Month: October 2022

Mishra, Sanket J.; Liu, Weiya; Beebe, Kristin; Banerjee, Monimoy; Kent, Caitlin N.; Munthali, Vitumbiko; Koren, John III; Taylor, John A. III; Neckers, Leonard M.; Holzbeierlein, Jeffrey; Blagg, Brian S. J. published their research in Journal of Medicinal Chemistry in 2021. The article was titled 《The Development of Hsp90β-Selective Inhibitors to Overcome Detriments Associated with pan-Hsp90 Inhibition》.Related Products of 27489-62-9 The article contains the following contents:

The 90 kD heat shock proteins (Hsp90) are mol. chaperones that are responsible for the folding of select proteins, many of which are directly associated with cancer progression. Consequently, inhibition of the Hsp90 protein folding machinery results in a combinatorial attack on numerous oncogenic pathways. Seventeen small-mol. inhibitors of Hsp90 have entered clin. trials for the treatment of cancer, all of which bind the Hsp90 N-terminus and exhibit pan-inhibitory activity against all four Hsp90 isoforms, which may lead to adverse effects. The development of Hsp90 isoform-selective inhibitors represents an alternative approach toward the treatment of cancer and may limit some of these detriments. Described herein, is a structure-based approach to develop isoform-selective inhibitors of Hsp90β, which induces the degradation of select Hsp90 clients without concomitant induction of Hsp90 levels. Together, these initial studies support the development of Hsp90β-selective inhibitors as a method for overcoming the detriments associated with pan-inhibition. In the experimental materials used by the author, we found trans-4-Aminocyclohexanol(cas: 27489-62-9Related Products of 27489-62-9)

trans-4-Aminocyclohexanol(cas: 27489-62-9) belongs to anime. Acylation is one of the most important reactions of primary and secondary amines; a hydrogen atom is replaced by an acyl group (a group derived from an acid, such as RCOOH or RSO3H, by removal of ―OH, such as RC(=O)―, RS(O)2―, and so on). Reagents may be acid chlorides (RCOC1, RSO2C1), anhydrides ((RCO)2O), or even esters (RCOOR′); the products are amides of the corresponding acids.Related Products of 27489-62-9

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Piyanuch, Pornthip; Patawanich, Pramsak; Sirirak, Jitnapa; Suwatpipat, Kullatat; Kamkaew, Anyanee; Burgess, Kevin; Wanichacheva, Nantanit published their research in Journal of Hazardous Materials in 2021. The article was titled 《Rapid and visual detection of Cd2+ based on aza-BODIPY near infrared dye and its application in real and biological samples for environmental contamination screening》.Application of 1195-59-1 The article contains the following contents:

Cadmium highly toxic and hazardous, and it can adversely affect human health leading to serious disorders. Herein, a water-soluble near-IR sensor based on aza-BODIPY (1) was developed for dual determination of Cd2+ in environmental and biol. media. This sensor exhibited color change from colorless to green along with a fluorescence enhancement in the near-IR (NIR) region via photoinduced electron transfer (PET) after complexation with Cd2+. Sensor 1 can be employed in aqueous media at physiol. pH for quant. monitoring. It shows rapid response with high sensitivity (detection limit of 2.8 ppb; linear correlation over [Cd2+] 1.33 – 6.67 μM) and selectivity over potentially interfering ions. NIR sensor 1 can be used to determine [Cd2+] in living cells and environmental samples. The results came from multiple reactions, including the reaction of 2,6-Pyridinedimethanol(cas: 1195-59-1Application of 1195-59-1)

2,6-Pyridinedimethanol(cas: 1195-59-1) belongs to pyridine. Pyridine’s structure is isoelectronic with that of benzene, but its properties are quite different. Pyridine is completely miscible with water, whereas benzene is only slightly soluble. Like all hydrocarbons, benzene is neutral (in the acid–base sense), but because of its nitrogen atom, pyridine is a weak base.Application of 1195-59-1

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Rostkowska, Hanna; Luchowska, Anna; Lapinski, Leszek; Nowak, Maciej J. published an article in 2021. The article was titled 《Effect of a Solid-Hydrogen Environment on UV-Induced Hydrogen-Atom Transfer in Matrix-Isolated Heterocyclic Thione Compounds》, and you may find the article in Journal of Physical Chemistry A.Product Details of 7748-36-9 The information in the text is summarized as follows:

To shed more light on the mechanisms of UV-induced hydrogen-atom-transfer processes in heterocyclic mols., phototautomeric thione → thiol reactions were investigated for thione compounds isolated in low-temperature Ar as well as in n-H2 (normal hydrogen) matrixes. These studies concerned thione compounds with a five-membered heterocyclic ring and thione compounds with a six-membered heterocyclic ring. The exptl. investigation of 2-thioimidazole and 3-thio-1,2,4-triazole (thione compounds with a five-membered heterocyclic ring) revealed that for the compounds isolated in solid n-H2 only trace amounts of thiol photoproducts were photogenerated; even though for the same compounds isolated in the solid Ar matrix, the thione → thiol photoconversion was nearly total. In contrast to that, for 3-thiopyridazine and 2-thioquinoline (thione compounds with a six-membered heterocyclic ring) isolated in solid n-H2, the UV-induced thione → thiol conversion occurred with the yield reaching 25-50% of the yield of the analogous process observed for the same species isolated in solid Ar. The obtained exptl. results allow us to conclude that the dissociation-association mechanism nearly exclusively governs the phototransformation in thione heterocycles with high barriers for tautomerization (such as thione compounds with a five-membered ring), whereas the strictly intramol. hydrogen-atom shift contributes to the mechanism of hydrogen-atom transfer in thione heterocycles with lower barriers (such as thione compounds with a six-membered ring). In the experimental materials used by the author, we found Oxetan-3-ol(cas: 7748-36-9Product Details of 7748-36-9)

Oxetan-3-ol(cas: 7748-36-9) is used as a reagent in the synthesis of 5-fluoro-4,6-dialkoxypyrimidine GPR119 agonists. It is also used as a reagent in the synthesis of cyclic sulfone hydroxyethylamines as potent and selective β-site APP-cleaving enzyme 1 (BACE1) inhibitors.Product Details of 7748-36-9

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Yang, Yang; Wang, Ke; Chen, Hao; Feng, Zhiqiang published an article in 2021. The article was titled 《Design, synthesis, evaluation, and SAR of 4-phenylindoline derivatives, a novel class of small-molecule inhibitors of the programmed cell death-1/ programmed cell death-ligand 1 (PD-1/PD-L1) interaction》, and you may find the article in European Journal of Medicinal Chemistry.Safety of 2-Aminopropane-1,3-diol The information in the text is summarized as follows:

The blockade of the PD-1/PD-L1 immune checkpoint pathway with small mols. is an emerging immunotherapeutic approach. A novel series of 4-phenylindoline derivatives were synthesized, and their inhibitory activity against the PD-1/PD-L1 protein-protein interaction (PPI) was evaluated through a homogenous time-resolved fluorescence (HTRF) assay. Among them, I and II exhibited potent activity with IC50 values of 17 nM and 12 nM, resp. Furthermore, I showed the promising inhibitory activity against the PD-1/PD-L1 interaction with the EC50 value of 0.43μM in a co-culture model of PD-L1/TCR Activator-expressing CHO cells and PD-1-expressing Jurkat cells. Besides, the structure-activity relationships (SAR) of the novel synthesized 4-phenylindoline derivatives was concluded, and the binding mode of II with the PD-L1 dimer was analyzed by mol. simulation and docking, demonstrating that the N-atom in the side chain of indoline fragment could interact with the amino acid residue of the PD-L1 protein to lead to the potent inhibitory activity. This study provided a new insight for further drug design.2-Aminopropane-1,3-diol(cas: 534-03-2Safety of 2-Aminopropane-1,3-diol) was used in this study.

2-Aminopropane-1,3-diol(cas: 534-03-2) belongs to anime. Large quantities of aliphatic amines are made synthetically. The most widely used industrial method is the reaction of alcohols with ammonia at a high temperature, catalyzed by metals or metal oxide catalysts (e.g., nickel or copper). Mixtures of primary, secondary, and tertiary amines are thereby produced.Safety of 2-Aminopropane-1,3-diol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Choe, Hye Rin; Han, Sung Su; Kim, Yong-Il; Hong, Changhyun; Cho, Eun Jin; Nam, Ki Min published an article in 2021. The article was titled 《Understanding and Improving Photocatalytic Activity of Pd-Loaded BiVO4 Microspheres: Application to Visible Light-Induced Suzuki-Miyaura Coupling Reaction》, and you may find the article in ACS Applied Materials & Interfaces.SDS of cas: 89466-08-0 The information in the text is summarized as follows:

The effective utilization of visible light is required for exploiting photocatalytic reactions in indoor and outdoor environments. In this study, Pd-supported BiVO4 microspheres (Pd-BiVO4) were prepared for visible light-induced photocatalytic reactions. Under irradiation with a white light-emitting diode, the obtained Pd-BiVO4 composite exhibited considerably improved catalytic activity for the decomposition of an organic dye compared with other BiVO4 catalysts. The Pd-BiVO4 composite was also effective for catalytic organic transformation via the visible light-induced Suzuki-Miyaura coupling reaction. The photogenerated electrons in the conduction band of BiVO4 flowed to the Pd nanoparticles and amplified cross-coupling reaction. The influence of the crystal structure and grain size of BiVO4 and the role of the deposited Pd nanoparticles were fully investigated to elucidate the visible light activity of the catalyst. This system highlights the possibility of an indoor light source with low energy d. for sustainable organic transformations. In the part of experimental materials, we found many familiar compounds, such as 2-Hydroxyphenylboronic acid(cas: 89466-08-0SDS of cas: 89466-08-0)

2-Hydroxyphenylboronic acid(cas: 89466-08-0) belongs to acyl phenylboronic acid. Phenylboronic acid (PBA) has been used to extract β-blockers (a class of aminoalcohol-containing drugs) from aqueous solution, rat, and human plasma. SDS of cas: 89466-08-0

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Gilbreth, Edward; Spann, Shawn; Lavrich, Richard J. published an article in 2022. The article was titled 《Conformational flexibility and hydrogen bonding in 5-aminopentanol》, and you may find the article in Journal of Molecular Spectroscopy.COA of Formula: C3H9NO The information in the text is summarized as follows:

Rotational spectra of two conformers of 5-aminopentanol have been recorded using a Fourier-transform microwave spectrometer. For conformer C-1, eighty-two hyperfine components from the twenty-four a-, b-, and c-type transitions measured were fit to the quadrupole coupling constants, χaa = -2.954(2) MHz, χbb = 2.386(3) MHz. For conformer C-2, the fit of the seventy-six hyperfine components from the twenty-four a- and b-type transitions measured yielded χaa = -3.636(1) MHz and χbb = 2.087(2) MHz. Rotational and centrifugal distortion constants determined from fits of the resulting unsplit line centers to the Watson A-reduction Hamiltonian are A = 3322.169(1) MHz, B = 1958.7382(9) MHz, C = 1402.5957(8) MHz, ΔJ = 0.60(2) kHz, ΔJK = -0.21(8) kHz, ΔK = 0.99(3) kHz, δJ = 0.203(7) kHz, and δK = 1.1(1) kHz for conformer C-1 and A = 3249.2215(6) MHz, B = 2027.9327(3) MHz, C = 1432.5846(3) MHz, ΔJ = 0.545(6) kHz, ΔJK = 0.25(2) kHz, ΔK = 0.39(5) kHz, δJ = 0.18(4) kHz, and δK = 0.96(3) kHz for conformer C-2. The two exptl. conformations are consistent with the two lowest energy ab initio MP2/6-311++G(d,p) structures. Both conformations of 5-aminopentanol are stabilized by an intramol. hydrogen bond from the alc. proton to amino nitrogen. The flexibility introduced by the five carbons in the alkyl group separating the amino and alc. functional groups resulted in the first appearance of multiple low energy conformers being detected relative to the four, three, and two carbons in 4-aminobutanol, 3-aminopropanol, and 2-aminoethanol resp. in which only one exptl. conformation was observed In addition to this study using 3-Aminopropan-1-ol, there are many other studies that have used 3-Aminopropan-1-ol(cas: 156-87-6COA of Formula: C3H9NO) was used in this study.

3-Aminopropan-1-ol(cas: 156-87-6) belongs to anime. Reaction with nitrous acid (HNO2), which functions as an acylating agent that is a source of the nitrosyl group (―NO), converts aliphatic primary amines to nitrogen and mixtures of alkenes and alcohols corresponding to the alkyl group in a complex process. This reaction has been used for analytical determination of primary amino groups in a procedure known as the Van Slyke method.COA of Formula: C3H9NO

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

In 2022,Govindaraju, Santhosh; Daniel, Nobi Kunnathu; Tabassum, Sumaiya published an article in Materials Today: Proceedings. The title of the article was 《Sulfamic acid catalyzed grinding: A facile one-pot approach for the synthesis of polysubstituted pyrazoles under green conditions》.Application In Synthesis of 3-Hydroxybenzaldehyde The author mentioned the following in the article:

A competent, rapid and simple grinding procedure for the synthesis of pharmacol. relevant polysubstituted pyrazoles catalyzed by sulfamic acid was reported via multicomponent reaction of substituted benzaldehydes, 4-nitrophenylacetonitrile, hydrazine hydrate, Et acetoacetate under solvent-free reaction conditions. In this reported protocol, four different reactants featuring diverse functional groups were assembled in one pot, enabling the synthesis of more diverse mol. structures in a facile manner. In the experimental materials used by the author, we found 3-Hydroxybenzaldehyde(cas: 100-83-4Application In Synthesis of 3-Hydroxybenzaldehyde)

3-Hydroxybenzaldehyde(cas: 100-83-4) can be used as a reactant along with ethyl acetoacetate and thiourea in the synthesis of corresponding dihydropyrimidine-2-thione (monastrol), using Yb(OTf)3 as a catalyst by Biginelli cyclocondensation reaction.Application In Synthesis of 3-Hydroxybenzaldehyde

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

In 2022,Tian, Jun; Yu, Shanshan; Guo, Hongyu; Zhu, Maoshuai; Lu, Kai; Jiang, Yixuan; Yang, Jiaqiao; Yu, Xiaoqi; Pu, Lin published an article in European Journal of Organic Chemistry. The title of the article was 《Enantioselective Fluorescent Recognition of β-Amino Alcohols by Stereoselective Cyclization》.Safety of (1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol The author mentioned the following in the article:

2,2′-Diformyl-1,1′-binaphthyl is found to exhibit highly enantioselective fluorescence enhancement in the presence of various β-amino alcs. and base. It provides a new method to determine the enantiomeric composition of those substrates and has potential for high throughput anal. Based on detailed spectroscopic analyses, it is proposed that a stereoselective cyclization of a β-amino alc. with the probe should occur to form a rigid macrocyclic intermediate, contributing to the greatly enhanced fluorescence. In the experimental materials used by the author, we found (1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol(cas: 126456-43-7Safety of (1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol)

(1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol(cas: 126456-43-7) belongs to anime. Reaction with nitrous acid (HNO2), which functions as an acylating agent that is a source of the nitrosyl group (―NO), converts aliphatic primary amines to nitrogen and mixtures of alkenes and alcohols corresponding to the alkyl group in a complex process. This reaction has been used for analytical determination of primary amino groups in a procedure known as the Van Slyke method.Safety of (1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

In 2022,Gu, Binbin; Hou, Anwei; Dickschat, Jeroen S. published an article in Beilstein Journal of Organic Chemistry. The title of the article was 《The stereochemical course of 2-methylisoborneol biosynthesis》.Name: Potassium sodium (2R,3R)-2,3-dihydroxysuccinate tetrahydrate The author mentioned the following in the article:

Both enantiomers of 2-methyllinalyl diphosphate (2-Me-LPP) were synthesized enantioselectively using Sharpless epoxidation as a key step and purification of enantiomerically enriched intermediates through HPLC separation on a chiral stationary phase. Their enzymic conversion with 2-methylisoborneol synthase (2MIBS) demonstrated that (R)-2-Me-LPP is the on-pathway intermediate, while a minor formation of 2-methylisoborneol from (S)-2-Me-LPP might be explained by isomerization to 2-Me-GPP and then to (R)-2-Me-LPP. In the experiment, the researchers used Potassium sodium (2R,3R)-2,3-dihydroxysuccinate tetrahydrate(cas: 6381-59-5Name: Potassium sodium (2R,3R)-2,3-dihydroxysuccinate tetrahydrate)

Potassium sodium (2R,3R)-2,3-dihydroxysuccinate tetrahydrate(cas: 6381-59-5) is a ferroelectric crystal with a high piezoelectric effect and electromechanical coupling coefficient. Name: Potassium sodium (2R,3R)-2,3-dihydroxysuccinate tetrahydrate It is utilized to break up emulsion in organic synthesis as well as a common precipitant in protein crystallography.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Category: alcohols-buliding-blocksIn 2013 ,《Characterization of salt interferences in second-harmonic generation detection of protein crystals》 appeared in Journal of Applied Crystallography. The author of the article were Closser, R. G.; Gualtieri, E. J.; Newman, J. A.; Simpson, G. J.. The article conveys some information:

Studies were undertaken to assess the merits and limitations of second-harmonic generation (SHG) for the selective detection of protein and polypeptide crystal formation, focusing on the potential for false positives from SHG-active salts present in crystallization media. The SHG activities of salts commonly used in protein crystallization were measured and quant. compared with reference samples. Out of 19 salts investigated, six produced significant background SHG and 15 of the 96 wells of a sparse-matrix screen produced SHG upon solvent evaporation SHG-active salts include phosphates, hydrated sulfates, formates and tartrates, while chlorides, acetates and anhydrous sulfates resulted in no detectable SHG activity. The identified SHG-active salts produced a range of signal intensities spanning nearly three orders of magnitude. However, even the weakest SHG-active salt produced signals that were several orders of magnitude greater than those produced by typical protein crystals. In general, SHG-active salts were identifiable through characteristically strong SHG and negligible two-photon-excited UV fluorescence (TPE-UVF). Exceptions included trials containing either potassium dihydrogen phosphate or ammonium formate, which produced particularly strong SHG, but with residual weak TPE-UVF signals that could potentially complicate discrimination in crystallization experiments using these precipitants. In the experiment, the researchers used many compounds, for example, Potassium sodium (2R,3R)-2,3-dihydroxysuccinate tetrahydrate(cas: 6381-59-5Category: alcohols-buliding-blocks)

Potassium sodium (2R,3R)-2,3-dihydroxysuccinate tetrahydrate(cas: 6381-59-5) is a ferroelectric crystal with a high piezoelectric effect and electromechanical coupling coefficient. Category: alcohols-buliding-blocks It is utilized to break up emulsion in organic synthesis as well as a common precipitant in protein crystallography.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts