Month: October 2022

《Zinc triflate catalyzed synthesis of thioethers》 was written by Baddam, Sudhakar Reddy; Neelam, Uday Kumar; Manne, Naga Raju; Adulla, Panasa Reddy; Bandichhor, Rakeshwar. Related Products of 63012-03-3 And the article was included in Chemistry & Biology Interface on April 30 ,2014. The article conveys some information:

Zinc triflate-catalyzed aralkylation of thiols using various substituted benzylic alcs. was developed for the synthesis of thioether (sulfide) derivatives This procedure presents a greener approach for the synthesis of sulfides. The experimental process involved the reaction of (3-Chlorophenyl)(phenyl)methanol(cas: 63012-03-3Related Products of 63012-03-3)

(3-Chlorophenyl)(phenyl)methanol(cas: 63012-03-3) belongs to hydroxy-containing compounds. Hydroxy groups participate in the dehydration reactions that link simple biological molecules into long chains. The creation of a peptide bond to link two amino acids to make a protein removes the −OH from the carboxy group of one amino acid.Related Products of 63012-03-3

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Alcohol – Wikipedia,
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《ZnMe2-Mediated, Direct Alkylation of Electron-Deficient N-Heteroarenes with 1,1-Diborylalkanes: Scope and Mechanism》 was written by Jo, Woohyun; Baek, Seung-yeol; Hwang, Chiwon; Heo, Joon; Baik, Mu-Hyun; Cho, Seung Hwan. Formula: C13H26B2O4This research focused onzinc promoted regioselective alkylation pyridine quinoline diborylalkane. The article conveys some information:

The regioselective, direct alkylation of electron-deficient N-heteroarenes is, in principle, a powerful and efficient way of accessing alkylated N-heteroarenes that are important core structures of many biol. active compounds and pharmaceutical agents. Herein, we report a ZnMe2-promoted, direct C2- or C4-selective primary and secondary alkylation of pyridines and quinolines using 1,1-diborylalkanes as alkylation sources. While substituted pyridines and quinolines exclusively afford C2-alkylated products, simple pyridine delivers C4-alkylated pyridine with excellent regioselectivity. The reaction scope is remarkably broad, and a range of C2- or C4-alkylated electron-deficient N-heteroarenes are obtained in good yields. Exptl. and computational mechanistic studies imply that ZnMe2 serves not only as an activator of 1,1-diborylalkanes to generate (α-borylalkyl)methylalkoxy zincate, which acts as a Lewis acid to bind to the nitrogen atom of the heterocycles and controls the regioselectivity, but also as an oxidant for rearomatizing the dihydro-N-heteroarene intermediates to release the product.Bis[(pinacolato)boryl]methane(cas: 78782-17-9Formula: C13H26B2O4) was used in this study.

Bis[(pinacolato)boryl]methane(cas: 78782-17-9) belongs to organoboron compounds.Formula: C13H26B2O4 Organoboron compounds have been a cornerstone of synthetic transformations for decades. Areas such as boron-containing catalysts, metalate chemistry, photoredox methods, and boryl anions have brought significant new developments in understanding and provided new reactivity upon.

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Computed Properties of C9H13NOOn November 2, 2020 ,《Site-Specific C(sp3)-H Aminations of Imidates and Amidines Enabled by Covalently Tethered Distonic Radical Anions》 appeared in Angewandte Chemie, International Edition. The author of the article were Zhao, Rong; Fu, Kang; Fang, Yuanding; Zhou, Jia; Shi, Lei. The article conveys some information:

The utilization of N-centered radicals to synthesize nitrogen-containing compounds has attracted considerable attention recently, due to their powerful reactivities and the concomitant construction of C-N bonds. However, the generation and control of N-centered radicals remain particularly challenging. We report a tethering strategy using SOMO-HOMO-converted distonic radical anions for the site-specific aminations of imidates and amidines with aid of the non-covalent interaction. This reaction features a remarkably broad substrate scope and also enables the late-stage functionalization of bioactive mols. Furthermore, the reaction mechanism is thoroughly investigated through kinetic studies, Raman spectroscopy, ESR spectroscopy, and d. functional theory calculations, revealing that the aminations likely involve direct homolytic cleavage of N-H bonds and subsequently controllable 1,5 or 1,6 hydrogen atom transfer. The experimental part of the paper was very detailed, including the reaction process of 2-Amino-2-(4-methylphenyl)ethan-1-ol(cas: 157142-48-8Computed Properties of C9H13NO)

2-Amino-2-(4-methylphenyl)ethan-1-ol(cas: 157142-48-8) belongs to anime. Amine, any member of a family of nitrogen-containing organic compounds that is derived, either in principle or in practice, from ammonia (NH3). Naturally occurring amines include the alkaloids, which are present in certain plants; the catecholamine neurotransmitters (i.e., dopamine, epinephrine, and norepinephrine); and a local chemical mediator, histamine, that occurs in most animal tissues.Computed Properties of C9H13NO

Referemce:
Alcohol – Wikipedia,
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Product Details of 20880-92-6On June 8, 2022, Zhou, Xukai; Yu, Tingting; Dong, Guangbin published an article in Journal of the American Chemical Society. The article was 《Site-Specific and Degree-Controlled Alkyl Deuteration via Cu-Catalyzed Redox-Neutral Deacylation》. The article mentions the following:

A Cu-catalyzed degree-controlled deacylative deuteration of diverse alkyl groups with the methylketone (acetyl) moiety as a traceless activating group was reported. The use of N-methylpicolino-hydrazonamide (MPHA) promotes efficient aromatization-driven C-C cleavage. Mono-, di-, and trideuteration at specific sites was selectively achieved. The reaction is redox-neutral with broad functional group tolerance. The utility of this method was demonstrated in forming a complete set of deuterated Et groups, merging with the Diels-Alder reaction, a net devinylative deuteration, and the synthesis of the d2-analog of Austedo. In the part of experimental materials, we found many familiar compounds, such as ((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol(cas: 20880-92-6Product Details of 20880-92-6)

((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol(cas: 20880-92-6) is a useful reactant for examining the effectiveness of sulfamate and sulfamide groups for the inhibition of carbonic anhydrase-​II (CA-​II)​.Product Details of 20880-92-6 And it is used as chiral auxiliaries in Michael and Aldol addition reactions.

Referemce:
Alcohol – Wikipedia,
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SDS of cas: 23828-92-4On October 31, 2019 ,《Design and evaluation of anti-fibrosis drug engineered resealed erythrocytes for targeted delivery》 appeared in Drug Delivery and Translational Research. The author of the article were Dey, Piyali; Banerjee, Subham; Mandal, Santa; Chattopadhyay, Pronobesh. The article conveys some information:

Resealed erythrocytes (RSE) are potential, site-specific carrier system for drug delivery with prolonged drug release activity. In this study, erythrocytes obtained from Wistar albino rats were loaded with ambroxol hydrochloride (AH) with the focus to convenience the lung targeting possibility of the carrier erythrocytes. AH loading in erythrocytes using preswell dilution technique with glutaraldehyde (GA) as a crosslinking agent was evaluated and validated. Drug-loaded erythrocyte was characterized in terms of in vitro drug release followed by osmotic fragility study which showed amplified drug entrapment efficiency (DEE) and Hb content values as well. In vivo lung fibrosis study, rats were sensitized to egg albumin by i.p. (i.p.) injection and then inhalation in a whole body inhalation chamber. A sign of inflammation, airway sub-mucosal fibrosis, hypertrophy, and hyperplasia was observed A series of in vivo studies were carried out to describe the effect of AH-loaded RSE including measurement of cytokines in Bronchoalveolar Lavage (BAL) fluid and histopathol. study. AH showed a stepwise reduced level of cytokines in BAL at a different time interval after being injected of AH-loaded RSE. Furthermore, in vivo lung distribution experiments were performed for optimized formulation, and degree of distribution of the drugs inside the targeted organ was found to be satisfactory. The results came from multiple reactions, including the reaction of trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride(cas: 23828-92-4SDS of cas: 23828-92-4)

trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride(cas: 23828-92-4) enhances pulmonary surfactant production and stimulates ciliary activity.SDS of cas: 23828-92-4 It promotes mucus clearance, facilitates expectoration and eases productive cough, allowing patients to breathe.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

In 2013,Chemistry – A European Journal included an article by Ogasawara, Masamichi; Arae, Sachie; Watanabe, Susumu; Nakajima, Kiyohiko; Takahashi, Tamotsu. Category: alcohols-buliding-blocks. The article was titled 《Kinetic Resolution of Planar-Chiral 1,2-Disubstituted Ferrocenes by Molybdenum-Catalyzed Asymmetric Intraannular Ring-Closing Metathesis》. The information in the text is summarized as follows:

The kinetic resolution of racemic planar-chiral 1,2-disubstituted ferrocene derivatives, e.g., rac-1-allyl-2-methallylferrocene (1b) was accomplished through a Mo catalyzed asym. intrannular ring-closing metathesis reaction. E.g., rac-1b reacted with the precatalysts, Mo(:NC6H3-2,6-iPr2)(:CHCMe2Ph)(NC4H2)2/(R)-3,3′-(2,4,6-iPr3C6H2)2-binaphthol (5 mol%) in dry benzene at room temperature to give (S)-1b in 37% yield (96% ee) and (+)(η5-cyclopentadienyl)(η5-4,7-dihydro-5-methylindenyl)iron(II) in 60% yield (72% ee). In the experimental materials used by the author, we found (R)-3,3′-Di-tert-butyl-5,5′,6,6′-tetramethylbiphenyl-2,2′-diol(cas: 329735-68-4Category: alcohols-buliding-blocks)

(R)-3,3′-Di-tert-butyl-5,5′,6,6′-tetramethylbiphenyl-2,2′-diol(cas: 329735-68-4) belongs to phenols. Phenols are more acidic than typical alcohols.Category: alcohols-buliding-blocks The acidity of the hydroxyl group in phenols is commonly intermediate between that of aliphatic alcohols and carboxylic acids (their pKa is usually between 10 and 12).

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

In 2019,Angewandte Chemie, International Edition included an article by Yu, Wan-Lei; Luo, Yong-Chun; Yan, Lei; Liu, Dan; Wang, Zhu-Yin; Xu, Peng-Fei. Product Details of 20880-92-6. The article was titled 《Dehydrogenative Silylation of Alkenes for the Synthesis of Substituted Allylsilanes by Photoredox, Hydrogen-Atom Transfer, and Cobalt Catalysis》. The information in the text is summarized as follows:

A synergistic catalytic method combining photoredox catalysis, hydrogen-atom transfer, and proton-reduction catalysis for the dehydrogenative silylation of alkenes was developed. With this approach, a highly concise route to substituted allylsilanes has been achieved under very mild reaction conditions without using oxidants. This transformation features good to excellent yields, operational simplicity, and high atom economy. Based on control experiments, a possible reaction mechanism is proposed. The experimental process involved the reaction of ((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol(cas: 20880-92-6Product Details of 20880-92-6)

((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol(cas: 20880-92-6) is a useful reactant for examining the effectiveness of sulfamate and sulfamide groups for the inhibition of carbonic anhydrase-​II (CA-​II)​. And it is used as chiral auxiliaries in Michael and Aldol addition reactions.Product Details of 20880-92-6

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

In 2022,Physical Chemistry Chemical Physics included an article by Shinkai, Takahiro; Hsu, Po-Jen; Fujii, Asuka; Kuo, Jer-Lai. Formula: C3H5F3O. The article was titled 《Infrared spectroscopy and theoretical structure analyses of protonated fluoroalcohol clusters: the impact of fluorination on the hydrogen bond networks》. The information in the text is summarized as follows:

To explore the impact of fluorination on the hydrogen bond networks of protonated alkylalcs., IR spectroscopy and theor. computations of protonated 2,2,2-trifluoroethanol clusters, H+(TFE)n, (n = 4-7), were performed. It has been demonstrated that the development of the hydrogen bond networks from a linear type to cyclic types occurs in this size region for the protonated alkylalc. clusters. In contrast, IR spectroscopy of H+(TFE)n in the OH/CH stretch region clearly indicated that the linear type structures are held in the whole size range, irresp. of temperature of the clusters. The extensive stable isomer structure search of H+(TFE)n based on our latest sampling approach supported the strong preference of the linear type hydrogen bond networks. Detailed analyses of the free OH stretching vibrational bands evidenced the intra- and intermol. OH···FC interactions in the clusters. In addition, IR spectra of protonated clusters of 2,2-difluoroethanol, 2,2-difluoropropanol, and 3,3,3-trifluoropropanol were measured for n = 4 and 5, and their spectra also indicated the effective inhibition of the cyclic hydrogen bond network formation by the fluorination.3,3,3-Trifluoropropan-1-ol(cas: 2240-88-2Formula: C3H5F3O) was used in this study.

3,3,3-Trifluoropropan-1-ol(cas: 2240-88-2) is a important organic intermediate. It can be used in agrochemical, pharmaceutical and dyestuff field.Formula: C3H5F3O

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Alcohol – Wikipedia,
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Lee, Minhan; Jung, Hoimin; Kim, Dongwook; Park, Jung-Woo; Chang, Sukbok published an article in Journal of the American Chemical Society. The title of the article was 《Modular Tuning of Electrophilic Reactivity of Iridium Nitrenoids for the Intermolecular Selective α-Amidation of β-Keto Esters》.Formula: C12H20O6 The author mentioned the following in the article:

Ir-catalyzed intermol. amino group transfer to β-keto esters (amides) to α-aminocarbonyl products with excellent chemoselectivity was reported. The key strategy was engineered electrophilicity of the putative Ir-nitrenoids by tuning electronic property of the κ2-N,O chelating ligands, thus facilitated nucleophilic addition of enol π-bonds of 1,3-dicarbonyl substrates. The results came from multiple reactions, including the reaction of ((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol(cas: 20880-92-6Formula: C12H20O6)

((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol(cas: 20880-92-6) is a useful reactant for examining the effectiveness of sulfamate and sulfamide groups for the inhibition of carbonic anhydrase-​II (CA-​II)​. And it is used as chiral auxiliaries in Michael and Aldol addition reactions.Formula: C12H20O6

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

The author of 《Development of sustained release matrix tablet formulation and evaluation of ambroxol hydrochloride》 were Chandra, S.; Kavibharathi, S.; Parthiban, M.; Suresh, R.; Alisha, A. Sheik; Nandhini, B.. And the article was published in World Journal of Pharmaceutical Research in 2020. Recommanded Product: trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride The author mentioned the following in the article:

A review. Ambroxyl is a Mucolytic expectorant. Ambroxyl has short half life (3- 4hrs) makes the development of sustained release forms extremely advantageous, Ambroxyl is a weak acidic pka 4.5 – 6, it has pH dependent solubility, characterized in low pH condition present in stomach, Which consequently delayed in onset of action, Formulation of SR tablet is effective approach for mucolytic expectorant it gives maximum action with prolong drug concentration due to sustained release from tablet matrix. Different formulation (F1 – F7) designed with HPMC K100, HPMC 5CPS, Povidone K30, MCCP. pre and post -compression parameters for all formulation were studied. Batch F7 selected as optimized batch on the basis of dissolution profile. The results came from multiple reactions, including the reaction of trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride(cas: 23828-92-4Recommanded Product: trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride)

trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride(cas: 23828-92-4) is a mucolytic expectorant and a metabolite of bromhexine.Recommanded Product: trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride It is used in the treatment of respiratory disorders characterized by viscous or excessive mucus.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts