Month: October 2022

《New complexes of liquid crystal discotic triphenylenes: induction of the double gyroid phase》 was written by Otmakhova, O. A.; Piryazev, A. A.; Bondarenko, G. N.; Shandryuk, G. A.; Maryasevskaya, A. V.; Merekalov, A. S.; Ivanov, D. A.; Talroze, R. V.. Electric Literature of C3H7BrOThis research focused ontriphenylene discotic liquid crystal preparation phase transition self assembly. The article conveys some information:

Electron donor-acceptor liquid crystals have been attracting considerable attention due to possible applications in optoelectronics and photonics. The creation of such charge transfer complexes is a powerful and flexible instrument for modifying the structures and properties compared to those of the initial components. In the present work, such an approach is exemplified on new complexes formed via non-covalent interactions of triphenylene discotics, namely, 2,3,6,7,10,11-hexakis(pentyloxy) triphenylene (H5T) and 2-(acryloyloxypropyloxy)-3,6,7,10,11-pentapentylox-triphenylene (TPh-3A), with an electron acceptor, β-(2,4,7-trinitro-9-fluorenylideneaminooxy) propionic acid (TNF-carb). The structure of thin supported films of H5T, TPh-3A and their blends with TNF-carb was investigated by grazing-incidence wide-angle X-ray scattering using a synchrotron source. At room temperature, the pristine discotics crystallize in orthorhombic unit cells whereas the self-assembly of H5T and TPh-3A with TNF-carb results in a double gyroid and hexagonal phases, resp. Formation of the double gyroid phase with the lattice parameter of 36.5 Å is driven by phase separation between the aromatic and alkyl regions of the system. It is supposed that the TNF-carb mols. of the complex are positioned in the nodes of the structure while the H5T mols. are located in the struts adjoining the nodes via triple junctions. For the hexagonal crystal of the TPh-3A/TNF-carb complex, the acceptor mols. are likely located in the interstices between the neighboring supramol. columns of TPh-3A. The mol. structures of the blends were also explored by means of FTIR spectroscopy. A detailed FTIR spectra anal. illustrates fine changes in inter-mol. bonds. For example, the initially dimerized acceptor mols. totally disappear in the complex structures whereas in TPh-3A/TNF-carb addnl. H-bonds between the carboxylate group in TNF-carb and the ester group of TPh-3A form. The exptl. data allows putting forward possible mol. models of the complex structures. The experimental process involved the reaction of 3-Bromopropan-1-ol(cas: 627-18-9Electric Literature of C3H7BrO)

3-Bromopropan-1-ol(cas: 627-18-9) is used in the synthesis of fluorescent halide-sensitive quinolinium dyes, chiral, quaternary prolines through cyclization of quaternary amino acids and molten salt-polymers. It is utilized for the study of micellar media and in microemulsions based on cationic or a nonionic surfactant by reacting with phenols.Electric Literature of C3H7BrO

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《Sustained co-delivery of ibuprofen and basic fibroblast growth factor by thermosensitive nanoparticle hydrogel as early local treatment of peri-implantitis》 was published in International Journal of Nanomedicine in 2019. These research results belong to Chen, Wenlei; Zhi, Min; Feng, Zujian; Gao, Pengfei; Yuan, Yuan; Zhang, Congcong; Wang, Yonglan; Dong, Anjie. Application In Synthesis of trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride The article mentions the following:

Objective: The aims of this study were to 1 encapsulate ibuprofen (IBU) and basic fibroblast growth factor (bFGF) in a thermosensitive micellar hydrogel, 2 test the biol. properties of this in situ drug delivery system, and 3 study the effect of hydrogel in promoting soft tissue healing after implant surgery and its anti-inflammatory function as an early local treatment of peri-implantitis. Materials and methods: A thermosensitive micellar hydrogel was prepared from amphiphilic copolymer poly(ε-caprolactone-co-1,4,8-trioxa [4.6]spiro-9-undecanone)-poly(ethylene glycol)-poly(ε-caprolactone-co-1,4,8-trioxa [4.6]spiro-9-undecanone) (PECT) nanoparticles and tested in vitro using a scanning electron microscope, rheometer, UV spectrophotometer, HPLC, and transmission electron microscope. The bFGF + IBU/PECT hydrogel formed a stable, water-dispersible nanoparticle core shell that was injectable at room temperature, hydrogel in situ at body temperature, and provided sustained release of both hydrophilic and hydrophobic drugs. The hydrogel promoted the proliferation and adhesion of human gingival fibroblasts, upregulated the expression of adhesion factors such as vinculin proteins, and showed anti-inflammatory properties. Conclusion: In situ preparation of IBU- and bFGF-loaded PECT hydrogel represents a promising drug delivery system with the potential to provide early local treatment for peri-implantitis. In the part of experimental materials, we found many familiar compounds, such as trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride(cas: 23828-92-4Application In Synthesis of trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride)

trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride(cas: 23828-92-4) enhances pulmonary surfactant production and stimulates ciliary activity.Application In Synthesis of trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride It promotes mucus clearance, facilitates expectoration and eases productive cough, allowing patients to breathe.

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《β-Selective Aroylation of Activated Alkenes by Photoredox Catalysis》 was published in Angewandte Chemie, International Edition in 2019. These research results belong to Lei, Zhen; Banerjee, Arghya; Kusevska, Elena; Rizzo, Eric; Liu, Peng; Ngai, Ming-Yu. Related Products of 20880-92-6 The article mentions the following:

Late-stage synthesis of α,β-unsaturated aryl ketones remains an unmet challenge in organic synthesis. Reported herein is a photocatalytic non-chain-radical aroyl chlorination of alkenes by a 1,3-chlorine atom shift to form β-chloroketones as masked enones that liberate the desired enones upon workup. This strategy suppresses side reactions of the enone products. The reaction tolerates a wide array of functional groups and complex mols. including derivatives of peptides, sugars, natural products, nucleosides, and marketed drugs. Notably, addition of 2,6-di-tert-butyl-4-methylpyridine enhances the quantum yield and efficiency of the cross-coupling reaction. Exptl. and computational studies suggest a mechanism involving PCET (proton-coupled electron transfer), formation and reaction of an α-chloro-α-hydroxy benzyl radical, and 1,3-chlorine atom shift. Thus, e.g., irradiation of a reaction mixture containing 4-fluorobenzoyl chloride, 1,1-diphenylethylene, fac-Ir(ppy)3 and 2,6-di-tert-butyl-4-methylpyridine in CHCl3 in CHCl3 with blue LEDs afforded I (85%) upon isolation. In the part of experimental materials, we found many familiar compounds, such as ((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol(cas: 20880-92-6Related Products of 20880-92-6)

((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol(cas: 20880-92-6) is a useful reactant for examining the effectiveness of sulfamate and sulfamide groups for the inhibition of carbonic anhydrase-​II (CA-​II)​.Related Products of 20880-92-6 And it is used as chiral auxiliaries in Michael and Aldol addition reactions.

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Safety of 3,3,3-Trifluoropropan-1-olOn November 15, 2021 ,《Synthetic cajaninstilbene acid derivatives eradicate methicillin-resistant Staphylococcus aureus persisters and biofilms》 appeared in European Journal of Medicinal Chemistry. The author of the article were Yu, Jia-Hui; Xu, Xiao-Fang; Hou, Wen; Meng, Ying; Huang, Mei-Yan; Lin, Jing; Chen, Wei-Min. The article conveys some information:

The Staphylococcus aureus can switch to a transient genotype-invariant dormancy, known as a persister, to survive treatment with high doses of antibiotics. This transient persister is an important reason underlying its resistance. There is an urgent need to find new antibacterial agents capable of eradicating methicillin-resistant S. aureus (MRSA) persisters. In this study, 37 new derivatives of cajaninstilbene acid (CSA) were designed and synthesized, and their biol. activity against MRSA persisters was evaluated. Most of the newly synthesized derivatives exhibit more potent antimicrobial properties against S. aureus and MRSA than CSA itself, and 23 of the 37 derivatives show a tendency to eradicate MRSA persisters. A representative compound, I, was demonstrated to target bacterial cell membranes. It eradicated the adherent biofilm of MRSA in a concentration dependent manner, and showed a synergistic antibacterial effect with piperacilin. In a model mouse abscess caused by MRSA persisters, I effectively reduced the bacterial load in vivo. These results indicate that I is a potential candidate for treatment of MRSA persister infections. In the experiment, the researchers used many compounds, for example, 3,3,3-Trifluoropropan-1-ol(cas: 2240-88-2Safety of 3,3,3-Trifluoropropan-1-ol)

3,3,3-Trifluoropropan-1-ol(cas: 2240-88-2) is a important organic intermediate. It can be used in agrochemical, pharmaceutical and dyestuff field.Safety of 3,3,3-Trifluoropropan-1-ol

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Frankowski, Kevin J.; Patnaik, Samarjit; Wang, Chen; Southall, Noel; Dutta, Dipannita; De, Soumitta; Li, Dandan; Dextras, Christopher; Lin, Yi-Han; Bryant-Connah, Marthe; Davis, Danielle; Wang, Feijun; Wachsmuth, Leah M.; Shah, Pranav; Williams, Jordan; Kabir, Md; Zhu, Edward; Baljinnyam, Bolormaa; Wang, Amy; Xu, Xin; Norton, John; Ferrer, Marc; Titus, Steve; Simeonov, Anton; Zheng, Wei; Mathews Griner, Lesley A.; Jadhav, Ajit; Aube, Jeffrey; Henderson, Mark J.; Rudloff, Udo; Schoenen, Frank J.; Huang, Sui; Marugan, Juan J. published an article in Journal of Medicinal Chemistry. The title of the article was 《Discovery and Optimization of Pyrrolopyrimidine Derivatives as Selective Disruptors of the Perinucleolar Compartment, a Marker of Tumor Progression toward Metastasis》.Reference of 4,4-Diethoxybutan-1-amine The author mentioned the following in the article:

A high-throughput, high-content assay was developed to identify novel small mols. that selectively reduce PNC prevalence in cancer cells. The pyrrolopyrimidine series able to reduce PNC prevalence in PC3M cancer cells at submicromolar concentrations without affecting cell viability was identified and further optimized. Structure-activity relationship exploration of the structural elements necessary for activity resulted in the discovery of several potent compounds Anal. of in vitro drug-like properties led to the discovery of the bioavailable analog, metarrestin, which has shown potent antimetastatic activity with improved survival in rodent models and is currently being evaluated in a first-in-human phase 1 clin. trial. The experimental part of the paper was very detailed, including the reaction process of 4,4-Diethoxybutan-1-amine(cas: 6346-09-4Reference of 4,4-Diethoxybutan-1-amine)

4,4-Diethoxybutan-1-amine(cas: 6346-09-4) belongs to anime. Milder oxidation, using reagents such as NaOCl, can remove four hydrogen atoms from primary amines of the type RCH2NH2 to form nitriles (R―C≡N), and oxidation with reagents such as MnO2 can remove two hydrogen atoms from secondary amines (R2CH―NHR′) to form imines (R2C=NR′). Tertiary amines can be oxidized to enamines (R2C=CHNR2) by a variety of reagents.Reference of 4,4-Diethoxybutan-1-amine

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Modukuri, Ram K.; Choudhary, Dharmendra; Gupta, Sampa; Rao, K. Bhaskara; Adhikary, Sulekha; Sharma, Tanuj; Siddiqi, Mohammad Imran; Trivedi, Ritu; Sashidhara, Koneni V. published their research in Bioorganic & Medicinal Chemistry on December 15 ,2017. The article was titled 《Benzofuran-dihydropyridine hybrids: A new class of potential bone anabolic agents》.Recommanded Product: 153759-59-2 The article contains the following contents:

A series of novel benzofuran-dihydropyridine hybrids were designed by mol. hybridization approach and evaluated for bone anabolic activities. Among the screened library, compound I significantly enhanced the ALP production and mineralized nodule formation, which are primary requisites in the process of in vitro osteogenesis. Oral administration of compound I at 10 mg·kg-1·day-1 for two weeks led to restoration of trabecular bone microarchitecture in drill hole fracture model by significantly increasing BV/TV and Tb. N. Furthermore, histol. and mol. studies showed compound I triggering the new bone regeneration in a drill hole defect site by increasing BMP expression. Furthermore, mol. modeling studies were performed to gain insight into the binding approach, which revealed that both benzofuran and dihydropyridine moieties are essential to show similar binding interactions to fit into the active site of BMP2 receptor, an important target of the osteogenic agents. The results suggest that compound I stimulates BMP2 synthesis in osteoblast cells that promotes new bone formation (∼40%) at the fracture site which helps in shorten the healing period. The experimental process involved the reaction of 5-(tert-Butyl)-4-hydroxyisophthalaldehyde(cas: 153759-59-2Recommanded Product: 153759-59-2)

5-(tert-Butyl)-4-hydroxyisophthalaldehyde(cas: 153759-59-2) belongs to phenols.Recommanded Product: 153759-59-2Deprotonation of a phenol forms a corresponding negative phenolate ion or phenoxide ion, and the corresponding salts are called phenolates or phenoxides (aryloxides according to the IUPAC Gold Book).

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Naito, Youichiro; Sugiura, Masanori; Yamaura, Yasunari; Fukaya, Chikara; Yokoyama, Kazumasa; Nakagawa, Yoshiaki; Ikeda, Tokuji; Senda, Mitsugi; Fujita, Toshio published an article in Chemical & Pharmaceutical Bulletin. The title of the article was 《Quantitative structure-activity relationship of catechol derivatives inhibiting 5-lipoxygenase》.Safety of 4-Butylbenzene-1,2-diol The author mentioned the following in the article:

Various catechol derivatives (β-substituted 3,4-dihydroxystyrenes, 1-substituted 3,4-dihydroxybenzenes, and 6-substituted 2,3-dihydroxynaphthalenes) were synthesized and their inhibition of 5-lipoxygenase was assayed. Their structure-activity relationships were examined quant. with substituent and structural parameters and regression anal. The variations of the inhibitory activity were explained in bilinear hydrophobic parameter (log P) terms, and steric (mol. thickness) and electronic (1H-NMR chem. shift of the proton adjacent to the catechol group) parameter terms. The hydrophobicity of the inhibitor mol. was important, and the optimum value of log P was ∼4.3-4.6, beyond which inhibition did not increase further. A lower electron d. of the aromatic ring containing the catechol group and the greater thickness of the lipophilic side chains were unfavorable to the activity. The results added a physicochem. basis for the selection of candidate compounds for developmental studies. In the experimental materials used by the author, we found 4-Butylbenzene-1,2-diol(cas: 2525-05-5Safety of 4-Butylbenzene-1,2-diol)

4-Butylbenzene-1,2-diol(cas: 2525-05-5) belongs to organoboron compounds. Organoboron compounds are versatile intermediates and as such are some of the most important classes of reagents in modern organic chemistry.Safety of 4-Butylbenzene-1,2-diol Organoboron compounds are less toxic than organostannane reagents, and unlike alkynylzinc and magnesium, many organoboron compounds possess remarkable oxidative and thermal stabilities.

Referemce:
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Pu, Yanchi; Zhang, Hao; Peng, Yao; Fu, Qiuyi; Yue, Qiming; Zhao, Yi; Guo, Li; Wu, Yong published their research in European Journal of Medicinal Chemistry on December 1 ,2019. The article was titled 《Dual-targeting liposomes with active recognition of GLUT5 and αvβ3 for triple-negative breast cancer》.Product Details of 20880-92-6 The article contains the following contents:

At present, chemo- and radiotherapies remain to be the mainstream methods for treating triple-neg. breast cancer (TNBC), which is known for poor prognosis and high rate of mortality. Two types of novel dual-targeting TNBC liposomes (Fru-RGD-Lip and Fru+RGD-Lip) that actively recognize both fructose transporter GLUT5 and integrin αvβ3 were designed and prepared in this work. Firstly, a Y-shaped Fru-RGD-chol ligand, where a fructose and peptide Arg-Gly-Asp (RGD) were covalently attached to cholesterol, was designed and synthesized. Then, the Fru-RGD-Lip was constructed by inserting Fru-RGD-chol into liposomes, while Fru+RGD-Lip was obtained by inserting both Fru-chol and RGD-chol (with the molar ratio of 1:1) into liposomes. The particle size, zeta potential, encapsulation efficiency and serum stability of the paclitaxel-loaded liposomes were characterized. The results indicated that the paclitaxel-loaded Fru-RGD-Lip had the strongest growth inhibition against GLUT5 and αvβ3 overexpressed MDA-MB-231 and 4T1 cells. The cellular uptake of Fru-RGD-Lip on MDA-MB-231 cells and 4T1 cells was 3.19- and 3.23-fold more than that of the uncoated liposomes (Lip). The uptake of Fru+RGD-Lip was slightly lower, giving a 2.81- and 2.90-fold increase than that of Lip in two cell lines, resp. The mechanism study demonstrated that the cellular uptake of both dual-targeting liposomes was likely to be recognized and mediated by GLUT5 and αvβ3 firstly, then endocytosed through comprehensive pathways in an energy-dependent manner. Moreover, Fru-RGD-Lip displayed the maximum accumulation, which was 2.62-fold higher than that of Lip for instance, at the tumor sites compared to other liposomes using in vivo imaging. Collectively, the liposomes co-modified by fructose and RGD have enormous potential in the development of targeted TNBC treatment, especially the covalently modified Fru-RGD-Lip, making it a promising multifunctional liposome. The experimental part of the paper was very detailed, including the reaction process of ((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol(cas: 20880-92-6Product Details of 20880-92-6)

((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol(cas: 20880-92-6) is a useful reactant for examining the effectiveness of sulfamate and sulfamide groups for the inhibition of carbonic anhydrase-​II (CA-​II)​. And it is used as chiral auxiliaries in Michael and Aldol addition reactions.Product Details of 20880-92-6

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The author of 《Exploration of the structure-activity relationship and druggability of novel oxazolidinone-based compounds as Gram-negative antibacterial agents》 were Ding, Shi; Ji, Jing-Chao; Zhang, Ming-Juan; Yang, Yu-She; Wang, Rui; Zhu, Xing-Long; Wang, Li-Hong; Zhong, Yi; Gao, Le; Lu, Man; Liu, Ju; Chen, Ye. And the article was published in Archiv der Pharmazie (Weinheim, Germany) in 2019. Synthetic Route of C3H6O2 The author mentioned the following in the article:

To gain further knowledge of the structure-activity relationship and druggability of novel oxazolidinone-based UDP-3-O-acyl-N-acetylglucosamine deacetylase (LpxC) inhibitors as Gram-neg. antibacterial agents, compounds containing the hydrophobic tails with different lengths and terminal substitutions were synthesized and their antibacterial activities against standard and clin. isolated Gram-neg. strains were evaluated. We summarized their structure-activity relationships and found that oxazolidinone-based compounds exhibited a narrower antibacterial spectrum compared with threonine-based compounds Furthermore, we parallelly compared the metabolic stabilities of the compounds with the classic threonine scaffold and the novel oxazolidinone scaffold in liver microsomes. The results indicated that the druggability of the oxazolidinone scaffold may be inferior to the classic threonine scaffold in the design of LpxC inhibitors. After reading the article, we found that the author used (R)-Oxiran-2-ylmethanol(cas: 57044-25-4Synthetic Route of C3H6O2)

(R)-Oxiran-2-ylmethanol(cas: 57044-25-4) is a chiral building block used to construct an epoxyvinyl iodide intermediate in a synthesis of a furanocembrane, a marine natural product.Synthetic Route of C3H6O2

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The author of 《Extraction and characterization of starch from the tubers of antigonon leptopus species》 were Hemke, A. T.; Sangle, N. D.; Chandak, K. K.; Pounikar, A. R.; Umekar, M. J.. And the article was published in World Journal of Pharmaceutical Research in 2020. Formula: C6H12O6 The author mentioned the following in the article:

Starch is a natural polymer and is a group of polysaccharides composed of glucopyranose units joined together by glycosidic linkages. Starch is an important polysaccharide extensively used in many industries like food, cosmetic, paper, textile, pharmaceutical etc. It is found to be present in appreciable quantity in stem, roots, leaves, seeds, fruits and tubers. Hence this study was conducted to isolate and characterize starch from tuber of Antigonon leptopus species. In this work starch from Antigonon leptopus tubure was extracted and % starch yield was calculated as well as evaluated for its macroscopic characters, Preliminary phytochem. screening of aqueous extract for the presence of carbohydrate, tannins , saponins and flavonoids. The result showed that there was a sufficient amount of starch yield. The compound microscope it showed the presence of round and oval shaped small and large starch particles, single as well as in groups. The diamond and prism shaped calcium oxalate crystals were also seen. Thus starch of tuber Antigonon leptopus species shows good properties and could serve as alternatives for the production of industrial products that may require starch. The results came from multiple reactions, including the reaction of rel-(3R,4S,5S,6R)-6-(Hydroxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetraol(cas: 54-17-1Formula: C6H12O6)

rel-(3R,4S,5S,6R)-6-(Hydroxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetraol(cas: 54-17-1) is the monohydrate form of the alpha isoform of D-glucopyranose, a synthetic simple monosaccharide that is used as an energy source.Formula: C6H12O6

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