect cells against oxidative damage associated with the effects of free radicals and UV radiation on the skin by reducing the expression of AP-1 and NF-kB factors and it slows down the process of photoaging of the skin. This study reviews literature on the skin care properties of resveratrol and its dermal bioavailability, metabolism, and dermal safety of application.

Journal of cosmetic and laser therapy : official publication of the European Society for Laser Dermatology published new progress about 501-36-0 . 501-36-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C14H12O3, Application In Synthesis of 501-36-0 .

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Api, A. M.; Belsito, D.; Botelho, D.; Bruze, M.; Burton, G. A. Jr.; Buschmann, J.; Cancellieri, M. A.; Dagli, M. L.; Date, M.; Dekant, W.; Deodhar, C.; Fryer, A. D.; Jones, L.; Joshi, K.; Kumar, M.; Lapczynski, A.; Lavelle, M.; Lee, I.; Liebler, D. C.; Moustakas, H.; Na, M.; Penning, T. M.; Ritacco, G.; Romine, J.; Sadekar, N.; Schultz, T. W.; Selechnik, D.; Siddiqi, F.; Sipes, I. G.; Sullivan, G.; Thakkar, Y.; Tokura, Y. published the artcile< RIFM fragrance ingredient safety assessment, linalool, CAS Registry number 78-70-6>, HPLC of Formula: 78-70-6, the main research area is .

There is no abstract available for this document.

Food and Chemical Toxicology published new progress about 78-70-6. 78-70-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C10H18O, HPLC of Formula: 78-70-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Xiang, Xiao-le; Jin, Guo-feng; Gouda, Mostafa; Jin, Yong-guo; Ma, Mei-hu published the artcile< Characterization and classification of volatiles from different breeds of eggs by SPME-GC-MS and chemometrics>, Recommanded Product: 2-Ethylhexan-1-ol, the main research area is chicken egg alkane aldehyde alc ketone terpenoid amine chemometrics; Characterization; Classification; Discriminate; Multivariate analysis; SPME-GC–MS; Shell hatching egg; Volatiles.

Volatiles of shell eggs were identified by SPME-GC-MS to characterize and discriminate white Leghorn (W), Hy-line brown (H) and Jing fen (J) hatching eggs with comparison, principal components (PC), partial least squares (PLS), random forest classification (RFC) and canonical discriminant (CD) analyses. DVB/CAR/PDMS fiber and extraction 60 min were suited to analyze the volatiles emitted from eggs. A total of 17 or 18 volatile compounds were identified in raw shell hatching eggs, namely, nonanal, decanal and 6-methly-5-hepten-2-one were the main volatile components with contributions that over 70%. The composition and/or profile of volatile compounds from W and H eggs were much more similar than J eggs. Hexanal, decanal, 6-methly-5-hepten-2-one, heptanal, etc. have greatly contributed to the distinction of W, H and J eggs in sparse (S)-PLS and orthogonal (O)-PLS models. The accuracy of RFC and CD model were 100%, 100% (initial) and 83.3% (cross-validation), resp. Heptanal, 6-methly-5-hepten-2-one, octanal, etc. were contributed pos. to the classification of W, H, J eggs in RFC, especially for heptanal.

Food Research International published new progress about Chemometrics. 104-76-7 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H18O, Recommanded Product: 2-Ethylhexan-1-ol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Gholinejad, Mohammad; Oftadeh, Erfan; Shojafar, Mohammad; Sansano, Jose M.; Lipshutz, Bruce H. published the artcile< Synergistic Effects of ppm Levels of Palladium on Natural Clinochlore for Reduction of Nitroarenes>, COA of Formula: C7H9NO, the main research area is aryl amine preparation green chem; nitroarene reduction pyridyltriazole clinochlore palladium nanocatalyst; clay; nitro compounds; palladium; reduction; synergistic effects.

The modified naturally occurring clay clinochlore with ppm amounts of palladium that leads to a new and very effective reagent for the reduction of numerous aromatic nitro species RNO2 (R = H3CC(O)NHC6H4, naphthalen-1-yl, pyridin-2-yl, etc.) has been augmented. When palladium nanoparticles are supported on pyridyltriazole-modified clinochlore, iron within clinochlore acts synergistically with palladium to catalyze the reduction of a wide variety of nitroarenes at room temperature in aqueous media. Based on E-factor calculations, the catalyst system is found to be in line with green chem. standards and can be recycled up to five times.

ChemSusChem published new progress about Aromatic amines Role: SPN (Synthetic Preparation), PREP (Preparation). 5344-90-1 belongs to class alcohols-buliding-blocks, and the molecular formula is C7H9NO, COA of Formula: C7H9NO.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Zhang, Yanke; Yang, Sufen; Yang, Yang; Liu, Teng published the artcile< Resveratrol induces immunogenic cell death of human and murine ovarian carcinoma cells>, Product Details of C14H12O3, the main research area is ovarian carcinoma resveratrol immunogenic cell death; Cytotoxic T cell; Immunogenic cell death; Ovarian carcinoma; Resveratrol.

Purpose: This study aimed to clarify whether immunogenic cell death (ICD) contributed to the anti-tumor action of resveratrol against ovarian carcinoma. Methods: Resveratrol suppressed cell proliferation and induced apoptosis in ovarian carcinoma cells. In addition, resveratrol treatment stimulated cell surface exposure of calreticulin, HMGB1 secretion and ATP release. Results: Vaccination with resveratrol-pretreated ID8 cells significantly inhibited growth of subsequent inoculated xenograft tumor. Direct administration with resveratrol suppressed tumor progression accompanied with compromised cell proliferation and enhanced cell apoptosis. We further characterized increases of both mature dendritic cells and cytotoxic T cells in xenograft tumor in response to resveratrol treatment, which also inhibited TGF-β production and stimulated both IL12p7 and IFN-γ secretion. Most importantly, we demonstrated that combination with PD-1 antibody greatly inhibited tumor growth, while depletion of CD8+ T cells by neutralizing antibody restored xenograft progression. Conclusion: Our data suggested resveratrol exerted anti-tumor action against ovarian cancer via both apoptosis and ICD pathways.

Infectious Agents and Cancer published new progress about CD8-positive T cell. 501-36-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C14H12O3, Product Details of C14H12O3.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Machado, Noelia D.; Fernandez, Mariana A.; Diaz, David Diaz published the artcile< Recent Strategies in Resveratrol Delivery Systems>, Computed Properties of 501-36-0, the main research area is review resveratrol delivery system photostability; drug delivery systems; encapsulation; nutrition; pharmaceutics; resveratrol.

A review. Resveratrol, a natural polyphenolic stilbenoid widely found in grapes and wines, displays beneficial properties such as cardio-protective, antioxidant and anti-inflammatory activities. Trans-resveratrol (RSV) is the most bioactive and more abundant stereoisomer found in nature. Despite the pos. properties of RSV, there are various factors that limit its effectiveness, including low aqueous solubility, low oral bioavailability and chem. instability. During the last years, an increasing number of strategies such as nano and micro encapsulation have been developed in order to overcome these limitations and enhance the use of RSV in nutritional and pharmaceutical applications. This Review summarizes the advances and main properties of several RSV carriers and delivery systems reported during the last 5 years.

ChemPlusChem published new progress about Anti-inflammatory agents. 501-36-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C14H12O3, Computed Properties of 501-36-0.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Dong, Hao; Xu, Cheng-Hua; Yang, Fang-Lu; Du, Lei; Liu, Chen-Long; Chen, Wen-Jing; Wang, Lin published the artcile< 1,4-butanediol selective dehydration to 3-butene-1-ol over calcium-zirconium-tin composite oxide catalysts>, COA of Formula: C4H8O, the main research area is calcium zirconium tin composite oxide catalyst butanediol selective dehydration.

Ca-Zr-Sn composite oxides catalysts for 1,4-butanediol (BDO) selective dehydration to 3-butene-1-ol (BTO) are synthesized by impregnation and co-precipitation in the present work. The results show that Ca-Zr-Sn catalysts prepared from co-precipitation by using NaOH-Na2CO3 mixing alkali solution as precipitant exhibit an excellent catalytic property for BDO dehydration to BTO. For instance, Ca-Zr-Sn oxide with Ca/Zr and Sn/Zr molar ratio of 0.68 and 0.28 calcined at 650 U+00B0C gives a BDO conversion and BTO selectivity of about 97% and 82%, resp., and exhibits no deactivation during 1000 h scale-up exptl. testing. X-ray diffraction results indicate that catalytic active centers for BDO dehydration to BTO are from Ca0.15Zr0.85O crystal phase. NH3- and CO2-temperature programmed desorption prove that the surface of obtained catalysts can provide a large amount of acid and base sites simultaneously. FT-IR spectra of pyridine-adsorbed samples show that acid sites on the surface of Ca-Zr-Sn oxide catalyst mainly exist in a state of Lewis acid, which activates terminal -OH groups of BDO mol. through complexing. The activated -OH interacts with β-H activated on base sites O2- anions relative to Ca species, thereby the CH2=CH- bonds are produced through dehydration to form BTO.

Catalysts published new progress about Calcination. 627-27-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C4H8O, COA of Formula: C4H8O.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Azizi, Kobra; Akrami, Sedigheh; Madsen, Robert published the artcile< Manganese(III) Porphyrin-Catalyzed Dehydrogenation of Alcohols to form Imines, Tertiary Amines and Quinolines>, Recommanded Product: 1-(4-Fluorophenyl)ethyl Alcohol, the main research area is manganese porphyrin chloride catalyst dehydrogenative coupling alcs amine; imine synthesis; tertiary amine synthesis; quinoline synthesis; alcohols; dehydrogenation; homogeneous catalysis; manganese; synthetic methods.

Manganese(III) porphyrin chloride complexes have been developed for the first time as catalysts for the acceptorless dehydrogenative coupling of alcs. and amines. The reaction has been applied to the direct synthesis of imines, tertiary amines and quinolines where only hydrogen gas and/or water are formed as the byproduct(s). The mechanism is believed to involve the formation of a manganese(III) alkoxide complex which degrades into the aldehyde and a manganese(III) hydride species. The latter reacts with the alc. to form hydrogen gas and thereby regenerates the alkoxide complex.

Chemistry – A European Journal published new progress about Aliphatic alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 403-41-8 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H9FO, Recommanded Product: 1-(4-Fluorophenyl)ethyl Alcohol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Aiura, Masato; Kanaoka, Yuichi published the artcile< Oxidation of pyrroles with benzoyl peroxide>, HPLC of Formula: 52160-51-7, the main research area is pyrrole oxidation benzoyl peroxide.

The pyrroles I (R = Me, PhCH2, Ph, p-MeOC6H4; R1 = R2 = H) were treated with (BzO)2 to give I (R1 = BzO, R2 = H, R1 = R2 = BzO). I (R = Me, Ph; R1 = CH2OHCHPhOH, CPh2OH; R2 = H) were cleaved with (BzO)2 to give I (R1 = BzO, R2 = H; R1 = R2 = BzO).

Heterocycles published new progress about Oxidation. 52160-51-7 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H9NO, HPLC of Formula: 52160-51-7.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts