Month: October 2022

In 2017,Edelstein, Emma K.; Namirembe, Sheila; Morken, James P. published 《Enantioselective Conjunctive Cross-Coupling of Bis(alkenyl)borates: A General Synthesis of Chiral Allylboron Reagents》.Journal of the American Chemical Society published the findings.Product Details of 78782-17-9 The information in the text is summarized as follows:

Pd-catalyzed conjunctive cross-coupling was used for the synthesis of enantioenriched allylboron reagents. This reaction employs nonsym. bis(alkenyl)borates as substrates and appears to occur by a mechanism that involves selective activation of the less substituted alkene followed by migration of the more substituted alkene during a Pd-induced metalate rearrangement.Bis[(pinacolato)boryl]methane(cas: 78782-17-9Product Details of 78782-17-9) was used in this study.

Bis[(pinacolato)boryl]methane(cas: 78782-17-9) belongs to organoboron compounds.Product Details of 78782-17-9 Organoboron compounds have been a cornerstone of synthetic transformations for decades. Areas such as boron-containing catalysts, metalate chemistry, photoredox methods, and boryl anions have brought significant new developments in understanding and provided new reactivity upon.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

In 2018,Armstrong, Roly J.; Nandakumar, Meganathan; Dias, Rafael M. P.; Noble, Adam; Myers, Eddie L.; Aggarwal, Varinder K. published 《Enantiodivergent Synthesis of Allenes by Point-to-Axial Chirality Transfer》.Angewandte Chemie, International Edition published the findings.Product Details of 78782-17-9 The information in the text is summarized as follows:

Nonracemic di-, tri-, and tetrasubstituted allenes were prepared by an enantiodivergent route using the homologation of (phenylselenyl)alkenylboronates such as I with lithiated alkyl diisopropylcarbamates generated with (+)-sparteine and s-BuLi and stereoselective oxidative syn-elimination and alkylative anti-elimination reactions as key steps. Nonracemic boronic esters such as II were prepared by homologation of α-seleno alkenyl boronic esters such as I with lithiated diisopropylcarbamates such as 4-MeOC6H4CH2CH2CH2OCONi-Pr2. Syn-elimination of II using mCPBA yielded the nonracemic (P)-allene III in >99% enantiospecificity, while anti-elimination of II by alkylation with MeOTf in CH2Cl2 followed by NaHCO3 in MeOH yielded (M)-allene IV in 98% enantiospecificity. By employing either oxidative or alkylative conditions, both syn and anti elimination could be achieved with complete stereospecificity. The process enables the synthesis of either M or P allenes from a single isomer of a point-chiral precursor and can be employed for the enantioselective assembly of di-, tri-, and tetrasubstituted allenes. In the experimental materials used by the author, we found Bis[(pinacolato)boryl]methane(cas: 78782-17-9Product Details of 78782-17-9)

Bis[(pinacolato)boryl]methane(cas: 78782-17-9) belongs to organoboron compounds. Organoboron compounds have been a cornerstone of synthetic transformations for decades. Areas such as boron-containing catalysts, metalate chemistry, photoredox methods, and boryl anions have brought significant new developments in understanding and provided new reactivity upon.Product Details of 78782-17-9

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

In 2018,Yamamoto, Takeshi; Murakami, Ryo; Komatsu, Satoko; Suginome, Michinori published 《Chirality-Amplifying, Dynamic Induction of Single-Handed Helix by Chiral Guests to Macromolecular Chiral Catalysts Bearing Boronyl Pendants as Receptor Sites》.Journal of the American Chemical Society published the findings.Formula: C9H11NO The information in the text is summarized as follows:

Helical chirality of poly(quinoxaline-2,3-diyl)s bearing a boronyl pendant at the 5-position of the quinoxaline ring was induced by condensation with chiral guests such as a diol, diamine, and amino alc. Reversible induction of a single-handed helical structure was achieved by using less than an equimolar amount of chiral amino alcs. to the boronyl pendants. Majority-rule-effect-based chiral amplification on the polyquinoxaline main chain was demonstrated with chiral amino alcs. with low enantiomeric excess (ee). The helical macromol. scaffold whose helicity was thus induced was utilized in palladium-catalyzed asym. silaboration of meso-methylenecyclopropane (up to 92% ee) by introducing (diarylphosphino)phenyl pendants at their side chains. In the experiment, the researchers used (1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol(cas: 126456-43-7Formula: C9H11NO)

(1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol(cas: 126456-43-7) belongs to anime. Amines characteristically form salts with acids; a hydrogen ion, H+, adds to the nitrogen. With the strong mineral acids (e.g., H2SO4, HNO3, and HCl), the reaction is vigorous. Salt formation is instantly reversed by strong bases such as NaOH. Neutral electrophiles (compounds attracted to regions of negative charge) also react with amines; alkyl halides (R′X) and analogous alkylating agents are important examples of electrophilic reagents.Formula: C9H11NO

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

In 2018,Iacono, Carmelo E.; Stephens, Thomas C.; Rajan, Teena S.; Pattison, Graham published 《A Coupling Approach for the Generation of α,α-Bis(enolate) Equivalents: Regioselective Synthesis of gem-Difunctionalized Ketones》.Journal of the American Chemical Society published the findings.Application of 78782-17-9 The information in the text is summarized as follows:

Regioselective α,α-difunctionalization adjacent to a ketone is a significant synthetic challenge. Here, we present a solution to this problem through the transition-metal-free coupling of esters with geminal bis(boron) compounds This forms an α,α-bis(enolate) equivalent which can be trapped with electrophiles including alkyl halides and fluorinating agents. This presents an efficient, convergent synthetic strategy for the synthesis of unsym. blocked ketones. After reading the article, we found that the author used Bis[(pinacolato)boryl]methane(cas: 78782-17-9Application of 78782-17-9)

Bis[(pinacolato)boryl]methane(cas: 78782-17-9) belongs to organoboron compounds. Organoboron compounds have been a cornerstone of synthetic transformations for decades. Areas such as boron-containing catalysts, metalate chemistry, photoredox methods, and boryl anions have brought significant new developments in understanding and provided new reactivity upon.Application of 78782-17-9

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

In 2019,Chemical Communications (Cambridge, United Kingdom) included an article by Tang, Jun; Cao, Shixiong; Wang, Jianli. Recommanded Product: 100-55-0. The article was titled 《CO2-switchable Pickering emulsions: efficient and tunable interfacial catalysis for alcohol oxidation in biphasic systems》. The information in the text is summarized as follows:

CO2-responsive Pickering emulsions were fabricated on the basis of polymeric nanoaggregates with adjustable surface wettability. The static Pickering emulsion system provides an efficient and sustainable platform for in situ separation and reuse of catalysts in biphasic reactions. The experimental process involved the reaction of 3-Pyridinemethanol(cas: 100-55-0Recommanded Product: 100-55-0)

3-Pyridinemethanol(cas: 100-55-0) belongs to pyridine. Pyridines are often used as catalysts or reagents; particular notice has been paid recently to how pyridine coordinates to metal centers enabling a wide range of valuable reactions. Recommanded Product: 100-55-0

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

In 2019,Journal of Molecular Liquids included an article by Abdul Samat, Nurul Fatin Nabilah; Yusoff, Rozita Binti; Aroua, Mohamed Kheireddine; Ramalingam, Anantharaj; Kassim, Mohd Azlan. HPLC of Formula: 534-03-2. The article was titled 《Solubility of CO2 in aqueous 2-amino-1, 3-propanediol (Serinol) at elevated pressures》. The information in the text is summarized as follows:

In this work, aqueous 2-amino-1, 3-propanediol solution (serinol) was investigated as a potential solvent for CO2 capture from different gas streams. Prior to CO2 solubility experiments, a qual. prediction technique was performed on serinol to ensure its potentiality as a CO2 capture solvent. This was done using COSMO-RS approach based on quantum chem. calculations Based on this approach, serinol showed good affinity towards hydrogen-bond donors which proved to be beneficial in developing intermol. interaction between serinol and CO2. The solubility of CO2 in serinol was then investigated at serinol concentrations ranging from 1 M to 3 M, temperatures ranging from 313.15 K to 353.15 K and CO2 partial pressures ranging from 1034.31 kPa to 2068.43 kPa. The solubility of CO2 in serinol reached a highest value of 1.64 mol of CO2/mol of serinol when the serinol concentration was 1 M, at 313.15 K and 2068.43 kPa. Meanwhile, Henry’s law constant of CO2 in serinol was calculated using N2O analogy at 313.15 K and 333.15 K for molar concentrations of 1 M and 3 M of serinol. Results showed that the phys. solubility of CO2 in serinol increased as the temperature and the concentration of the solution decreased. The lowest value of Henry’s law constant of CO2 was 599.4 kPa·m3·kmol-1, for 1 M of serinol at 313.15 K. In the part of experimental materials, we found many familiar compounds, such as 2-Aminopropane-1,3-diol(cas: 534-03-2HPLC of Formula: 534-03-2)

2-Aminopropane-1,3-diol(cas: 534-03-2) belongs to anime. To avoid the problem of multiple alkylation, methods have been devised for “blocking” substitution so that only one alkyl group is introduced. The Gabriel synthesis is one such method; it utilizes phthalimide, C6H4(CO)2NH, whose one acidic hydrogen atom has been removed upon the addition of a base such as KOH to form a salt.HPLC of Formula: 534-03-2

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

In 2019,Journal of Physics: Conference Series included an article by Aderohunmu, Damilola V.; Ajani, Olayinka O.; Oduselu, Gbolahan O.; Adebiyi, Ezekiel F.. Reference of 3-Hydroxybenzaldehyde. The article was titled 《Microwave-assisted synthesis of coumarin-based 5,6-dihydro pyrimidin-2(1H)-one derivatives》. The information in the text is summarized as follows:

Microwave assisted synthesis of novel coumarin-based 5,6-dihydropyrimidin-2(1H)-one derivatives was achieved via a three-step synthetic approach. The reaction was initiated with catalyst supported multicomponent reaction to produce 3-acetylcoumarin which upon condensation with five aromatic aldehydes furnished chalcones. Microwave assisted reaction of chalcones with lone pair donor and urea led to the formation of the targeted coumarin-based 5,6- dihydropyrimidin-2(1H)-ones in good-to-excellent yields. The structures were established using spectroscopic data and notable phys. properties and the results obtained were consistent with the expected structure of the products. The compounds were good for further study to authenticate their applications in drug design and material science research. After reading the article, we found that the author used 3-Hydroxybenzaldehyde(cas: 100-83-4Reference of 3-Hydroxybenzaldehyde)

3-Hydroxybenzaldehyde(cas: 100-83-4) can be used as a reactant along with ethyl acetoacetate and thiourea in the synthesis of corresponding dihydropyrimidine-2-thione (monastrol), using Yb(OTf)3 as a catalyst by Biginelli cyclocondensation reaction.Reference of 3-Hydroxybenzaldehyde

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

The author of 《Photo-Cross-Linkable Coumarin-Based Poly(ε-caprolactone) for Light-Controlled Design and Reconfiguration of Shape-Memory Polymer Networks》 were Defize, Thomas; Thomassin, Jean-Michel; Ottevaere, Heidi; Malherbe, Cedric; Eppe, Gauthier; Jellali, Rachid; Alexandre, Michael; Jerome, Christine; Riva, Raphael. And the article was published in Macromolecules (Washington, DC, United States) in 2019. Name: 3-Bromopropan-1-ol The author mentioned the following in the article:

Photochem. cross-linked shape-memory polymer (SMP) materials have been achieved by functionalizing chain-ends of star-shaped poly(ε-caprolactone) (PCL) with 7-hydroxypropoxy-4-methylcoumarin followed by photodimerization of these end-groups. The kinetics of the network formation in function of the photosensitizer concentration has been studied by swelling experiments and rheol. Thanks to the design of a dedicated homemade mold, highly reproducible irradiation conditions have been achieved allowing to study the network formation and properties, especially the shape-memory properties, in relation to the coumarin dimerization degree as determined by Raman spectroscopy. In optimized conditions, PCL-based SMP materials exhibiting high fixity and recovery have been achieved in remarkably short irradiation time, typically 5 min. In addition, the precise control of the network cross-link d. with the irradiation time, so as the high stability of the formed networks toward temperature variations was also demonstrated allowing the fine-tuning of the network properties by the irradiation process. Finally, the reversible character of the coumarin dimerization under light irradiation of appropriate wavelength has been quantified by Raman spectroscopy. The dimer photocleavage allows the photoreconfiguration of the networks offering the ability to modify the “”permanent”” shape of the SMP material, while preserving the excellent shape-memory properties. In the experiment, the researchers used 3-Bromopropan-1-ol(cas: 627-18-9Name: 3-Bromopropan-1-ol)

3-Bromopropan-1-ol(cas: 627-18-9) is used in the synthesis of fluorescent halide-sensitive quinolinium dyes, chiral, quaternary prolines through cyclization of quaternary amino acids and molten salt-polymers. It is utilized for the study of micellar media and in microemulsions based on cationic or a nonionic surfactant by reacting with phenols.Name: 3-Bromopropan-1-ol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

《Iron(II)-Catalyzed Biomimetic Aerobic Oxidation of Alcohols》 was published in Angewandte Chemie, International Edition in 2020. These research results belong to Guethmundsson, Arnar; Schlipkoeter, Kim Elisabeth; Baeckvall, Jan-E.. COA of Formula: C7H7BrO The article mentions the following:

The first iron(II)-catalyzed biomimetic aerobic oxidation of alcs was reported. The principle of this oxidation, which involved several electron-transfer steps, was reminiscent of biol. oxidation in respiratory chain. The electron transfer from alc. to mol. oxygen occurred with aid of three coupled catalytic redox systems, led to a low-energy pathway. An iron transfer-hydrogenation complex was utilized as a substrate-selective dehydrogenation catalyst, along with an electron-rich quinone and an oxygen-activating Co(salen)-type complex as electron-transfer mediators. Various primary and secondary alcs. were oxidized in air to the corresponding aldehydes or ketones with this method in good to excellent yields. In the part of experimental materials, we found many familiar compounds, such as (4-Bromophenyl)methanol(cas: 873-75-6COA of Formula: C7H7BrO)

(4-Bromophenyl)methanol(cas: 873-75-6) undergoes three-component reaction with acetylferrocene and arylboronic acid to give ferrocenyl ketones containing biaryls.COA of Formula: C7H7BrO It undergoes efficient trimethylsilylation reaction with 1,1,1,3,3,3-hexamethyldisilazane in the presence of catalytic amount of aspartic acid in acetonitrile.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

《Anticonvulsant and analgesic in neuropathic pain activity in a group of new aminoalkanol derivatives》 was published in Bioorganic & Medicinal Chemistry Letters in 2020. These research results belong to Panczyk, Katarzyna; Rapacz, Anna; Furgala-Wojas, Anna; Salat, Kinga; Koczurkiewicz-Adamczyk, Paulina; Lucjanek, Martyna; Skiba-Kurek, Iwona; Karczewska, Elzbieta; Sowa, Aleksandra; Zelaszczyk, Dorota; Siwek, Agata; Popiol, Justyna; Pekala, Elzbieta; Marona, Henryk; Waszkielewicz, Anna. Recommanded Product: trans-4-Aminocyclohexanol The article mentions the following:

As part of the presented research, thirteen new aminoalkanol derivatives were designed and obtained by chem. synthesis. In vivo studies (mice, i.p.) showed anticonvulsant activity (MES) of nine compounds, and in the case of one compound (R,S-trans-2-((2-(2,3,5-trimethylphenoxy)ethyl)amino)cyclohexan-1-ol, 4) both anticonvulsant (ED50 MES = 15.67 mg/kg, TD50 rotarod = 78.30 mg.kg, PI = 5.00) and analgesic activity (OXA-induced neuropathic pain, active at 15 mg/kg). For selected active compounds addnl. in vitro studies have been performed, including receptor studies (5-HT1A), evaluation of antioxidant activity (DPPH assay), metabolism studies as well as safety panel (mutagenicity, safety in relation to the gastrointestinal flora, cytotoxicity towards astrocytes as well as impact on their proliferation and cell cycle). In the experiment, the researchers used trans-4-Aminocyclohexanol(cas: 27489-62-9Recommanded Product: trans-4-Aminocyclohexanol)

trans-4-Aminocyclohexanol(cas: 27489-62-9) belongs to anime. Nitrous acid converts secondary amines (aliphatic or aromatic) to N-nitroso compounds (nitrosamines): R2NH + HNO2 → R2N―NO. Some nitrosamines are potent cancer-inducing substances, and their possible formation is a serious consideration when nitrites, which are salts of nitrous acid, are present in foods or pharmaceutical preparations. Tertiary amines give rise to nitrosamines more slowly; an alkyl group is eliminated as an aldehyde or ketone, along with nitrous oxide, N2O.Recommanded Product: trans-4-Aminocyclohexanol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts