Month: October 2022

Zharkov, Mikhail N.; Arabadzhi, Svetlana S.; Kuchurov, Ilya V.; Zlotin, Sergei G. published the artcile< Continuous nitration of alcohols in a Freon flow>, HPLC of Formula: 104-76-7, the main research area is alc nitration continuous Freon flow.

The first ever installation for continuous nitration in a liquefied gas mobile phase was developed. The installation was used to convert 2-ethylhexan-1-ol, diethylene glycol, and glycerol into their corresponding nitro esters. The starting compounds were treated with a 10% excess of dinitrogen pentoxide in liquefied 1,1,1,2-tetrafluoroethane (TFE) medium. The flow reactions proceeded at room temperature and ≤10 bar pressure with excellent conversion and selectivity. An important feature of the developed procedure is TFE recycling which prevents its release into the atm. The proposed approach for nitro esters flow production outperforms the known batch-type analogs in terms of having a far better specific productivity (by two orders of magnitude), reduced fire and explosion risks, and less pronounced neg. impact on the environment. The enumerated advantages along with equipment availability lay the foundation for the development of a highly efficient nitration technol., which is characterized by reduced amounts of waste by employing a TFE medium.

Reaction Chemistry & Engineering published new progress about Nitration. 104-76-7 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H18O, HPLC of Formula: 104-76-7.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Zohrevandi, Mina; Mozafari, Roya; Ghadermazi, Mohammad published the artcile< A nickel nanoparticle engineered CoFe2O4/SiO2-NH2@carboxamide composite as a novel scaffold for the oxidation of sulfides and oxidative coupling of thiols>, Electric Literature of 699-12-7, the main research area is nickel carboxamide complex supported cobalt ferrite nanoparticle catalyst preparation; sulfoxide green preparation; sulfide oxidation nickel carboxamide complex catalyst; disulfide green preparation; thiol oxidative coupling nickel carboxamide complex catalyst.

A new Ni-carboxamide complex supported on CoFe2O4 nanoparticles (CoFe2O4/SiO2-NH2@carboxamide-Ni) was prepared The carboxamide host material unit generated cavities that stabilized the nickel nanoparticles effectively and prevented the aggregation and separation of these particles on the surface. This compound was appropriately characterized using FT-IR spectroscopy, FE-SEM, ICP-OES, EDX, XRD, TGA anal., VSM and X-ray at. mapping. The catalytic oxidation of sulfides to give sulfoxides RS=OR1 [R = Ph, 4-BrC6H4, Bn, etc.; R1 = H, Me, Ph, etc.] and oxidative coupling of thiols to give disulfides R2S-SR2 [R2 = Ph, 4-MeC6H4, Bn, etc.] in the presence of the designed catalyst was explored as a highly selective catalyst using hydrogen peroxide as a green oxidant. The easy separation, simple workup, excellent stability of the nanocatalyst, short reaction times, non-explosive materials as well as appropriate yields of the products were some outstanding advantages of this protocol.

RSC Advances published new progress about Disulfides Role: SPN (Synthetic Preparation), PREP (Preparation). 699-12-7 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H10OS, Electric Literature of 699-12-7.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Sader, Jonathan K.; Molder, Bryce A.; Wulff, Jeremy E. published the artcile< A Chan-Evans-Lam approach to trisubstituted vinyl ethers>, Synthetic Route of 627-27-0, the main research area is trisubstituted vinyl ether preparation; vinyl trifluoroborate primary aliphatic alc Chan Evans Lam coupling; dihydroisobenzofuran preparation vinyl ether redox relay Heck reaction.

Trisubstituted vinyl ethers were accessed via Chan-Evans-Lam coupling of vinyl trifluoroborates and primary aliphatic alcs. This approach complements prior methods that required the use of neat liquid alc. coupling partners. A palladium-catalyzed redox-relay Heck reaction was used to convert several vinyl ethers into aldehyde-functionalized 1,3-dihydroisobenzofurans.

Organic & Biomolecular Chemistry published new progress about Aliphatic alcohols Role: RCT (Reactant), RACT (Reactant or Reagent) (primary). 627-27-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C4H8O, Synthetic Route of 627-27-0.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Alderborn, G.; Lang, P. O.; Sagstrom, A.; Kristensen, A. published the artcile< Compression characteristics of granulated materials. I. Fragmentation propensity and compactibility of some granulations of a high dosage drug>, Safety of Sodium 5,5′-(diazene-1,2-diyl)bis(2-hydroxybenzoate), the main research area is granule compactibility fragmentation ethanol binder; azobishydroxybenzoate granule tablet property.

Three granulations of a fairly water-soluble high-dosage drug, di-Na 3,3′-azobis(6-hydroxybenzoate), were produced by intensive mixing with poly(vinylpyrrolidone), and dissolved in 3 liquids with different amounts of EtOH and water, as binder. The granulations were mixed with dry binders or with a lubricant and granulations and mixtures were compressed at 30 MPa and the tablet strength was measured. The tablet strength increased with increasing amount of EtOH in the binder solution The increase and decrease in tablet strength due to the addition of dry binder and lubricant, resp., were also dependent on the amount of EtOH in the binder solution and indicated that the degree of fragmentation varied between the granulations. Heckel plots and tablet surface area-compaction pressure profiles confirmed the finding that the degree of fragmentation of the granules increased with increasing amount of EtOH in the binding solution A good correlation between fragmentation propensity of the granulations and tensile strength of the tablets was found.

International Journal of Pharmaceutics published new progress about Pharmaceutical granules. 6054-98-4 belongs to class alcohols-buliding-blocks, and the molecular formula is C14H8N2Na2O6, Safety of Sodium 5,5′-(diazene-1,2-diyl)bis(2-hydroxybenzoate).

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Yang, Shao-Qian; Wang, Yi-Fan; Zhao, Wei-Cheng; Lin, Guo-Qiang; He, Zhi-Tao published the artcile< Stereodivergent Synthesis of Tertiary Fluoride-Tethered Allenes via Copper and Palladium Dual Catalysis>, COA of Formula: C9H8O, the main research area is fluoroester conjugated enyne copper palladium hydrocarbonation catalyst; allene stereoselective preparation gold cyclization; fluorinated hydrofuran stereoselective preparation.

Herein we describe a protocol for the unprecedented stereodivergent synthesis of tertiary fluoride-tethered allenes bearing a stereogenic center and stereogenic axis via Cu/Pd synergistic catalysis. A broad scope of conjugated enynes are coupled with various α-fluoroesters in high yields with high diastereoselectivities and generally >99% ee. In addition, the four stereoisomers of the allene products ensure precise access to the corresponding four stereoisomers of the fluorinated hydrofurans via a novel stereodivergent axial-to-central chirality transfer process.

Journal of the American Chemical Society published new progress about Alkenynes Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation) (conjugated). 10602-04-7 belongs to class alcohols-buliding-blocks, and the molecular formula is C9H8O, COA of Formula: C9H8O.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Pacheco-Hernandez, Yesenia; Sanchez-Hernandez, Gloria Rubi; Reyes-Cervantes, Eric; Romero-Arenas, Omar; Perez-Xochipa, Ivonne; Villa-Ruano, Nemesio published the artcile< Chemical Variation and Pharmacological Properties of Dyssodia decipiens Essential Oil>, Product Details of C10H18O, the main research area is verbenone limonene beta caryophyllene linalool essential oil Dyssodia; Dyssodia decipiens; bioactive compounds; biological activity; flavor and fragrances; volatile profiling.

Dyssodia decipiens is one of the seven recognized species within the Dyssodia genus, which has economic and social relevance in Mexico. Herein, we report on the volatile characterization and pharmacol. activity of D. decipiens. The essential oils (2017-2019) contained verbenone (30.8-60.9%), limonene (5.6-35.5%), β-caryophyllene (7.8-19.8%) and linalool (4.5-12.4%) as major constituents along the studied years. Antifungal properties were probed on Candida albicans ATCC 90028, ATCC 10231 (fluconazole resistant) and five clin. isolates (IS1-IS5). Flower essential oils had the best anti-C. albicans activity (MIC 59.2-93.5μg mL-1), and limonene (MIC 125.5-188.4μg mL-1) and β-caryophyllene (MIC 104.3-184.2μg mL-1) were involved in this effect. SEM examination revealed that D. decipiens essential oils produced an evident lysis on the fungus. Mosquito repellent activity was demonstrated on Aedes aegypti, a vector of dengue, chikungunya and zika viruses. The repellent activity of leaf essential oils (20%) was effective within 1-5 h post-treatment (>90%) and it was stronger (p<0.01) than that of com. DEET. The evaluation of the four major volatiles (10% each) produced similar results to those of essential oils. Finally, leaf essential oils showed a moderate antiproliferative activity on the lines OVCAR-3 (LD50 56.5-85.7μg mL-1), and verbenone (LD50 65.3μg mL-1) and β-caryophyllene (LD50 43.6μg mL-1) were linked to this effect. Chemistry & Biodiversity published new progress about Aedes aegypti. 78-70-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C10H18O, Product Details of C10H18O.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Sundar, Smrithi; Sandilya, Avilasha A.; Priya, M. Hamsa published the artcile< Unraveling the Influence of Osmolytes on Water Hydrogen-Bond Network: From Local Structure to Graph Theory Analysis>, Recommanded Product: (2S,3R,4S,5S,6R)-6-(Hydroxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetraol, the main research area is osmolyte water hydrogen bond network MD simulations graph theory; protein conformation water osmolyte MD simulation graph theory.

Water structure in aqueous osmolyte solutions, deduced from the slight alteration in the water-water radial distribution function, the decrease in water-water hydrogen bonding, and tetrahedral ordering based only on the orientation of nearest water mols. derived from the mol. dynamics simulations, appears to have been perturbed. A careful anal., however, reveals that the hydrogen bonding and the tetrahedral ordering around a water mol. in binary solutions remain intact as in neat water when the contribution of osmolyte-water interactions is appropriately incorporated. Furthermore, the distribution of the water binding energies and the water excess chem. potential of solvation in solutions are also pretty much the same as in neat water. Osmolytes are, therefore, well integrated into the hydrogen-bond network of water. Indeed, osmolytes tend to preferentially hydrogen bond with water mols. and their interaction energies are strongly correlated to their hydrogen-bonding capability. The graph network anal., further, illustrates that osmolytes act as hubs in the percolated hydrogen-bond network of solutions The degree of hydrogen bonding of osmolytes predominantly determines all of the network properties. Osmolytes like ethanol that form fewer hydrogen bonds than a water mol. disrupt the water hydrogen-bond network, while other osmolytes that form more hydrogen bonds effectively increase the connectivity among water mols. Our observation of minimal variation in the local structure and the vitality of osmolyte-water hydrogen bonds on the solution network properties clearly imply that the direct interaction between protein and osmolytes is solely responsible for the protein stability. Further, the relevance of hydrogen bonds on solution properties suggests that the hydrogen-bonding interaction among protein, water, and osmolyte could be the key determinant of the protein conformation in solutions

Journal of Chemical Information and Modeling published new progress about Binding energy (of water mols.). 492-62-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H12O6, Recommanded Product: (2S,3R,4S,5S,6R)-6-(Hydroxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetraol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Savych, Olena; Kuchkovska, Yuliya O.; Bogolyubsky, Andrey V.; Konovets, Anzhelika I.; Gubina, Kateryna E.; Pipko, Sergey E.; Zhemera, Anton V.; Grishchenko, Alexander V.; Khomenko, Dmytro N.; Brovarets, Volodymyr S.; Doroschuk, Roman; Moroz, Yurii S.; Grygorenko, Oleksandr O. published the artcile< One-Pot Parallel Synthesis of 5-(Dialkylamino)tetrazoles>, Computed Properties of 6850-39-1, the main research area is one pot parallel combinatorial synthesis dialkylaminotetrazole; aminotetrazole library preparation; 2,2,2-trifluoroethylthiocarbamate; REAL (readily accessible) compounds; heterocyclization; tetrazoles; thiourea.

Two protocols for the combinatorial synthesis of 5-(dialkylamino)tetrazoles were developed. The best success rate (67%) was shown by the method that used primary and secondary amines, 2,2,2-trifluoroethylthiocarbamate, and sodium azide as the starting reagents. The key steps included the formation of unsym. thiourea, subsequent alkylation with 1,3-propane sultone and cyclization with azide anion. A 559-member aminotetrazole library was synthesized by this approach; the overall readily accessible (REAL) chem. space covered by the method exceeded 7 million feasible compounds

ACS Combinatorial Science published new progress about Amines Role: RCT (Reactant), RACT (Reactant or Reagent). 6850-39-1 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H13NO, Computed Properties of 6850-39-1.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Carlomagno, C.; Banfi, P. I.; Gualerzi, A.; Picciolini, S.; Volpato, E.; Meloni, M.; Lax, A.; Colombo, E.; Ticozzi, N.; Verde, F.; Silani, V.; Bedoni, M. published the artcile< Human salivary Raman fingerprint as biomarker for the diagnosis of Amyotrophic Lateral Sclerosis>, Application of C6H12O6, the main research area is human amyotrophic lateral sclerosis saliva Raman fingerprint biomarker diagnosis.

Abstract: Amyotrophic Lateral Sclerosis (ALS) is a neurodegenerative disease leading to progressive and irreversible muscle atrophy. The diagnosis of ALS is time-consuming and complex, with the clin. and neurophysiol. evaluation accompanied by monitoring of progression and a long procedure for the discrimination of similar neurodegenerative diseases. The delayed diagnosis strongly slows the potential development of adequate therapies and the time frame for a prompt intervention. The discovery of new biomarkers could improve the disease diagnosis, as well as the therapeutic and rehabilitative effectiveness and monitoring of the pathol. progression. In this work saliva collected from 19 patients with ALS, 10 affected by Parkinson’s disease, 10 affected by Alzheimer’s disease and 10 healthy subjects, was analyzed using Raman spectroscopy, optimizing the parameters for detailed and reproducible spectra. The statistical multivariate anal. of the data revealed a significant difference between the groups, allowing the discrimination of the disease onset. Correlation of Raman data revealed a direct relationship with paraclin. scores, identifying multifactorial biochem. modifications related to the pathol. The proposed approach showed a promising accuracy in ALS onset discrimination, using a fast and sensitive procedure that can make more efficient the diagnostic procedure and the monitoring of therapeutic and rehabilitative processes in ALS.

Scientific Reports published new progress about Alzheimer disease. 492-62-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H12O6, Application of C6H12O6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Chen, Jian; Zhu, Shaolin published the artcile< Nickel-Catalyzed Multicomponent Coupling: Synthesis of α-Chiral Ketones by Reductive Hydrocarbonylation of Alkenes>, Recommanded Product: 1-(4-Fluorophenyl)ethyl Alcohol, the main research area is alpha ketone preparation regio chemo enantioselective; alkene benzyl chloride ethyl chloroformate reductive hydroformylation carbonylation nickel; NHP ester amino acid alkene propylchloroformate reductive hydroformylation carbonylation.

A nickel-catalyzed, multicomponent regio- and enantioselective coupling via sequential hydroformylation and carbonylation from readily available starting materials has been developed. This modular multicomponent hydrofunctionalization strategy enables the straightforward reductive hydrocarbonylation of a broad range of unactivated alkenes to produce a wide variety of unsym. dialkyl ketones bearing a functionalized α-stereocenter, including enantioenriched chiral α-aryl ketones and α-amino ketones. It uses chiral bisoxazoline as a ligand, silane as a reductant, chloroformate as a safe CO source, and a racemic secondary benzyl chloride or an N-hydroxyphthalimide (NHP) ester of a protected α-amino acid as the alkylation reagent. The benign nature of this process renders this method suitable for late-stage functionalization of complex mols.

Journal of the American Chemical Society published new progress about Alkenes Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 403-41-8 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H9FO, Recommanded Product: 1-(4-Fluorophenyl)ethyl Alcohol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts