Month: October 2022

Zhu, Kaili; Xu, Xudong; Xu, Mengqiu; Deng, Ping; Wu, Wenbo; Ye, Wei; Weng, Zihui; Su, Yue; Wang, Huijie; Xiao, Fei; Fang, Zeping; Gao, Peng published the artcile< One-Pot Synthesis of Tensile-Strained PdRuCu Icosahedra toward Electrochemical Hydrogenation of Alkene>, HPLC of Formula: 627-27-0, the main research area is alkene lead ruthenium copper icosahedra one pot synthesis.

Electrochem. hydrogenation (ECH) uses electricity to drive proton (H+) reduction for hydrogenation, which can greatly reduce energy supply and environmental pollution, representing an ideal alternative to traditional thermal hydrogenation. In this work, we put forward tensile-strained PdRuCu alloy to promote ECH. Tensile strain promotes the adsorption of C=C by changing the d-band center. Meanwhile, alloying Ru and Cu into Pd lattice facilitates hydrogenation by weakening Pd-H bonding. Therefore, PdRuCu icosahedra display excellent ECH performance of 2-methyl-3-buten-2-ol (MBE) with specific activity of 227.4μmolMBE nm-2 min-1 at -0.3 V vs. reversible hydrogen electrode (RHE), about 16.1 and 10.5 times higher than that of com. Pd/C and Ru/C, resp. In addition, PdRuCu icosahedra was excellent in the scaling up of substrate concentration combined with anisyl alc. oxidation to produce high-value added anisaldehyde at anode. This work provides a guideline for the rational design of highly active and durable metallic catalyst in ECH.

ChemElectroChem published new progress about Adsorption. 627-27-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C4H8O, HPLC of Formula: 627-27-0.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Wang, Hua; Bo, Yang; Liu, Yang; Xu, Ming; Cai, Kaimin; Wang, Ruibo; Cheng, Jianjun published the artcile< In vivo cancer targeting via glycopolyester nanoparticle mediated metabolic cell labeling followed by click reaction>, Name: (2S,3R,4S,5R)-2-Amino-3,4,5,6-tetrahydroxyhexanal hydrochloride, the main research area is cancer targeting glycopolyester nanoparticle metabolic cell labeling; Cancer targeting; Cell labeling; Click chemistry; Drug design; Sugar.

We developed glycopolyesters (GPs) via azido-sugar initiated ring-opening polymerization of O-carboxyanhydrides (OCAs) and achieved efficient in vivo cancer targeting via GP-nanoparticle (GP-NP) mediated metabolic cell labeling followed by Click reaction. GP-NP shows controlled release of azido-sugars and can efficiently label LS174T colon cancer cells with azido groups in tumor-bearing mice. The exogenously introduced azido groups render excellent in vivo cancer targeting and retention of dibenzocyclooctyne-Cy5 (DBCO-Cy5) with an increasing tumor retention enhancement over time (68% at 6 h, 105% at 24 h, and 191% at 48 h) compared to control mice without azido labeling. The tumor accumulation of DBCO-doxorubicin is also significantly enhanced in GP-NP pretreated mice, resulting in improved in vivo anticancer efficacy. This study, for the first time, proposes the use of azido-sugar initiated polymerization of OCAs to form sugar delivery vehicles with high stability and controlled release, and demonstrates the increasing tumor targeting effect of DBCO-cargo over time by azido-modified tumor cells.

Biomaterials published new progress about Antitumor agents. 5505-63-5 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H14ClNO5, Name: (2S,3R,4S,5R)-2-Amino-3,4,5,6-tetrahydroxyhexanal hydrochloride.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Wang, Hanhan; Hu, Mengjun; Wang, Xiao-Na; Chang, Junbiao published the artcile< Metal-free hydroalkoxylation of ynesulfonamides with alcohols>, COA of Formula: C4H8O, the main research area is alkoxy enamide preparation regioselective diastereoselective; ynesulfonamide alc hydroalkoxylation triflic acid catalyst.

Efforts for developing a convenient and expeditious method for synthesizing alkoxy-substituted enamides RS(O)2N(R1)C(OR3)=CHR2 (R = Me, 4-methylphenyl, 4-nitrophenyl, 4-chlorophenyl, 4-methoxyyphenyl; R1 = Me, n-Bu, Bn, allyl; R2 = Me, Ph, thiophen-2-yl, etc.; R3 = Et, Bn, cyclopentyl, etc.) via nucleophilic addition of alcs. R3OH to ynesulfonamides RS(O)2N(R1)CCR2 were described. This sequence is completely regioselective and highly stereoselective, and leads to the hydroalkoxylation products in high yields under mild reaction conditions.

Organic & Biomolecular Chemistry published new progress about Alkoxylation catalysts, reductive (regioselective). 627-27-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C4H8O, COA of Formula: C4H8O.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Hendy, Cecilia M.; Smith, Gavin C.; Xu, Zihao; Lian, Tianquan; Jui, Nathan T. published the artcile< Radical Chain Reduction via Carbon Dioxide Radical Anion (CO2•-)>, Recommanded Product: But-3-en-1-ol, the main research area is radical chain reduction carbon dioxide radical anion.

We developed an effective method for reductive radical formation that utilizes the radical anion of carbon dioxide (CO2•-) as a powerful single electron reductant. Through a polarity matched hydrogen atom transfer (HAT) between an electrophilic radical and a formate salt, CO2•- formation occurs as a key element in a new radical chain reaction. Here, radical chain initiation can be performed through photochem. or thermal means, and we illustrate the ability of this approach to accomplish reductive activation of a range of substrate classes. Specifically, we employed this strategy in the intermol. hydroarylation of unactivated alkenes with (hetero)aryl chlorides/bromides, radical deamination of arylammonium salts, aliphatic ketyl radical formation, and sulfonamide cleavage. We show that the reactivity of CO2•- with electron-poor olefins results in either single electron reduction or alkene hydrocarboxylation, where substrate reduction potentials can be utilized to predict reaction outcome.

Journal of the American Chemical Society published new progress about Aliphatic aldehydes Role: RCT (Reactant), RACT (Reactant or Reagent) (radical reduction of aliphatic aldehydes). 627-27-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C4H8O, Recommanded Product: But-3-en-1-ol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Koruyucu, Meryem; Saltan, Fehmi; Kok, Gokhan; Akat, Hakan; Salman, Yesim published the artcile< Novel sugar based acrylate: synthesis, characterization and polymerization>, HPLC of Formula: 4064-06-6, the main research area is novel sugar based acrylate synthesis polymerization.

The present study has demonstrated that novel acrylic glycopolymers are successfully prepared by using monosaccharides containing an acrylate group (9-12). For this purpose, sugar based acrylate monomers were synthesized via ring opening method (Method B) and homopolymerization of this sugar oxypropylacrylates was performed using free radical polymerization The characterization of all the monomers and polymers were verified by 1HNMR, 13CNMR, FTIR and GPC techniques. The Glass transition temperatures and thermal characteristics of the polymers were also analyzed by using DSC and TG techniques. The thermal stability of prepared polymers have changed with the stereochem. of the carbohydrate moiety. Also, the mol. weight of the polymers has affected the thermal stability.

Journal of Polymer Materials published new progress about Glass transition temperature. 4064-06-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C12H20O6, HPLC of Formula: 4064-06-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Park, Yunjeong; Ryu, Jae-Sang published the artcile< Formal synthesis of (±)-sedamine through gold(I)-catalyzed intramolecular dehydrative amination of sulfamate esters tethered to allylic alcohols>, Application of C4H8O, the main research area is dehydrative amination cyclization alkylation ring closing metathesis gold catalyst; sedamine formal synthesis.

A concise formal synthesis of (±)-sedamine (I) has been accomplished. The synthesis is straightforward and demonstrates high efficiency. Key steps involve gold(I)-catalyzed cyclization of sulfamate esters tethered to allylic alcs., sulfamate N-alkylation, and ring-closing metathesis.

Tetrahedron Letters published new progress about Alkylation. 627-27-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C4H8O, Application of C4H8O.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Kai, Hiroyuki; Morioka, Yasuhide; Tomida, Minoru; Takahashi, Tadashi; Hattori, Maki; Hanasaki, Kohji; Koike, Katsumi; Chiba, Hiroki; Shinohara, Shunji; Kanemasa, Toshiyuki; Iwamoto, Yuka; Takahashi, Kohji; Yamaguchi, Yoshitaka; Baba, Takahiko; Yoshikawa, Takayoshi; Takenaka, Hideyuki published the artcile< 2-Arylimino-5,6-dihydro-4H-1,3-thiazines as a new class of cannabinoid receptor agonists. Part 2: Orally bioavailable compounds>, Recommanded Product: (1-(Aminomethyl)cyclopropyl)methanol, the main research area is cannabinoid receptor analgesia oral bioavailability thiazine derivative SAR.

Structure-activity relationships and efforts to optimize the pharmacokinetic profile of a class of 2-arylimino-5,6-dihydro-4H-1,3-thiazines as cannabinoid receptor agonists are described. Among the compounds examined, compound 14 showed potent affinity and high selectivity for CB2, and compound 23 showed potent affinities against CB1 and CB2. These compounds displayed oral bioavailability.

Bioorganic & Medicinal Chemistry Letters published new progress about Analgesics. 45434-02-4 belongs to class alcohols-buliding-blocks, and the molecular formula is C5H11NO, Recommanded Product: (1-(Aminomethyl)cyclopropyl)methanol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Fernandes, Rodney A.; Yadav, Sandhya S.; Kumar, Praveen published the artcile< Palladium-catalyzed anti-Markovnikov oxidative acetalization of activated olefins with iron(III) sulphate as the reoxidant>, Application of C4H8O, the main research area is styrene pinacole palladium catalyst regioselective oxidative acetalization green chem; arylmethyl tetramethyl dioxolane preparation; arylallyl ether pinacole palladium catalyst regioselective acetalization green chem; aryloxyethyl tetramethyl dioxolane preparation; arylacrylate pinacole palladium catalyst regioselective oxidative acetalization green chem; phenyl tetramethyl dioxolanyl acetate preparation; arylhomoallyl alc pinacole palladium catalyst regioselective acetalization green chem; aryltetramethyl dioxolanyl propanol preparation.

This paper disclosed the efficient palladium-catalyzed anti-Markovnikov oxidative acetalization of activated terminal olefins with iron(III) sulfate as the reoxidant. This methodol. required mild reaction conditions and shows high regioselectivity toward anti-Markovnikov products and compatibility with a wide range of functional groups. Iron(III) sulfate was the sole reoxidant used in this method. Various olefins like vinylarenes, aryl-allylethers, aryl or benzyl acrylates and homoallylic alcs. all reacted well providing anti-Markovnikov acetals, some of which represent orthogonally functionalized 1,3- and 1,4-dioxygenated compounds

Organic & Biomolecular Chemistry published new progress about Acetalization (regioselective). 627-27-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C4H8O, Application of C4H8O.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Bedenko, S. P.; Dement’ev, K. I.; Tret’yakov, V. F. published the artcile< Kinetics of Liquid-Phase Condensation of Propylene with Formaldehyde over H-MFI and H-BEA Zeolites>, Name: But-3-en-1-ol, the main research area is propylene formaldehyde zeolite liquid phase condensation kinetic.

This study investigated the kinetic patterns of the liquid-phase Prins condensation of propylene with formaldehyde in the range of 120-180°C over H-MFI and H-BEA zeolites. The apparent reaction order with respect to formaldehyde was found to vary between 0.1 and 0.2 for H-BEA and to be close to zero for H-MFI. The apparent activation energy for H-MFI and H-BEA was 26.1±0.6 kJ/mol and 20.0±4.0 kJ/mol, resp. Based on these results, the reaction was demonstrated to occur in the intradiffusion or transition region; the calculated Thiele modulus and effectiveness factor further confirmed this fact. The diffusion limitations were partially removed by raising the initial formaldehyde concentration, as indicated by an increase in the apparent order of formaldehyde conversion to 1.0 for H-BEA and to 0.4 in the H-MFI case. To describe the substrate transformations observed, a modernized reaction mechanism was proposed.

Petroleum Chemistry published new progress about Ammonium-exchanged zeolites, NH4-beta Role: CAT (Catalyst Use), USES (Uses) (CP 814E). 627-27-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C4H8O, Name: But-3-en-1-ol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Kirmizi, N. Ipek; Aydin, Volkan; Akici, Narin; Bayar, Banu; Akici, Ahmet published the artcile< Utilization of biotechnological drugs in rare diseases requiring the use of off-label drugs in children in Turkey>, Quality Control of 1492-18-8, the main research area is biotechnol drug rare disease OLDU child; biotechnological drugs; canakinumab; pediatrics; rare disease; Off-label drug use.

Pediatric patients, especially those with rare diseases, represent a population that has a high tendency towards offlabel drug use (OLDU) and needs a more careful practice of pharmacotherapy than in adults. We aimed to investigate biotechnol. drug use in children with rare diseases requiring OLDU. This retrospective study examined all single-diagnosed OLDU applications (n = 5792) for 4992 children (<18-yr) in Turkey. Applications of rare diseases were selected, and their descriptive characteristics were examined, including demog. features of patients, biotechnol. drug utilization status, and disease categories. The off-label statuses of the drugs at the end of 2020 were also examined In total, 77.7% (n = 4501) of OLDU applications were made for rare diseases. Biotechnol. drug use was higher in rare disease applications than in nonrare diseases (37.9% vs. 19.2%, resp.; p < 0.0001). Canakinumab was the top applied biotechnol. drug (73.2%). Compared to that in small-mol. drugs, the mean age of patients was higher in biotechnol. drug-containing applications (8.1 ± 5.3 vs. 9.7 ± 4.9, resp.; p < 0.0001). Biotechnol. drug use was higher in nonneoplastic rare diseases (40.3%) than in neoplastic rare diseases (26.4%), (p < 0.0001). At the end of 2020, the approval status of the off-label indications covered in 2016 was significantly higher for rare (24.4%) vs. nonrare (5.2%, p < 0.0001) diseases and for biotechnol. (32.3%) vs. smallmol. (13.9%, p < 0.0001) drugs. In total, 87.7% of the drugs would have to be still used in the off-label setting at the end of 2020. It was seen that more than three-quarters of the pediatric OLDU applications are for rare diseases, and the need for biotechnol. OLDU in this group is almost 2-fold of small-mol. drug use. While further projected findings imply a higher approval tendency for rare diseases and biotechnol. drugs, there seems to be more room for improvement for pediatric drug use. Turkish Journal of Medical Sciences published new progress about Blood. 1492-18-8 belongs to class alcohols-buliding-blocks, and the molecular formula is C20H21CaN7O7, Quality Control of 1492-18-8.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts