Month: October 2022

The author of 《Functionalized Anion-Exchange Membranes Facilitate Electrodialysis of Citrate and Phosphate from Model Dairy Wastewater》 were Paltrinieri, Laura; Huerta, Elisa; Puts, Theo; van Baak, Willem; Verver, Albert B.; Sudhoelter, Ernst J. R.; de Smet, Louis C. P. M.. And the article was published in Environmental Science & Technology in 2019. Safety of 3-Aminopropan-1-ol The author mentioned the following in the article:

Here, the preparation of a new, functional anion-exchange membrane (AEM), containing guanidinium groups as the anion-exchanging sites (Gu-100), is described as well as the membrane characterization by XPS, water uptake, permselectivities, and elec. resistances. The functional membrane was also used in pH-dependent electrodialysis experiments using model dairy wastewater streams. The properties of the new membrane are compared to those of a com. available anion-exchange membrane bearing conventional quaternary ammonium groups (Gu-0). Guanidinium was chosen for its specific binding properties toward oxyanions: e.g., phosphate. This functional moiety was covalently coupled to an acrylate monomer via a facile two-step synthesis to yield bulk-modified membranes upon polymerization Significant differences were observed in the electrodialysis experiments for Gu-0 and Gu-100 at pH 7, showing an enhanced phosphate and citrate transport for Gu-100 in comparison to Gu-0. At pH 10 the difference is much more pronounced: for Gu-0 membranes almost no phosphate and citrate transport could be detected, while the Gu-100 membranes transported both ions significantly. We conclude that having guanidinium groups as anion-exchange sites improves the selectivity of AEMs. As the presented monomer synthesis strategy is modular, we consider the implementation of functional groups into a polymer-based membrane via the synthesis of tailor-made monomers as an important step toward selective ion transport, which is relevant for various fields, including water treatment processes and fuel cells.3-Aminopropan-1-ol(cas: 156-87-6Safety of 3-Aminopropan-1-ol) was used in this study.

3-Aminopropan-1-ol(cas: 156-87-6) belongs to anime. Many important products require amines as part of their syntheses. Methylamine is utilized in the production of the analgesic meperidine (trade name Demerol) and the photographic developer Metol (trademark), and dimethylamine is used in the synthesis of the antihistamine diphenhydramine (trade name Benadryl), the solvent dimethylformamide (DMF), and the rocket propellant 1,1-dimethylhydrazine. The synthesis of the insect repellent N,N-diethyl-m-toluamide (DEET) incorporates diethylamine while that of the synthetic fibre Kevlar requires aromatic amines.Safety of 3-Aminopropan-1-ol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

The author of 《New polymeric adsorbent materials used for removal of phenolic derivatives from wastewaters》 were Davidescu, Corneliu-Mircea; Ardelean, Radu; Popa, Adriana. And the article was published in Pure and Applied Chemistry in 2019. Name: 3-Hydroxybenzaldehyde The author mentioned the following in the article:

For the treatment of waste waters containing phenols or phenolic compounds several unconventional methods are applied, such as: inverse osmosis, coagulation, solvent extraction, flotation-coagulation combined processes, adsorption, and anaerobic processes. From all used remediation processes adsorption has a higher applicability degree due to its main advantages: simplicity, ease of use and operation and high efficiency. It is important to develop and use new adsorbents with higher regeneration degree and longer life time. Chem. modification of polymeric matrixes with pendant functional groups is a valuable method used to improve the surface and interface chem. of polymeric adsorbents, to achieve better adsorption performance and to design tailor-made adsorbents with respect to specific pollutants. In present study new adsorbent materials were obtained starting from chloromethylated styrene-divinylbenzene copolymers with different degrees of crosslinking (6.7%, 12% and resp. 15% DVB), functionalized by reaction with 3-hydroxibenzaldehyde. The polymeric intermediates were further modified by polymer-analogous reaction with iso-propylamine and diethylphosphite with the aim to improve their adsorptive properties. The obtained polymeric adsorbents were tested for remediation of waters containing phenol (P), 2,3-dimethylphenol (2,3-DMP) and 2,4,6-trimethyl-phenol (2,4,6-TMP). Based on obtained exptl. data the adsorption mechanism, process kinetics and thermodn. were studied.3-Hydroxybenzaldehyde(cas: 100-83-4Name: 3-Hydroxybenzaldehyde) was used in this study.

3-Hydroxybenzaldehyde(cas: 100-83-4) can be used as a reactant along with ethyl acetoacetate and thiourea in the synthesis of corresponding dihydropyrimidine-2-thione (monastrol), using Yb(OTf)3 as a catalyst by Biginelli cyclocondensation reaction.Name: 3-Hydroxybenzaldehyde

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

The author of 《Direct growth of covalent organic framework nanofiltration membranes on modified porous substrates for dyes separation》 were Pan, Fusheng; Guo, Weixiong; Su, Yanlei; Khan, Niaz Ali; Yang, Hao; Jiang, Zhongyi. And the article was published in Separation and Purification Technology in 2019. Formula: C9H6O6 The author mentioned the following in the article:

Covalent organic frameworks (COFs) are emerging as crystalline porous materials for advanced membranes, due to their regular pore structures and high porosity. The fabrication of defect-free ultrathin COFs membranes is still very challenging, since the poor COF-substrate affinity hampers the nucleation of COF crystallites. In this work, a facile direct growth method was developed to deposit continuous imine-based COF layer (TpPa-1, synthesized by the Schiff-base reactions of 1,3,5-triformylphloroglucinol (Tp) with p-phenylenediamine (Pa-1)). Aldehydes groups were firstly immobilized on polyacrylonitrile (PAN) porous substrate as the nucleation sites to promote the growth of continuous TpPa-1 layer via a good COF-to-substrate adhesion. Fourier transform IR spectroscopy (FTIR), scanning electron microscope (SEM) and X-ray diffractometer (XRD) confirmed the formation of COF layer. The TpPa-1/HPAN membrane exhibited high water flux of 418.5 L/(m2 h MPa) under the operation pressure of 0.1 MPa and excellent dyes rejection (93.91% for Orange GII and over 99% for Methyl blue, Congo red and Alcian blue). The high separation performance, coupled with its facile fabrication and remarkable stability, may render imine-based COFs membrane promising for wastewater treatment. In the experimental materials used by the author, we found 2,4,6-Trihydroxybenzene-1,3,5-tricarbaldehyde(cas: 34374-88-4Formula: C9H6O6)

2,4,6-Trihydroxybenzene-1,3,5-tricarbaldehyde(cas: 34374-88-4) is a member of phloroglucinol derivatives. Regarding monomeric phloroglucinols, this group encompasses acryl phloroglucinols, phloroglucinol-terpene adducts, phloroglucinol glycosides, halogenated phloroglucinols, prenylated phloroglucinols, and cyclicroup polyketides.Formula: C9H6O6

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

The author of 《Mitochondrial-targeted Hsp90 C-terminal inhibitors manifest anti-proliferative activity》 were Zhang, Zheng; Banerjee, Monimoy; Davis, Rachel E.; Blagg, Brian S. J.. And the article was published in Bioorganic & Medicinal Chemistry Letters in 2019. Application In Synthesis of 3-Bromopropan-1-ol The author mentioned the following in the article:

The development of C-terminal heat shock protein 90 kDa (Hsp90) inhibitors has emerged as a potential treatment for cancer. Similarly, small mols. that target the mitochondria have proven to be efficacious towards cancer, as the reprogramming of mitochondrial function is often associated with oncogenic transformation. Herein, we report the development of triphenylphosphonium (TPP)-conjugated Hsp90 C-terminal inhibitors, their anti-proliferative activity, and accumulation in the mitochondria. In general, TPP-conjugated Hsp90 C-terminal inhibitors were found to manifest increased activity against various cancer cell lines when compared to the parent compounds In the experimental materials used by the author, we found 3-Bromopropan-1-ol(cas: 627-18-9Application In Synthesis of 3-Bromopropan-1-ol)

3-Bromopropan-1-ol(cas: 627-18-9) was used in the synthesis of fluorescent halide-sensitive quinolinium dyes and molten salt-polymers. Furthermore, it was used in the synthesis of chiral, quaternary prolines via cyclization of quaternary amino acids.Application In Synthesis of 3-Bromopropan-1-ol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

The author of 《Ligand-Promoted Iron(III)-Catalyzed Hydrofluorination of Alkenes》 were Xie, Yongtao; Sun, Peng-Wei; Li, Yuxin; Wang, Siwei; Ye, Mengchun; Li, Zhengming. And the article was published in Angewandte Chemie, International Edition in 2019. Category: alcohols-buliding-blocks The author mentioned the following in the article:

An iron-catalyzed hydrofluorination of unactivated alkenes has been developed. The use of a multidentate ligand and the fluorination reagent N-fluorobenzenesulfonimide (NFSI) proved to be critical for this reaction, which afforded various fluorinated compounds in up to 94 % yield. In the experiment, the researchers used 5-Hexen-1-ol(cas: 821-41-0Category: alcohols-buliding-blocks)

5-Hexen-1-ol(cas: 821-41-0) is used in cyclization to a tetrahydropyran by phenylselenoetherification. It is also used as a building block in synthetic chemistry.Category: alcohols-buliding-blocks

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

The author of 《Reduction-responsive poly (ethylene glycol)-dexamethasone biarm conjugate and its self-assembled nanomicelles: Preparation, physicochemical characterization, and thiol-triggered drug release》 were Ngoc, Van Tran Thi; Hwang, Hee Sook; Kim, Yugyeong; Kang, Han Chang; Huh, Kang Moo. And the article was published in Polymers for Advanced Technologies in 2019. Formula: C3H9NO2 The author mentioned the following in the article:

In this study, a reduction-responsive poly (ethylene glycol)-dexamethasone biarm conjugate was synthesized as intracellular targeted drug delivery carriers. The hydroxyl end group of methoxy poly (ethylene glycol) (mPEG) was modified to introduce a biarm structure with bioreducible disulfide bond and amine end groups. Dexamethasone (Dex) as a nuclear targeting moiety was conjugated to the amine end groups of mPEG biarm derivatives, mPEG-(NH2)2 or mPEG-(ss-NH2)2, with or without bioreducible disulfide bonds. The bioreducible and nonreducible mPEG-Dex biarm conjugates, R-mPEG-Dex and N-mPEG-Dex, were synthesized and characterized by various anal. methods, proton NMR (1H-NMR), Fourier transform IR spectroscopy (FT-IR), dynamic light scattering (DLS), and fluorescence measurements. Amphiphilic mPEG-Dex conjugates self-assembled in aqueous solutions to form nanoparticles (NPs) with a size range of 130 to 150 nm, and their critical micelle concentrations (CMCs) were determined to be 12.4 and 15.3 mg/L, resp., for bioreducible and nonreducible ones. The R-mPEG-Dex NPs maintained good colloidal stability in the presence of bovine serum albumin (BSA) for more than 1 wk but demonstrated a significant change in colloidal stability in the presence of dithiothreitol (DTT). In DTT-containing phosphate-buffered saline (PBS), the bioreducible NPs showed not only reduction-responsive destabilization with PEG shedding but also thiol-dependent drug release profile. Our observations indicated that the R-mPEG-Dex NPs have a promising prospective as an efficient nanocarrier for intracellular targeted delivery of various anticancer drugs. In addition to this study using 2-Aminopropane-1,3-diol, there are many other studies that have used 2-Aminopropane-1,3-diol(cas: 534-03-2Formula: C3H9NO2) was used in this study.

2-Aminopropane-1,3-diol(cas: 534-03-2) belongs to anime. Aniline, ethanolamines, and several other amines are major industrial commodities used in making rubber, dyes, pharmaceuticals, and synthetic resins and fibres and for a host of other applications. Most of the numerous methods for the preparation of amines may be broadly divided into two groups: (1) chemical reduction (replacement of oxygen with hydrogen atoms in the molecule) of members of several other classes of organic nitrogen compounds and (2) reactions of ammonia or amines with organic compounds.Formula: C3H9NO2

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

《Allylic Amination of Alkenes with Iminothianthrenes to Afford Alkyl Allylamines》 was published in Journal of the American Chemical Society in 2020. These research results belong to Cheng, Qiang; Chen, Junting; Lin, Songyun; Ritter, Tobias. HPLC of Formula: 821-41-0 The article mentions the following:

Allylic C-H amination is currently accomplished with (sulfon)amides or carbamates. Here we show the first allylic amination that can directly afford alkyl allylamines, enabled by the reactivity of thianthrene-based nitrogen sources that can be prepared from primary amines in a single step. In the experiment, the researchers used many compounds, for example, 5-Hexen-1-ol(cas: 821-41-0HPLC of Formula: 821-41-0)

5-Hexen-1-ol(cas: 821-41-0) is a volatile organic compound. Further, it is used to prepare 6-bromo-hex-1-ene by reaction with phosphorus tribromide.HPLC of Formula: 821-41-0

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

《Highly Productive α-Alkylation of Ketones with Alcohols Mediated by an Ir-Oxalamidato/Solid Base Catalyst System》 was published in Organic Process Research & Development in 2020. These research results belong to Shimizu, Hideo; Maeda, Hironori; Nara, Hideki. Recommanded Product: 5-Hexen-1-ol The article mentions the following:

An Ir-oxalamidato complexes I [R = Ph, 2-MeC6H4, 2-Me-4-OH-5-t-BuC6H2, etc.] were synthesized and examined for their catalytic activity in the synthesis of alkylated ketones R1C(O)R2 [R1 = Me, n-hexyl, CH2CH2C6H5, etc.; R2 = n-hexyl, CH2CH2C6H5, 4-OMeC6H4CH2CH2, etc.]. Synthesized Ir-oxalamidato complex I [R = 2-Me-4-OH-5-t-BuC6H2] in combination with a solid base (e.g., magnesium aluminometasilicate/Ca(OH)2) significantly improved the catalyst productivity in α-alkylation of Me ketones with primary alcs. Optimization through systematic variation of the oxalamidato ligand led to a practical turnover number (TON) of 10 000-40 000. In the experimental materials used by the author, we found 5-Hexen-1-ol(cas: 821-41-0Recommanded Product: 5-Hexen-1-ol)

5-Hexen-1-ol(cas: 821-41-0) is a volatile organic compound. Further, it is used to prepare 6-bromo-hex-1-ene by reaction with phosphorus tribromide.Recommanded Product: 5-Hexen-1-ol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

《Aminothiazolones as potent, selective and cell active inhibitors of the PIM kinase family》 was published in Bioorganic & Medicinal Chemistry in 2020. These research results belong to Quevedo, Camilo E.; Bataille, Carole J. R.; Byrne, Simon; Durbin, Matthew; Elkins, Jon; Guillermo, Abigail; Jones, Alan M.; Knapp, Stefan; Nadali, Anna; Walker, Roderick G.; Wilkinson, Isabel V. L.; Wynne, Graham M.; Davies, Stephen G.; Russell, Angela J.. Formula: C6H7BO3 The article mentions the following:

We have previously reported the discovery of a series of rhodanine-based inhibitors of the PIM family of serine/threonine kinases. Here we described the optimization of those compounds to improve their physicochem. and ADME properties as well as reducing their off-targets activities against other kinases. Through mol. modeling and systematic structure activity relationship (SAR) studies, advanced mols. with high inhibitory potency, reduced off-target activity and minimal efflux were identified as new pan-PIM inhibitors. One example of an early lead, I, was found to inhibit PIMs with nanomolar potency (15 nM for PIM1), inhibit proliferation of two PIM-expressing leukemic cancer cell lines, MV4-11 and K562, and to reduce intracellular phosphorylation of a PIM substrate in a concentration dependent manner. The experimental part of the paper was very detailed, including the reaction process of 2-Hydroxyphenylboronic acid(cas: 89466-08-0Formula: C6H7BO3)

2-Hydroxyphenylboronic acid(cas: 89466-08-0) belongs to acyl phenylboronic acid. Phenylboronic acid (PBA) has been used to extract β-blockers (a class of aminoalcohol-containing drugs) from aqueous solution, rat, and human plasma. Formula: C6H7BO3

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

《Rational combination of covalent-organic framework and nano TiO2 by covalent bonds to realize dramatically enhanced photocatalytic activity》 was published in Applied Catalysis, B: Environmental in 2020. These research results belong to Li, Chang-Cheng; Gao, Meng-Yao; Sun, Xiao-Jun; Tang, Hong-Liang; Dong, Hong; Zhang, Feng-Ming. Recommanded Product: 34374-88-4 The article mentions the following:

Rationally combining the advantage of inorganic and organic semiconductors to construct a heterojunction is an effective way to boost the photocatalytic activity of materials, while it is still a great challenge to tightly integrate these two different components together. In this work, for the first time, the TpPa-1-COF, an excellent visible-light harvesting covalent-organic frameworks (COFs), and TiO2 were combined together by covalent bonds to construct a heterojunction. The resulting TiO2-TpPa-1-COF hybrid materials show efficient photocatalytic activity under visible light irradiation Especially, TiO2-TpPa-1-COF (1:3) exhibits the optimized photocatalytic H2 evolution rate of 11.19 mmol g-1 h-1 and apparent quantum efficiency of 7.6% at λ = 420 nm, which is 5.3 and 3.0 times higher than the TpPa-1-COF and TiO2/TpPa-1-COF, resp. Further investigations confirm that the covalent connection between TiO2 and TpPa-1-COF components can largely improve the transfer of photogenerated charges of COF, leading to the efficient H2 evolution activity. In the experimental materials used by the author, we found 2,4,6-Trihydroxybenzene-1,3,5-tricarbaldehyde(cas: 34374-88-4Recommanded Product: 34374-88-4)

2,4,6-Trihydroxybenzene-1,3,5-tricarbaldehyde(cas: 34374-88-4) is a member of phloroglucinol derivatives.Recommanded Product: 34374-88-4For acyl phloroglucinols, it is considered the largest category of compounds among phloroglucinols of natural characteristics.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts