Month: October 2022

Sirianni, Quinton E. A.; Rabiee Kenaree, Amir; Gillies, Elizabeth R. published the artcile< Polyglyoxylamides: Tuning Structure and Properties of Self-Immolative Polymers>, Computed Properties of 76-84-6, the main research area is ethyl glyoxylate homopolymer post treated amine selfimmolative polyglyoxylamide.

Polyglyoxylamides (PGAms) were prepared and studied as self-immolative polymers (SIPs). PGAms were synthesized by postpolymn. modification of poly(Et glyoxylate) (PEtG) with amines. PGAms retained the important stimuli-responsive depolymerization property of polyglyoxylates, but exhibited different thermal properties as polyglyoxylates, and some were water-soluble A depolymerizable PGAm analog of poly(ethylene glycol) was prepared, demonstrating the capability to synthesize more complex PGAm graft copolymers.

Macromolecules (Washington, DC, United States) published new progress about Amidation. 76-84-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C19H16O, Computed Properties of 76-84-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Wang, Xianyang; Wang, Peng; Li, Dongwei; Li, Ming published the artcile< 2,4-Dinitrobenzenesulfonamide-Directed SN2-Type Displacement Reaction Enables Synthesis of β-D-Glycosaminosides>, Computed Properties of 4064-06-6, the main research area is nitrobenzenesulfonamide nucleophilic substitution glycosaminoside synthesis glycosylation synthon; Neisseria meningitidis capsular polysaccharide oligosaccharide glycosylation synthesis aminoglycoside glycosaminoside.

An efficient protocol to construct β-D-gluco-/galactosaminosyl linkages was established using nonparticipating and strong electron-withdrawing C-2-2,4-dinitrobenzenesulfonamide (DNsNH)-directed SN2-like glycosylation of glycosyl ortho-hexynylbenzoates. The reaction is applicable to a wide range of O-, N-, and C-nucleophiles and features convenient conversion of DNsNH into AcNH in high yield under mild conditions. Oligomerization-ready trisaccharide, composed of β-D-(1→3)-glucosamino residues, has been achieved, setting a solid foundation for the synthesis of oligosaccharides associated with Neisseria meningitidis capsular polysaccharide.

Organic Letters published new progress about Aminoglycosides Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 4064-06-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C12H20O6, Computed Properties of 4064-06-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Modak, Arindam; Nandi, Mahasweta; Bhaumik, Asim published the artcile< Titanium containing periodic mesoporous organosilica as an efficient catalyst for the epoxidation of alkenes>, Name: 2,4,6-Trihydroxyisophthalaldehyde, the main research area is titanium periodic mesoporous organosilica catalyst epoxidation alkene.

A new class of titanium containing organic-inorganic hybrid periodic mesoporous organosilica (Ti-LHMS-3) has been synthesized, which contain bis(propyliminomethyl)-phloroglucinol moiety in the pore-wall. The precursor organosilane compound is obtained by Vilsmeier-Haack formylation of phloroglucinol followed by its Schiff base condensation with 3-aminopropyl-triethoxysilane (APTES). The hybrid titananosilicate is finally obtained through in situ condensation of this as-prepared organosilane precursor and tetraethylorthosilicate with titanium isopropoxide under hydrothermal conditions. The material has been thoroughly characterized by using powder X-ray diffraction (PXRD), nitrogen adsorption/desorption, transmission and scanning electron microscopic, and FTIR spectroscopic tools. This hybrid mesoporous titanosilicate material showed excellent catalytic activity in the epoxidation of alkenes under mild liquid phase reaction conditions using tert-Bu hydroperoxide (TBHP) as the oxidant.

Catalysis Today published new progress about Alkenes Role: RCT (Reactant), RACT (Reactant or Reagent). 4396-13-8 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H6O5, Name: 2,4,6-Trihydroxyisophthalaldehyde.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Zhang, Mengxun; Chen, Tie; Fang, Shisong; Wu, Weihua; Wang, Xin; Wu, Haiqiang; Xiong, Yongai; Song, Jun; Li, Chenyang; He, Zhendan; Lee, Chi-Sing published the artcile< Peroxide- and transition metal-free electrochemical synthesis of α,β-epoxy ketones>, Quality Control of 627-27-0, the main research area is epoxy ketone preparation antitumor activity diastereoselective green chem electrochem.

A novel electrochem. method for the synthesis of α,β-epoxy ketones I (R = 2-methylphenyl, 3-iodophenyl, 2,3-dihydro-1-benzofuran-6-yl, etc.; R1 = 4-methylphenyl, 5-fluoro-2-methoxyphenyl, naphthalen-2-yl, etc.) is reported. With KI as the redox mediator, Me ketones RC(O)CH3 reacted with aldehydes R1CHO under peroxide- and transition metal-free electrolytic conditions and afforded α,β-epoxy ketones I in one pot (36 examples, 52-90% yield). This safe and environmental-friendly method has a broad substrate scope and can readily provide a variety of α,β-epoxy ketones I in gram-scales for evaluation of their anti-cancer activities.

Organic & Biomolecular Chemistry published new progress about Alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 627-27-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C4H8O, Quality Control of 627-27-0.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Tagami, Takuma; Aoki, Yuma; Kawamura, Shintaro; Sodeoka, Mikiko published the artcile< 1,2-Bis-perfluoroalkylations of alkenes and alkynes with perfluorocarboxylic anhydrides via the formation of perfluoroalkylcopper intermediates>, Application In Synthesis of 10602-04-7, the main research area is bis perfluoroalkyl preparation; alkene alkyne perfluorocarboxylic anhydride perfluoroalkylation copper mediator perfluoroalkylcopper intermediate.

A novel, Cu-mediated protocol toward the 1,2-bis-perfluoroalkyaltion of alkenes/alkynes was developed. The method proceeded with perfluorocarboxylic anhydrides as inexpensive and readily available perfluoroalkyl sources. Diacyl peroxide was generated in situ from the perfluorocarboxylic anhydrides and H2O2. The key step in this reaction is the formation of a stable perfluoroalkylcopper intermediate that is achieved with the aid of a bipyridyl ligand. Subsequent reaction of the intermediate with perfluoroalkyl-containing alkyl or vinyl radicals affords the desired products.

Organic & Biomolecular Chemistry published new progress about Alkenes Role: RCT (Reactant), RACT (Reactant or Reagent). 10602-04-7 belongs to class alcohols-buliding-blocks, and the molecular formula is C9H8O, Application In Synthesis of 10602-04-7.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Castagnoli, Emmanuelle; Backlund, Peter; Talvitie, Oskari; Tuomi, Tapani; Valtanen, Arja; Mikkola, Raimo; Hovi, Hanna; Leino, Katri; Kurnitski, Jarek; Salonen, Heidi published the artcile< Emissions of DEHP-free PVC flooring>, Electric Literature of 104-76-7, the main research area is PVC C9 alc volatile organic compound indoor air pollution; 2-ethylhexanol; C9-alcohol; PVC; TVOC; flooring; phthalates.

Degrading 2-ethylhexyl-containing PVC floorings (eg DEHP-PVC floorings) and adhesives emit 2-ethylhexanol (2-EH) in the indoor air. The danger of flooring degradation comes from exposing occupants to harmful phthalates plasticisers (eg DEHP), but not from 2-EH as such. Since the EU banned the use of phthalates in sensitive applications, the market is shifting to use DEHP-free and alternative types of plasticisers in PVC products. However, data on emissions from DEHP-free PVC floorings are scarce. This study aimed at assessing the surface and bulk emissions of two DEHP-free PVC floorings over three years. The floorings were glued on the screed layer of concrete casts at 75%, 85%, and 95% RH. The volatile organic compounds (VOCs) were actively sampled using FLEC (surface emissions) and micro-chamber/thermal extractor (μ-CTE, bulk emissions) onto Tenax TA adsorbents and analyzed with TD-GC-MS. 2-EH, C9-alcs., and total volatile organic compound (TVOC) emissions are reported. Emissions at 75% and 85% RH were similar. As expected, the highest emissions occurred at 95% RH. 2-EH emissions originated from the adhesive. Because the two DEHP-free floorings tested emitted C9-alcs. at all tested RH, it makes the detection of flooring degradation harder, particularly if the adhesive used does not emit 2-EH.

Indoor Air published new progress about Alcohols, C9 Role: POL (Pollutant), OCCU (Occurrence). 104-76-7 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H18O, Electric Literature of 104-76-7.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Maiti, Sudip; Li, Yingzi; Sasmal, Sheuli; Guin, Srimanta; Bhattacharya, Trisha; Lahiri, Goutam Kumar; Paton, Robert S.; Maiti, Debabrata published the artcile< Expanding chemical space by para-C-H arylation of arenes>, Application In Synthesis of 492-62-6, the main research area is biaryl scaffold preparation.

A robust catalytic system that displayed unique efficacy toward para-arylation of highly functionalized substrates such as drug entities, giving access to structurally diversified biaryl scaffolds, e.g., I was developed. This diversification process provided access to an expanded chem. space for further exploration in drug discovery. Further, the applicability of the transformation was realized through the synthesis of drug mols. bearing a biphenyl fragment. Computational and exptl. mechanistic studies further provided insight into the catalytic cycle operative in this versatile C-H arylation protocol.

Nature Communications published new progress about Aryl iodides Role: RCT (Reactant), RACT (Reactant or Reagent). 492-62-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H12O6, Application In Synthesis of 492-62-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Zhai, Pingan; Li, Wenhui; Lin, Jianying; Huang, Shuangping; Gao, Wenchao; Li, Xing published the artcile< N-Alkyl nitrones as substrates for access to N-aryl isoxazolidines via a catalyst-free one-pot three-component reaction with nitroso compounds and olefins>, Computed Properties of 627-27-0, the main research area is nitrosobenzene methylmethanimine oxide ethene catalyst free three component reaction; phenyl isoxazoldine preparation regioselective chemoselective diastereoselective.

N-Alkyl nitrones were used as the starting materials to construct various N-aryl isoxazolidines, via a catalyst-free one-pot three-component reaction with nitroso compounds and olefins. The mechanism investigations indicated that the in-situ formation of N-aryl nitrones from the reaction of N-alkyl nitrones and nitrosoarenes was the key step. The protocol features broad substrate scope, good to excellent chemo-, regio- and diastereo-selectivities, and moderate to excellent yields for most substrates.

Organic Chemistry Frontiers published new progress about Alkenes Role: RCT (Reactant), RACT (Reactant or Reagent). 627-27-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C4H8O, Computed Properties of 627-27-0.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Eriksson, Alf; Nyholm, Leif published the artcile< Electrochemical detection of disodium 3,3'-azobis-(6-hydroxy-)benzoate (olsalazine sodium)>, Synthetic Route of 6054-98-4, the main research area is olsalazine sodium electrochem detection liquid chromatog; solubility olsalazine sodium electrochem detection LC.

Electrochem. detection of disodium 3,3′-azobis-(6-hydroxy-)benzoate, olsalazine sodium, in reversed phase liquid chromatog. is shown to provide a detection limit of 40 fmol and a linear range extending up to 4 nmol for an injection volume of 20 μL. The method has been used for the determination of the solubility of olsalazine sodium in aqueous solutions The solubility was found to be 2 × 10-8 M and 4 × 10-6 M at pH 1.0 and 3.5, resp.

Electroanalysis published new progress about Reversed phase liquid chromatography. 6054-98-4 belongs to class alcohols-buliding-blocks, and the molecular formula is C14H8N2Na2O6, Synthetic Route of 6054-98-4.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Sudhakaran, Swetha; Taketoshi, Ayako; Siddiki, S. M. A. Hakim; Murayama, Toru; Nomura, Kotohiro published the artcile< Transesterification of Ethyl-10-undecenoate Using a Cu-Deposited V2O5 Catalyst as a Model Reaction for Efficient Conversion of Plant Oils to Monomers and Fine Chemicals>, Safety of But-3-en-1-ol, the main research area is transesterification ethyl undecenoate copper vanadium oxide catalyst plant oil.

Transesterification of ethyl-10-undecenoate (derived from castor oil) with 1,4-cyclohexanedimethanol over a recyclable Cu-deposited V2O5 catalyst afforded 1,ω-diene, the corresponding cyclohexane-1,4-diylbis(methylene) bis(undec-10-enoate), a promising monomer for the synthesis of biobased polyesters, in an efficient manner. Deposition of Cu plays an important role in proceeding the reaction with high selectivity, and both the activity and the selectivity are preserved for five recycled runs by the addition of the substrates. The present catalyst was effective for transesterification with other alcs., especially primary alcs., demonstrating a possibility of using this catalyst for efficient conversion of plant oil to various fine chems.

ACS Omega published new progress about Castor oil Role: RCT (Reactant), RACT (Reactant or Reagent). 627-27-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C4H8O, Safety of But-3-en-1-ol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts