Month: October 2022

Utsukihara, Takamitsu; Horiuchi, C. Akira published the artcile< Production of chiral aromatic alcohol by acetophenone and 1-arylethanol derivatives using vegetables>, Computed Properties of 403-41-8, the main research area is Ducus Solanum chiral aromatic alc acetophenone arylethanol.

We have studied the biotransformation of acetophenone derivatives (1a-1f) and 1-arylethanol derivatives (2a-2e, 2g, 2h) using various vegetables. It is found that the reduction of acetophenone derivatives (1a-1f) using carrot (Ducus carota) gives (S)-1-arylethanols with high enantioselectivity. On the other hand, biooxidation of 1-arylethanols (2a-2e, 2g, 2h) using potato (Solanum tuberosum) is oxidized to give (R)-1-arylethanols as major product with high stereoselectivity. Carrot (D. carota) is the best catalyst for this reduction and shows a good reaction yield and enantioselectivity. On the other hand, it is found that the racemic alcs. are converted into the corresponding (R)-alcs. with high ee using Japanese potato (S. tuberosum) as catalyst. The availability of the enzymic system using various vegetables is convenient and an eco-friendly system.

Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry published new progress about Allium cepa. 403-41-8 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H9FO, Computed Properties of 403-41-8.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Hu, Caijuan; Li, Guoxun; Mu, Yu; Wu, Wenxi; Cao, Bixuan; Wang, Zixuan; Yu, Hainan; Guan, Peipei; Han, Li; Li, Liya; Huang, Xueshi published the artcile< Discovery of Anti-TNBC Agents Targeting PTP1B: Total Synthesis, Structure-Activity Relationship, In Vitro and In Vivo Investigations of Jamunones>, Name: 2,4,6-Trihydroxyisophthalaldehyde, the main research area is jamunone analog preparation antitumor triple neg breast cancer.

Twenty-three natural jamunone analogs along with a series of jamunone-based derivatives were synthesized and evaluated for their inhibitory effects against breast cancer (BC) MDA-MB-231 and MCF-7 cells. The preliminary structure-activity relationship revealed that the length of aliphatic side chain and free phenolic hydroxyl group at the scaffold played a vital role in anti-BC activities and the Me group on chromanone affected the selectivity of mols. against MDA-MB-231 and MCF-7 cells. Among them, jamunone M (I; JM) was screened as the most effective anti-triple-neg. breast cancer (anti-TNBC) candidate with a high selectivity against BC cells over normal human cells. Mechanistic investigations indicated that JM could induce mitochondria-mediated apoptosis and cause G0/G1 phase arrest in BC cells. Furthermore, JM significantly restrained tumor growth in MDA-MB-231 xenograft mice without apparent toxicity. Interestingly, JM could downregulate phosphatidylinositide 3-kinase (PI3K)/Akt pathway by suppressing protein-tyrosine phosphatase 1B (PTP1B) expression. These findings revealed the potential of JM as an appealing therapeutic drug candidate for TNBC.

Journal of Medicinal Chemistry published new progress about Antitumor agents. 4396-13-8 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H6O5, Name: 2,4,6-Trihydroxyisophthalaldehyde.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Mattocks, A. R. published the artcile< Liver cell enlargement in rats given hydroxymethylpyrroles analogous to pyrrolizidine alkaloid metabolites, followed later by the hepatotoxin dimethylnitrosamine>, Electric Literature of 52160-51-7, the main research area is hydroxymethylpyrrole DMN liver.

Male rats aged 4-5 wk were given single doses of pyrrolic alcs. having alkylating properties similar to those of pyrrolizidine alkaloid metabolites, followed several days later by 1 of the hepatotoxins, DMN [62-75-9], thioacetamide (TA) [62-55-5] or CCl4 [56-23-5]. After 24-32 days the livers of animals given the pyrroles 1-methyl-2,3-bis(hydroxymethyl)pyrrole (I) [53365-77-8] or 1-phenyl-5-methyl-2,3-bis(hydroxymethyl)pyrrole (II) [68384-87-2] and then DMN, contained enlarged parenchymal cells (megalocytes) similar to those seen in chronic pyrrolizidine alkaloid poisoning. At this time such abnormal cells were not found in rats given any of the other pyrroles followed by DMN, or compound I and then TA or CCl4.

Toxicology Letters published new progress about Liver. 52160-51-7 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H9NO, Electric Literature of 52160-51-7.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Alhamed, Samiyah; Alnakhli, Jawzah; Boadi, William; Beni, Ryan published the artcile< Triphenylmethanol conjugates of triptorelin as anti-lipid peroxidation prodrugs>, Electric Literature of 76-84-6, the main research area is triphenylmethanol triptorelin antilipid peroxidation.

Antioxidants are substances that can prevent or slow damage to cells caused by free radicals, unstable mols. that the body produces as a reaction to environmental and other pressures. Free radicals may play a role in heart disease, cancer and other diseases. If the body cannot process and remove free radicals efficiently, oxidative stress can result. This can harm cells and body function. Free radicals are also known as reactive oxygen species (ROS). In this research, Triptorelin (TRP) conjugates of triphenylmethanol derivatives (TPMs) were synthesized to evaluate their in vitro lipid peroxidation potency. Comparative lipid peroxidation assays between TRP-TPMs conjugates and the corresponding TPMs derivatives were measured using thiobarbituric reactive substance (TBARS) in a dose- and time-dependent manner following the Fenton’s pathway. Overall, TBARS decreased between 20% – 30% for the treated samples of synthesized conjugates compared to their resp. control phys. mixtures These data suggest that TRP-TPMs derivatives can be used to improve the biol. activity of TRP.

Open Journal of Medicinal Chemistry published new progress about Lipid peroxidation. 76-84-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C19H16O, Electric Literature of 76-84-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Sharma, Rohit; Abbat, Sheenu; Mudududdla, Ramesh; Vishwakarma, Ram A.; Bharatam, Prasad V.; Bharate, Sandip B. published the artcile< ortho-Quinone methides: TFA-mediated generation in water and trapping with lactams and styrenes>, Formula: C8H6O5, the main research area is quinone methide TFA generation water trapping lactam styrene.

A simple and efficient trifluoroacetic acid mediated protocol for ortho-amidomethylation of phenols in aqueous medium was described. Developed protocol has a good substrate scope, involves mild reaction conditions, and products are obtained in good yields. The quantum chem. calculations were performed in implicit solvent (water) conditions, which helped in tracing the reaction mechanism and getting insights on the possible reaction pathway, which involves the N-C bond formation and simultaneous hydrogen transfer to give final product. The applicability of this protocol for 1-pot synthesis of flavans from phenols, formaldehyde and styrene also was demonstrated.

Tetrahedron Letters published new progress about Cycloaddition reaction. 4396-13-8 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H6O5, Formula: C8H6O5.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Adhikary, Subhasis D.; Mandal, Debaprasad published the artcile< Polyoxometalate catalyzed imine synthesis: Investigation of mechanistic pathways>, Application In Synthesis of 5344-90-1, the main research area is preparation crystal structure zinc tungsten polyoxometalate complex; thermal decomposition zinc tungsten polyoxometalate complex; zinc tungsten polyoxometalate complex catalyst imine synthesis; imine preparation.

The syntheses of imines by oxidative coupling of primary alcs. and amines were achieved by using 2 mol% polyoxometalate (POM) Na12[WZn3(H2O)2(ZnW9O34)2] (Zn-WZn3) catalyst in the presence of t-BuOK and di-oxygen with excellent conversion (up to 100%) and selectivity (up to 100%). Non-noble metal-based POM catalyst in the presence of base represents a new reaction protocol for the selective synthesis of imine from both aromatic and aliphatic primary amines with functional group tolerance. Control experiment shows the formation of di-oxygen bind Zn-WZn3 activated species. The electron-d. of POM is mostly situated on the surface oxygen atoms of W-O-W bonds which can engage the alc. OH group and helps for the imine selectivity in the second step of imine synthesis.

Tetrahedron published new progress about Crystal structure. 5344-90-1 belongs to class alcohols-buliding-blocks, and the molecular formula is C7H9NO, Application In Synthesis of 5344-90-1.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Hou, Chih-Yao; Tain, You-Lin; Yu, Hong-Ren; Huang, Li-Tung published the artcile< The effects of resveratrol in the treatment of metabolic syndrome>, Reference of 501-36-0 , the main research area is resveratrol metabolic syndrome review; high-fat diet; metabolic syndrome; resveratrol; resveratrol derivatives.

A review. Resveratrol, also known as 3,5,4′-trihydroxystilbene, is a natural polyphenol that occurs as a phytoalexin. It is produced by plant sources such as grapes, apples, blueberries, plums, peanuts, and other oilseeds. This compound has a variety of effects on human health and diseases. This review summarizes the mounting evidence that resveratrol is helpful in treating metabolic syndrome and related disorders. Resveratrol can be provided either early as a reprogramming agent or later as part of treatment. A few of the main mechanisms underlying the beneficial effects of resveratrol on metabolic syndrome are outlined. This review also discusses the potential of resveratrol derivatives as a complementary or alternative medicine. In conclusion, resveratrol could be a useful regimen for the prevention and treatment of metabolic syndrome and its related conditions.

International Journal of Molecular Sciences published new progress about Cardiovascular disease. 501-36-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C14H12O3, Reference of 501-36-0 .

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Iftikhar, Rabeeya; Ansari, Asma; Siddiqui, Nadir Naveed; Hussain, Fayaz; Aman, Afsheen published the artcile< Structural elucidation and cytotoxic analysis of a fructan based biopolymer produced extracellularly by Zymomonas mobilis KIBGE-IB14>, Synthetic Route of 492-62-6, the main research area is Zymomonas levan cytotoxicity fibroblast biomedical application; Chemical characterization; Cytotoxicity; Exopolysaccharide; Levan; NIH/3T3 Cell line.

Fructan based biopolymers have been extensively characterized and explored for their potential applications. Linear chained biopolymers, like levan-type fructan, have gained attention because they have exhibited unconventional stretchable and unbendable properties along with biodegradable and biocompatible nature. Current study deals with the chem. characterization and cytotoxic anal. of fructose based exopolysaccharide that was extracellularly produced by an indigenously isolated bacterial species (Zymomonas mobilis KIBGE-IB14). Maximum yield of exopolysaccharide (44.7 gL-1) was attained after 72 h of incubation at 30°C under shaking conditions (180 rpm) when the culture medium was supplemented with 150.0 gL-1 of sucrose as a sole carbon source. This exopolysaccharide displayed high water solubility index (96.0%) with low water holding capacity (17.0%) and an intrinsic viscosity of about 0.447 dL g-1. This biopolymer exhibited a characteristic linear homopolysaccharide structure of levan when characterized using Fourier Transform IR (FTIR), NMR (NMR) spectroscopy (1H, 13C, TOCSY and NOESY) while, Atomic Force Microscopy (AFM) revealed its pointed and thorny structure. The decomposition temperature of levan was approx. 245°C as revealed by Thermal Gravimetric Anal. (TGA). X-Ray Diffraction (XRD) results revealed its amorphous nature with crystalline phase. Cytotoxicity of different concentrations of levan was investigated against mouse fibroblast cell lines by measuring their cellular metabolic activity and it was noticed that a higher concentration of levan (2.0 mg ml-1) permitted the normal cell growth of NIH/3T3 cell lines. This non-cytotoxic and biocompatible nature suggests that this levan has the capability to be utilized in food and drug-based formulations as it exhibited biomedical potential.

Carbohydrate Research published new progress about Biocompatibility. 492-62-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H12O6, Synthetic Route of 492-62-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Rasouli, Mohsen; Zolfigol, Mohammad Ali; Moslemin, Mohammad Hossien; Mohebat, Razieh; Chehardoli, Gholamabbas published the artcile< H2O2 as a green and environmentally benign reagent for the oxidation of sulfides in the presence of {[K.18-Crown-6]X3}n (X=Br, I) compared with some other organic tribromides>, Category: alcohols-buliding-blocks, the main research area is sulfoxide preparation green chem; sulfide oxidation hydrogen peroxide crown ether trihalide.

In the presence of {[K.18-Crown-6]X3}n (X = Br, I)-as interesting trihalide reagents, organic sulfides were oxidized to their corresponding sulfoxides using H2O2 as a green reagent. {[K.18-Crown-6]X3}n activates H2O2 via in situ generation of HOX and variously substituted sulfides were selectively transformed into the corresponding sulfoxides. The obtained results of {[K.18-Crown-6]X3}n with some other organic tribromides have been compared. Unexpectedly, in most cases, the results were similar.

Eurasian Chemical Communications published new progress about Green chemistry. 699-12-7 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H10OS, Category: alcohols-buliding-blocks.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Irvine, Jennifer D.; Takahashi, Lori; Lockhart, Karen; Cheong, Jonathan; Tolan, John W.; Selick, H. E.; Grove, J. Russell published the artcile< MDCK (Madin-Darby canine kidney) cells: a tool for membrane permeability screening>, Safety of Sodium 5,5′-(diazene-1,2-diyl)bis(2-hydroxybenzoate), the main research area is membrane permeability drug screening MDCK Caco2; high throughput screening MDCK Caco2 drug bioavailability; assay membrane permeability screening drug pharmacokinetics.

The goal of this work was to investigate the use of MDCK (Madin-Darby canine kidney) cells as a possible tool for assessing the membrane permeability properties of early drug discovery compounds Apparent permeability (Papp) values of 55 compounds with known human absorption values were determined using MDCK cell monolayers. For comparison, Papp values of the same compounds were also determined using Caco-2 cells, a well-characterized in vitro model of intestinal drug absorption. Monolayers were grown on 0.4-μm Transwell-COL membrane culture inserts. MDCK cells were seeded at high d. and cultured for 3 days, and Caco-2 cells were cultured under standard conditions for 21 to 25 days. Compounds were tested using 100 μM donor solutions in transport medium (pH 7.4) containing 1% DMSO. The Papp values in MDCK cells correlated well with those in Caco-2 cells (r2 = 0.79). Spearman’s rank correlation coefficient for MDCK Papp and human absorption was 0.58 compared with 0.54 for Caco-2 Papp and human absorption. These results indicate that MDCK cells may be a useful tool for rapid membrane permeability screening.

Journal of Pharmaceutical Sciences published new progress about Analysis. 6054-98-4 belongs to class alcohols-buliding-blocks, and the molecular formula is C14H8N2Na2O6, Safety of Sodium 5,5′-(diazene-1,2-diyl)bis(2-hydroxybenzoate).

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts