Month: October 2022

The author of 《Formulation development and evaluation of gastroretentive floating tablets of ambroxol hydrochloride》 were Malviya, Yogendra; Kondalkar, Avinash. And the article was published in Journal of Drug Delivery and Therapeutics in 2019. Application In Synthesis of trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride The author mentioned the following in the article:

The present study is focused on the development of gastroretentive floating drug delivery system of ambroxol hydrochloride, which acts as a mucolytic agent that is reported to be useful in gastric neoplasms which are designed to increase the gastric residence time, thus prolonging the drug release in the stomach. Gastro retentive floating tablets of ambroxol hydrochloride were prepared by direct compression method using altered concentrations of HPMC K4, HPMC K15 and PVP K30 as polymers. Sodium bicarbonate and citric acid was used as gas releasing agent. The prepared tablets of ambroxol hydrochloride were evaluated for hardness, thickness, friability, weight variation, drug content uniformity, buoyancy lag time, total floating time, in-vitro dissolution study, etc. All the compositions were resulted in adequate Pharmacopoeial limits. Compatibility studies was execution during FTIR shown that there was absence of probable chem. interaction between pure drug and excipients. The varying concentration of gas generating agent and polymers was found to affect on in-vitro drug release and floating lag time. In vitro drug release of floating gastro retentive tablet of ambroxol hydrochloride shown that the formulation F6 was found to be the best formulation as it releases 99.87% in a controlled manner for an extended period of time (up to 12 h). The release data was fitted to various math. models such as Higuchi, Korsmeyer-Peppas, First order and Zero order to evaluate the kinetics and mechanism of the drug release. The optimized formulation (F6) showed no significant change in phys. parameters such as, hardness, friability, weight variation and %drug content for accelerated stability condition at 40±2°C temperature and 75±5% relative humidity for a period 3 mo. Prepared floating tablets of ambroxol hydrochloride may prove to be a potential candidate for safe and effective controlled drug delivery over an extended period of time for gastro retentive drug delivery system. In the part of experimental materials, we found many familiar compounds, such as trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride(cas: 23828-92-4Application In Synthesis of trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride)

trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride(cas: 23828-92-4) is a mucolytic expectorant and a metabolite of bromhexine.Application In Synthesis of trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride It is used in the treatment of respiratory disorders characterized by viscous or excessive mucus.

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In 2017,Alachouzos, Georgios; Lenselink, Eelke B.; Mulder-Krieger, Thea; de Vries, Henk; IJzerman, Adriaan P.; Louvel, Julien published 《Synthesis and evaluation of N-substituted 2-amino-4,5-diarylpyrimidines as selective adenosine A1 receptor antagonists》.European Journal of Medicinal Chemistry published the findings.Safety of trans-4-Aminocyclohexanol The information in the text is summarized as follows:

Aminodiarylpyrimidines such as I were prepared as potential selective adenosine A1 receptor antagonists, based on a scaffold with high affinity for human adenosine A1 receptors but limited selectivity over adenosine A2a receptors. The effect of aryl structure and amino group substituents on adenosine A1 receptor antagonism and selectivity was determined I was identified as a potent (Ki(hA1AR) = 7.7 nM) and selective (Ki(hA2AAR) = 1389 nM) antagonist at the human adenosine A1 receptor; mol. docking calculations at adenosine A1 and A2a receptors were used to rationalize the effect of the 4-hydroxycyclohexyl substituent on selectivity and the nature of the pyrimidine substituents on affinity. In the experiment, the researchers used trans-4-Aminocyclohexanol(cas: 27489-62-9Safety of trans-4-Aminocyclohexanol)

trans-4-Aminocyclohexanol(cas: 27489-62-9) belongs to anime. The reaction of alkyl halides, R―X, where X is a halogen, or analogous reagents with ammonia (or amines) is useful with certain compounds. Not all alkyl halides are effective reagents; the reaction is sluggish with secondary alkyl groups and fails with tertiary ones. Its usefulness is largely confined to primary alkyl halides (those having two hydrogen atoms on the reacting site).Safety of trans-4-Aminocyclohexanol

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In 2018,European Journal of Inorganic Chemistry included an article by Hastings, Samantha D.; Cagle, Ethan C.; Totsch, Timothy R.; Tyus, Shakyra D.; Gray, Gary M.. Recommanded Product: 1195-59-1. The article was titled 《Comparative Study of Novel Phosphordiamidite and Phosphite Ligands Used in Alkene Hydroformylation; Synthesis, Characterization, Metalation, and Catalytic Evaluation》. The information in the text is summarized as follows:

Three novel ligands have been prepared by the reactions of 1,1′-(chlorophosphinediyl)bis(1H-pyrrole) with either 2-pyridinemethanol or 2,6-pyridinedimethanol or the reaction of 1,1′-biphenyl-2,2′-diyl phosphorochloridite with 2-pyridinemethanol. Measurement of |1JP-Se| values demonstrate that the phosphite donor is less basic than the phosphoramidite donors. Coordination preferences of the ligands in octahedral cis-tetracarbonylmolybdenum(0) and square planar cis-dichloropalladium(II) complexes have been evaluated using multinuclear NMR and x-ray crystallog. Rhodium(I) complexes of the bidentate ligands have been evaluated as catalysts for styrene hydroformylation, and their activities are nearly double those of catalysts containing traditional phosphites. The regioselectivities of the RhI complexes of the bidentate ligands are not significantly different at 80° and 20 atm and are not affected by the addition of a lithium salt. In contrast, changing reaction conditions causes the % n-aldehyde to vary from 15 to 50%. The regioselectivity of the catalyst containing the bidentate phosphoramidite/pyridine ligand was more sensitive to pressure than temperature with both effects being significant. In the experimental materials used by the author, we found 2,6-Pyridinedimethanol(cas: 1195-59-1Recommanded Product: 1195-59-1)

2,6-Pyridinedimethanol(cas: 1195-59-1) belongs to pyridine. Pyridine derivatives lend themselves to many roles in the spirited field of supramolecular chemistry – whether as the ligand backbone of metal-organic polymers or presiding over the key electronic stations of nanodevices. In biochemistry, pyridine-containing cofactors are necessary nutrients on which our lives depend. Recommanded Product: 1195-59-1

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In 2019,Analytical Chemistry (Washington, DC, United States) included an article by Hu, Kun; Lv, Yuanxia; Ye, Fanggui; Chen, Tao; Zhao, Shulin. Formula: C9H6O6. The article was titled 《Boric-Acid-Functionalized Covalent Organic Framework for Specific Enrichment and Direct Detection of cis-Diol-Containing Compounds by Matrix-Assisted Laser Desorption/Ionization Time-of-Flight Mass Spectrometry》. The information in the text is summarized as follows:

Design and synthesis of a novel matrix that serves as highly selective adsorption material are significant for the matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) anal. of small mols. in complicated biosamples. The authors presented a facile 1-pot strategy for the synthesis of boric-acid-functionalized covalent organic frameworks (B-COFs) by using 2,4,6-trihydroxy-1,3,5-benzenetrialdehyde, benzidine, and 4-aminophenyl-boronic acid as ligands. Compared with bare COFs, the B-COFs have similar crystallinity, sp. surface, and well-developed pore structure. The surface area and average pore size of B-COFs were 238.0 m2/g and 1.2 nm, resp. The resulting material was used as an adsorbent for selective enrichment of cis-diol-containing compounds based on an affinity reaction between phenylboronic acid and cis-diol. Using luteolin, riboflavin, and pyrocatechol as model analytes, the enrichment ability of B-COFs as a matrix was examined by MALDI-TOF MS assay, and its high selectivity against target analytes was obtained in the presence of 100 times more anti-nonspecific compounds than that even in the complicated biosample. The limits of detection for luteolin, riboflavin, and pyrocatechol were as low as fg/mL with B-COF enrichment. The B-COFs were further employed and validated for specific enrichment and direct detection of target analytes with complex samples such as human serum, milk, and Capsicum samples. Large surface area, numerous boric-acid active sites, and super stability make B-COFs with high enrichment capacity, high selectivity and sensitivity, satisfying reproducibility, and excellent applicability in MALDI-TOF MS assays. In the part of experimental materials, we found many familiar compounds, such as 2,4,6-Trihydroxybenzene-1,3,5-tricarbaldehyde(cas: 34374-88-4Formula: C9H6O6)

2,4,6-Trihydroxybenzene-1,3,5-tricarbaldehyde(cas: 34374-88-4) is a member of phloroglucinol derivatives.Formula: C9H6O6Phloroglucinols are known for their broad-spectrum antiviral, antibacterial, antifungal, antihelminthic, and phytotoxic activities.

Referemce:
Alcohol – Wikipedia,
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In 2019,Chemical Communications (Cambridge, United Kingdom) included an article by Liu, Cheng; Xia, Jiahao; Ji, Shaobo; Fan, Zhiyuan; Xu, Huaping. Quality Control of 3-Bromopropan-1-ol. The article was titled 《Visible-light-induced metathesis reaction between diselenide and ditelluride》. The information in the text is summarized as follows:

The Se-Te bond was prepared by a metathesis reaction between diselenides and ditellurides, which could be manipulated with the presence or absence of visible light. Addnl., the apparent activation energy of the exchange process was measured to be only 28.01 kJ mol-1, explaining the high reactivity and sensitivity to light. The experimental process involved the reaction of 3-Bromopropan-1-ol(cas: 627-18-9Quality Control of 3-Bromopropan-1-ol)

3-Bromopropan-1-ol(cas: 627-18-9) was used in the synthesis of fluorescent halide-sensitive quinolinium dyes and molten salt-polymers. Furthermore, it was used in the synthesis of chiral, quaternary prolines via cyclization of quaternary amino acids.Quality Control of 3-Bromopropan-1-ol

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The author of 《Facile and efficient protocols for C-C and C-N bond formation reactions using a superparamagnetic palladium complex as reusable catalyst》 were Karimi Zarchi, Mohammad Ali; Darbandizadeh Mohammad Abadi, Seyed Shahab Addin. And the article was published in Research on Chemical Intermediates in 2019. Application In Synthesis of 3-Hydroxybenzaldehyde The author mentioned the following in the article:

Facile and efficient protocols for some multicomponent coupling reactions such as the Suzuki reaction and synthesis of polyhydroquinoline and 2,3-dihydroquinazoline-4-(1H)-one derivatives using a superparamagnetic palladium complex as catalyst was developed. The results came from multiple reactions, including the reaction of 3-Hydroxybenzaldehyde(cas: 100-83-4Application In Synthesis of 3-Hydroxybenzaldehyde)

3-Hydroxybenzaldehyde(cas: 100-83-4) is used as an ionophore, during the development of an highly selective and sensitive PVC membrane sensor, which can be used as a Tb3+ ion selective electrode.Application In Synthesis of 3-Hydroxybenzaldehyde

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The author of 《Multifunctional isoquinoline-oxazoline ligands of chemical and biological importance》 were Li, Wei; Wang, Guotong; Lai, Jixing; Li, Shengkun. And the article was published in Chemical Communications (Cambridge, United Kingdom) in 2019. Application of 126456-43-7 The author mentioned the following in the article:

Multifunctional isoquinoline-oxazolines (MIQOXs) were conceived and synthesized from com. available chiral amino acids. The multifunctional role of MIQOXs was demonstrated by Pd-catalyzed highly enantioselective addition of arylboronic acids to nitrostyrenes, and by the discovery of novel antifungal candidates. In addition to this study using (1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol, there are many other studies that have used (1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol(cas: 126456-43-7Application of 126456-43-7) was used in this study.

(1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol(cas: 126456-43-7) belongs to anime. Amine, any member of a family of nitrogen-containing organic compounds that is derived, either in principle or in practice, from ammonia (NH3). Naturally occurring amines include the alkaloids, which are present in certain plants; the catecholamine neurotransmitters (i.e., dopamine, epinephrine, and norepinephrine); and a local chemical mediator, histamine, that occurs in most animal tissues.Application of 126456-43-7

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The author of 《Mechanochromic luminescent covalent organic frameworks for highly selective hydroxyl radical detection》 were Liu, Wei; Cao, Yuping; Wang, Wenzhuang; Gong, Deyan; Cao, Ting; Qian, Jing; Iqbal, Kanwal; Qin, Wenwu; Guo, Huichen. And the article was published in Chemical Communications (Cambridge, United Kingdom) in 2019. Application In Synthesis of 2,4,6-Trihydroxybenzene-1,3,5-tricarbaldehyde The author mentioned the following in the article:

The mechanochromic luminescence phenomenon was first reported in the low-cost mechanochem. (MC) synthesis process of a covalent organic framework (COF-TpMA (MC)) prepared using triformylphloroglucinol (Tp) and melamine (MA) as precursors, which shows excellent performance as a hydroxyl radical ( ̇OH) detector in living systems. This work not only shows a new kind of mechanochromic luminescent material but also exhibits a close relationship between the π-π stacking and luminescence properties of COF materials. In the experiment, the researchers used 2,4,6-Trihydroxybenzene-1,3,5-tricarbaldehyde(cas: 34374-88-4Application In Synthesis of 2,4,6-Trihydroxybenzene-1,3,5-tricarbaldehyde)

2,4,6-Trihydroxybenzene-1,3,5-tricarbaldehyde(cas: 34374-88-4) is a member of phloroglucinol derivatives. Regarding monomeric phloroglucinols, this group encompasses acryl phloroglucinols, phloroglucinol-terpene adducts, phloroglucinol glycosides, halogenated phloroglucinols, prenylated phloroglucinols, and cyclicroup polyketides.Application In Synthesis of 2,4,6-Trihydroxybenzene-1,3,5-tricarbaldehyde

Referemce:
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The author of 《Efficient production of red Monascus pigments with single non-natural amine residue by in situ chemical modification》 were Huang, Yaolin; Liu, Lujie; Zheng, Gaowei; Zhang, Xuehong; Wang, Zhilong. And the article was published in World Journal of Microbiology & Biotechnology in 2019. Reference of (1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol The author mentioned the following in the article:

Filamentous fungi Monascus sp. has been utilized for fermentative production of food colorant (Red Yeast Rice) for more than 1000 years in China. The main colorant components of Red Yeast Rice are mixture of red Monascus pigments (RMPs) with various primary amine residues. In the present work, the non-natural primary amine p-aminobenzamide, exhibiting as non-involved in nitrogen microbial metabolism, nontoxicity to microbial cells, and chem. reactivity with orange Monascus pigments (OMPs), was screened. Based on the screened result, RMPs with the single p-aminobenzamide residue were produced by cell suspension culture in a nonionic surfactant micelle aqueous solution via in situ chem. modification of OMPs. Furthermore, in situ chem. modification of OMPs also provided a strategy for maintaining a relatively low OMP concentration and then efficient accumulation of high concentration of RMPs (3.3 g/l). The experimental process involved the reaction of (1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol(cas: 126456-43-7Reference of (1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol)

(1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol(cas: 126456-43-7) belongs to anime. Left-handed and right-handed forms (mirror-image configurations, known as optical isomers or enantiomers) are possible when all the substituents on the central nitrogen atom are different (i.e., the nitrogen is chiral). With amines, there is extremely rapid inversion in which the two configurations are interconverted.Reference of (1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol

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The author of 《Effect of scaffold structures on the artificial light-harvesting systems: a case study with an AIEE-active pillar[5]arene dyad》 were Zhu, Yao; Xu, Linxian; Wang, Lingyun; Tang, Hao; Cao, Derong. And the article was published in Chemical Communications (Cambridge, United Kingdom) in 2019. Related Products of 24388-23-6 The author mentioned the following in the article:

Artificial light-harvesting systems were assembled as nanoparticles by an AIEE-active pillar[5]arene dyad H1, a complimentary fluorescent ditopic guest G2, and an optically silent tritopic guest G1 in water with CTAB. The formation of H1-G1 supramol. polymers enhanced the G2 emission and the H1-G2 energy transfer, confirming the importance of scaffold structures in the systems. After reading the article, we found that the author used 4,4,5,5-Tetramethyl-2-phenyl-1,3,2-dioxaborolane(cas: 24388-23-6Related Products of 24388-23-6)

4,4,5,5-Tetramethyl-2-phenyl-1,3,2-dioxaborolane(cas: 24388-23-6) also known as boronate ester, is generally used in metal-catalyzed C-C bond formation reactions like Suzuki–Miyaura reaction.Related Products of 24388-23-6

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