Month: October 2022

Shi, Yang; Ye, Yun-Fang; Zhang, Bi-Wei; Liu, Yong; Wang, Jun-Hui published the artcile< Purification, structural characterization and immunostimulatory activity of polysaccharides from Umbilicaria esculenta>, Recommanded Product: (2S,3S,4R,5R)-2,3,4,5,6-Pentahydroxyhexanal, the main research area is Umbilicaria esculenta polysaccharide immunostimulatory activity; Immunostimulatory activity; Polysaccharides of Umbilicaria esculenta; Structural characterization.

In this study, an active component UP1-1 was isolated from Chinese Huangshan Umbilicaria esculenta via hot water extraction and purified by anion-exchange and gel-filtration chromatog. UP1-1 mainly composed of galactose, mannose and glucose in a molar ratio of 0.8:1.0:4.6 with an average mol. weight of 281 kDa. Methylation anal. of UP1-1 revealed the major glycosidic bonds comprised 1,6-linked Glcp, 1,4-linked Glcp, t-linked Glcp, 1,3,6-linked Manp, 1,3-linked Galp, t-linked Galp at the ratio of 2.28:0.38:0.32:0.63:0.25:0.29. Structural anal. results revealed that the backbone of UP1-1 consisted of (6)-β-D-Glcp-(1→ ,→6)-β-D-Manp-(1→, → 4)-β-D-Glcp-(1 → residues with side chains of →3)-β-D-Galp-1→, β-D-Galp-1→ and β-D-Glcp-1→ branches located at O-3 position of → 6-β-D-Manp-1→. Immunostimulatory activity tests showed that UP1-1 could promote the phagocytic activity and NO production of RAW 264.7 cells in a dose-dependent manner. UP1-1 could significantly improve the proliferation effect of RAW 264.7 cells at the concentration of 50 μg/mL. Thus, UP1-1 exerted good immunostimulatory activity, suggesting that UP1-1 has a great potential application in pharmacol. industry.

International Journal of Biological Macromolecules published new progress about Anion exchange membranes. 3458-28-4 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H12O6, Recommanded Product: (2S,3S,4R,5R)-2,3,4,5,6-Pentahydroxyhexanal.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Ghosh, Titli; Mukherji, Ananya; Kancharla, Pavan K. published the artcile< Open-Close Strategy toward the Organocatalytic Generation of 2-Deoxyribosyl Oxocarbenium Ions: Pyrrolidine-Salt-Catalyzed Synthesis of 2-Deoxyribofuranosides>, Formula: C12H20O6, the main research area is stereoselective glycosylation catalyst organocatalytic disaccharide preparation; organocatalytic deoxyribosyl oxocarbenium pyrrolidine catalyzed synthesis disaccharide deoxyribofuranoside.

The reaction of secondary amine salts with 2-deoxy-ribofuranoses under forcible conditions leads to the putative furanosyl oxocarbenium ion that is trapped with various alcs. to provide 2-deoxy-ribofuranosides. The observed anomeric selectivities range from an equimolar mixture to complete α-selectivity in the case of bulky sugar acceptors. Owing to the mechanism and temperature of the transformation, the generated oxocarbenium ion shows little or no facial preference towards the nucleophilic attack of non-carbohydrate acceptors and leads to a mixture of anomers in the case of benzyl and acetyl protected donors. However, the conformationally less flexible tetraisopropylsilyl protected donor reacted with both sugar and non-sugar acceptors in a stereoselective fashion. Besides, the glycosylation with 2-cyanoethanol gave the product with unexpected beta-selectivity presumably due to nitrile effect. The operationally simple organocatalytic protocol provides easy access to otherwise difficult 2-deoxy-ribofuranosides/disaccharides.

European Journal of Organic Chemistry published new progress about Disaccharides Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 4064-06-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C12H20O6, Formula: C12H20O6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Leskow, Carla Coluccio; Conte, Mariana; del Pozo, Talia; Bermudez, Luisa; Lira, Bruno Silvestre; Gramegna, Giovanna; Baroli, Irene; Burgos, Estanislao; Zavallo, Diego; Kamenetzky, Laura; Asis, Ramon; Gonzalez, Mauricio; Fernie, Alisdair Robert; Rossi, Magdalena; Osorio, Sonia; Carrari, Fernando published the artcile< The cytosolic invertase NI6 affects vegetative growth, flowering, fruit set, and yield in tomato>, Formula: C6H10O8, the main research area is Solanum invertase vegetative growth flowering fruit yield; Carbon partitioning; cytosolic invertase; signaling; sucrose metabolism; tomato.

Sucrose metabolism is important for most plants, both as the main source of carbon and via signaling mechanisms that have been proposed for this mol. A cleaving enzyme, invertase (INV) channels sucrose into sink metabolism Although acid soluble and insoluble invertases have been largely investigated, studies on the role of neutral invertases (A/N-INV) have lagged behind. Here, we identified a tomato A/N-INV encoding gene (NI6) co-localizing with a previously reported quant. trait locus (QTL) largely affecting primary carbon metabolism in tomato. Of the eight A/N-INV genes identified in the tomato genome, NI6 mRNA is present in all organs, but its expression was higher in sink tissues (mainly roots and fruits). A NI6-GFP fusion protein localized to the cytosol of mesophyll cells. Tomato NI6-silenced plants showed impaired growth phenotype, delayed flowering and a dramatic reduction in fruit set. Global gene expression and metabolite profile analyses of these plants revealed that NI6 is not only essential for sugar metabolism, but also plays a signaling role in stress adaptation. We also identified major hubs, whose expression patterns were greatly affected by NI6 silencing; these hubs were within the signaling cascade that coordinates carbohydrate metabolism with growth and development in tomato.

Journal of Experimental Botany published new progress about Arabidopsis. 87-73-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H10O8, Formula: C6H10O8.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Mohd, Azirah; Zainal, Nurhafiza; Tan, Kim-Kee; AbuBakar, Sazaly published the artcile< Resveratrol affects Zika virus replication in vitro>, Recommanded Product: (E)-5-(4-Hydroxystyryl)benzene-1,3-diol, the main research area is resveratrol phytoalexin antiviral agent zika virus infection.

Here, a plant-secreted phytoalexin, resveratrol (RES), was investigated for its ability to inhibit ZIKV replication in vitro. Several RES treatment regimens were used. The ZIKV titers of mock- and RES-treated infected cell cultures were determined using the focus-forming assay and the Zika mRNA copy number as determined using qRT-PCR. Our results suggested that RES treatment reduced ZIKV titers in a dose-dependent manner. A reduction of >90% of virus titer and ZIKV mRNA copy number was achieved when infected cells were treated with 80μM of RES post-infection. Pre-incubation of the virus with 80μM RES showed >30% reduction in ZIKV titers and ZIKV mRNA copy number, implying potential direct virucidal effects of RES against the virus. The RES treatment reduced >70% virus titer in the anti-adsorption assay, suggesting the possibility that RES also interferes with ZIKV binding. However, there was no significant decrease in ZIKV titer when a short-period of RES treatment was applied to cells before ZIKV infection (pre-infection) and after the virus bound to the cells (virus internalization inhibition), implying that RES acts through its continuous presence in the cell cultures after virus infection. Overall, our results suggested that RES exhibited direct virucidal activity against ZIKV and possessed anti-ZIKV replication properties, highlighting the need for further exploration of RES as a potential antiviral mol. against ZIKV infection.

Scientific Reports published new progress about Antiviral agents. 501-36-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C14H12O3, Recommanded Product: (E)-5-(4-Hydroxystyryl)benzene-1,3-diol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Hu, Liangzhen; Hussain, Muhammad Ijaz; Deng, Qingfu; Liu, Qing; Feng, Yangyang; Zhang, Xiaohui; Xiong, Yan published the artcile< I2/Li2CO3-promoted cyanation of diarylalcohols through a dual activation process>, Safety of Triphenylmethanol, the main research area is unsaturated nitrile phenylnitirile preparation dual activated cyanation diarylalc.

One-step base promoted strategy for cyanation of α,α-diaryl alcs. has been developed under mild and transition metal-free conditions. This method provides a straightforward and facile way towards the synthesis of β,γ-unsaturated nitriles and α-phenylnitiriles from α-vinyl carbinols and α,α-diaryl methanols, resp., up to 99% yield. Moreover, various azides and ethers could also be accessed from their resp. nucleophiles under standard reaction conditions.

Tetrahedron published new progress about Alcohols Role: RCT (Reactant), RACT (Reactant or Reagent) (α,α-diaryl). 76-84-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C19H16O, Safety of Triphenylmethanol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Valihura, K. V.; Larina, O. V.; Kyriienko, P. I.; Balakin, D. Yu.; Soloviev, S. O. published the artcile< Influence of Modifying Additives of Lanthanum and Cerium Oxides on Acid-Base Characteristics and Catalytic Properties of MgO-Al2O3 Systems in the Process of Gas-Phase Conversion of Ethanol to 1-Butanol>, Formula: C8H18O, the main research area is butanol ethanol lanthanum cerium magnesium aluminum oxide catalytic property.

The process of ethanol condensation to 1-butanol in the presence of MgO-Al2O3 systems modified with lanthanum and cerium oxide additives was studied. It is shown that MgO-Al2O3 doping with lanthanum and cerium oxides leads to an increase in the total concentration of acid and basic sites on the surface of the catalysts. It was found that increasing the concentration of basic sites for La- and Ce-containing samples promotes an increase in the yield of acetaldehyde but does not lead to an increase in the yield of 1-butanol due to a decrease in the number of aldol condensation sites. Increasing the concentration ratio of basic and acid sites of the surface helps to increase the productivity of the catalyst for 1-butanol.

Theoretical and Experimental Chemistry published new progress about Alcohols Role: IMF (Industrial Manufacture), PREP (Preparation). 104-76-7 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H18O, Formula: C8H18O.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Tironi, Matteo; Hopkinson, Matthew N. published the artcile< Silver-Catalyzed Nucleophilic Deoxydifluoromethylthiolation of Activated Aliphatic Alcohols with BT-SCF2H>, Related Products of 10602-04-7, the main research area is difluoromethylthioether preparation; aliphatic alc difluoromethyl thio methylbenzothiazolium triflate nucleophilic deoxydifluoromethylthiolation silver.

Deoxygenative conversion of alcs. into difluoromethylthioethers is reported using 2-((difluoromethyl)thio)-3-methylbenzo[d]thiazol-3-ium triflate (BT-SCF2H) as a source of -SCF2H anions. The presence of silver(I) triflate as a catalyst was found to be crucial for stabilizing the in situ-generated anion, while the concomitant formation of a reactive 2-(alkoxy)benzothiazolium electrophile likely ensures a fast onward substitution reaction, avoiding the build-up of -SCF2H. To the best of authors’ knowledge, this process represents the first report of a direct nucleophilic substitution reaction with -SCF2H and delivers products containing the medicinally relevant difluoromethylthio motif in a single step from widely available alcs.

European Journal of Organic Chemistry published new progress about Aralkyl alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 10602-04-7 belongs to class alcohols-buliding-blocks, and the molecular formula is C9H8O, Related Products of 10602-04-7.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Xu, Siliang; Luo, Huaiyong; Chen, Haiwen; Guo, Jianbin; Yu, Bolun; Zhang, Huan; Li, Weitao; Chen, Weigang; Zhou, Xiaojin; Huang, Li; Liu, Nian; Lei, Yong; Liao, Boshou; Jiang, Huifang published the artcile< Optimization of extraction of total trans-resveratrol from peanut seeds and its determination by HPLC>, HPLC of Formula: 501-36-0 , the main research area is tran resveratrol peanut extraction optimization; high performance liquid chromatography; peanut seed; response surface methodology; trans-resveratrol.

Resveratrol, a stilbene phytoalexin in plants, is believed to benefit human health. In this study, an optimized enzyme-assisted method was developed to extract the total content of trans-resveratrol (free or combined with glucose) in peanut seeds, followed by detection using high-performance liquid chromatog. The extraction process was optimized by Box-Behnken design and response surface methodol. The optimized enzyme concentration, digestion time, pH, and temperature were 3.02 g/L, 57.06 min, 5.88, and 51.05°C, resp. Validation tests indicated that the exptl. yield of trans-resveratrol was 0.183 ± 0.007μg/g with a relative standard deviation of 3.87% (n = 5) under the optimal condition, which was closely agreed with the predicted value (0.182μg/g). The recoveries obtained from the spiked samples were varied from 89.4 to 103.9%. Therefore, this study will provide a useful method for quantification of total trans-resveratrol in peanut seeds.

Journal of Separation Science published new progress about Arachis hypogaea. 501-36-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C14H12O3, HPLC of Formula: 501-36-0 .

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Newton, Christopher G.; Tran, Duc N.; Wodrich, Matthew D.; Cramer, Nicolai published the artcile< One-Step Multigram-Scale Biomimetic Synthesis of Psiguadial B>, Recommanded Product: 2,4,6-Trihydroxyisophthalaldehyde, the main research area is caryophyllene benzaldehyde diformylphloroglucinol biomimetic three component coupling cascade; psiguadial B biomimetic synthesis; biomimetic synthesis; cyclization; natural products; terpenoids; total synthesis.

A gram-scale synthesis of psiguadial B (I), a purported inhibitor of human hepatoma cell growth, has been achieved in one step by a biomimetic three-component coupling of caryophyllene, benzaldehyde, and diformylphloroglucinol. This cascade reaction is catalyzed by N,N’-dimethylethylenediamine, and proceeds at ambient temperature to generate four stereocenters, two rings, one C-O bond, and three C-C bonds. Combined computational and exptl. investigations suggest the biosynthesis of the natural product is non-enzyme mediated, and is the result of a Michael addition between caryophyllene and a reactive ortho-quinone methide, followed by two sequential intramol. cationic cyclization events.

Angewandte Chemie, International Edition published new progress about Biomimetic synthesis. 4396-13-8 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H6O5, Recommanded Product: 2,4,6-Trihydroxyisophthalaldehyde.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Fogacci, Federica; Tocci, Giuliano; Presta, Vivianne; Fratter, Andrea; Borghi, Claudio; Cicero, Arrigo F. G. published the artcile< Effect of resveratrol on blood pressure: A systematic review and meta-analysis of randomized, controlled, clinical trials>, Reference of 501-36-0, the main research area is Resveratrol; blood pressure; meta-analysis; metaregression; type 2 diabetes.

Results of previous clin. trials evaluating the effect of resveratrol supplementation on blood pressure (BP) are controversial. We aimed to assess the impact of resveratrol on BP through systematic review of literature and meta-anal. of available randomized, controlled clin. trials (RCTs). Literature search included SCOPUS, PubMed-Medline, ISI Web of Science and Google Scholar databases up to 17th Oct. 2017 to identify RCTs investigating the impact of resveratrol on BP. Two review authors independently extracted data on study characteristics, methods and outcomes. Overall, the impact of resveratrol on BP was reported in 17 trials. Administration of resveratrol did not significantly affect neither systolic BP [weighted mean difference (WMD): -2.5 95% CI:(-5.5, 0.6) mmHg; p=0.116; I2=62.1%], nor diastolic BP [WMD: -0.5 95% CI:(-2.2, 1.3) mmHg; p=0.613; I2=50.8], nor mean BP [MAP; WMD: -1.3 95% CI:(-2.8, 0.1) mmHg; p=0.070; I2=39.5%] nor pulse pressure [PP; WMD: -0.9 95% CI:(-3.1, 1.4) mmHg; p=0.449; I2=19.2%]. However, significant WMDs were detected in subsets of studies categorized according to high resveratrol daily dosage (≥300 mg/day) and presence of diabetes. Meta-regression anal. revealed a pos. association between systolic BP-lowering resveratrol activity (slope: 1.99; 95% CI: 0.05, 3.93; two-tailed p= 0.04) and Body Mass Index (BMI) at baseline, while no association was detected neither between baseline BMI and MAP-lowering resveratrol activity (slope: 1.35; 95% CI: -0.22, 2.91; two-tailed p= 0.09) nor between baseline BMI and PP-lowering resveratrol activity (slope: 1.03; 95% CI: -1.33, 3.39; two-tailed p= 0.39). Resveratrol was fairly well-tolerated and no serious adverse events occurred among most of the eligible trials. The favorable effect of resveratrol emerging from the current meta-anal. suggests the possible use of this nutraceutical as active compound in order to promote cardiovascular health, mostly when used in high daily dose (≥300 mg/day) and in diabetic patients.

Critical Reviews in Food Science and Nutrition published new progress about 501-36-0. 501-36-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C14H12O3, Reference of 501-36-0.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts