Month: October 2022

Electric Literature of C3H9NO2In 2019 ,《Novel fatty acid-based pH-responsive nanostructured lipid carriers for enhancing antibacterial delivery》 was published in Journal of Drug Delivery Science and Technology. The article was written by Osman, Nawras; Omolo, Calvin A.; Gannimani, Ramesh; Waddad, Ayman Y.; Rambharose, Sanjeev; Mocktar, Chunderika; Singh, Sanil; Parboosing, Raveen; Govender, Thirumala. The article contains the following contents:

The present study is aimed at the employment of novel fatty acid derived lipids for the preparation of pH-responsive nanostructured lipid carriers (NLCs) for vancomycin (VCM) i.v. delivery against resistant and sensitive Staphylococcus aureus bacteria. Two branched lipids [stearic acid derived solid lipid and oleic acid derived liquid lipid] were synthesized, characterized and used to fabricate NLCs by hot homogenization technique. Particle size, polydispersity index, zeta potential and encapsulation efficiency were 225.2 ± 9.1 nm, 0.258 ± 0.02, -9.2 ± 2.7 mV and 88.7 ± 13.12%, resp. An understanding of drug encapsulation efficiencies and formation of the NLCs were supported by in silico studies. In vitro antibacterial activity revealed that VCM loaded-NLCs had higher activity against methicillin-susceptible and resistant Staphylococcus aureus than the bare VCM. Cell viability study showed that NLCs had 2.5-fold better killing percentage than the bare drug at similar concentrations Furthermore, the in vivo efficacy of VCM loaded-NLCs was assessed in a mouse model of MRSA skin infection. MRSA CFU load of the skin treated with NLCs was 37-fold lower than bare VCM (p < 0.05). This novel pH-responsive NLCs may, therefore, show potential for efficient and enhanced antibiotic delivery. The experimental process involved the reaction of 2-Aminopropane-1,3-diol(cas: 534-03-2Electric Literature of C3H9NO2)

2-Aminopropane-1,3-diol(cas: 534-03-2) belongs to anime. Amine, any member of a family of nitrogen-containing organic compounds that is derived, either in principle or in practice, from ammonia (NH3). Naturally occurring amines include the alkaloids, which are present in certain plants; the catecholamine neurotransmitters (i.e., dopamine, epinephrine, and norepinephrine); and a local chemical mediator, histamine, that occurs in most animal tissues.Electric Literature of C3H9NO2

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Safety of (1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-olIn 2022 ,《Stereoselective Helix-Sense-Selective Cationic Polymerization of N-Vinylcarbazole Using Chiral Lewis Acid Catalysis》 was published in Journal of the American Chemical Society. The article was written by Sorensen, Cole C.; Leibfarth, Frank A.. The article contains the following contents:

Helical polymers with a defined main-chain atropoisomeric conformation are important materials in high value applications such as nonlinear optics and chiral separations Currently, no methods exist for the cationic helix-sense-selective polymerization of prochiral vinyl monomers, which limits access to a number of potentially valuable optically active helical polymers. Here, we demonstrate the first stereoselective cationic helix-sense-selective polymerization of a prochiral vinyl monomer, which provides access to optically active helixes of poly(N-vinylcarbazole). Chiral bis(oxazoline)-scandium Lewis acids serve as chiral counterions to polymerize N-vinylcarbazole into highly isotactic (up to 94% meso triads) polymers. Mechanistic investigations uncovered the distinct phenomenon that are responsible for independent control of conformational (i.e., helicity) and configurational (i.e., tacticity) stereochem. Polymer helicity was strongly influenced by the stereoselectivity of the first monomer propagation, whereas polymer tacticity was dictated by the thermodynamically controlled conformation of the growing polymer chain end. Overall, this method expands the suite of accessible helical polymers through helix-sense-selective polymerization and provides mechanistic insight into how polymer tacticity and helicity can be controlled independently. The experimental process involved the reaction of (1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol(cas: 126456-43-7Safety of (1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol)

(1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol(cas: 126456-43-7) belongs to anime. Milder oxidation, using reagents such as NaOCl, can remove four hydrogen atoms from primary amines of the type RCH2NH2 to form nitriles (R―C≡N), and oxidation with reagents such as MnO2 can remove two hydrogen atoms from secondary amines (R2CH―NHR′) to form imines (R2C=NR′). Tertiary amines can be oxidized to enamines (R2C=CHNR2) by a variety of reagents.Safety of (1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Name: 3-Bromopropan-1-olIn 2021 ,《How to Choose a Secondary Interaction to Improve Stretchability of Associative Polymers?》 was published in Macromolecules (Washington, DC, United States). The article was written by Yang, Huanhuan; Wu, Shilong; Chen, Quan. The article contains the following contents:

This study focuses on the stretchability of brittle ionomers after introducing three types of hydrogen bonds, i.e., dual, triple, and quadruple hydrogen bonds. The introduction of dual or triple hydrogen bonds that are weaker than the ionic association improves the stretchability, and better improvement has been achieved for the triple hydrogen bonds. In comparison, the introduction of quadruple hydrogen bonds that are equally strong as the ionic association does not show this type of improvement. This result strongly indicates that there is an optimized strength ratio between the first (the stronger ionic) network and the secondary (the weaker hydrogen-bonding) network, i.e., the secondary network should be considerably weaker but still not too weaker than the first network. When this condition is satisfied, continuous dissociation and association of the secondary network weaken the chain retraction after the strain-induced breakup of the first network, thereby suppressing the formation of defects or microscopic cracks that potentially grow into the macroscopic fracture. In addition to this study using 3-Bromopropan-1-ol, there are many other studies that have used 3-Bromopropan-1-ol(cas: 627-18-9Name: 3-Bromopropan-1-ol) was used in this study.

3-Bromopropan-1-ol(cas: 627-18-9) is used in the synthesis of fluorescent halide-sensitive quinolinium dyes, chiral, quaternary prolines through cyclization of quaternary amino acids and molten salt-polymers. It is utilized for the study of micellar media and in microemulsions based on cationic or a nonionic surfactant by reacting with phenols.Name: 3-Bromopropan-1-ol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Related Products of 627-18-9In 2021 ,《Synthesis of novel acyl derivatives of 3-(4,5,6,7-tetrabromo-1H-benzimidazol-1-yl)propan-1-ols-intracellular TBBi-based CK2 inhibitors with proapoptotic properties》 was published in International Journal of Molecular Sciences. The article was written by Chojnacki, Konrad; Winska, Patrycja; Karatsai, Olena; Koronkiewicz, Miroslawa; Milner-Krawczyk, Malgorzata; Wielechowska, Monika; Redowicz, Maria Jolanta; Bretner, Maria; Borowiecki, Pawel. The article contains the following contents:

Protein kinase CK2 has been considered as an attractive drug target for anti-cancer therapy. The synthesis of N-hydroxypropyl TBBi and 2MeTBBi derivatives as well as their resp. esters was carried out by using chemoenzymic methods. Concomitantly with kinetic studies toward recombinant CK2, the influence of the obtained compounds on the viability of two human breast carcinoma cell lines (MCF-7 and MDA-MB-231) was evaluated using MTT assay. Addnl., an intracellular inhibition of CK2 as well as an induction of apoptosis in the examined cells after the treatment with the most active compounds were studied by Western blot anal., phase-contrast microscopy and flow cytometry method. The results of the MTT test revealed potent cytotoxic activities for most of the newly synthesized compounds (EC50 4.90 to 32.77 μM), corresponding to their solubility in biol. media. We concluded that derivatives with the Me group decrease the viability of both cell lines more efficiently than their non-methylated analogs. Furthermore, inhibition of CK2 in breast cancer cells treated with the tested compounds at the concentrations equal to their EC50 values correlates well with their lipophilicity since derivatives with higher values of logP are more potent intracellular inhibitors of CK2 with better proapoptotic properties than their parental hydroxyl compounds After reading the article, we found that the author used 3-Bromopropan-1-ol(cas: 627-18-9Related Products of 627-18-9)

3-Bromopropan-1-ol(cas: 627-18-9) is used in the synthesis of fluorescent halide-sensitive quinolinium dyes, chiral, quaternary prolines through cyclization of quaternary amino acids and molten salt-polymers. It is utilized for the study of micellar media and in microemulsions based on cationic or a nonionic surfactant by reacting with phenols.Related Products of 627-18-9

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

《Sea buckthorn extract loaded into solid lipid nanoparticles》 was published in Molecular Crystals and Liquid Crystals in 2019. These research results belong to Manea-Saghin, Ana-Maria; Marin, Cosmina Andreea. Recommanded Product: rel-(3R,4S,5S,6R)-6-(Hydroxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetraol The article mentions the following:

The sea buckthorn extract used for this study was obtained from dry sea buckthorn berries. The aim of this study was to synthesize by high shear homogenization method and to characterize new solid lipid nanoparticles loaded with sea buckthorn extract, nanoparticles which show high antioxidant activity. The obtained solid lipid nanoparticles have been firstly characterized by particle diameter and phys. stability using dynamic light scattering method. The particle morphol. was examined by transmission electron microscopy and the properties of sea buckthorn extract-loaded nanoparticles have been evaluated by an appropriate in vitro anal. (chemiluminescence method). The antimicrobial properties of newly developed nano-materials were also evaluated. In addition to this study using rel-(3R,4S,5S,6R)-6-(Hydroxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetraol, there are many other studies that have used rel-(3R,4S,5S,6R)-6-(Hydroxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetraol(cas: 54-17-1Recommanded Product: rel-(3R,4S,5S,6R)-6-(Hydroxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetraol) was used in this study.

rel-(3R,4S,5S,6R)-6-(Hydroxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetraol(cas: 54-17-1) is oxidized in various tissues under either aerobic or anaerobic conditions through glycolysis; the oxidation reaction produces carbon dioxide, water, and ATP.Recommanded Product: rel-(3R,4S,5S,6R)-6-(Hydroxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetraol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Category: alcohols-buliding-blocksOn March 28, 2009, Xu, Yi; Jia, Xin; Panke, Sven; Li, Zhi published an article in Chemical Communications (Cambridge, United Kingdom). The article was 《Asymmetric dihydroxylation of aryl olefins by sequential enantioselective epoxidation and regioselective hydrolysis with tandem biocatalysts》. The article mentions the following:

Chiral aryl vicinal diols were obtained in high ee and yield by asym. dihydroxylation of aryl olefins with tandem biocatalysts, an enantioselective styrene monooxygenase, and a regioselective epoxide hydrolase.(1S)-1-(2-chlorophenyl)ethane-1,2-diol(cas: 133082-13-0Category: alcohols-buliding-blocks) was used in this study.

(1S)-1-(2-chlorophenyl)ethane-1,2-diol(cas: 133082-13-0) belongs to hydroxy-containing compounds. Hydroxy groups participate in the dehydration reactions that link simple biological molecules into long chains. The joining of a fatty acid to glycerol to form a triacylglycerol removes the −OH from the carboxy end of the fatty acid.Category: alcohols-buliding-blocks

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Electric Literature of C12H14O3On May 25, 2018, Singh, L. Ravithej; Kumar, Ajeet; Upadhyay, Akanksha; Gupta, Sampa; Palanati, Gopala Reddy; Sikka, Kamakshi; Siddiqi, Mohammad Imran; Yadav, Prem N.; Sashidhara, Koneni V. published an article in European Journal of Medicinal Chemistry. The article was 《Discovery of coumarin-dihydroquinazolinone analogs as niacin receptor 1 agonist with in-vivo anti-obesity efficacy》. The article mentions the following:

Rational designing and synthesis of coumarin-dihydroquinazolinone conjugates such as I [R1 = Me, i-Pr, s-Bu, etc.; R2 = H, 2-thienyl, 3,4-(MeO)2, etc.] to evaluate their agonist activity at GPR109a receptor was presented. Among the synthesized small mol. library, compound I [R1 = Me, R2 = 4-MeO] displayed robust agonist action at GPR109a with EC50 < 11nM. Homol. model of human GPR109a protein was generated to realize the binding interaction of the active mol. with the active site of GPR109a. Further, the efficacy of active compound I [R1 = Me, R2 = 4-MeO] was supported by in-vivo experiments which showed reduced body weight in diet induced obese mice model. Interestingly, compound I [R1 = Me, R2 = 4-MeO] reduced leptin in blood plasma and total serum cholesterol. These results suggested that the coumarin-dihydroquinazolinone conjugate is a suitable scaffold to further expand the chem. diversity and make them potential niacin receptor 1 agonist. After reading the article, we found that the author used 5-(tert-Butyl)-4-hydroxyisophthalaldehyde(cas: 153759-59-2Electric Literature of C12H14O3)

5-(tert-Butyl)-4-hydroxyisophthalaldehyde(cas: 153759-59-2) belongs to phenols.Deprotonation of a phenol forms a corresponding negative phenolate ion or phenoxide ion, and the corresponding salts are called phenolates or phenoxides (aryloxides according to the IUPAC Gold Book).Electric Literature of C12H14O3

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

In 2019,Journal of Biomaterials Science, Polymer Edition included an article by Guo, Qianqian; Zhang, Xinge. Reference of rel-(3R,4S,5S,6R)-6-(Hydroxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetraol. The article was titled 《Synthesized of glucose-responsive nanogels labeled with fluorescence molecule based on phenylboronic acid by RAFT polymerization》. The information in the text is summarized as follows:

We reported on the fabrication of sugar-responsive nanogels covalently incorporated with 3-acrylamidophenylboronic acid (AAPBA) as glucose-recognizing moiety, 2-(acrylamido)glucopyranose (AGA) as biocompatible moiety, and boron dipyrromethene (BODIPYMA) as fluorescence donor mol. The p(AAPBA-AGA-BODIPYMA) nanogels were synthesized via reversible addition-fragmentation chain transfer (RAFT) polymerization in the mixture solvents of H2O/ethanol. Nanogels could respond to glucose and size of nanogels increased after treating with 3 mg/mL glucose medium. The fluorescent intensity of nanogels varied dependent on different glucose concentrations Besides, insulin, a model drug, can be encapsulated into nanogels with the loading amount up to 8.2%. The drug release was dependent on the content of AAPBA moieties in nanogels and glucose concentrations in release medium. The investigation on the cytotoxicity of nanogels revealed that nanogels had good compatibility. Such glucose-responsive nanogels have potential in detection and treatment of diabetes. In the part of experimental materials, we found many familiar compounds, such as rel-(3R,4S,5S,6R)-6-(Hydroxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetraol(cas: 54-17-1Reference of rel-(3R,4S,5S,6R)-6-(Hydroxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetraol)

rel-(3R,4S,5S,6R)-6-(Hydroxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetraol(cas: 54-17-1) is oxidized in various tissues under either aerobic or anaerobic conditions through glycolysis; the oxidation reaction produces carbon dioxide, water, and ATP.Reference of rel-(3R,4S,5S,6R)-6-(Hydroxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetraol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

In 2019,Microscopy Research and Technique included an article by Gomes, Raimundo Nonato S.; Bhattacharjee, Tanmoy T.; Carvalho, Luis Felipe C. S.; Soares, Luis Eduardo S.. Recommanded Product: trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride. The article was titled 《Adverse effects of respiratory disease medicaments and tooth brushing on teeth: A scanning electron microscopy, X-ray fluorescence and infrared spectroscopy study》. The information in the text is summarized as follows:

The present study aims to evaluate the effect of brushing with fluoride dentifrice on teeth severely affected by erosion due to respiratory medicaments. Enamel (n = 50) and dentin (n = 50) bovine specimens were prepared and treated with artificial saliva (S-control), acebrofilin hydrochloride (AC), ambroxol hydrochloride (AM), bromhexine hydrochloride (BR), and salbutamol sulfate (SS) and subjected to cycles of demineralization (immersing in 3 mL, 1 min, three times a day at intervals of 1 h, for 5 days) followed by remineralization (saliva, 37°C, 1 h). Simulated brushing with fluoridated toothpaste was performed using 810 strokes in a reciprocal-action brushing simulator. SEM, micro energy dispersive X-ray fluorescence (μ-EDXRF) spectroscopy and attenuated total reflection Fourier transform IR (ATR FTIR) spectroscopy were then performed. μ-EDXRF images showed extensive erosion after treatment with all medicaments. SEM images showed enamel erosion in order SS > BR > AC = AM > S after brushing and fluoridation. FTIR results were in agreement. In case of dentin, μ-EDXRF measurements showed significant difference in mineral content (percent weight of calcium and phosphate) in SS + brushing + fluoridation treated enamel compared to control, while μ-EDXRF images showed erosive effects in the order SS > AM>BR > AC = S post brushing + fluoridation. SEM images showed erosion in the order SS > AM = BR > AC > S post brushing + fluoridation. Again, FTIR multivariate results were in agreement. Overall, our study shows that proper oral care is critical when taking certain medication. The study also demonstrates the possible use of FTIR for rapid clin. monitoring of tooth erosion in clinics. In addition to this study using trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride, there are many other studies that have used trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride(cas: 23828-92-4Recommanded Product: trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride) was used in this study.

trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride(cas: 23828-92-4) is a medication indicated to alleviate chest congestion associated with conditions that include bronchitis, pneumonia, bronchospasm asthma, cough, and allergy.Recommanded Product: trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride Preclinically, ambroxol, the active ingredient of Mucosolvan, has been shown to increase respiratory tract secretion.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

The author of 《Carbon nanotube-based, serially connected terahertz sensor with enhanced thermal and optical efficiencies》 were Suzuki, Daichi; Takida, Yuma; Kawano, Yukio; Minamide, Hiroaki; Terasaki, Nao. And the article was published in Science and Technology of Advanced Materials in 2022. Computed Properties of C13H19Br2ClN2O The author mentioned the following in the article:

Owing to their high thermal and optical performances, carbon nanotube (CNT) films are used in various photo-thermo-elec. (PTE) applications, such as terahertz (THz) sensing and energy harvesting. To improve the performance of PTE devices, a device structure should be designed based on a deep understanding of the thermal and optical responses of the CNT film. However, the optical properties of CNT films in the THz frequency region remain unclear because of the difficulties associated with device processing and measurements. Herein, we report our findings on the thermal and optical characteristics of CNT films. The shape of the CNT film that maximizes the product of the thermal and optical factors (optimal structure of the PTE sensor) depends on the frequency of the irradiating electromagnetic wave. The optimal film thickness and width values for THz irradiation range from 300-600 nm and 50-70μm, resp. Subsequently, we fabricated a serially connected, multi-element PTE sensor with an optimal device structure and enhanced the detection sensitivity by approx. 13 times compared with a single-element PTE sensor. In addition, we demonstrated the first THz spectroscopy application using a PTE sensor. The findings of this study, thermal/optical factor enhancement, and micro-sized CNT film processing technol. can be used to improve the performance of all CNT-based photothermal devices, including PTE sensors and thermoelec. generators. After reading the article, we found that the author used trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride(cas: 23828-92-4Computed Properties of C13H19Br2ClN2O)

trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride(cas: 23828-92-4) is a mucolytic expectorant and a metabolite of bromhexine.Computed Properties of C13H19Br2ClN2O It is used in the treatment of respiratory disorders characterized by viscous or excessive mucus.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts