Month: October 2022

Lakk-Bogath, Dora; Kripli, Balazs; Meena, Bashdar I.; Speier, Gabor; Kaizer, Jozsef published the artcile< Catalytic and stoichiometric C-H oxidation of benzylalcohols and hydrocarbons mediated by nonheme oxoiron(IV) complex with chiral tetrapyridyl ligand>, Formula: C19H16O, the main research area is oxidation hydroxylation benzylalc hydrocarbon kinetic nonheme oxoiron complex.

Bioinspired chiral iron(II) complex [((R)-(-)-N4Py*)FeII(MeCN)]2+ (1) (N4Py* = N,N-bis(2-pyridylmethyl)-1,2-di(2-pyridyl)ethylamine) has been shown to efficiently catalyze the benzylic C-H oxidation of ethylbenzene with tert-Bu hydroperoxide (TBHP), H2O2, and meta-chloroperoxybenzoic acid (mCPBA) resulting in enantiomerically enriched 1-phenylethanol up to 12.5% ee and the corresponding acetophenone, where the [FeIV(N4Py*)(O)]2+ (2) intermediate has been detected by UV/visible spectrometry. The stoichiometric oxidation of benzyl alc. and various hydrocarbon derivatives including the asym. hydroxylation of ethylbenzene with 2 has also been investigated. Detailed kinetic, and mechanistic studies (kinetic isotope effect (KIE) of 31 and 38, and Hammett correlation with ρ = -0.32 and -0.98 for PhCH2OH and PhCH3, resp., and the linear correlation between the normalized bimol. reaction rates and bond dissociation energies (BDECH)) indicated that the rate-determining step in these reactions above involves hydrogen-atom transfer between the substrate and the Fe(IV)-oxo species. The stoichiometric 2-mediated hydroxylation of ethylbenzene affords 1-phenylethanol in up to 33% ee, suggesting clear evidence for the involvement of the oxoiron(IV) species in the enantioselective step. The moderate enantioselectivity may be explained by the epimerization of the long-lived substrate radical before the rebound step (non-rebound mechanism, where kep > kreb). The kinetic resolution of the resulting chiral alc. due to its metal-based overoxidn. process into acetophenone in the catalytic metal-based ethylbenzene oxidation can be excluded.

Inorganic Chemistry Communications published new progress about Aralkyl alcohols Role: RCT (Reactant), RACT (Reactant or Reagent) (benzylalcs.). 76-84-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C19H16O, Formula: C19H16O.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Rodriguez-Lopez, Maria Isabel; Mercader-Ros, Maria Teresa; Pellicer, Jose Antonio; Gomez-Lopez, Vicente M.; Martinez-Romero, Domingo; Nunez-Delicado, Estrella; Gabaldon, Jose A. published the artcile< Evaluation of monoterpene-cyclodextrin complexes as bacterial growth effective hurdles>, COA of Formula: C10H18O, the main research area is monoterpene cyclodextrin complex antimicrobial agent.

Monoterpenes have antimicrobial properties but are associated with strong smells and flavors that limit their use in foods; therefore, strategies to keep their effectivity using lower concentrations are required. This work tested the antimicrobial capacity of thymol, carvacrol and linalool free or complexed in hydroxypropyl-β-cyclodextrins (HP- β-CDs) using two complexation methods. To this, these monoterpenes were complexed in HP- β-CDs by the solubility method or a microwave-assisted method, spray dried and their antimicrobial capacity was tested on Escherichia coli and Staphylococcus aureus by determining minimal inhibitory concentration and minimal bactericidal concentration The results show significant differences (p < 0.05) between the complexed and uncomplexed forms. In addition, thanks to the complexation of monoterpenes, the use of lower concentrations of these has been reached to achieve the same level of inhibition than uncomplexed forms. Likewise, it has been found that a lower minimal inhibitory concentration (MIC) is achieved for the solubility method for both microorganisms (3.82 mM for thymol and 2.44 mM for carvacrol in E. coli; and 3.91 and 2.61 mM, resp. for S. aureus) than for the microwave method. This implies that a lower concentration of these compounds can be used to inhibit microbial growth in foods, which should minimize their effects on their smell and taste. Food Control published new progress about Escherichia coli. 78-70-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C10H18O, COA of Formula: C10H18O.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Wen, Jiawei; Wu, Jie; Yu, Haiqing; Fan, Gang; He, Yang published the artcile< Correlation analysis between genetic and chemical differences of Nardostachys jatamansi from different habitats in Ganzi Tibetan Autonomous Prefecture, Sichuan Province, China>, Electric Literature of 492-62-6, the main research area is nardostachys jatamansi metabolite marker extract phylogenetic mol evolution.

In the traditional Tibetan medicinal system, the medicinal parts of Nardostachys jatamansi (D.Don) DC. include the dried roots and rhizomes, which is effective in treating various diseases. In this study, mol. evolutionary anal. based on three markers (i.e., ITS, matK and rbcL), and principal component anal. combined with 1H NMR measurements were used to assess the genetic and chem. differences of the N. jatamansi from different habitats in Ganzi Tibetan Autonomous Prefecture, Sichuan Province, China. The results showed that the ITS marker was highly effective to identify the intraspecific variation of N. jatamansi. Furthermore, the results of the chem. anal. indicated that the nardosinone and sucrose, as the metabolite landmarks, can distinguish the different habitats of N. jatamansi in Ganzi Tibetan Autonomous Prefecture, Sichuan Province, China. Moreover, combining the chem. anal. with phylogenetic anal., the results indicated that the metabolites differences may be affected not only by genetic structures but also by environmental factors. These findings provide valuable references for the effective protection and exploitation of N. jatamansi resources.

Biochemical Systematics and Ecology published new progress about DNA extraction. 492-62-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H12O6, Electric Literature of 492-62-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Thapa, Samir Bahadur; Pandey, Ramesh Prasad; Park, Yong Il; Sohng, Jae Kyung published the artcile< Biotechnological advances in resveratrol production and its chemical diversity>, Recommanded Product: (E)-5-(4-Hydroxystyryl)benzene-1,3-diol, the main research area is chemical diversity; metabolic engineering; microbial production; resveratrol.

The very well-known bioactive natural product, resveratrol (3,5,4′-trihydroxystilbene), is a highly studied secondary metabolite produced by several plants, particularly grapes, passion fruit, white tea, and berries. It is in high demand not only because of its wide range of biol. activities against various kinds of cardiovascular and nerve-related diseases, but also as important ingredients in pharmaceuticals and nutritional supplements. Due to its very low content in plants, multi-step isolation and purification processes, and environmental and chem. hazards issues, resveratrol extraction from plants is difficult, time consuming, impracticable, and unsustainable. Therefore, microbial hosts, such as Escherichia coli, Saccharomyces cerevisiae, and Corynebacterium glutamicum, are commonly used as an alternative production source by improvising resveratrol biosynthetic genes in them. The biosynthesis genes are rewired applying combinatorial biosynthetic systems, including metabolic engineering and synthetic biol., while optimizing the various production processes. The native biosynthesis of resveratrol is not present in microbes, which are easy to manipulate genetically, so the use of microbial hosts is increasing these days. This review will mainly focus on the recent biotechnol. advances for the production of resveratrol, including the various strategies used to produce its chem. diverse derivatives

Molecules published new progress about 501-36-0. 501-36-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C14H12O3, Recommanded Product: (E)-5-(4-Hydroxystyryl)benzene-1,3-diol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Bernath, G.; Lang, K. L.; Gondos, Gy.; Marai, P.; Kovacs, K. published the artcile< Stereochemical studies on 1,3-difunctional cyclopentane, cyclohexane, and cycloheptane derivatives>, Application of C6H13NO, the main research area is review stereochem functional cycloalkane.

A review of cyclic 1,3-amino alcs. with 92 references Stereospecific syntheses, kinetic studies, N → O acyl migrations were summarized.

Acta Physica et Chemica published new progress about Amines Role: PRP (Properties). 6850-39-1 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H13NO, Application of C6H13NO.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Qiu, Junqiang; Zhang, Hua; Wang, Zhenyu published the artcile< Ultrasonic degradation of Polysaccharides from Auricularia auricula and the antioxidant activity of their degradation products>, Recommanded Product: (2S,3S,4R,5R)-2,3,4,5,6-Pentahydroxyhexanal, the main research area is Auricularia polysaccharide antioxidant ultrasonic degradation.

Auricularia auricula polysaccharide (AAP) were purified and degraded using ultrasonic wave with the degradation kinetics model fitted to 1/Mt – 1/M0 = k • t. Followed that the morphol., intrinsic viscosity, viscosity-average mol. weight, antioxidant activity of AAP and their degradation products were in vitro investigated. Results showed the intrinsic viscosity and viscosity-average mol. weight of AAP decreased significantly (p < 0.05) with increasing ultrasonic time and their microscopic sizes were reduced after degradation In addition, ultrasonic wave destroyed the helix structure and changed the monosaccharide proportion of AAP. SEM anal. displayed some morphol. difference existing in polysaccharides before and after degradation More importantly, the antioxidant activities in vitro of AAP after degradation were significantly increased (p < 0.05) and AAPUD12h displayed the strongest antioxidant activity. These results indicate that ultrasonic degradation may be a suitable way to improve the antioxidant activity of natural polysaccharides. LWT--Food Science and Technology published new progress about Auricularia auricula-judae. 3458-28-4 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H12O6, Recommanded Product: (2S,3S,4R,5R)-2,3,4,5,6-Pentahydroxyhexanal.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Zhang, Xin; Ang, Esther Cai Xia; Yang, Ziqi; Kee, Choon Wee; Tan, Choon-Hong published the artcile< Synthesis of chiral sulfinate esters by asymmetric condensation>, Application of C4H10O2, the main research area is alc sulfinate pentanidium catalyst enantioselective condensation; sulfinate ester preparation.

Here a straightforward access to enantioenriched sulfinate esters via asym. condensation of prochiral sulfinates and alcs. using pentanidium as an organocatalyst was reported. This study successfully coupled a wide range of sulfinates and bioactive alcs. stereoselectively. The initial sulfinates was prepared from existing sulfone and sulfonamide drugs and the resulting sulfinate esters were versatile for transformations to diverse chiral sulfur pharmacophores. Through late-stage diversification 11,12 of celecoxib and other drug derivatives, was demonstrate the viability of this unified approach towards sulfur stereogenic centers.

Nature (London, United Kingdom) published new progress about Condensation reaction catalysts (stereoselective). 6290-03-5 belongs to class alcohols-buliding-blocks, and the molecular formula is C4H10O2, Application of C4H10O2.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Pannu, Naveet; Bhatnagar, Archana published the artcile< Resveratrol: from enhanced biosynthesis and bioavailability to multitargeting chronic diseases>, Product Details of C14H12O3, the main research area is review antioxidative antiinflammatory immunomodulating resveratrol bioavailability; Biosynthesis; Cardiovascular diseases; Diabetes; Neurological diseases; Pharmacokinetics; Resveratrol.

A review. Resveratrol, a phytoalexin with a wide range of pharmacol. properties is synthesized by plants in response to stress, injury, infection or UV radiations. As it is a secondary metabolite with many health promoting properties, various methods employing microorganisms and genetic manipulation of different synthetic enzymes, have been comprehensively studied to increase its production This flavonoid is extensively researched due to its pharmacol. properties such as anti-oxidative, anti-inflammatory and immuno-modulating effects. Knowledge of these properties of resveratrol has led to elaborate studies on its effect on diabetes, neurodegenerative diseases, cancer, ageing, obesity and cardiovascular diseases. At mol. level it targets sirtuin, adenosine monophosphate kinase, nuclear Factor-κB, inflammatory cytokines, anti-oxidant enzymes along with cellular processes such as angiogenesis, apoptosis, mitochondrial biogenesis, gluconeogenesis and lipid metabolism This discusses the properties of resveratrol and the different approaches of addressing the unfavorable synthesis and pharmacokinetics of this stilbene. Pre-clin. evaluations of resveratrol on diabetes mellitus, cardiovascular and neurol. diseases are elaborately discussed and the underlying pathways involved in its therapeutic activity have been given paramount importance. Following the pre-clin. studies, clin. trials on the same reveal the efficacy of resveratrol in the effective management of these diseases. This provides an intricate insight on resveratrol’s significance from a dietary component to a therapeutic agent.

Biomedicine & Pharmacotherapy published new progress about Aging, animal. 501-36-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C14H12O3, Product Details of C14H12O3.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Cerulli, Antonietta; Masullo, Milena; Piacente, Sonia published the artcile< Metabolite Profiling of Helichrysum italicum Derived Food Supplements by 1H-NMR-Based Metabolomics>, COA of Formula: C6H12O6, the main research area is Helichrysum italicum food supplement metabolomics multivariate data analysis; Helichrysum italicum derived food supplements; NMR metabolomics; green extractions; multivariate data analysis.

Helichrysum italicum is a medicinal plant from the Mediterranean area, widely used in traditional medicine for its anti-inflammatory, antibacterial and antioxidant properties and for its preventive effects on microcirculation diseases. Due to these properties, it finds large applications in cosmetic, food and pharmaceutical fields. Addnl., hydroalcoholic extracts and mother tinctures based on H. italicum represent products with a high com. value, widely distributed not only in drug stores but also on online markets. The different extraction procedures used can greatly affect the fingerprints of the extracts, resulting in a different qual. or quant. profile of the chem. constituents responsible for biol. activity. The aim of the present study was to characterize the composition of bioactive compounds present in water-ethanol and glycerol extracts of H. italicum derived food supplements. Metabolite profiles of the extracts were obtained by 1H NMR experiments and data were processed by multivariate statistical anal. to highlight differences in the extracts and to evidence the extracts with the highest concentrations of bioactive metabolites. In detail, this work highlights how derived food supplements of H. italicum obtained using ethanol-water mixtures ranging from 45% to 20% of ethanol represent the products with the highest amount of both primary (amino acids) and secondary metabolites including 3,4-dicaffeoylquinic acid (9), chlorogenic acid (10), 3,5-dicaffeoylquinic acid (11), and kaempferol 3-O-glucopyranoside (12). Moreover, it is evident that the use of an ethanol-water mixture 20:80 is the most suitable method to afford the highest number of phenolic compounds, while food-derived supplements obtained by glycerol extraction are characterized by a high amount of β-glucose and α-glucose and a low content of phenolic compounds

Molecules published new progress about Bioactive agents. 492-62-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H12O6, COA of Formula: C6H12O6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Jiang, Yueyang; Lin, Song; Yan, Houchun; Guo, Hongyue; Li, Qingsong published the artcile< Liquid-liquid equilibrium data measurement and thermodynamic modelling for ternary mixtures composed of water, diethylene glycol dimethyl ether and different solvents at 298.2 K>, Product Details of C8H18O, the main research area is water diethylene glycol dimethyl ether liquid equilibrium thermodn modeling.

Liquid-liquid equilibrium (LLE) data for water + diethylene glycol di-Me ether + {methyl iso-Bu carbinol, Me iso-Bu ketone, Me iso-Pr ketone, Me tert-Bu ether, n-octanol and 2-ethyl-1-hexanol} was measured at 298.2 K under 101.3 kPa. The effect of separating diethylene glycol di-Me ether from water is evaluated by the distribution coefficient and the separation coefficient The Othmer-Tobias and Hand equations were chosen to examine the exptl. LLE data. Meanwhile, the data was correlated by the NRTL and UNIQUAC thermodn. models with AAD% less than 0.55 and RMSD% less than 0.77. The separation performance of six solvents was compared using the σ-profile anal. via the exploration of the intermol. interaction.

Journal of Chemical Thermodynamics published new progress about Density. 104-76-7 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H18O, Product Details of C8H18O.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts