Month: October 2022

Maier, Thomas M.; Gawron, Martin; Coburger, Peter; Bodensteiner, Michael; Wolf, Robert; van Leest, Nicolaas P.; de Bruin, Bas; Demeshko, Serhiy; Meyer, Franc published the artcile< Low-Valence Anionic α-Diimine Iron Complexes: Synthesis, Characterization, and Catalytic Hydroboration Studies>, Synthetic Route of 403-41-8, the main research area is iron diimine low valent complex preparation ketone hydroboration catalyst; crystal mol structure iron diimine low valent ferrate complex.

The synthesis of rare anionic heteroleptic and homoleptic α-diimine iron complexes is described. Heteroleptic BIAN complexes [(cod)Fe(BIAN)][K([18]c-6)(thf)0.5] (1) and [(dnbe)Fe(BIAN)][K([18]c-6)(thf)2] (2; H2BIAN = N,N’-Dipp2-1,2-acenaphtylenediamine, cod = 1,5-cyclooctadiene, dnbe = 5,5′-dinorbornene-6,6′-diyl)were synthesized by reduction of the [(BIAN)FeBr2] precursor complex using stoichiometric amounts of potassium graphite in the presence of the corresponding olefin. The electronic structure of these paramagnetic species was investigated by numerous spectroscopic analyses (NMR, EPR, 57Fe Mossbauer, UV-vis), magnetic measurements (Evans NMR method, SQUID), and theor. techniques (DFT, CASSCF). Whereas anion 1 is a low-spin complex, anion 2 consists of an intermediate-spin Fe(III) center. Both complexes are efficient precatalysts for the hydroboration of carbonyl compounds under mild reaction conditions. The reaction of bis(anthracene) ferrate(1-) gave the homoleptic BIAN complex 3-[K([18]c-6)(thf)], which is less catalytically active. The electronic structure was elucidated with the same techniques as described for complexes 1-[K([18]c-6)(thf)0.5] and 2-[K([18]c-6)(thf)2] and revealed an Fe(II) species in a quartet ground state. Highly reduced ferrate anions were synthesized and structurally characterized. The mol. structures were elucidated by X-ray crystallog. Because of the presence of redox-active α-diimine ligands, the electronic situation was thoroughly analyzed using high-level quantum chem. calculations 57Fe-Mossbauer, EPR, NMR, and UV-vis spectroscopies and SQUID magnetization measurements were employed to characterize the spectroscopic and magnetic properties. Two of the new complexes prepared are precatalysts for the hydroboration of carbonyl compounds requiring low catalyst loadings.

Inorganic Chemistry published new progress about Crystal structure. 403-41-8 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H9FO, Synthetic Route of 403-41-8.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Hosseiny Davarani, Saied Saeed; Pourahadi, Ahmad; Ghasemzadeh, Peivand published the artcile< Quantification of controlled release leuprolide and triptorelin in rabbit plasma using electromembrane extraction coupled with HPLC-UV>, Application In Synthesis of 104-76-7, the main research area is HPLC UV plasma determination controlled release leuprolide triptorelin pharmacokinetics; electromembrane extraction HPLC controlled release leuprolide triptorelin; Electromembrane extraction; Leuprolide; Pharmacokinetic; Rabbit plasma; Triptorelin.

An electromembrane extraction followed by HPLC-UV technique was developed and validated for quantification of leuprolide and triptorelin in rabbit plasma. The influencing parameters on the extraction efficiency were optimized using exptl. design methodol. The optimized conditions were found to be; supported liquid membrane: a mixture of 1-octanol and 2-Et hexanol (1:1) containing 10% volume/volume di(2-ethylhexyl) phosphate, applied voltage: 5 V, extraction time: 5 min, pH of the donor phase: 4.5 and pH of the acceptor phase: 1.0. The optimized method was validated for linearity, intraday and interday precision, and accuracy in rabbit plasma. The range of quantification for both peptides was 0.5-1000 ng/mL with regression coefficients higher than 0.994. Relative recoveries of leuprolide and triptorelin were found to be 80.3 and 75.5%, resp. Limits of quantification and detection for both peptides were found to be 0.5 and 0.15 ng/mL, resp. The validated method was successfully applied to pharmacokinetic study of the 1-mo depot formulations of each peptide after s.c. administration to rabbits.

Electrophoresis published new progress about Blood analysis. 104-76-7 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H18O, Application In Synthesis of 104-76-7.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Geringer, Scott A.; Singh, Yashapal; Hoard, Daniel J.; Demchenko, Alexei V. published the artcile< A Highly Efficient Glycosidation of Glycosyl Chlorides by Using Cooperative Silver(I) Oxide-Triflic Acid Catalysis>, Synthetic Route of 4064-06-6, the main research area is cooperative silver catalyzed glycosidation benzoyl benzyl protected glycosyl chloride; activation; carbohydrates; glycosyl chlorides; glycosylation; silver oxide.

Following our discovery that silver(I) oxide-promoted glycosylation with glycosyl bromides can be greatly accelerated in the presence of catalytic TMSOTf or TfOH, we report herein a new discovery that glycosyl chlorides are even more effective glycosyl donors under these reaction conditions. The developed reaction conditions work well with a variety of glycosyl chlorides. Both benzoylated and benzylated chlorides have been successfully glycosidated, and these reaction conditions proved to be effective in coupling substrates containing nitrogen and sulfur atoms. Another convenient feature of this glycosylation is that the progress of the reaction can be monitored visually; its completion can be judged by the disappearance of the characteristic dark color of Ag2O.

Chemistry – A European Journal published new progress about Benzoyl group (protecting). 4064-06-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C12H20O6, Synthetic Route of 4064-06-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Graton, J.; Besseau, F.; Goupille, A.; Le Questel, J.-Y. published the artcile< Hydrogen-bond acidity of silanols: A combined experimental and theoretical study>, Name: Triphenylmethanol, the main research area is quantum chem hydrogen bond acidity silanol.

The hydrogen-bond (H-bond) donating ability of a series of silanol derivatives has been determined by FTIR spectrometry and complemented by quantum chem. calculations at the DFT (MPWB1K/6-31+G(d,p)) level. The equilibrium constants of complexation with N-methylpyrrolidinone have been measured in CCl4 solutions These data expand the pKAHY scale previously covering the field of aliphatic alcs., phenols and fluorohydrins. Compared to the corresponding alc. derivatives, the silanol chem. function is a stronger H-bond donor, although the observed frequency shifts, ΔνOH, suggest much greater differences in donor strength than is actually observed The electrostatic potential descriptor, Vα(r), is successfully used to complete the pKAHY vs. Vα(r) relationship, a helpful methodol. to validate the exptl. data and to estimate the H-bond acidity of unavailable, unstable, or immiscible compounds

Journal of Molecular Structure published new progress about Acidity. 76-84-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C19H16O, Name: Triphenylmethanol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Firsin, I. D.; Chuchelkin, I. V.; Gavrilov, V. K.; Trunina, V. M.; Zimarev, V. S.; Zheglov, S. V.; Gavrilov, K. N.; Goulioukina, N. S. published the artcile< Chiral P*,S-bidentate diamidophosphites with 1,2-thioether alcohol-based exocyclic substituents in asymmetric Pd-catalyzed reactions>, COA of Formula: C8H10OS, the main research area is chiral bidentate diamidophosphite thioether alc exocyclic palladium catalyst.

Chiral P*,S-diamidophosphites with a 1,3,2-diazaphospholidine core and exocyclic 1,2-hydroxyl-thioether fragments were prepared These asym. inducers provided up to 86% ee in the Pd-catalyzed allylic substitution of (E)-1,3-diphenylallyl acetate with di-Me malonate and pyrrolidine, and up to 76% in the Pd-mediated allylic alkylation of cinnamyl acetate with Et 2-oxocyclohexane-1-carboxylate.

Phosphorus, Sulfur and Silicon and the Related Elements published new progress about Allylic alkylation catalysts, stereoselective. 699-12-7 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H10OS, COA of Formula: C8H10OS.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Yin, Li-Ming; Sun, Meng-Chan; Si, Xiao-Ju; Yang, Dandan; Song, Mao-Ping; Niu, Jun-Long published the artcile< Nickel-Catalyzed anti-Markovnikov Hydrodifluoroalkylation of Unactivated Alkenes>, Product Details of C4H8O, the main research area is alkene difluoroalkyl bromide nickel catalyst regioselective anti Markovnikov hydrodifluoroalkylation; ethyldifluorooxo phenylamino alkanoate preparation.

An efficient Ni-catalyzed hydrodifluoroalkylation of unactivated alkenes with bromodifluoroacetate by using PhSiH3 as hydride source was developed. The transformation affords aliphatic difluorides with anti-Markovnikov regioselectivity. A wide range of highly remote alkenes, simple alkenes, drug mols., com. available CF2 precursors, and even nonfluorinated substrates are competent in this reaction under mild conditions, demonstrating the practicability of the strategy. Moreover, mechanistic studies indicated that the difluoroalkyl radical might be a key intermediate to this transformation.

Organic Letters published new progress about Alkenes Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 627-27-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C4H8O, Product Details of C4H8O.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Killiny, Nabil; Nehela, Yasser; George, Justin; Rashidi, Mahnaz; Stelinski, Lukasz L.; Lapointe, Stephen L. published the artcile< Phytoene desaturase-silenced citrus as a trap crop with multiple cues to attract Diaphorina citri, the vector of Huanglongbing>, Quality Control of 87-73-0, the main research area is phytoene desaturase citrus Diaphorina citri HLB infection; Attract and kill; Carotenoids; Citrus; Diaphorina citri; Electrical Penetration Graph; Phytoene desaturase; Trap crop.

Huanglongbing (HLB) is one of the most destructive diseases in citrus worldwide. Unfortunately, HLB has no cure and management relies on insecticides to reduce populations of the vector, Diaphorina citri Kuwayama (Hemiptera: Liviidae). We propose an attract-and-kill strategy using a trap crop as an alternative to vector control to reduce transmission of the pathogen, ‘Candidatus Liberibacter asiaticus’. We evaluated vector response to phytoene desaturase-silenced citrus trees using virus-induced gene silencing technol. Citrus tristeza virus (CTV) was used to produce a phytoene desaturase-silenced citrus (CTV-tPDS) that expresses visual, olfactory, and gustatory cues to attract D. citri. We found that D. citri were more attracted to CTV-tPDS plants with noticeably better fecundity and overall population fitness than on control plants. Moreover, rearing D. citri on CTV-tPDS plants significantly increased their survival probability compared with those reared on control plants. CTV-tPDS plants possessed reduced content of both carotenoid and chlorophyll pigments resulting in a consistent photobleached phenotype on citrus leaves which provided a sufficient close-range visual attractant to stimulate D. citri landing. Addnl., CTV-tPDS plants exhibited an enriched profile of volatile organic compounds (VOCs), which offered adequate olfactory cues to attract psyllid from long-range. Finally, CTV-tPDS plants exhibited an enriched metabolite content of phloem sap and leaves which offered appropriate gustatory cues that influenced probing/feeding behavior. We believe that introducing CTV-tPDS plants (as a trap crop) to D. citri-infested orchards will attract and congregate psyllids to facilitate their removal from the target crop with insecticides or by other means. This new strategy could be deployed relatively quickly and economically to HLB-impacted citrus industries. Moreover, it is an eco-friendly strategy because it should partially reduce the input of chem. insecticides ameliorating the indirect cost of HLB infection.

Plant Science (Shannon, Ireland) published new progress about Aversive behavior, taste aversion. 87-73-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H10O8, Quality Control of 87-73-0.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Goksel, Yaman; Zor, Kinga; Rindzevicius, Tomas; Thorhauge Als-Nielsen, Bodil Elise; Schmiegelow, Kjeld; Boisen, Anja published the artcile< Quantification of Methotrexate in Human Serum Using Surface-Enhanced Raman Scattering-Toward Therapeutic Drug Monitoring>, Electric Literature of 1492-18-8, the main research area is surface enhanced Raman spectroscopy therapeutic drug monitoring methotrexate blood; methotrexate; patient samples; point-of-care detection; quantitative SERS; surface-enhanced Raman scattering; therapeutic drug monitoring.

Therapeutic drug monitoring (TDM) can improve clin. care when using drugs with pharmacokinetic variability and a narrow therapeutic window. Rapid, reliable, and easy-to-use detection methods are required in order to decrease the time of anal. and can also enable TDM in resource-limited settings or even at bedside. Monitoring methotrexate (MTX), an anticancer drug, is critical since it is needed to follow the drug clearance rate and decide how to administer the rescue drug, leucovorin (LV), in order to avoid toxicity and even death. We show that with the optimized nanopillar-assisted separation (NPAS) method using surface-enhanced Raman scattering, we were able to measure MTX in PBS and serum in the linear range of 5-150μM and confirmed that MTX detection can be carried out even in the presence of LV. Addnl., when NPAS was combined with centrifugal filtration, a quantification limit of 2.1μM for MTX in human serum sample was achieved. The developed detection method enables fast detection (10 min) and quantification of MTX from human serum (>90% accuracy). Furthermore, we show the potential of the developed method for TDM, when quantifying MTX from clin. samples, collected from patients who are undergoing high-dose MTX therapy.

ACS Sensors published new progress about Blood analysis. 1492-18-8 belongs to class alcohols-buliding-blocks, and the molecular formula is C20H21CaN7O7, Electric Literature of 1492-18-8.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Tallman, Keri A.; Allen, Luke B.; Klingelsmith, Korinne; Anderson, Allison; Genaro-Mattos, Thiago C.; Mirnics, Karoly; Porter, Ned A.; Korade, Zeljka published the artcile< Prescription Medications Alter Neuronal and Glial Cholesterol Synthesis>, Recommanded Product: (3S,9S,10R,13R,14R,17R)-10,13-Dimethyl-17-((R)-6-methylheptan-2-yl)-2,3,4,9,10,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-ol, the main research area is drug toxicity placenta blood brain barrier cholesterol neurodevelopmental disorder; antipsychotic antidepressant antiarrhythmic neuron astrocyte dehydrocholesterol DHCR7 enzyme; 7-DHC; DHCR7; DMG method; cholesterol; desmosterol; pharmaceuticals.

Mouse brain contains over 100 million neuronal, glial, and other support cells. Developing neurons and astrocytes synthesize their own cholesterol, and disruption of this process can occur by both genetic and chem. mechanisms. In this study we have exposed cultured murine neurons and astrocytes to six different prescription medications that cross the placenta and blood-brain barriers and analyzed the effects of these drugs on cholesterol biosynthesis by an LC-MS/MS protocol that assays 14 sterols and 7 oxysterols in a single run. Three antipsychotics (haloperidol, cariprazine, aripiprazole), two antidepressants (trazodone and sertraline), and an antiarrhythmic (amiodarone) inhibited one or more sterol synthesis enzymes. The result of the exposures was a dose-dependent increase in levels of various sterol intermediates and a decreased level of cholesterol in the cultured cells. Four prescription medications (haloperidol, aripiprazole, cariprazine, and trazodone) acted primarily on the DHCR7 enzyme. The result of this exposure was an increase in 7-dehydrocholesterol in neurons and astrocytes to levels that were comparable to those found in cultured neurons and astrocytes from transgenic mice that carried a Dhcr7 pathogenic mutation modeling the neurodevelopmental disorder Smith-Lemli-Opitz syndrome.

ACS Chemical Neuroscience published new progress about Antiarrhythmics. 434-16-2 belongs to class alcohols-buliding-blocks, and the molecular formula is C27H44O, Recommanded Product: (3S,9S,10R,13R,14R,17R)-10,13-Dimethyl-17-((R)-6-methylheptan-2-yl)-2,3,4,9,10,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-ol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts