Month: October 2022

McKay, G.; Blair, H. S.; Gardner, J. G.; McConvey, I. F. published the artcile< Two-resistance mass transfer model for the adsorption of various dyestuffs onto chitin>, Name: Sodium 5,5′-(diazene-1,2-diyl)bis(2-hydroxybenzoate), the main research area is dye adsorption chitin wastewater; mass transfer model chitin dye.

The kinetics of the adsorption of various dyes onto chitin (I) [1398-61-4] were studied. The dyes used are Neoland Blue 2G (II) [6370-08-7], Eriochrome Flavin A (III) [6054-98-4], and Solophenyl Brown 3RL (IV) [6409-83-2] and a number of process variables were considered, such as adsorbent mass and dye concentration The mass transfer model is based on the assumption of a pseudoirreversible isotherm and 2 resistances to mass transfer. These are external mass transfer and internal pore diffusion mass transfer. The rate of adsorption of dyes onto I can be described by an external mass transfer coefficient and a pore diffusion coefficient The external mass transfer coefficients are 5.0 × 10-5, 5.0 × 10-5, and 1.0 × 10-5 m/s and the pore diffusivities are 3.0 × 10-10 and 4.0 × 10-11 m2/s for II, III, and IV, resp.

Journal of Applied Polymer Science published new progress about Adsorptive wastewater treatment. 6054-98-4 belongs to class alcohols-buliding-blocks, and the molecular formula is C14H8N2Na2O6, Name: Sodium 5,5′-(diazene-1,2-diyl)bis(2-hydroxybenzoate).

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Zu, Han; Zhang, Hui; Fan, Anwen; Gu, Jie; Nie, Yao; Luo, Pengjie; Xu, Yan published the artcile< Highly efficient synthesis of (R)-1,3-butanediol via anti-Prelog reduction of 4-hydroxy-2-butanone with absolute stereoselectivity by newly isolated Pichia kudriavzevii>, Application of C4H10O2, the main research area is butanediol asym reduction hydroxybutanone stereoselectivity Pichia biosynthesis sequence.

(R)-1,3-butanediol is an important pharmaceutical intermediate, and the synthesis of (R)-1,3-butanediol using green biol. methods has recently been of interest for industrial application. Here, a novel strain QC-1 that efficiently transforms 4-hydroxy-2-butanone to (R)-1,3-butanediol was isolated from soil samples. Based on morphol., physiol., and biochem. tests and 5.8S-internal transcribed spacer sequencing, the strain was identified as Pichia kudriavzevii QC-1. The reaction conditions were optimized to 35°C, pH 8.0, rotation speed 200 rpm, and 6:5 mass ratio of glucose to 4-hydroxy-2-butanone. Evaluation of the effects of 4-hydroxy-2-butanone concentrations on yield and cell survival rate showed that 85.60 g·L-1 product accumulated, with an enantiomeric excess of more than 99%, when 30 g·L-1 4-hydroxy-2-butanone was added at 0, 10, and 30 h in a 3-L bioreactor. Thus, strain QC-1 showed excellent catalytic activity and stereoselectivity for the synthesis of (R)-1,3-butanediol from 4-hydroxy-2-butanone.

Chinese Journal of Chemical Engineering published new progress about Concentration (condition). 6290-03-5 belongs to class alcohols-buliding-blocks, and the molecular formula is C4H10O2, Application of C4H10O2.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Zhang, Leilei; Xu, Yue; Lou, Boxuan; Qin, Xiaolan; Zhang, Lijuan; Liu, Xijian; Yuan, Haikuan; Zhang, Yan; Rohani, Sohrab; Lu, Jie published the artcile< Effect of Additives on Preferential Crystallization for the Chiral Resolution of Citrulline: Experimental, Statistical, and Molecular Dynamics Simulation Studies>, Reference of 6290-03-5, the main research area is preferential crystallization chiral resolution citrulline.

The molar fraction solubilities of L-, D-, and DL-citrulline were first determined in aqueous solutions with different concentrations of (R)-1,3-butanediol from 283.15 to 328.15 K under 101.3 kPa using the gravimetric method. Then, based on solid-state characterizations such as powder X-ray diffraction (PXRD), Fourier transform IR (FTIR) spectroscopy, thermal gravity anal. (TGA), differential scanning calorimetry (DSC), and ternary phase diagram, the nature of crystalline DL-citrulline was considered to be a racemic compound Then, the rates and parameters of primary nucleation of three species in mixtures of water and (R)-1,3-butanediol were exptl. derived through the classical nucleation theory (CNT). After that, topol. electrostatic potentials and radial distribution functions were analyzed for exploring the intermol. interactions between the mols., and the Yasuoka-Matsumoto (YM) method was employed to simulate the nucleation process. However, the calculated nucleation rates by YM were shown to be 2 orders of magnitude greater than those derived through CNT. Finally, the effect of additives on the appearance probability (P) of racemic and enantiomeric nuclei from the same DL-citrulline solutions at a supersaturation ratio of 2.63 was statistically investigated from 140 nucleation experiments It was interestingly found that there was only a minor difference between the appearance probabilities of both enantiomeric crystals among 20 batches of nucleations in the absence of additives; however, in the presence of additives, enantiomeric crystals with the same chirality as the additives were totally inhibited, which were utilized for the chiral enrichment of the studied racemic system. By coupling the addition of additives and seeds, L-citrulline or D-citrulline crystals with optical purity above 99% can be produced with a yield up to 25.4% through chiral enrichment from an initial ee of 88%.

Crystal Growth & Design published new progress about Activation energy. 6290-03-5 belongs to class alcohols-buliding-blocks, and the molecular formula is C4H10O2, Reference of 6290-03-5.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Dubey, Abhishek; Rahaman, S. M. Wahidur; Fayzullin, Robert R.; Khusnutdinova, Julia R. published the artcile< Transfer Hydrogenation of Carbonyl Groups, Imines and N-Heterocycles Catalyzed by Simple, Bipyridine-Based MnI Complexes>, Application In Synthesis of 403-41-8, the main research area is bipyridine manganese complex preparation UV visible spectra crystal structure; carbonyl compound bipyridine manganese complex transfer hydrogenation; benzylideneaniline bipyridine manganese complex transfer hydrogenation; azaarene bipyridine manganese complex transfer hydrogenation.

A simple bipyridine-based Mn catalysts were developed that act as active catalysts for transfer hydrogenation of ketones, aldehydes and imines. For the first time, Mn-catalyzed transfer hydrogenation of N-heterocycles was reported. The highest catalytic activity among complexes with variously substituted ligands was observed for the complex bearing two OH groups in bipyridine. Deuterium labeling experiments suggested a monohydride pathway.

ChemCatChem published new progress about Alcohols Role: SPN (Synthetic Preparation), PREP (Preparation). 403-41-8 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H9FO, Application In Synthesis of 403-41-8.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Tang, Yun-Zhi; Tan, Yu-Hui; Chen, Shao-Hu; Chao, Yan-Wen; Wang, Ping published the artcile< Synthesis, characterization and crystal structures of two alkaline-earth metal complexes of olsalazine>, Reference of 6054-98-4, the main research area is olsalazine magnesium calcium aqua polymer complex preparation structure; crystal structure magnesium calcium olsalazine aqua polymer complex.

Two one-dimensional linear coordination polymers, [Mg(L)·4(H2O)] (1, H2L = olsalazine) and [Ca(L)·4(H2O)] (2) were obtained from self-assembly of CaCl2 or MgSO4 with olsalazine and their structures determined by single crystal x-ray diffraction. Both complexes are one-dimensional polymers, with crystal data for complex 1: P2(1)/c, a 9.5224(18), b 11.309(2), c 16.211(3) Å, β 106.648(3)°, V 1672.6(6) Å3, Z = 4, space group R1 = 0.0695, wR2 = 0.2183, for complex 2: space group P4(3)2(1)2, a 10.4006(2), b 10.4006(2), c 32.0746(10) Å, V 3469.59(14) Å3, Z = 8, R1 = 0.0332, wR2 = 0.1015. In the complexes, Mg and Ca adopt totally different coordination modes. Alk.-earth Mg has a six-coordinate octahedral geometry, however, in 2, the local coordination geometry around calcium atom can be best described as a slightly distorted pentagonal bipyramid crystallizing in a homo-chiral space group. Olsalazine in both compounds also adopts dissimilar coordination modes.

Journal of Coordination Chemistry published new progress about Crystal structure. 6054-98-4 belongs to class alcohols-buliding-blocks, and the molecular formula is C14H8N2Na2O6, Reference of 6054-98-4.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Cavallo, Marzia; Arnodo, Davide; Mannu, Alberto; Blangetti, Marco; Prandi, Cristina; Baratta, Walter; Baldino, Salvatore published the artcile< Deep eutectic solvents as H2-sources for Ru(II)-catalyzed transfer hydrogenation of carbonyl compounds under mild conditions>, Related Products of 52160-51-7, the main research area is aldehyde ketone transfer hydrogenation ruthenium catalyst deep eutectic solvent.

The employment of easily affordable ruthenium(II)-complexes as pre-catalysts in the transfer hydrogenation of carbonyl compounds in deep eutectic media is described for the first time. The eutectic mixture tetrabutylammonium bromide/formic acid = 1/1 (TBABr/HCOOH = 1/1) acts both as reaction medium and hydrogen source. The addition of a base is required for the process to occur. An extensive optimization of the reaction conditions has been carried out, in terms of catalyst loading, type of complexes, H2-donors, reaction temperature and time. The combination of the dimeric complex [RuCl(p-cymene)-μ-Cl]2 (0.01-0.05 equivalent) and the ligand dppf (1,1′-ferrocenediyl-bis(diphenylphosphine)ferrocene) in 1/1 molar ratio has proven to be a suitable catalytic system for the reduction of several and diverse aldehydes and ketones to their corresponding alcs. under mild conditions (40-60°) in air, showing from moderate to excellent tolerability towards different functional groups (halogen, cyano, nitro, phenol). The reduction of imine compounds to their corresponding amine derivatives was also studied. In addition, the comparison between the results obtained in TBABr/HCOOH and in organic solvents suggests a non-innocent effect of the DES medium during the process.

Tetrahedron published new progress about Aldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 52160-51-7 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H9NO, Related Products of 52160-51-7.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Ren, Boxu; Kwah, Marabeth Xin-Yi; Liu, Cuiliu; Ma, Zhaowu; Shanmugam, Muthu K.; Ding, Lingwen; Xiang, Xiaoqiang; Ho, Paul Chi-Lui; Wang, Lingzhi; Ong, Pei Shi; Goh, Boon Cher published the artcile< Resveratrol for cancer therapy: Challenges and future perspectives>, Recommanded Product: (E)-5-(4-Hydroxystyryl)benzene-1,3-diol, the main research area is review cancer resveratrol therapy; Cancer treatment; Pharmacodynamics; Pharmacokinetics; Resveratrol; Toxicity.

A review. Resveratrol (3,4′,5-trihydroxy-trans-stilbene) has been expected to ameliorate cancer and foster breakthroughs in cancer therapy. Despite thousands of preclin. studies on the anticancer activity of resveratrol, little progress has been made in translational research and clin. trials. Most studies have focused on its anticancer effects, cellular mechanisms, and signal transduction pathways in vitro and in vivo. In this review, we aimed to discern the causes that prevent resveratrol from being used in cancer treatment. Among the various limitations, poor pharmacokinetics and low potency seem to be the two main bottlenecks of resveratrol. In addition, resveratrol-induced nephrotoxicity in multiple myeloma patients hinders its further development as an anticancer drug. New insights and strategies have been proposed to accelerate the conversion of resveratrol from bench to bedside. In the interim, the most promising approach is to enhance the bioavailability of resveratrol with new formulations. Alternatively, more potent analogs of resveratrol could be developed to augment its anticancer potency. Given all the gaps mentioned, much work remains to be done. However, if remarkable progress can be made, resveratrol may finally be used for cancer therapy.

Cancer Letters (New York, NY, United States) published new progress about Antitumor agents. 501-36-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C14H12O3, Recommanded Product: (E)-5-(4-Hydroxystyryl)benzene-1,3-diol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Hosseiny Davarani, Saied Saeed; Pourahadi, Ahmad; Ghasemzadeh, Peivand published the artcile< Quantification of controlled release leuprolide and triptorelin in rabbit plasma using electromembrane extraction coupled with HPLC-UV>, Application In Synthesis of 104-76-7, the main research area is HPLC UV plasma determination controlled release leuprolide triptorelin pharmacokinetics; electromembrane extraction HPLC controlled release leuprolide triptorelin; Electromembrane extraction; Leuprolide; Pharmacokinetic; Rabbit plasma; Triptorelin.

An electromembrane extraction followed by HPLC-UV technique was developed and validated for quantification of leuprolide and triptorelin in rabbit plasma. The influencing parameters on the extraction efficiency were optimized using exptl. design methodol. The optimized conditions were found to be; supported liquid membrane: a mixture of 1-octanol and 2-Et hexanol (1:1) containing 10% volume/volume di(2-ethylhexyl) phosphate, applied voltage: 5 V, extraction time: 5 min, pH of the donor phase: 4.5 and pH of the acceptor phase: 1.0. The optimized method was validated for linearity, intraday and interday precision, and accuracy in rabbit plasma. The range of quantification for both peptides was 0.5-1000 ng/mL with regression coefficients higher than 0.994. Relative recoveries of leuprolide and triptorelin were found to be 80.3 and 75.5%, resp. Limits of quantification and detection for both peptides were found to be 0.5 and 0.15 ng/mL, resp. The validated method was successfully applied to pharmacokinetic study of the 1-mo depot formulations of each peptide after s.c. administration to rabbits.

Electrophoresis published new progress about Blood analysis. 104-76-7 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H18O, Application In Synthesis of 104-76-7.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Geringer, Scott A.; Singh, Yashapal; Hoard, Daniel J.; Demchenko, Alexei V. published the artcile< A Highly Efficient Glycosidation of Glycosyl Chlorides by Using Cooperative Silver(I) Oxide-Triflic Acid Catalysis>, Synthetic Route of 4064-06-6, the main research area is cooperative silver catalyzed glycosidation benzoyl benzyl protected glycosyl chloride; activation; carbohydrates; glycosyl chlorides; glycosylation; silver oxide.

Following our discovery that silver(I) oxide-promoted glycosylation with glycosyl bromides can be greatly accelerated in the presence of catalytic TMSOTf or TfOH, we report herein a new discovery that glycosyl chlorides are even more effective glycosyl donors under these reaction conditions. The developed reaction conditions work well with a variety of glycosyl chlorides. Both benzoylated and benzylated chlorides have been successfully glycosidated, and these reaction conditions proved to be effective in coupling substrates containing nitrogen and sulfur atoms. Another convenient feature of this glycosylation is that the progress of the reaction can be monitored visually; its completion can be judged by the disappearance of the characteristic dark color of Ag2O.

Chemistry – A European Journal published new progress about Benzoyl group (protecting). 4064-06-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C12H20O6, Synthetic Route of 4064-06-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts