Month: October 2022

Yu, Juan; Ji, Hai-yu; Liu, Chao; Liu, An-jun published the artcile< The structural characteristics of an acid-soluble polysaccharide from Grifola frondosa and its antitumor effects on H22-bearing mice>, COA of Formula: C6H12O6, the main research area is Grifola hepatoma macrophage proliferation mannose glucose anticancer; Anti-tumor activity; Grifola frondosa acid-soluble polysaccharide; Structural characteristics.

The edible mushroom G. frondosa has been used as a kind of functional food for the prevention and therapy of various diseases in Asian countries. In the present work, a novel acid-soluble polysaccharide (GFAP) was successfully isolated from G. frondosa under room temperature and hydrochloric acid solution treatment. Results of chem. composition anal., UV and HPGPC spectra showed that GFAP mainly contained 94.28% of carbohydrate with the average mol. weight of about 644.9 kDa. GC, FT-IR, NMR and methylation anal. further indicated that GFAP was a neutral sugar mainly composed of (1 → 3)-β-D-Glcp and (1 → 3)-α-D-Manp. The in vivo antitumor experiments demonstrated that GFAP could effectively protect thymuses and spleens of tumor-bearing mice and inhibit the growth of H22 solid tumors with the inhibitory rate of 36.72%. Besides, GFAP could significantly improve the activities of NK cells, macrophages, CD19+ B cells and CD4+ T cells, leading to the apoptosis of H22 cells via G0/G1 phase arrested. Our data demonstrated that GFAP holds great application prospect to be a safe and effective antitumor adjuvant in the future.

International Journal of Biological Macromolecules published new progress about Apoptosis. 3458-28-4 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H12O6, COA of Formula: C6H12O6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Gupta, Shivangi; Maji, Ankur; Panja, Dibyajyoti; Halder, Mita; Kundu, Sabuj published the artcile< CuO NPs catalyzed synthesis of quinolines, pyridines, and pyrroles via dehydrogenative coupling strategy>, Product Details of C7H9NO, the main research area is hydroxymethyl aniline ketone copper nanocatalyst oxidative coupling reaction; quinoline preparation; hydroxypropanamine ketone copper nanocatalyst oxidative coupling reaction; pyridine preparation; hydroxyethanamine ketone copper nanocatalyst oxidative coupling reaction; pyrrole preparation.

Copper oxide nanoparticles catalyzed efficient synthesis of quinolines, pyridines, and pyrroles via alc. dehydrogenative coupling strategy are reported. Employing this catalytic system, various functionalized quinolines, pyridines, and pyrroles were synthesized efficiently from different amino alcs. with a diverse range of ketones. A number of control experiments were performed to shed light on the mechanism. This catalyst was recycled up to 6th run and notably, no significant loss was observed in its catalytic activity.

Journal of Catalysis published new progress about Amino alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 5344-90-1 belongs to class alcohols-buliding-blocks, and the molecular formula is C7H9NO, Product Details of C7H9NO.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Cheng, Chak Kwong; Luo, Jiang-Yun; Lau, Chi Wai; Chen, Zhen-Yu; Tian, Xiao Yu; Huang, Yu published the artcile< Pharmacological basis and new insights of resveratrol action in the cardiovascular system>, Formula: C14H12O3, the main research area is .

Resveratrol (trans-3,4′,5-trihydroxystilbene) belongs to the family of natural phytoalexins. Resveratrol first came to our attention in 1992, following reports of the cardioprotective effects of red wine. Thereafter, resveratrol was shown to exert antioxidant, anti-inflammatory, anti-proliferative, and angio-regulatory effects against atherosclerosis, ischemia, and cardiomyopathy. This article critically reviews the current findings on the mol. basis of resveratrol-mediated cardiovascular benefits, summarizing the broad effects of resveratrol on longevity regulation, energy metabolism, stress resistance, exercise mimetics, circadian clock, and microbiota composition In addition, this article also provides an update, both preclinically and clin., on resveratrol-induced cardiovascular protection and discusses the adverse and inconsistent effects of resveratrol reported in both preclin. and clin. studies. Although resveratrol has been claimed as a master anti-aging agent against several age-associated diseases, further detailed mechanistic investigation is still required to thoroughly unravel the therapeutic value of resveratrol against cardiovascular diseases at different stages of disease development.

British Journal of Pharmacology published new progress about 501-36-0 . 501-36-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C14H12O3, Formula: C14H12O3.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Zeng, Haisu; Wu, Jing; Li, Sihan; Hui, Christina; Ta, Anita; Cheng, Shu-Yuan; Zheng, Shengping; Zhang, Guoqi published the artcile< Copper(II)-Catalyzed Selective Hydroboration of Ketones and Aldehydes>, Name: 1-(4-Fluorophenyl)ethyl Alcohol, the main research area is divalent copper catalyzed chemoselective hydroboration ketone aldehyde; nonanuclear copper complex one pot self assembly preparation.

A novel nonanuclear copper(II) complex obtained by a facile one-pot self-assembly was found to catalyze the hydroboration of ketones and aldehydes with the absence of an activator under mild, solvent-free conditions. The catalyst is air- and moisture-stable, displaying high efficiency (1980 h-1 turnover frequency, TOF) and chemoselectivity on aldehydes over ketones and ketones over imines. This represents a rare example of divalent copper catalyst for the hydroboration of carbonyls.

Organic Letters published new progress about Alcohols Role: SPN (Synthetic Preparation), PREP (Preparation). 403-41-8 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H9FO, Name: 1-(4-Fluorophenyl)ethyl Alcohol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Chakrabortty, Pekham; Biswas, Surajit; Das, Anjan; Dolai, Malay; Islam, Sk Manirul published the artcile< Diformylphloroglucinol derived imine based covalent organic frameworks (PHTA) as efficient organocatalyst for conversion of isocyanates to urea derivatives>, Recommanded Product: 2,4,6-Trihydroxyisophthalaldehyde, the main research area is diformylphloroglucinol covalent organic framework preparation surface structure; aryl isocyanate organocatalyst dimerization; diaryl urea preparation.

New two-dimensional porous covalent organic frameworks (PHTA) with imine linkers was synthesized and effectively utilized as metal free catalytic system for the synthesis of urea derivatives from a wide range of isocyanates under inert atm. The material has been thoroughly characterized using powder XRD, HRTEM, FESEM, BET, FT-IR, XPS and a structure-activity relationship was established. The imine based covalent organic framework owing to its highly conjugated system permits superior conduction efficiency of carriers, thereby exhibiting better performance and exceptional reusability and selectivity (> 99%) towards generation of urea derivatives from the corresponding isocyanates. At room temperature the solvent free catalytic process under nitrogen atm. requires short range of reaction duration (2 h) to produce high yields (84-96%) of urea derivatives from resp. isocyanates. The catalytic route of urea synthesis in presence of organocatalyst PHTA was suitably described by theor. calculations (DFT) method. The heterogeneity and recyclability nature of the catalyst was checked for five cycles and the obtained result portrayed its good catalytic effectiveness.

Molecular Catalysis published new progress about Binding energy. 4396-13-8 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H6O5, Recommanded Product: 2,4,6-Trihydroxyisophthalaldehyde.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Kui, Tony; Chardin, Charline; Rouden, Jacques; Livi, Sebastien; Baudoux, Jerome published the artcile< Sulfonates as Versatile Structural Counterions of Epoxidized Salts>, Reference of 627-27-0, the main research area is epoxidized salt sulfonate versatile structure; epoxidation; ionic liquids; metathesis; monomers; sulfonates.

Ionic liquids have recently emerged as monomers to synthesize multifunctional polymeric materials. Among such species, ionic epoxy-based networks represent promising but underdeveloped materials that are hindered by tricky access to the functionalized ionic liquid monomers. To date, the reported epoxidized imidazolium salts have focused on highly toxic epichlorohydrin. This study concerns flexible and efficient methods to synthesize versatile building blocks with sulfonates as valuable anions. The judicious combination of an aliphatic or aromatic sulfonate with an imidazolium leads to new epoxidized salts with high structural variability and good chem. and thermal stability (>300°C).

ChemSusChem published new progress about Epoxidation. 627-27-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C4H8O, Reference of 627-27-0.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Moon, Hye Won; Maity, Ayan; Radosevich, Alexander T. published the artcile< Ancillary Tethering Influences σ3-P vs σ5-P Speciation and Enables Intermolecular S-H Oxidative Addition to Nontrigonal Phosphorus Compounds>, Formula: C19H16O, the main research area is dibenzoazepine phosphoramide preparation oxidative addition alc thiol phosphorane; crystal structure dibenzoazepine alkoxy alkylthio phosphorane; mol structure dibenzoazepine alkoxy alkylthio phosphorane.

The design and synthesis of dibenzoazepine-based nontrigonal phosphorus(III) triamide (2), bearing a peripheral ethylene bridge is described. By comparison to a compound lacking the ethylene bridge, PN(o-NMeC6H4)2 (1), the dibenzoazepine 2 is shown to exclusively form σ5-P oxidative addition products upon E-H addition (E = OR, SR) in preference to a σ3-P adduct from cooperative addition across one P-N bond. The resulting pentacoordinate phosphoranes have been characterized by multinuclear NMR spectroscopy and X-ray crystallog. DFT calculations on relative energies of σ3-P and σ5-P species indicate that the ethylene linker in 2 energetically destabilizes the σ3-P tautomer of the phosphorane product (2·[H][E]) by constraining rotation along the C-N bond, favoring formation of σ5-P phosphoranes by ring-chain tautomerism.

Organometallics published new progress about Azepines Role: PEP (Physical, Engineering or Chemical Process), PRP (Properties), RCT (Reactant), SPN (Synthetic Preparation), PROC (Process), RACT (Reactant or Reagent), PREP (Preparation) (dibenzo[b,f]azepines). 76-84-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C19H16O, Formula: C19H16O.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Mondal, John; Borah, Parijat; Modak, Arindam; Zhao, Yanli; Bhaumik, Asim published the artcile< Cu-Grafted Functionalized Mesoporous SBA-15: A Novel Heterogeneous Catalyst for Facile One-Pot Three-Component C-S Cross-Coupling Reaction of Aryl Halides in Water>, Computed Properties of 4396-13-8, the main research area is copper grafted SBA15 coupling aryl halide benzyl bromide thiourea; aryl alkyl thioether synthesis.

A highly ordered 2D hexagonal Cu-grafted functionalized mesoporous SBA-15 (Cu-PIF-SBA-15) has been designed through postsynthetic modification of mesoporous SBA-15. Surface functionalization technique has been employed to synthesize -NH2 functionalized mesoporous SBA-15 material. Schiff base condensation of this -NH2 functionalized SBA-15 with phloroglucinol dialdehyde leads to the formation of PIF-SBA-15. Reaction of PIF-SBA-15 with Cu-(OAc)2·H2O in ethanol under reflux leads to the formation of Cu-PIF-SBA-15 catalyst. This Cu-PIF-SBA-15 catalyst exhibits excellent catalytic activity in a one-pot three-component C-S coupling reaction for a diverse range of aryl halides (bromide and chloride) with thiourea and benzyl bromide in aqueous medium to offer aryl alkyl thioether in very good yields [e.g., 4-bromoanisole + thiourea + benzyl bromide → 4-MeOC6H4SCH2Ph (79%)]. Due to the strong binding ability of the imine-N and phenolic-OH functional groups present in the phloroglucinol diimine moiety of the framework, the anchored Cu-(II) could not leach out from the surface of the mesoporous catalyst during the course of reaction, and it has been observed that six repetitive reaction cycles could not cause any appreciable loss in the catalytic activity of this material.

Organic Process Research & Development published new progress about Aryl bromides Role: RCT (Reactant), RACT (Reactant or Reagent). 4396-13-8 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H6O5, Computed Properties of 4396-13-8.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Durgadevi, Ravindran; Veera Ravi, Arumugam; Alexpandi, Rajaiah; Krishnan Swetha, Thirukannamangai; Abirami, Gurusamy; Vishnu, Selvam; Karutha Pandian, Shunmugaiah published the artcile< Virulence targeted inhibitory effect of linalool against the exclusive uropathogen Proteus mirabilis>, Related Products of 78-70-6, the main research area is urinary tract infection linalool proteus biofilm virulence; Antibiofilm activity; antivirulence activity; crystalline biofilm; linalool; motility; proteus.

Proteus mirabilis is one of the leading causes of catheter-associated UTIs (CAUTI) in individuals with prolonged urinary catheterization. Since, biofilm assisted antibiotic resistance is reported to complicate the treatment strategies of P. mirabilis infections, the present study was aimed to attenuate biofilm and virulence factor production in P. mirabilis. Linalool is a naturally occurring monoterpene alc. found in a wide range of flowers and spice plants and has many biol. applications. In this study, linalool exhibited concentration dependent anti-biofilm activity against crystalline biofilm of P. mirabilis through reduced production of the virulence enzyme urease that raises the urinary pH and drives the formation of crystals (struvite) in the biofilm. The results of q-PCR anal. unveiled the down regulation of biofilm/virulence associated genes upon linalool treatment, which was in correspondence with the in vitro bioassays. Thus, this study reports the feasibility of linalool acting as a promising anti-biofilm agent against P. mirabilis mediated CAUTI.

Biofouling published new progress about Biofilms (microbial). 78-70-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C10H18O, Related Products of 78-70-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Zhu, Man; Chen, Yao; Zhao, Ninghui; Bai, Hua; Zhang, Keqin; Huang, Xiaowei published the artcile< Multiple olfactory pathways contribute to the lure process of Caenorhabditis elegans by pathogenic bacteria>, SDS of cas: 104-76-7, the main research area is Caenorhabditis multiple olfactory pathway lure process pathogenic bacteria; B. nematocida B16; Caenorhabditis elegans; attractant; chemotaxis; host; olfactory signaling pathway; pathogenic bacteria.

Abstract: Chemosensation is indispensable for the survival of Caenorhabditis elegans to discriminate food and pathogenic bacteria in their living environment. Food-like odors emitted by the pathogen Bacillus nematocida B16 for trapping its hosts and an olfactory signaling pathway responsible to sense the attractant 2-heptanone were identified in our previous study. Here, we further explore how the worms recognize the attractive mols. indole and 2-Et hexanol, which have different chem. properties and modest nematode-luring ability. We show that the chemotaxis toward indole and 2-Et hexanol requires the G protein-coupled receptors encoded by str-193 on AWC and str-7 on AWA. In a further genetic screen for downstream effectors in olfactory signaling cascades, the Gα subunit GSA-1, guanylyl cyclase ODR-1 and DAF-11 and the cGMP-gated channel TAX-2/TAX-4 were found to be necessary for indole sensation, whereas the TRPV channels OSM-9/OCR-2 and the PLC pathway activated by GPA-6 are responsible for the detection of 2-Et hexanol. Altogether, our current work further clarifies the distinct olfactory signaling pathways through which C. elegans senses different chems. and is lured by B. nematocida B16, improving our comprehensive understanding of the mechanisms by which bacterial pathogens effectively infect their hosts.

Science China: Life Sciences published new progress about Bacillus nematocida (B16). 104-76-7 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H18O, SDS of cas: 104-76-7.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts