Month: October 2022

Thiyagarajan, Subramanian; Gunanathan, Chidambaram published the artcile< Ruthenium-Catalyzed Selective Hydrogenation of Epoxides to Secondary Alcohols>, Reference of 403-41-8, the main research area is secondary alc preparation green chem; epoxide regioselective hydrogenation ruthenium catalyst.

A ruthenium(II)-catalyzed highly selective Markovnikov hydrogenation of terminal epoxides to secondary alcs. is reported. Diverse substitutions on the aryl ring of styrene oxides are tolerated. Benzylic, glycidyl, and aliphatic epoxides as well as diepoxides also underwent facile hydrogenation to provide secondary alcs. with exclusive selectivity. Metal-ligand cooperation-mediated ruthenium trans-dihydride formation and its reaction involving oxygen and the less substituted terminal carbon of the epoxide is envisaged for the origin of the observed selectivity.

Organic Letters published new progress about Epoxides Role: RCT (Reactant), RACT (Reactant or Reagent). 403-41-8 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H9FO, Reference of 403-41-8.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Cutolo, Maurizio; Soldano, Stefano; Sulli, Alberto; Smith, Vanessa; Gotelli, Emanuele published the artcile< Influence of seasonal vitamin D changes on clinical manifestations of rheumatoid arthritis and systemic sclerosis>, Category: alcohols-buliding-blocks, the main research area is review vitamin D rheumatoid arthritis systemic sclerosis; circadian rhythms; connective tissue diseases; rheumatoid arthritis; systemic sclerosis; vitamin D.

A review. Vitamin D [1,25(OH)2D-calcitriol] is basically a steroid hormone with pleiotropic biol. effects, and its impact on the regulation of immune system may influence several clin. conditions. Calcidiol (25OHD), as precursor of calcitriol, derives, for the most part (80%), from cutaneous cholesterol (7-dehydrocholesterol) under the action of UV-B (sunlight). Consequently, serum concentrations fluctuate during the year following the circannual rhythm of sun exposition. We will update about the available evidence regarding the complex influence of seasonal vitamin D changes on two different chronic connective tissue diseases, namely rheumatoid arthritis (RA) and systemic sclerosis (SSc). Notably, RA is an emblematic model of autoimmune disease with prevalent joint inflammatory features, while SSc is mainly an autoimmune progressive pro-fibrotic disease. However, in both conditions, low serum concentrations of 25OHD are involved in the pathogenesis of the diseases, and emerging data report their impact on clin. manifestations.

Frontiers in Immunology published new progress about Autoimmune disease. 434-16-2 belongs to class alcohols-buliding-blocks, and the molecular formula is C27H44O, Category: alcohols-buliding-blocks.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Yu, Zhenming; Zhao, Conghui; Zhang, Guihua; Da Silva, Jaime A. Teixeira; Duan, Jun published the artcile< Genome-wide identification and expression profile of TPS Gene family in Dendrobium officinale and the role of DoTPS10 in linalool biosynthesis>, Application of C10H18O, the main research area is tps10 tps linalool gene expression Dendrobium; abiotic stress; methyl jasmonate; orchids; terpene synthase; terpenes.

Terpene synthase (TPS) is a critical enzyme responsible for the biosynthesis of terpenes, which possess diverse roles in plant growth and development. Although many terpenes have been reported in orchids, limited information is available regarding the genome-wide identification and characterization of the TPS family in the orchid, Dendrobium officinale. By integrating the D. officinale genome and transcriptional data, 34 TPS genes were found in D. officinale. These were divided into four subfamilies (TPS-a, TPS-b, TPS-c, and TPS-e/f). Distinct tempospatial expression profiles of DoTPS genes were observed in 10 organs of D. officinale. Most DoTPS genes were predominantly expressed in flowers, followed by roots and stems. Expression of the majority of DoTPS genes was enhanced following exposure to cold and osmotic stresses. Recombinant DoTPS10 protein, located in chloroplasts, uniquely converted geranyl diphosphate to linalool in vitro. The DoTPS10 gene, which resulted in linalool formation, was highly expressed during all flower developmental stages. Me jasmonate significantly up-regulated DoTPS10 expression and linalool accumulation. These results simultaneously provide valuable insight into understanding the roles of the TPS family and lay a basis for further studies on the regulation of terpenoid biosynthesis by DoTPS in D. officinale.

International Journal of Molecular Sciences published new progress about Abies grandis. 78-70-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C10H18O, Application of C10H18O.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Simental-Mendia, Luis E.; Guerrero-Romero, Fernando published the artcile< Effect of resveratrol supplementation on lipid profile in subjects with dyslipidemia: A randomized double-blind, placebo-controlled trial>, HPLC of Formula: 501-36-0 , the main research area is dyslipidemia lipid lowering agent resveratrol; Dyslipidemia; Lipid profile; Lipids; Randomized controlled trial; Resveratrol.

Objectives: The aim of this study was to explore the effect of resveratrol supplementation on lipid profile in individuals with dyslipidemia. Methods: Apparently healthy men and non-pregnant women 20 to 65 y of age with new diagnosis of dyslipidemia were enrolled in a randomized double-blind, placebo-controlled trial and randomly allocated to receive either resveratrol 100mg/d or placebo (sucrose 0.5 g/d) for 2 mo. Smoking, alc. intake, diabetes, acute or chronic renal or hepatic diseases, malignancy, cardiovascular disease, serum triacylglycerol levels ≥400mg/dL, low-d. lipoprotein cholesterol levels ≥190mg/dL, and consumption of lipid-lowering drugs or supplements containing resveratrol were exclusion criteria. Results: Seventy-one individuals with new diagnosis of dyslipidemia were enrolled and randomly allocated to the resveratrol (n = 35) or placebo groups (n = 36). At baseline, there were no significant differences between the study groups. After intervention period, individuals in the resveratrol group showed a significant decrease in total cholesterol (201.4 ± 34.4 vs. 220.6 ± 37.4, P = 0.04) and triacylglycerol (133.4 ± 55.3 vs. 166.7 ± 68.5, P = 0.04) concentrations compared with the placebo group, without significant statistical differences for high-d. lipoprotein cholesterol and low-d. lipoprotein cholesterol levels. Conclusion: The results suggest that resveratrol supplementation significantly reduces total cholesterol and triacylglycerol concentrations in individuals with dyslipidemia.

Nutrition (New York, NY, United States) published new progress about Dyslipidemia. 501-36-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C14H12O3, HPLC of Formula: 501-36-0 .

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Jeandet, Philippe; Clement, Christophe; Cordelier, Sylvain published the artcile< Regulation of resveratrol biosynthesis in grapevine: new approaches for disease resistance?>, Related Products of 501-36-0 , the main research area is review phytoalexin resveratrol disease resistance.

A review. Transcription factors are key components in the regulation of metabolic pathways underlying numerous plant functions. Jiang et al. (2019) showed that the WRKY8 transcription factor fine-tunes biosynthesis of the phytoalexin resveratrol in grapevine through neg. regulation of the stilbene synthase gene. This paves the way for new approaches in our understanding of the regulation of phytoalexin biosynthesis in plants and, through this, improved phytoalexin production in engineered disease resistance.

Journal of Experimental Botany published new progress about Disease resistance, plant. 501-36-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C14H12O3, Related Products of 501-36-0 .

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Xie, Dong-Tai; Chen, Hong-Lei; Wei, Dian; Wei, Bang-Yi; Li, Zheng-Hu; Zhang, Jian-Wu; Yu, Wei; Han, Bing published the artcile< Regioselective Fluoroalkylphosphorylation of Unactivated Alkenes by Radical-Mediated Alkoxyphosphine Rearrangement>, Reference of 627-27-0, the main research area is regioselective fluoroalkyl phosphorylation unactivated alkene radical alkoxyphosphine rearrangement; fluoroiodoalkyl phosphine oxide preparation crystal mol structure; Alkenes; Multicomponent Reactions; Radicals; Reaction Mechanisms; Regioselectivity.

A novel distal radical rearrangement of alkoxyphosphine is developed for the first time and applied to the regioselective radical fluoroalkylphosphorylation of unactivated olefins. By employing a one-pot two-step reaction of (bis)homoallylic alcs., organophosphine chlorides, and fluoroalkyl iodides under CFL (compact fluorescence light) irradiation, a series of fluoroalkylphosphorylated alkyl iodides and alcs. are easily synthesized by regiospecific installing a phosphonyl onto the inner carbon of terminal olefins and further iodination/hydroxylation. Mechanism studies reveal that the migration undergoes a distinctive radical cyclization/β-scission on the lone electron pair of phosphorus, resulting in C-P bond formation and C-O bond cleavage.

Angewandte Chemie, International Edition published new progress about Alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 627-27-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C4H8O, Reference of 627-27-0.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Diemoz, Kayla M.; Franz, Annaliese K. published the artcile< NMR Quantification of Hydrogen-Bond-Activating Effects for Organocatalysts including Boronic Acids>, Synthetic Route of 76-84-6, the main research area is NMR quantification hydrogen bond activation organocatalyst boronic acid.

The hydrogen-bonding activation for 66 organocatalysts has been quantified using a 31P NMR binding experiment with triethylphosphine oxide (TEPO). Diverse structural classes, including phenols, diols, silanols, carboxylic acids, boronic acids, and phosphoric acids, were examined with a variety of steric and electronic modifications to understand how the structure and secondary effects contribute to hydrogen-bonding ability and catalysis. Hammett plots demonstrate high correlation for the Δδ 31P NMR shift to Hammett parameters, establishing the ability of TEPO binding to predict electronic trends. Upon correlation to catalytic activity in a Friedel-Crafts addition reaction, data demonstrate that 31P NMR shifts correlate to catalytic activity better than pKa values. Boronic acids were investigated, and 31P NMR binding experiments predicted strong hydrogen-bonding ability, for which catalytic activity was confirmed, resulting in the greatest rate enhancement observed in the Friedel-Crafts addition of all organocatalysts studied. A detailed investigation supports that boronic acid activation proceeds through hydrogen-bonding interactions and not coordination with the Lewis acidic boron center. Using 31P NMR spectroscopy offers a simple and rapid tool to quantify and predict hydrogen-bonding abilities for the design and applications of new organocatalysts and supramol. synthons.

Journal of Organic Chemistry published new progress about Alcohols Role: CAT (Catalyst Use), PEP (Physical, Engineering or Chemical Process), PRP (Properties), USES (Uses), PROC (Process). 76-84-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C19H16O, Synthetic Route of 76-84-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Lu, Linbin; Zhuang, Tingting; Shao, Erqian; Liu, Yanhong; He, Huimin; Shu, Zhimin; Huang, Yan; Yao, Yichen; Lin, Shan; Lin, Shaoqin; Chen, Xi; Chen, Xiong published the artcile< Association of antibiotic exposure with the mortality in metastatic colorectal cancer patients treated with bevacizumab-containing chemotherapy: A hospital-based retrospective cohort study>, Synthetic Route of 1492-18-8, the main research area is metastatic colorectal cancer bevacizumab chemotherapy antibiotic medication.

Preclin. studies showed that antibiotic exposure played a role in clin. outcomes in patients with chemotherapy via modulation of microbiota. However, it remains unknown whether antibiotic exposure during the bevacizumab therapy affects the clin. outcomes in metastatic colorectal cancer(mCRC) patients. This study aimed to examine the association between the antibiotic medication and the clin. outcomes in mCRC patients with bevacizumab therapy. This retrospective cohort anal. included 147 mCRC patients treated with bevacizumab. The hazard ratio of death was estimated using three Cox proportional hazards models with (1) never vs ever; (2) never vs 1-6 days and 7-40 days;(3) increase per day, and further tested using propensity score matching (PSM) and landmark anal. A smooth curve technique was used to explore the shape of dose-response relationship. Compared with the non-antibiotic group, antibiotic exposure was inversely associated with the mortality in the antibiotic group after adjustment for demog. and other potential confounders (a history of medication: HR, 0.650(95%CI: 0.360 to 1.173); an increase per day: HR, 0.967(CI: 0.924 to 1.011); 1-6 days: HR, 0.859(CI: 0.441 to 1.674); 7-40 days: HR, 0.474(CI: 0.225 to 0.999); P for trend = 0.040). A test for the interaction between sex was statistically significant (p = 0.016). A similar result was found as measured by landmark and PSM anal. Significant neg. dose-response relationship was shown by smooth curve anal. in the male patients but not female after adjustment for confounders(p = 0.028). No association was found between the antibiotic medication and adverse events of bevacizumab. Antibiotic exposure could be inversely associated with the mortality in mCRC patients treated with bevacizumab.

PLoS One published new progress about Antibiotics. 1492-18-8 belongs to class alcohols-buliding-blocks, and the molecular formula is C20H21CaN7O7, Synthetic Route of 1492-18-8.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Zhang, Shi-Qi; Cui, Yao; Guo, Bin; Young, David J.; Xu, Ze; Li, Hong-Xi published the artcile< Efficient synthesis of quinazolines by the iron-catalyzed acceptor-less dehydrogenative coupling of (2-aminophenyl)methanols and benzamides>, Name: (2-Aminophenyl)methanol, the main research area is preparation quinazolines iron catalyzed acceptorless dehydrogenative coupling; aminophenylmethanols benzamides heterocyclization.

The acceptor-less dehydrogenation coupling (ADC) of (2-aminophenyl)methanols with benzamides was achieved with catalytic FeCl2·4H2O in an efficient synthesis of quinazolines. This simple catalytic system is atom-economical, environmentally benign and suited to a variety of substrates.

Tetrahedron published new progress about Benzamides Role: RCT (Reactant), RACT (Reactant or Reagent). 5344-90-1 belongs to class alcohols-buliding-blocks, and the molecular formula is C7H9NO, Name: (2-Aminophenyl)methanol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Muthuvinothini, A.; Stella, S. published the artcile< Surface modified nanoparticles: a green catalyst for the reduction of ketones>, Related Products of 403-41-8, the main research area is metal oxide glycerol nanoparticle green catalyst ketone reduction.

In the present study, a creative and eco-friendly synthetic method was demonstrated for the reduction of ketones using surface modified metal oxide nanoparticles (MO NPs). Nickel oxide, iron oxide and copper oxide nanoparticles were biosynthesized from the aqueous immature fruit extract of Cocos nucifera and the nanoparticle’s surface was modified using glycerol to improve the catalytic efficiency. Surface modification of the nanoparticles enhanced the catalytic activity of nanoparticles as compared to the unmodified metal oxide nanoparticles (MO NPs) for the reduction of ketones. Among the MO NPs used as catalysts for the reduction of acetophenone derivatives, glycerol modified iron oxide nanoparticles showed greater results with 74%-91% of yield due to its uniform morphol. The catalyst retained its stability even after seven repeated cycles of reaction.

Inorganic and Nano-Metal Chemistry published new progress about Coconut. 403-41-8 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H9FO, Related Products of 403-41-8.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts