Month: October 2022

Ling, Huiping; Li, Hong; Chen, Meijun; Lai, Baolong; Zhou, Haiming; Gao, Hui; Zhang, Jiangye; Huang, Yan; Tao, Yiwen published an article in 2021. The article was titled 《Discovery of a Highly Potent and Novel Gambogic Acid Derivative as an Anticancer Drug Candidate》, and you may find the article in Anti-Cancer Agents in Medicinal Chemistry.SDS of cas: 627-18-9 The information in the text is summarized as follows:

Gambogic Acid (GA), a promising anti-cancer agent isolated from the resin of Garcinia species in Southeast Asia, exhibits high potency in inhibiting a wide variety of cancer cells growth. Moreover, the fact that it is amenable to chem. modification makes GA an attractive mol. for the development of anti-cancer agents. Gambogic acid-3-(4-pyrimidinyloxy) Pr ester (compound 4) was derived from the reaction between 4-hydroxypropoxy pyrimidine and GA. Its structure was elucidated by comprehensive anal. of ESIMS, HRESIMS, 1 D NMR data. Anti-tumor activities of compound 4 and GA in vitro against HepG-2, A549 and MCF-7 cells were investigated by MTT assay. FITC/PI dye was used to test apoptosis. The binding affinity difference of compound 4 and GA binding to IKKΒ was studied by using Discovery Studio 2016. Compound 4 was successfully synthesized and showed strong inhibitory effects on HepG-2, A549 and MCF-7 cells lines with an IC<> 50 value of 1.49±0.11, 1.37±0.06 and 0.64±0.16μM, resp. Mol. docking study demonstrated that four more hydrogen bonds were established between IKKΒ and compound 4, compared with GA. Our results suggested that compound 4 showed significant effects in inducing apoptosis. Further mol. docking study indicated that the introduction of pyrimidine could improve GAs binding affinity to IKKbeta. Compound 4 may serve as a potential lead compound for the development of new anti-cancer drugs. In the experiment, the researchers used 3-Bromopropan-1-ol(cas: 627-18-9SDS of cas: 627-18-9)

3-Bromopropan-1-ol(cas: 627-18-9) was used in the synthesis of fluorescent halide-sensitive quinolinium dyes and molten salt-polymers. Furthermore, it was used in the synthesis of chiral, quaternary prolines via cyclization of quaternary amino acids.SDS of cas: 627-18-9

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Wong, Siu Wai; Vivash, Lucy; Mudududdla, Ramesh; Nguyen, Nghi; Hermans, Stefan J.; Shackleford, David M.; Field, Judith; Xue, Lian; Aprico, Andrea; Hancock, Nancy C.; Haskali, Mohammad; Stashko, Michael A.; Frye, Stephen V.; Wang, Xiaodong; Binder, Michele D.; Ackermann, Uwe; Parker, Michael W.; Kilpatrick, Trevor J.; Baell, Jonathan B. published an article in 2021. The article was titled 《Development of [18F]MIPS15692, a radiotracer with in vitro proof-of-concept for the imaging of MER tyrosine kinase (MERTK) in neuroinflammatory disease》, and you may find the article in European Journal of Medicinal Chemistry.Application of 27489-62-9 The information in the text is summarized as follows:

MER tyrosine kinase (MERTK) upregulation is associated with M2 polarization of microglia, which plays a vital role in neuroregeneration following damage induced by neuroinflammatory diseases such as multiple sclerosis (MS). Therefore, a radiotracer specific for MERTK could be of great utility in the clin. management of MS, for the detection and differentiation of neuroregenerative and neurodegenerative processes. This study aimed to develop an [18F] ligand with high affinity and selectivity for MERTK as a potential positron emission tomog. (PET) radiotracer. MIPS15691 and MIPS15692 were synthesized and kinase assays were utilized to determine potency and selectivity for MERTK. Both compounds were shown to be potent against MERTK, with resp. IC50 values of 4.6 nM and 4.0 nM, and were also MERTK-selective. Plasma and brain pharmacokinetics were measured in mice and led to selection of MIPS15692 over MIPS15691. X-ray crystallog. was used to visualize how MIPS15692 is recognized by the enzyme. [18F]MIPS15692 was synthesized using an automated iPHASE FlexLab module, with a molar activity (Am) of 49 ± 26 GBq/μmol. The radiochem. purity of [18F]MIPS15692 was >99% and the decay-corrected radiochem. yields (RCYs) were determined as 2.45 ± 0.85%. Brain MERTK protein d. was measured by a saturation binding assay in the brain slices of a cuprizone mouse model of MS. High levels of specific binding of [18F]MIPS15692 to MERTK were found, especially in the corpus callosum/hippocampus (CC/HC). The in vivo PET imaging study of [18F]MIPS15692 suggested that its neuroPK is sub-optimal for clin. use. Current efforts are underway to optimize the neuroPK of our next generation PET radiotracers for maximal in vivo utility. The experimental process involved the reaction of trans-4-Aminocyclohexanol(cas: 27489-62-9Application of 27489-62-9)

trans-4-Aminocyclohexanol(cas: 27489-62-9) belongs to anime. Amines have a free lone pair with which they can coordinate to metal centers. Amine–metal bonds are weaker because amines are incapable of backbonding, but they are still important for sensing applications.While stronger than hydrogen bonds, amine–metal bonds are still weaker than both covalent and ionic bonds.Application of 27489-62-9

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Fallica, Antonino Nicolo; Barbaraci, Carla; Amata, Emanuele; Pasquinucci, Lorella; Turnaturi, Rita; Dichiara, Maria; Intagliata, Sebastiano; Gariboldi, Marzia Bruna; Marras, Emanuela; Orlandi, Viviana Teresa; Ferroni, Claudia; Martini, Cecilia; Rescifina, Antonio; Gentile, Davide; Varchi, Greta; Marrazzo, Agostino published an article in 2021. The article was titled 《Nitric Oxide Photo-Donor Hybrids of Ciprofloxacin and Norfloxacin: A Shift in Activity from Antimicrobial to Anticancer Agents》, and you may find the article in Journal of Medicinal Chemistry.Safety of 3-Aminopropan-1-ol The information in the text is summarized as follows:

The potential anticancer effect of fluoroquinolone antibiotics has been recently unveiled and related to their ability to interfere with DNA topoisomerase II. We herein envisioned the design and synthesis of novel Ciprofloxacin and Norfloxacin nitric oxide (NO) photo-donor hybrids to explore the potential synergistic antitumor effect exerted by the fluoroquinolone scaffold and NO eventually produced upon light irradiation Anticancer activity, evaluated on a panel of tumor cell lines, showed encouraging results with IC50 values in the low micromolar range. Some compounds displayed intense antiproliferative activity on triple-neg. and doxorubicin-resistant breast cancer cell lines, paving the way for their potential use to treat aggressive, refractory and multidrug-resistant breast cancer. No significant additive effect was observed on PC3 and DU145 cells following NO release. Conversely, antimicrobial photodynamic experiments on both Gram-neg. and Gram-pos. microorganisms displayed a significant killing rate in Staphylococcus aureus, accounting for their potential effectiveness as selective antimicrobial photosensitizers. The experimental part of the paper was very detailed, including the reaction process of 3-Aminopropan-1-ol(cas: 156-87-6Safety of 3-Aminopropan-1-ol)

3-Aminopropan-1-ol(cas: 156-87-6) belongs to anime. The methylamines occur in small amounts in some plants. Many polyfunctional amines (i.e., those having other functional groups in the molecule) occur as alkaloids in plants—for example, mescaline, 2-(3,4,5-trimethoxyphenyl)ethylamine; the cyclic amines nicotine, atropine, morphine, and cocaine; and the quaternary salt choline, N-(2-hydroxyethyl)trimethylammonium chloride, which is present in nerve synapses and in plant and animal cells.Safety of 3-Aminopropan-1-ol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Papa Spadafora, Bruna; Moreira Ribeiro, Francisco Wanderson; Matsushima, Jullyane Emi; Ariga, Elaine Miho; Omari, Isaac; Soares, Priscila Machado Arruda; de Oliveira-Silva, Diogo; Vinhato, Elisangela; McIndoe, J. Scott; Carita Correra, Thiago; Rodrigues, Alessandro published an article in 2021. The article was titled 《Regio- and diastereoselective Pd-catalyzed aminochlorocyclization of allylic carbamates: scope, derivatization, and mechanism》, and you may find the article in Organic & Biomolecular Chemistry.Safety of Potassium sodium (2R,3R)-2,3-dihydroxysuccinate tetrahydrate The information in the text is summarized as follows:

The regio- and diastereoselective synthesis of oxazolidinones I [R1 = Et, Ph, 2-naphthyl, etc.; R2 = P(O)(OEt)2, Ph, Ts, etc.] via a Pd-catalyzed vicinal C-N/C-Cl bond-forming reaction from internal alkenes of allylic carbamates was reported. The oxazolidinones were obtained in yields of 44 to 95% with high to excellent diastereoselectivities (from 6 : 1 to >20 : 1 dr) from readily available precursors. This process was scalable and the products were suitable for the synthesis of useful amino alcs. A detailed theor. and exptl. mechanistic study was carried out to describe that the reaction proceeds through an anti-aminopalladation of the alkene followed by an oxidative C-Pd(II) cleavage with retention of the carbon stereochem. to yield the major diastereomer. The role of Cu(II) in a C-Cl bond-forming mechanism step had also been proposed. The results came from multiple reactions, including the reaction of Potassium sodium (2R,3R)-2,3-dihydroxysuccinate tetrahydrate(cas: 6381-59-5Safety of Potassium sodium (2R,3R)-2,3-dihydroxysuccinate tetrahydrate)

Potassium sodium (2R,3R)-2,3-dihydroxysuccinate tetrahydrate(cas: 6381-59-5) is a ferroelectric crystal with a high piezoelectric effect and electromechanical coupling coefficient. Safety of Potassium sodium (2R,3R)-2,3-dihydroxysuccinate tetrahydrate It may be used as a constituent to prepare DNS (3,5- dinitrosalicylic acid) reagent and Fehling′s solution B, which are used in the determination of reducing sugar.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

In 2022,Ikeda, Shuhei; Kajita, Yuichi; Miyamoto, Maki; Matsumiya, Kouta; Ishii, Tsuyoshi; Nishi, Toshiya; Gay, Sean C.; Lane, Weston; Constantinescu, Cristian C.; Alagille, David; Papin, Caroline; Tamagnan, Gilles; Kuroita, Takanobu; Koike, Tatsuki published an article in European Journal of Medicinal Chemistry. The title of the article was 《Design and synthesis of aryl-piperidine derivatives as potent and selective PET tracers for cholesterol 24-hydroxylase (CH24H)》.Recommanded Product: 18621-18-6 The author mentioned the following in the article:

Cholesterol 24-hydroxylase (CH24H, CYP46A1) is a cytochrome P 450 family enzyme that maintains the homeostasis of brain cholesterol. Soticlestat, a potent and selective CH24H inhibitor, is in development as a therapeutic agent for Dravet syndrome and Lennox-Gastaut syndrome. Herein, we report the discovery of aryl-piperidine derivatives as potent and selective CH24H positron emission tomog. (PET) tracers which can be used for dose guidance of a clin. CH24H inhibitor and as a diagnostic tool for CH24H-related pathol. Starting from compound I (IC50 = 16 nM, logD = 1.7), which was reported as a CH24H inhibitor with lower lipophilicity, a 18F-labeling site (3-fluoroazetidine) was incorporated by structure-based drug design (SBDD) utilizing the co-crystal structure of a compound I analog. Subsequent optimization to adjust key parameters for PET tracers, such as potency, lipophilicity, brain penetration, and unbound plasma protein binding, enabled compound II [Ar = 4-FC6H4, X = N] (IC50 = 8.8 nM) and compound II [Ar = 4-chloropyrazol-1-yl, X = CH] (IC50 = 8.7 nM) as PET imaging candidates. Selectivity of these compounds for CH24H was validated by a brain distribution study using CH24H-WT and KO mice. In non-human primate PET imaging, [18F] labeled analogs showed similar regional uptake in the brain, indicating that these tracers were specific to the CH24H-expressed regions and validated the expression of CH24H in the living brain by different tracers. After reading the article, we found that the author used Azetidin-3-ol hydrochloride(cas: 18621-18-6Recommanded Product: 18621-18-6)

Azetidin-3-ol hydrochloride(cas:18621-18-6) is one of azetidine.Azetidines (azacyclobutanes) constitute a well-known class of heterocyclic compounds. Azetidine scaffold has been discovered in several natural products.Recommanded Product: 18621-18-6 Several pharmacologically important synthetic compounds also contain azetidine ring. Because of inherent ring strain, the synthesis of azetidines is a challenging endeavor.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

In 2022,Yao, Qi-Jun; Chen, Jia-Hao; Song, Hong; Huang, Fan-Rui; Shi, Bing-Feng published an article in Angewandte Chemie, International Edition. The title of the article was 《Cobalt/Salox-Catalyzed Enantioselective C-H Functionalization of Arylphosphinamides》.COA of Formula: C9H11NO The author mentioned the following in the article:

Previous methods on Co(III)-catalyzed asym. C-H activation rely on the use of tailor-made cyclopentadienyl-ligated Co(III) complexes, which require lengthy steps for the preparation Herein, the authors report an unprecedented enantioselective C-H functionalization enabled by a simple Co/salicyloxazoline (Salox) catalysis. The chiral Salox ligands can be easily prepared in one step from salicylonitrile and chiral amino alcs. A broad range of P-stereogenic compounds were synthesized in high yields with excellent enantioselectivities (45 examples, up to 99% yield and >99% ee). The isolation and characterization of several intermediates provided insights into the generation of active catalytic Co species, the action of Salox, and the mode of stereocontrol. The experimental part of the paper was very detailed, including the reaction process of (1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol(cas: 126456-43-7COA of Formula: C9H11NO)

(1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol(cas: 126456-43-7) belongs to anime. Hydrogen peroxide (H2O2) and peroxy acids generally add an oxygen atom to the nitrogen of amines. With primary amines, this step is normally followed by further oxidation, leading to nitroso compounds, RNO, or nitro compounds, RNO2. Secondary amines are converted to hydroxylamines, R2NOH, and tertiary amines to amine oxides, R3NO.COA of Formula: C9H11NO

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Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

In 2022,Guo, Ruoxuan; Liu, Yang; Huo, Yingzhong; Zhang, Anrui; Hong, Jiahui; Ai, Yuejie published an article in Journal of Colloid and Interface Science. The title of the article was 《Chelating effect between uranyl and pyridine N containing covalent organic frameworks: A combined experimental and DFT approach》.Product Details of 34374-88-4 The author mentioned the following in the article:

Covalent organic frameworks (COFs) are promising adsorbents for removing heavy metal ions, and have high crystallinity, a porous structure, and conjugated stability. N-containing functional groups are known to have great affinity for uranyl ions. In this work, to explore the peculiarity of the pyridine N structure as an efficient adsorbent, we chose 2,2′-dipyridine-5,5′-diamine (Bpy) and pyridine-2,5′-diamine (Py) as the core skeletons, and 1,3,5-triformylphloroglucinol (Tp) as the linker to synthesize two crystalline and stable N-containing COFs named TpBpy and TpPy, resp., through a facile solvothermal method. Characterization results demonstrated that TpBpy and TpPy possessed regularly growing pore sizes, large sp. surface areas and relatively strong thermal resistances. The results of batch experiments showed that both COF materials were capable of the effective removal of uranyl with uptake capacities of 115.45 mg g-1 and 291.79 mg g-1, resp. In addition, d. functional theory (DFT) simulations highlighted the beneficial chelation effect of the double N structure in pyridine monomers for removing uranyl ions. Combining systematic exptl. and theor. analyses, the adsorption process and interaction mode of porous COFs and UO2+2 were revealed, to provide predictable support for the application of pyridine N-containing COFs in the field of environmental remediation.2,4,6-Trihydroxybenzene-1,3,5-tricarbaldehyde(cas: 34374-88-4Product Details of 34374-88-4) was used in this study.

2,4,6-Trihydroxybenzene-1,3,5-tricarbaldehyde(cas: 34374-88-4) is a member of phloroglucinol derivatives. Regarding monomeric phloroglucinols, this group encompasses acryl phloroglucinols, phloroglucinol-terpene adducts, phloroglucinol glycosides, halogenated phloroglucinols, prenylated phloroglucinols, and cyclicroup polyketides.Product Details of 34374-88-4

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Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Recommanded Product: 6-Aminohexan-1-olIn 2020 ,《Photoactivated Polymersome Nanomotors: Traversing Biological Barriers》 appeared in Angewandte Chemie, International Edition. The author of the article were Shao, Jingxin; Cao, Shoupeng; Williams, David S.; Abdelmohsen, Loai K. E. A.; van Hest, Jan C. M.. The article conveys some information:

Synthetic nanomotors are appealing delivery vehicles for the dynamic transport of functional cargo. Their translation toward biol. applications is limited owing to the use of non-degradable components. Furthermore, size has been an impediment owing to the importance of achieving nanoscale (ca. 100 nm) dimensions, as opposed to microscale examples that are prevalent. Herein, we present a hybrid nanomotor that can be activated by near-IR (NIR)-irradiation for the triggered delivery of internal cargo and facilitated transport of external agents to the cell. Utilizing biodegradable poly(ethylene glycol)-b-poly(D,L-lactide) (PEG-PDLLA) block copolymers, with the two blocks connected via a pH sensitive imine bond, we generate nanoscopic polymersomes that are then modified with a hemispherical gold nanocoat. This Janus morphol. allows such hybrid polymersomes to undergoing photothermal motility in response to thermal gradients generated by plasmonic absorbance of NIR irradiation, with velocities ranging up to 6.2±1.10μm s-1. These polymersome nanomotors (PNMs) are capable of traversing cellular membranes allowing intracellular delivery of mol. and macromol. cargo. In the experimental materials used by the author, we found 6-Aminohexan-1-ol(cas: 4048-33-3Recommanded Product: 6-Aminohexan-1-ol)

6-Aminohexan-1-ol(cas: 4048-33-3) can undergo cyclization over copper supported on γ-alumina and magnesia to form hexahydro-1H-azepine. It may be used along with glutaric acid to generate poly(ester amide)s with excellent film- and fiber forming properties.Recommanded Product: 6-Aminohexan-1-ol

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Alcohol – Wikipedia,
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SDS of cas: 4048-33-3In 2021 ,《Electrostatic spinning based on aqueous polyurethane block-modified polycaprolactone and its hydrophilicity study》 appeared in Macromolecular Materials and Engineering. The author of the article were Wang, Faqiang; Wang, Xueting; Xi, Yanni; Liu, Kexin; Li, Zhanxiong. The article conveys some information:

In this study, waterborne polyurethane hydrophilic block copolymer PCL-b-WPU is obtained through step-growth addition polymerization reaction to improve the hydrophilicity of polycaprolactone (PCL). Then, films are prepared via solution casting method and electrospinning. PCL-b-WPU nanofibrous membranes have a higher initial water contact angle of 106°, but they can be completely wetted from the surface to the back within 120 s, with good wet absorption and quick-drying performance. Hollow fibers are fabricated via coaxial electrospinning by controlling the process parameters. PCL-b-WPU is used as shell material and polyoxyethylene as the core. Low-field NMR technol. is used to analyze the moisture distribution and the state of water within solid, porous, and porous hollow fibers. Their bound water is 14.5%, 27.5%, and 31.1%, resp. These results suggest that the introduction of the WPU chain and the construction of a rough surface significantly improve the hydrophilicity of PCL. PCL-b-WPU membranes are expected to be further developed and utilized for moisture-absorbing and quick-drying textiles, wound dressings, and biol. scaffolds. In the part of experimental materials, we found many familiar compounds, such as 6-Aminohexan-1-ol(cas: 4048-33-3SDS of cas: 4048-33-3)

6-Aminohexan-1-ol(cas: 4048-33-3) can undergo cyclization over copper supported on γ-alumina and magnesia to form hexahydro-1H-azepine. It may be used along with glutaric acid to generate poly(ester amide)s with excellent film- and fiber forming properties.SDS of cas: 4048-33-3

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Reference of 5-Hexen-1-olIn 2020 ,《First total synthesis of 5(S)-hydroxyrecifeiolide》 appeared in Synthetic Communications. The author of the article were Kalyankar, Kondbarao Balasaheb; Das, Saibal. The article conveys some information:

The first total synthesis of recently isolated 5(S)-hydroxyrecifeiolide (I) has been described in ten straight forward linear steps with 14% of overall yield. The key reaction involves Jacobsen’s hydrolytic kinetic resolution, Copper catalyzed Grignard reaction, Steglich esterification and ring closing metathesis reaction using Grubbs 2nd generation catalyst making the synthesis very elegant and simple. The stereogenic center at C5 was generated via Jacobsen’s HKR which was confirmed by the Mandelate ester strategy as well as HPLC purity. In addition to this study using 5-Hexen-1-ol, there are many other studies that have used 5-Hexen-1-ol(cas: 821-41-0Reference of 5-Hexen-1-ol) was used in this study.

5-Hexen-1-ol(cas: 821-41-0) is used in cyclization to a tetrahydropyran by phenylselenoetherification. It is also used as a building block in synthetic chemistry.Reference of 5-Hexen-1-ol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts