Month: October 2022

Giofre, Sabrina; Molteni, Letizia; Nava, Donatella; Lo Presti, Leonardo; Beccalli, Egle Maria published an article in 2021. The article was titled 《Enantio- and Regioselective Palladium(II)-Catalyzed Dioxygenation of (Aza-)Alkenols》, and you may find the article in Angewandte Chemie, International Edition.Category: alcohols-buliding-blocks The information in the text is summarized as follows:

An oxidative Pd-catalyzed intra-intermol. dioxygenation of (aza-)alkenols were reported, with total regioselectivity. To study the stereoselectivity, different chiral ligands as well as different hypervalent-iodine compounds was compared. In particular, by using a C-6 modified pyridinyl-oxazoline (Pyox) ligand and hypervalent iodine bearing an aromatic ring, an excellent enantio- and diastereoselectivity was achieved. In the experiment, the researchers used many compounds, for example, 5-Hexen-1-ol(cas: 821-41-0Category: alcohols-buliding-blocks)

5-Hexen-1-ol(cas: 821-41-0) is used in cyclization to a tetrahydropyran by phenylselenoetherification. It is also used as a building block in synthetic chemistry.Category: alcohols-buliding-blocks

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

In 2022,Ding, Yi-Xuan; Zhu, Zhou-Hao; Chen, Mu-Wang; Yu, Chang-Bin; Zhou, Yong-Gui published an article in Angewandte Chemie, International Edition. The title of the article was 《Rhodium-Catalyzed Asymmetric Hydrogenation of All-Carbon Aromatic Rings》.Recommanded Product: 89466-08-0 The author mentioned the following in the article:

Compared with heteroarenes, homogeneous asym. hydrogenation of all-carbon aromatic rings is a longstanding challenge in organic synthesis due to the strong aromaticity and difficult enantioselective control. Herein, authors report the rhodium/diphosphine-catalyzed asym. hydrogenation of all-carbon aromatic rings, affording a series of axially chiral cyclic compounds with high enantioselectivity through desymmetrization or kinetic resolution In addition, the central-chiral cyclic compounds were also obtained by asym. hydrogenation of phenanthrenes bearing a directing group. The key to success is the introduction of chiral diphosphine ligands with steric hindrance and strong electron-donating properties. The axially chiral monophosphine ligands could be obtained by simple conversion of the hydrogenation products bearing the phosphine atom. The experimental process involved the reaction of 2-Hydroxyphenylboronic acid(cas: 89466-08-0Recommanded Product: 89466-08-0)

2-Hydroxyphenylboronic acid(cas: 89466-08-0) belongs to acyl phenylboronic acid. Phenylboronic acid (PBA) has been used to extract β-blockers (a class of aminoalcohol-containing drugs) from aqueous solution, rat, and human plasma. Recommanded Product: 89466-08-0

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

In 2022,Xu, Haiting; Luo, Ruifeng; Dong, Lingling; Pu, Xiulan; Chen, Qiyan; Ye, Naijing; Qi, Shanshan; Han, Xiaoqin; Nie, Wenbiao; Fu, Chaomei; Hu, Yichen; Zhang, Jinming; Gao, Fei published an article in Nanomedicine (New York, NY, United States). The title of the article was 《pH/ROS dual-sensitive and chondroitin sulfate wrapped poly (β-amino ester)-SA-PAPE copolymer nanoparticles for macrophage-targeted oral therapy for ulcerative colitis》.Formula: C4H11NO The author mentioned the following in the article:

An oral nanoparticle (NPs) encapsulated in chitosan/alginate hydrogel (CA-Gel) with dual-sensitive in pH and reactive oxygen species (ROS) was developed to load curcumin (CUR) based on the intracellular-specific characteristics of macrophages. Chondroitin sulfate (CS) wrapped PBAE-SA-PAPE with intracellular pH/ROS dual-sensitive characteristics and CUR via a simple nanopptn. method to form NPs (CS-CUR-NPs), and mixed CA-Gel to acquire the final preparation (CS-CUR-NPs-Gel). CS-CUR-NPs displayed an ideal average particle size (179.19 ± 5.61 nm) and high encapsulating efficiency (94.74 ± 1.15%). CS showed a good targeting ability on macrophages and the CA-Gel contribution in protecting NPs from being destroyed in the upper gastrointestinal tract. As expected, CS-CUR-NPs-Gel could significantly alleviate inflammation in DSS-induced UC mice via TLR4-MAPK/NF-ΚB pathway. This study is the first to attempt to design a novel pH/ROS dual-stimulated release strategy in helping intracellular CUR delivery and anticipated for efficient anti-UC therapy. In the experimental materials used by the author, we found 4-Aminobutan-1-ol(cas: 13325-10-5Formula: C4H11NO)

4-Aminobutan-1-ol(cas: 13325-10-5) is used in the synthesis of NSAIDs with anti-inflammatory properties. Also used in the synthesis of polyamine transport ligands with specificity against human cancers allowing easy access to specific cancer cells.Formula: C4H11NO

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

In 2022,Tu, Chenhao; Ma, Nana; Xu, Qingli; Guo, Wenyue; Zhou, Lanxin; Zhang, Guisheng published an article in International Journal of Quantum Chemistry. The title of the article was 《Computational study on the mechanism of metal-free photochemical borylation of aryl halides》.Category: alcohols-buliding-blocks The author mentioned the following in the article:

C-radical borylation is a significant approach for the construction of carbonboron bond. Photochem. borylation of aryl halides successfully applied this strategy. However, precise mechanisms, such as the generation of aryl radicals and the role of base additive (TMDAM) and water, remain controversy in these reactions. In this study, photochem. borylation of aryl halides has been researched by d. functional theory (DFT) calculations Indeed, the homolytic cleavage of the CX bond under irradiation with UV-light is a key step for generation of aryl radicals. Nevertheless, the generation of aryl radicals may also undergo the process of single electron transfer and the heterolytic carbonhalogen bond cleavage sequence, and the latter is favorable during the reaction. The experimental process involved the reaction of 4,4,5,5-Tetramethyl-2-phenyl-1,3,2-dioxaborolane(cas: 24388-23-6Category: alcohols-buliding-blocks)

4,4,5,5-Tetramethyl-2-phenyl-1,3,2-dioxaborolane(cas: 24388-23-6) also known as boronate ester, is generally used in metal-catalyzed C-C bond formation reactions like Suzuki–Miyaura reaction.Category: alcohols-buliding-blocks

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

In 2022,Corpas, Javier; Gomez-Mendoza, Miguel; Ramirez-Cardenas, Jonathan; de la Pena O’Shea, Victor A.; Mauleon, Pablo; Gomez Arrayas, Ramon; Carretero, Juan C. published an article in Journal of the American Chemical Society. The title of the article was 《One-Metal/Two-Ligand for Dual Activation Tandem Catalysis: Photoinduced Cu-Catalyzed Anti-hydroboration of Alkynes》.Related Products of 7748-36-9 The author mentioned the following in the article:

A dual catalyst system based on ligand exchange of two diphosphine ligands possessing different properties in a copper complex has been devised to merge metal- and photocatalytic activation modes. This strategy has been applied to the formal anti-hydroboration of activated internal alkynes via a tandem sequence in which Cu/Xantphos catalyzes the B2pin2-syn-hydroboration of the alkyne whereas Cu/BINAP serves as a photocatalyst for visible light-mediated isomerization of the resulting alkenyl boronic ester. Photochem. studies by means of UV-vis absorption, steady-state and time-resolved fluorescence, and transient absorption spectroscopy have allowed characterizing the photoactive Cu/BINAP species in the isomerization reaction and its interaction with the intermediate syn-alkenyl boronic ester through energy transfer from the triplet excited state of the copper catalyst. In addition, mechanistic studies shed light into catalyst speciation and the interplay between the two catalytic cycles as critical success factors. The results came from multiple reactions, including the reaction of Oxetan-3-ol(cas: 7748-36-9Related Products of 7748-36-9)

Oxetan-3-ol(cas: 7748-36-9) is used as a reagent in the synthesis of 5-fluoro-4,6-dialkoxypyrimidine GPR119 agonists. It is also used as a reagent in the synthesis of cyclic sulfone hydroxyethylamines as potent and selective β-site APP-cleaving enzyme 1 (BACE1) inhibitors.Related Products of 7748-36-9

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

COA of Formula: C4H12KNaO10In 2014 ,《Ultrasensitive resonance scattering (RS) spectral detection for trace tetracycline in milk using aptamer-coated nanogold (ACNG) as a catalyst》 appeared in Journal of Agricultural and Food Chemistry. The author of the article were Luo, Yanfang; He, Lan; Zhan, Shenshan; Wu, Yuangen; Liu, Le; Zhi, Wenting; Zhou, Pei. The article conveys some information:

This paper reports an ultrasensitive resonance scattering (RS) method to detect tetracycline (TET) in milk based on the competition of aptamers between nanogold and TET, aggregation of naked nanogold, nanocatalytic Fehling reaction, and RS signals of catalytic product Cu2O cubic. The detection principle was confirmed by the nanoparticle size analyzer (NANOS), SEM, and X-ray diffraction (XRD). The variations of RS intensity had good linear correlation with TET concentrations, and the limit of detection was calculated as 11.6 nM. The proposed method was successfully applied for anal. of TET in milk, with total recoveries ranging from 105 to 109%. After reading the article, we found that the author used Potassium sodium (2R,3R)-2,3-dihydroxysuccinate tetrahydrate(cas: 6381-59-5COA of Formula: C4H12KNaO10)

Potassium sodium (2R,3R)-2,3-dihydroxysuccinate tetrahydrate(cas: 6381-59-5) is a ferroelectric crystal with a high piezoelectric effect and electromechanical coupling coefficient. COA of Formula: C4H12KNaO10 As a Biuret reagent, it is used to measure the protein concentration. Furthermore, it is used as laxative and is also used in food industry.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Synthetic Route of C13H26B2O4In 2017 ,《Enantioselective Synthesis of anti-1,2-Oxaborinan-3-enes from Aldehydes and 1,1-Di(boryl)alk-3-enes Using Ruthenium and Chiral Phosphoric Acid Catalysts》 was published in Journal of the American Chemical Society. The article was written by Miura, Tomoya; Nakahashi, Junki; Zhou, Wang; Shiratori, Yota; Stewart, Scott G.; Murakami, Masahiro. The article contains the following contents:

A cationic Ru(II) complex catalyzes double-bond transposition of 1,1-di(boryl)alk-3-enes to generate in situ 1,1-di(boryl)alk-2-enes, which then undergo chiral H3PO4 catalyzed allylation of aldehydes producing homoallylic alcs. with a (Z)-vinylboronate moiety. 1,2-Anti stereochem. is installed in an enantioselective manner. The (Z)-geometry forged in the products allows their isolation in a form of 1,2-oxaborinan-3-enes, upon which further synthetic transformations are operated. The experimental process involved the reaction of Bis[(pinacolato)boryl]methane(cas: 78782-17-9Synthetic Route of C13H26B2O4)

Bis[(pinacolato)boryl]methane(cas: 78782-17-9) belongs to organoboron compounds. Organoboron compounds have been a cornerstone of synthetic transformations for decades. Areas such as boron-containing catalysts, metalate chemistry, photoredox methods, and boryl anions have brought significant new developments in understanding and provided new reactivity upon.Synthetic Route of C13H26B2O4

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Name: 3-PyridinemethanolIn 2019 ,《Uniform silver nanoparticles on tunable porous N-doped carbon nanospheres for aerobic oxidative synthesis of aryl nitriles from benzylic alcohols》 was published in Applied Organometallic Chemistry. The article was written by Hashemi, Alireza Nemati; Eshghi, Hossein; Lamei, Kamran. The article contains the following contents:

Tunable N-doped carbon nanospheres were prepared from sucrose as carbon source and tris(2-aminoethyl)amine (TAEA) as nitrogen source by a simple and easily reproducible method. It was demonstrated that the tunable N-doping of carbon spheres could be realized by altering the ratio of TAEA in the raw materials. The content of doped nitrogen, surface area, pore volume and pore size of carbon nanospheres were increased with the increasing of TAEA amount in the hydrothermal process. Prepared N-doped carbon nanospheres acted as solid ligand for anchoring of Ag NPs which was generated via chem. reduction of Ag ions. Benzylic alcs. and aldehydes were converted into the aryl nitriles R-CN [R = Ph, 3-pyridyl, 3-HOC6H4, etc.] by using Ag/N-CS-1 nanospheres as the catalyst and O2 as the oxidant, efficiently. This catalyst was stable and could use for 6 successful runs. The experimental process involved the reaction of 3-Pyridinemethanol(cas: 100-55-0Name: 3-Pyridinemethanol)

3-Pyridinemethanol(cas: 100-55-0) belongs to pyridine. Pyridines, quinolines, and isoquinolines have found a function in almost all aspects of organic chemistry. Pyridine has found use as a solvent, base, ligand, functional group, and molecular scaffold. As structural elements, these moieties are potent electron-deficient groups, metal-directing functionalities, fluorophores, and medicinally important pharmacophores. Name: 3-Pyridinemethanol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

COA of Formula: C6H15NOIn 2021 ,《Stepwise Crystallization and Induced Microphase Separation in Nucleobase-Monofunctionalized Supramolecular Poly(ε-caprolactone)》 was published in Macromolecules (Washington, DC, United States). The article was written by Li, Xing; Xu, Wenqing; Chang, Xiaohua; Zheng, Ying; Ni, Lingling; Shan, Guorong; Bao, Yongzhong; Pan, Pengju. The article contains the following contents:

End functionalization of homopolymers by noncovalent binding units is a straightforward approach to prepare supramol. polymers with a broad application scope as stimuli-responsive functional materials. Crystallization and microphase separation of end groups and polymer blocks can lead to the formation of short- and long-range ordered structures in end-functionalized supramol. polymers. Herein, we report the controlled synthesis, stepwise crystallization kinetics, and crystallization-induced microphase separation and structural evolution of a novel end-functionalized supramol. polymer, thymine-monofunctionalized poly(ε-caprolactone) (PCL-Thy). PCL-Thy with high end functionality and adjustable composition was synthesized by ring-opening polymerization using hydroxyl-functionalized thymine as the initiator. PCL-Thy showed a double-crystalline nature; its thymine units and PCL blocks crystallized and melted in a stepwise manner in the cooling and subsequent heating processes. The crystallization of thymine units from the melt resulted in an ordered and aligned thymine stack, which further drove the microphase separation and long-range lamellar organization of the PCL-Thy. The subsequent crystallization of PCL blocks occurred in a confined manner between the pre-existing thymine lamellae and slightly decreased the regularity of lamellar ordering. The PCL chains, which crystallized between the thymine lamellae, transformed from nonfolded to single-folded crystals upon increasing the PCL block length. This work offers important insights into crystallization-induced microphase separation and hierarchical ordering in double-crystalline supramol. polymers. In the experiment, the researchers used 6-Aminohexan-1-ol(cas: 4048-33-3COA of Formula: C6H15NO)

6-Aminohexan-1-ol(cas: 4048-33-3) can undergo cyclization over copper supported on γ-alumina and magnesia to form hexahydro-1H-azepine. It may be used along with glutaric acid to generate poly(ester amide)s with excellent film- and fiber forming properties.COA of Formula: C6H15NO

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

HPLC of Formula: 126456-43-7In 2020 ,《CuII/TEMPO-Catalyzed Enantioselective C(sp3)-H Alkynylation of Tertiary Cyclic Amines through Shono-Type Oxidation》 was published in Angewandte Chemie, International Edition. The article was written by Gao, Pei-Sen; Weng, Xin-Jun; Wang, Zhen-Hua; Zheng, Chao; Sun, Bing; Chen, Zhi-Hao; You, Shu-Li; Mei, Tian-Sheng. The article contains the following contents:

A novel strategy for asym. Shono-type oxidative cross-coupling has been developed by merging copper catalysis and electrochem., affording C1-alkynylated tetrahydroisoquinolines with good to excellent enantioselectivity. The use of TEMPO as a co-catalytic redox mediator is crucial not only for oxidizing a tetrahydroisoquinoline to an iminium ion species but also for decreasing the oxidation potential of the reaction. A novel bisoxazoline ligand is also reported. The results came from multiple reactions, including the reaction of (1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol(cas: 126456-43-7HPLC of Formula: 126456-43-7)

(1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol(cas: 126456-43-7) belongs to anime. Primary amines having a tertiary alkyl group (R3CNH2) are difficult to prepare with most methods but are made industrially by the Ritter reaction. In this method a tertiary alcohol reacts with hydrogen cyanide (HCN) in the presence of a concentrated strong acid; a formamide, RNH―CHO, is formed first, which then undergoes hydrolysis.HPLC of Formula: 126456-43-7

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts