Month: October 2022

Li, Xiang; Shen, Bing; Yao, Xiao-Qiang; Yang, Dan published the artcile< A Small Synthetic Molecule Forms Chloride Channels to Mediate Chloride Transport across Cell Membranes>, Quality Control of 35564-86-4, the main research area is chloride channel plasma membrane permeability bilayer.

Synthetic ion channels that mimic the functions of natural ion channels are of great interest in chem., biochem., biol., and materials science. In this paper, we present a novel small synthetic mol. that self-assembles to form chloride channels in lipid bilayers. This compound is the smallest mol. known to form potent synthetic chloride ion channels. It can also partition into plasma membranes of living cells and therein increase anion permeability. This compound has the potential to become a novel lead compound for the treatment of human diseases associated with Cl- channel dysfunctions.

Journal of the American Chemical Society published new progress about Bilayer biological membrane. 35564-86-4 belongs to class alcohols-buliding-blocks, and the molecular formula is C7H18ClNO5, Quality Control of 35564-86-4.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Aburas, Hani; Ispirli, Humeyra; Taylan, Osman; Yilmaz, Mustafa Tahsin; Dertli, Enes published the artcile< Structural and physicochemical characterisation and antioxidant activity of an α-D-glucan produced by sourdough isolate Weissella cibaria MED17>, Product Details of C6H12O6, the main research area is Weissella sourdough alpha D glucan antioxidant activity; Antioxidant polysaccharides; Exopolysaccharides; Functional roles.

An exopolysaccharide (EPS) producer slimy-mucoid type colony was isolated from sourdough and identified as Weissella cibaria MED17. The 1H and 13C NMR spectra of EPS MED17 demonstrated that this EPS was a dextran type glucan ((1 → 6)-linked α-D-glucose core structure) containing (1 → 3)-linked α-D-glucose branches and proportion of (1 → 6)-linked α-D-glucose units to (1 → 3)-linked α-D-glucose units was 94.3:5.7%. The FTIR anal. also confirmed the (1 → 6)-linked α-D-glucose linkage. A high level of thermal stability was observed for glucan MED17 as no degradation up to 300 °C was observed by TGA and DSC anal. The XRD anal. of glucan MED17 showed its semi- crystalline nature and its compact sheet-like morphol. was observed by SEM anal. Finally, antioxidant characteristics of glucan MED17 were determined by ABTS and DPPH radical scavenging activity tests that revealed a moderate antioxidant activity of glucan MED17. These findings show potential techno-functional characteristics of glucan MED17.

International Journal of Biological Macromolecules published new progress about Exopolysaccharides Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 492-62-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H12O6, Product Details of C6H12O6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Jennings, Julia J.; Milic, Mira; Targos, Karina; Franz, Annaliese K. published the artcile< NMR quantification of H-bond donating ability for bioactive functional groups and isosteres>, Reference of 76-84-6, the main research area is pharmaceutical hydrogen bond donor functional group NMR spectroscopy; (31)P NMR spectroscopy; Binding interaction; Drug fragment; Drug molecule; Hydrogen-bond donors; Isostere; Molecular interactions; Parameterization; Small molecules; TEPO.

The H-bond donating ability for 127 compounds including drug fragments and isosteres have been quantified using a simple and rapid method with 31P NMR spectroscopy. Functional groups important to medicinal chem. were evaluated including carboxylic acids, alcs., phenols, thioic acids and nitrogen group H-bond donors. 31P NMR shifts for binding to a phosphine oxide probe have a higher correlation with equilibrium constants for H-bonding (log KHA) than acidity (pKa), indicating that these binding experiments are representative of H-bonding ability and not proton transfer. Addnl., 31P NMR binding data for carboxylic acid isosteres correlates with physicochem. properties such as lipophilicity, membrane permeability and plasma protein binding. This method has been used to evaluate the H-bond donating ability of small mol. drug compounds such as NSAIDs and antimicrobials.

European Journal of Medicinal Chemistry published new progress about Antimicrobial agents. 76-84-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C19H16O, Reference of 76-84-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Shi, Honghui; Yang, Endian; Yang, Heyue; Huang, Xiaoling; Zheng, Mengxia; Chen, Xiaoyang; Zhang, Junjie published the artcile< Dynamic changes in the chemical composition and metabolite profiles of drumstick (Moringa oleifera Lam.) leaf flour during fermentation>, Product Details of C6H10O8, the main research area is Moringa Aspergillus Candida Bacillus carbohydrate amino acids myoinositol oligosaccharides.

Solid-state fermentation (SSF) using mixed strains can increase the nutritional value and antioxidant content of Moringa oliefera Lam. leaf flour (MLF). However, little is known about the chem. composition and metabolite profiles of MLF during the fermentation process. In this work, mixed strains of Aspergillus Niger, Candida utilis and Bacillus subtilis were inoculated into MLF for SSF. The MLF′s contents of crude protein (CP), crude fiber (CF), water soluble carbohydrate (WSC), reducing sugar, tannin and phytic acid all changed significantly as fermentation proceeded. A metabolomic anal. was performed using GC-TOF-MS, resulting in the identification of 347 metabolites. Fermentation with mixed strains significantly affected levels of amino acids, sugars, and organic acids; concentrations of most amino acids, oligosaccharides, organic acids, nucleosides, γ-aminobutyric acid (GABA), and myo-inositol were higher after 3 d of SSF than at the start. Addnl., several intermediate metabolites were detected in 3 d fermented MLF. The mixed microorganisms′ metabolic activity thus seems to peak after 3 d of fermentation under the tested conditions. These results provide new insights into the changes in the chem. composition and metabolite content of MLF during SSF and reveal possibilities for producing valuable compounds via this process.

LWT–Food Science and Technology published new progress about Amino acids Role: ANT (Analyte), BSU (Biological Study, Unclassified), ANST (Analytical Study), BIOL (Biological Study). 87-73-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H10O8, Product Details of C6H10O8.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Luna, F. Murilo T.; Salmin, Davi Costa; Santiago, Vanessa S.; Maia, Francisco J. N.; Silva, Francisco O. N.; Mazzetto, Selma E.; Cavalcante, Celio L. Jr. published the artcile< Oxidative stability of acylated and hydrogenated ricinoleates using synthetic and natural antioxidants>, Name: 2-Ethylhexan-1-ol, the main research area is acylated hydrogenated ricinoleate antioxidant thermo oxidative stability.

As increasing environmental policies constrains are imposed, the demand for biodegradable products also increases. Although vegetable oils present some properties that favor its use for formulation of a bio-based lubricant, its poor resistance to oxidation hinders its application as such. In this study, the thermo-oxidative stability of bio-based products was compared to petroleum-based lubricants and vegetable oils through the PetroOXY method. Chem. modifications in the ricinoleic acids were carried out using long-chain alcs. in esterification reactions. Acetates were obtained from ricinoleates with and without hydrogenation steps. Addnl., com. antioxidants and phenolic compounds (saturated and unsaturated cardanol) obtained from cashew nut shell liquid were added to the synthesized samples with higher induction times. The results show that the chem. modified bio-based products exhibited improved oxidative stability (up to 6 times) and depressed pour point (-42°C) when compared to pure castor oil. Overall, the addition of antioxidants increased from 6 to 20 times the oxidative stability of the bio-based products. Pr gallate and saturated cardanol showed higher efficiency for retarding the oxidative process of bio-based samples than the com. antioxidants.

Journal of Chemistry published new progress about Acetylation. 104-76-7 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H18O, Name: 2-Ethylhexan-1-ol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Meng, Xin; Che, Chengchuan; Zhang, Junming; Gong, Zhijin; Si, Meiru; Yang, Ge; Cao, Li; Liu, Jinfeng published the artcile< Structural characterization and immunomodulating activities of polysaccharides from a newly collected wild Morchella sextelata>, Computed Properties of 3458-28-4, the main research area is polysaccharide Morchella sextelata immunomodulator macrophage; Immunomodulatory; Morchella sextelata; Polysaccharides; Purification.

A purified polysaccharide was acquired from a newly collected wild Morchella. The strain identification initially showed that the strain was Morchella sextelata. This study aimed to investigate the structural features and immunomodulating activities of the polysaccharide. Polysaccharide extracted from mycelia was purified by DEAE-cellulose chromatog. and Sephadex G-25 size-exclusion chromatog. in sequence. The main fraction of polysaccharide (MSP-II) was obtained during purification process. High Performance Liquid Chromatog. (HPLC) anal. revealed that MSP-II was composed of Glc, Ara, Gal, Man, Rha, Fuc, GalUA and GluUA in ratio of 34.95:8.7:9.55:4.55:5.0:1.45:12.7:7.65. The structure of MSP-II was furtherly analyzed by FT-IR spectrum and 1 H and 13 C NMR spectroscopy, the results showed that MSP contained β glycosidic bonds as well as Α glycosidic linkages. In vitro tests proved that MSP-II could not only promote the proliferation and phagocytosis of RAW264.7 cells, but also induce the section of nitric oxide (NO) of macrophages. Consequently, the polysaccharide has a potent immunomodulatory activity by stimulating macrophages and can be considered as a novel potential immunopotentiator in medical and food industries.

International Journal of Biological Macromolecules published new progress about Cell proliferation. 3458-28-4 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H12O6, Computed Properties of 3458-28-4.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Li, Dan; Wang, Gangcheng; Jin, Guoguo; Yao, Ke; Zhao, Zhenjiang; Bie, Liangyu; Guo, Yongjun; Li, Ning; Deng, Wenying; Chen, Xiaobin; Chen, Beibei; Liu, Yuanyuan; Luo, Suxia; Guo, Zhiping published the artcile< Resveratrol suppresses colon cancer growth by targeting the AKT/STAT3 signaling pathway>, Application In Synthesis of 501-36-0 , the main research area is resveratrol anticancer cell growth AKT STAT3 signaling colon cancer.

Colon cancer is a common type of cancer worldwide and accounts for a significant number of cancer-related deaths. Although surgical techniques and treatment strategies for colon cancer have advanced over the past two decades, the prognosis has not improved considerably. Resveratrol, a natural stilbene compound, possesses antioxidant, cardioprotective and anticancer properties. However, the role of resveratrol in colon cancer has not been fully elucidated. The present study demonstrated that resveratrol inhibited cell proliferation and colony growth in DLD1 and HCT15 colon cancer cells, but did not affect normal colon epithelial cells. The resveratrol-mediated inhibition of cell proliferation correlated with an induction of apoptosis and with G1 phase cell cycle arrest in colon cancer cells. Addnl., resveratrol treatment decreased the protein expression levels of cyclin D1, cyclin E2 and BCL2 apoptosis regulator, while it increased BCL2 associated X and tumor protein p53, all of which are involved in the regulation of cell cycle and apoptosis. Notably, the results obtained from in silico computational screening identified AKT serine/threonine kinase 1 (AKT1) and AKT2 as novel targets of resveratrol. Computational docking suggested that there are three or four possible hydrogen bonds in the active pocket of AKT1 and AKT2 that contribute to the mode of action of resveratrol. The present study confirmed that resveratrol bound to AKT1 and AKT2 with a pull-down assay. Furthermore, knockdown of AKT1 and AKT2 inhibited cell proliferation and colony growth, by attenuating cell cycle progression and increasing apoptosis in colon cancer cells, effects that were similar to those caused by resveratrol treatment. Taken together, the present results suggest that the targeting effects of resveratrol to AKT1 and AKT2 may be a potent strategy for chemoprevention or therapy for colon cancer.

International Journal of Molecular Medicine published new progress about Antitumor agents. 501-36-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C14H12O3, Application In Synthesis of 501-36-0 .

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Pastor, Raul Francisco; Restani, Patrizia; Di Lorenzo, Chiara; Orgiu, Francesca; Teissedre, Pierre-Louis; Stockley, Creina; Ruf, Jean Claude; Quini, Claudia Ines; Garcia Tejedor, Nuria; Gargantini, Raquel; Aruani, Carla; Prieto, Sebastian; Murgo, Marcelo; Videla, Rodolfo; Penissi, Alicia; Iermoli, Roberto Hector published the artcile< Resveratrol, human health and winemaking perspectives>, Computed Properties of 501-36-0, the main research area is review resveratrol wine; Resveratrol; oxidative stress; wine and health; winemaking.

A review. Resveratrol, (3, 5, 4′-trihydroxystilbene) is a non-flavonoid polyphenol stilbene synthesized by plants when damaged by infectious diseases or ionizing radiation. Although present in more than seventy plant species, grapes and wine are the major dietary contributors of resveratrol, responsible for 98% of the daily intake. In 1992, Renaud and De Lorgeril first linked wine polyphenols, including resveratrol, to the potential health benefits ascribed to regular and moderate wine consumption (the so called “”French Paradox””). Since then, resveratrol has received increasing scientific interest, leading to research on its biol. actions, and to a large number of published papers, which have been collected and discussed in this review. The relatively low amounts of resveratrol measured in wine following moderate consumption, however, may be insufficient to mitigate biol. damage, such as that due to oxidative stress. On this basis, the authors also highlight the importance of viticulture and the winemaking process to enhance resveratrol concentrations in wine in order to bolster potential health benefits.

Critical Reviews in Food Science and Nutrition published new progress about Homo sapiens. 501-36-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C14H12O3, Computed Properties of 501-36-0.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Genc, Sertac; Gulcemal, Suleyman; Gunnaz, Salih; Cetinkaya, Bekir; Gulcemal, Derya published the artcile< Synthesis of α-Alkylated Ketones via Selective Epoxide Opening/Alkylation Reactions with Primary Alcohols>, Category: alcohols-buliding-blocks, the main research area is ketone alkyl preparation regioselective; alc primary epoxide opening alkylation reaction NHC iridium catalyst.

A new method for converting terminal epoxides I (R = Ph, naphthalen-2-yl, decyl, etc.) and primary alcs. R1CH2OH (R1 = hexyl, 2-aminophenyl, thiophen-2-yl, 3-ferrocenyl, etc.) into α-alkylated ketones RC(O)(CH2)2R1, 3,3′-(1,4-phenylene)bis(1-phenylpropan-1-one) and 2-phenylquinoline under borrowing hydrogen conditions is reported. The procedure involves a one-pot epoxide ring opening and alkylation via primary alcs. in the presence of an N-heterocyclic carbene iridium(I) catalyst, under aerobic conditions, with water as the side product.

Organic Letters published new progress about Alkylation catalysts, regioselective. 5344-90-1 belongs to class alcohols-buliding-blocks, and the molecular formula is C7H9NO, Category: alcohols-buliding-blocks.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Delahunty, Ian; Li, Jianwen; Jiang, Wen; Lee, Chaebin; Yang, Xueyuan; Kumar, Anil; Liu, Zhi; Zhang, Weizhong; Xie, Jin published the artcile< 7-Dehydrocholesterol Encapsulated Polymeric Nanoparticles As a Radiation-Responsive Sensitizer for Enhancing Radiation Therapy>, COA of Formula: C27H44O, the main research area is 7-dehydrocholesterol; colon carcinoma; nanoparticles; radiation therapy; radiosensitizers.

Therapeutics that can be activated by radiation in situ to enhance the efficacy of radiotherapy are highly desirable. Herein, 7-Dehydrocholesterol (7-DHC), a biosynthetic precursor of cholesterol, as a radiosensitizer, exploiting its ability to propagate the free radical chain reaction is explored. The studies show that 7-DHC can react with radiation-induced reactive oxygen species and in turn promote lipid peroxidation, double-strand breaks, and mitochondrial damage in cancer cells. For efficient delivery, 7-DHC is encapsulated into poly(lactic-co-glycolic acid) nanoparticles, forming 7-DHC@PLGA NPs. When tested in CT26 tumor bearing mice, 7-DHC@PLGA NPs significantly enhanced the efficacy of radiotherapy, causing complete tumor eradication in 30% of the treated animals. After treatment, 7-DHC is converted to cholesterol, causing no detectable side effects or hypercalcemia. 7-DHC@PLGA NPs represent a radiation-responsive sensitizer with great potential in clin. translation.

Small published new progress about 434-16-2. 434-16-2 belongs to class alcohols-buliding-blocks, and the molecular formula is C27H44O, COA of Formula: C27H44O.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts