Month: October 2022

The author of 《Light-responsive serinol-based polyurethane nanocarrier for controlled drug release》 were Sun, Jingjiang; Rust, Tarik; Kuckling, Dirk. And the article was published in Macromolecular Rapid Communications in 2019. Recommanded Product: 534-03-2 The author mentioned the following in the article:

In the present work, a new and facile strategy for the synthesis of light-responsive polyurethanes (LrPUs) based on serinol with o-nitrobenzyl pendent groups is developed. Stable monodisperse nanoparticles from these LrPUs can be formulated reproducibly in a simple manner, which is shown by dynamic light scattering (DLS) measurements. Upon irradiation with UV light, both polymers and nanoparticles undergo rapid degradation, which is investigated by DLS, SEM, size exclusion chromatog., and UV-vis spectroscopy. The nanoparticles are also employed for the encapsulation of the model drug Nile Red, and by exposure to UV light, a burst release of the payload is detected via fluorescence spectroscopy. This strategy can be easily applied to the straightforward synthesis of various new serinol-based monomers with different stimuli-responsive properties and therefore expand the family of biodegradable polymers. The experimental part of the paper was very detailed, including the reaction process of 2-Aminopropane-1,3-diol(cas: 534-03-2Recommanded Product: 534-03-2)

2-Aminopropane-1,3-diol(cas: 534-03-2) belongs to anime. Nitrous acid converts secondary amines (aliphatic or aromatic) to N-nitroso compounds (nitrosamines): R2NH + HNO2 → R2N―NO. Some nitrosamines are potent cancer-inducing substances, and their possible formation is a serious consideration when nitrites, which are salts of nitrous acid, are present in foods or pharmaceutical preparations. Tertiary amines give rise to nitrosamines more slowly; an alkyl group is eliminated as an aldehyde or ketone, along with nitrous oxide, N2O.Recommanded Product: 534-03-2

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

The author of 《Metabolomics as read-across tool: An example with 3-aminopropanol and 2-aminoethanol》 were Sperber, S.; Wahl, M.; Berger, F.; Kamp, H.; Lemke, O.; Starck, V.; Walk, T.; Spitzer, M.; Van Ravenzwaay, B.. And the article was published in Regulatory Toxicology and Pharmacology in 2019. Synthetic Route of C3H9NO The author mentioned the following in the article:

Read-across and grouping is one of the most commonly used alternative approaches for data gap filling in registrations submitted under the REACH Regulation as defined by the European Chems. Agency (ECHA) in their Read-Across Assessment Framework (RAAF, 2017). At the same time, the application of read-across is rejected by ECHA frequently due to various reasons. As a major reason hereof, applicants fail to reduce the level of remaining uncertainty intrinsical to every read-across approach compared to testing a substance exptl. Recently, the use of metabolomics to support read-across cases with biol. information has been reported in a case study with phenoxy herbicides (Ravenzwaay et al., 2016). In the present case-study a weight-of-evidence read-across approach from 2-aminoethanol (MEA = source) to 3-aminopropanol (3AP = target) with metabolomics as supporting evidence reducing the remaining uncertainties is reported. We demonstrate the high structural similarity of the two analogous substances based on the available data and we report how metabolome data add confidence concerning mechanistic similarity in this read-across approach. Finally, the herein described read-across case supported by metabolomics is used to cover the data gaps in repeated dose and reproductive toxicity endpoint of 3AP via weight of evidence for the REACH-registration. In the experiment, the researchers used 3-Aminopropan-1-ol(cas: 156-87-6Synthetic Route of C3H9NO)

3-Aminopropan-1-ol(cas: 156-87-6) belongs to anime. Many important products require amines as part of their syntheses. Methylamine is utilized in the production of the analgesic meperidine (trade name Demerol) and the photographic developer Metol (trademark), and dimethylamine is used in the synthesis of the antihistamine diphenhydramine (trade name Benadryl), the solvent dimethylformamide (DMF), and the rocket propellant 1,1-dimethylhydrazine. The synthesis of the insect repellent N,N-diethyl-m-toluamide (DEET) incorporates diethylamine while that of the synthetic fibre Kevlar requires aromatic amines.Synthetic Route of C3H9NO

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

The author of 《Chemoselective Palladium-Catalyzed Suzuki-Miyaura Cross-Coupling of (Diborylmethyl)silanes with Alkenyl Bromides》 were Kim, Junghoon; Lee, Eunsung; Cho, Seung Hwan. And the article was published in Asian Journal of Organic Chemistry in 2019. Name: Bis[(pinacolato)boryl]methane The author mentioned the following in the article:

Herein, the authors report the development of a Pd-catalyzed chemoselective cross-coupling of (diborylmethyl)silanes with alkenyl bromides. The reaction shows broad scope with respect to alkenyl bromides and (diborylmethyl)silanes, affording a range of α-silyl-substituted allylic boronate esters in good-to-excellent yields. The practicality of the developed coupling reaction is demonstrated by the gram-scale synthesis of α-silyl-substituted allylic boronate ester. The experimental part of the paper was very detailed, including the reaction process of Bis[(pinacolato)boryl]methane(cas: 78782-17-9Name: Bis[(pinacolato)boryl]methane)

Bis[(pinacolato)boryl]methane(cas: 78782-17-9) belongs to organoboron compounds. Organoboron compounds have been a cornerstone of synthetic transformations for decades. Areas such as boron-containing catalysts, metalate chemistry, photoredox methods, and boryl anions have brought significant new developments in understanding and provided new reactivity upon.Name: Bis[(pinacolato)boryl]methane

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

The author of 《pH-Responsive Nanoparticles Targeted to Lungs for Improved Therapy of Acute Lung Inflammation/Injury》 were Zhang, Can Yang; Lin, Wenjing; Gao, Jin; Shi, Xutong; Davaritouchaee, Maryam; Nielsen, Amy E.; Mancini, Rock J.; Wang, Zhenjia. And the article was published in ACS Applied Materials & Interfaces in 2019. Electric Literature of C3H9NO The author mentioned the following in the article:

Dysregulated vascular inflammation is the underlying cause of acute lung inflammation/injury (ALI). Bacterial infections and trauma cause ALI that may rapidly lead to acute respiratory distress syndrome (ARDS). There are no pharmacol. therapies available to patients with ALI/ARDS, partially as drugs cannot specifically target the lungs. Herein, we developed a stimuli-responsive nanoparticle (NP) to target inflammatory lungs for ALI therapies. The NP is composed of a sharp acid-sensitive segment poly(β-amino esters) as a core for drug loading and controlled release and a polyethylene glycol-biotin on the particle surface available for bioconjugation, enabling lung targeting and extended circulation. The studies on dissipative particle dynamics simulation and characteristics of NPs suggest that anti-ICAM-1 antibodies can be coated to the particle surface and this coating is required to enhance lung targeting of NPs. A model drug of anti-inflammatory agent TPCA-1 is encapsulated in NPs with a high drug-loading content at 24% (weight/weight). In the mouse ALI model, our TPCA-1-loaded NPs coated with anti-ICAM-1 can target inflamed lungs after i.v. injection, followed by drug release triggered by the acid environment, thus mitigating lung inflammation and injury. Our studies reveal the rational design of nanotherapeutics for improved therapy of ALI, which may be applied to treating a wide range of vascular inflammation. The experimental process involved the reaction of 3-Aminopropan-1-ol(cas: 156-87-6Electric Literature of C3H9NO)

3-Aminopropan-1-ol(cas: 156-87-6) belongs to anime. Amine, any member of a family of nitrogen-containing organic compounds that is derived, either in principle or in practice, from ammonia (NH3). Naturally occurring amines include the alkaloids, which are present in certain plants; the catecholamine neurotransmitters (i.e., dopamine, epinephrine, and norepinephrine); and a local chemical mediator, histamine, that occurs in most animal tissues.Electric Literature of C3H9NO

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

《Chemoselective Union of Olefins, Organohalides, and Redox-Active Esters Enables Regioselective Alkene Dialkylation》 was published in Journal of the American Chemical Society in 2020. These research results belong to Yang, Tao; Jiang, Yi; Luo, Yixin; Lim, Joel Jun Han; Lan, Yu; Koh, Ming Joo. Quality Control of 3-Bromopropan-1-ol The article mentions the following:

Multicomponent catalytic processes that can generate multiple C(sp3)-C(sp3) bonds in a single step under mild conditions, particularly those that employ inexpensive catalysts and substrates, are highly sought-after in chem. research for complex mol. synthesis. Here, we disclose an efficient Ni-catalyzed reductive protocol that chemoselectively merges alkenyl amides with two different aliphatic electrophiles. Starting materials are readily accessible from stable and abundant feedstock, and products are furnished in up to >98:2 regioisomeric ratios. The present strategy eliminates the use of sensitive organometallic reagents, tolerates a wide array of complex functionalities, and enables regiodivergent addition of two primary alkyl groups bearing similar electronic and steric attributes across aliphatic C=C bonds with exquisite control of site selectivity. Utility is underscored by the concise synthesis of bioactive compounds and postreaction functionalizations leading to structurally diverse scaffolds. DFT studies revealed that the regiochem. outcome originates from the orthogonal reactivity and chemoselectivity profiles of in situ generated organonickel species. In the experimental materials used by the author, we found 3-Bromopropan-1-ol(cas: 627-18-9Quality Control of 3-Bromopropan-1-ol)

3-Bromopropan-1-ol(cas: 627-18-9) was used in the synthesis of fluorescent halide-sensitive quinolinium dyes and molten salt-polymers. Furthermore, it was used in the synthesis of chiral, quaternary prolines via cyclization of quaternary amino acids.Quality Control of 3-Bromopropan-1-ol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

《Design and synthesis of azaindole heterocycle decorated new scaffold in fluorometric sensing of F- and H2PO4-》 was published in Journal of Heterocyclic Chemistry in 2020. These research results belong to Ghosh, Kumaresh; Ali, Sk. Sarfaraj; Joardar, Soumen. Recommanded Product: 7748-36-9 The article mentions the following:

7-Azaindole has been used in designing new mol. structure 1 on enediyne spacer for its application in anion sensing. New structure 1 has been established as efficient fluorescent sensor of H2PO4- and F- ions in CH3CN containing 1% DMSO. While in presence of H2PO4- the emission at 418 nm is decreased to the significant extent in nonratiometric fashion, a ratiometric response in presence of F- is noted with a sharp isoemissive point and two anions are effectively distinguished over a series of other anions tested. A similar study on model compound 2 with indole motifs is done to prove the pivotal role of extra ring nitrogen in azaindole of 1 in the binding process. In the experiment, the researchers used many compounds, for example, Oxetan-3-ol(cas: 7748-36-9Recommanded Product: 7748-36-9)

Oxetan-3-ol(cas: 7748-36-9) is used as a reagent in the synthesis of 5-fluoro-4,6-dialkoxypyrimidine GPR119 agonists. It is also used as a reagent in the synthesis of cyclic sulfone hydroxyethylamines as potent and selective β-site APP-cleaving enzyme 1 (BACE1) inhibitors.Recommanded Product: 7748-36-9

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

《Efficient aerial oxidation of different types of alcohols using ZnO nanoparticle-MnCO3-graphene oxide composites》 was published in Applied Organometallic Chemistry in 2020. These research results belong to Adil, Syed Farooq; Assal, Mohamed E.; Shaik, Mohammed Rafi; Kuniyil, Mufsir; Hashmi, Azhar; Khan, Mujeeb; Khan, Aslam; Tahir, Muhammad Nawaz; Al-Warthan, Abdulrahman; Siddiqui, Mohammed Rafiq H.. Synthetic Route of C7H7BrO The article mentions the following:

In this study, nanocomposites of graphene oxide (GRO) and ZnO nanoparticle-doped MnCO3 ([ZnO-MnCO3/(1%)GRO]) were synthesized via a facile, straightforward co-precipitation technique. Interestingly, it was noticed that the incorporation of GRO in the catalytic system could noticeably improve the catalytic efficiency compared to a catalyst (ZnO-MnCO3) without GRO, for aerial oxidation of benzyl alc. (BzOH) employing O2 as a nature-friendly oxidant under base-free conditions. The impacts of various reaction factors were thoroughly explored to optimize reaction conditions using oxidation of BzOH to benzaldehyde (BzH) as a model substrate. The catalysts were characterized using X-ray diffraction, thermogravimetric anal., Fourier transform IR spectroscopy, field-emission SEM, Energy dispersive X-ray spectroscopy (EDX), Brunauer-Emmett-Teller (BET), and Raman spectroscopy. The (1%)ZnO-MnCO3/(1%)GRO exhibited significant specific activity (67 mmol.g-1.hr-1) with full conversion of BzOH and >99% BzH selectivity within just 6 min. The catalytic efficiency of the (1%)ZnO-MnCO3/(1%)GRO nanocomposite was significantly better than the (1%)ZnO-MnCO3/(1%)HRG and (1%)ZnO-MnCO3 catalysts, presumably due to the existence of oxygen-possessing groups on the GRO surface and as well as a very high surface area that could have been instrumental in uniformly dispersing the active sites of the catalyst, i.e., ZnO-MnCO3. Under optimum circumstances, various kinds of alcs. ROH (R = benzyl, furan-2-ylmethyl, cyclohexyl, 1-phenylethyl, etc.) were selectively transformed to resp. carbonyls, e.g., cyclohexanone with full convertibility over the (1%)ZnO-MnCO3/(1%)GRO catalyst. Furthermore, the highly effective (1%)ZnO-MnCO3/(1%)GRO catalyst could be successfully reused and recycled over five consecutive runs with a marginal reduction in its performance and selectivity.(4-Bromophenyl)methanol(cas: 873-75-6Synthetic Route of C7H7BrO) was used in this study.

(4-Bromophenyl)methanol(cas: 873-75-6) undergoes three-component reaction with acetylferrocene and arylboronic acid to give ferrocenyl ketones containing biaryls.Synthetic Route of C7H7BrO It is used in the synthesis of amphiphilic, symmetric rod-coil, triblock copolymer of poly(9,9-didodecylfluorene-2,7-diyl) and poly(hydroxyl ethyl methacrylate)

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

《Copper and nickel immobilized on cytosine@MCM-41: as highly efficient, reusable and organic-inorganic hybrid nanocatalysts for the homoselective synthesis of tetrazoles and pyranopyrazoles》 was published in Applied Organometallic Chemistry in 2020. These research results belong to Nikoorazm, Mohsen; Tahmasbi, Bahman; Gholami, Shahab; Moradi, Parisa. Safety of 3-Hydroxybenzaldehyde The article mentions the following:

In this work, a green approach was reported for efficient synthesis of biol. active tetrazole and pyranopyrazole derivatives in the presence of Cu-Cytosine@MCM-41 and Ni-Cytosine@MCM-41 (copper (II) and nickel (II) catalyst on the modified MCM-41 using cytosine). The synthesis of tetrazoles and pyranopyrazoles in the presence of these catalysts was performed in green solvents such as water or poly (ethylene glycol) (PEG). All products were obtained in high TOF (turnover frequency) numbers in the presence of these catalysts, which indicate the high efficiency of these catalysts in the synthesis of tetrazole and pyranopyrazole derivatives The prepared catalysts were characterized by various techniques such as BET, TGA, XRD, FT-IR, SEM, EDS, WDX, TEM, and AAS. Mesoporous structure of these catalysts was confirmed by nitrogen adsorption-desorption isotherms. These catalysts can be recovered and reused for several runs without significant change in their catalytic activity or metal capacity. The recovered catalysts have been characterized by XRD, SEM, EDS, WDX, FT-IR and AAS techniques, by which their heterogeneous nature has been confirmed. In addition to this study using 3-Hydroxybenzaldehyde, there are many other studies that have used 3-Hydroxybenzaldehyde(cas: 100-83-4Safety of 3-Hydroxybenzaldehyde) was used in this study.

3-Hydroxybenzaldehyde(cas: 100-83-4) can be used as a reactant along with ethyl acetoacetate and thiourea in the synthesis of corresponding dihydropyrimidine-2-thione (monastrol), using Yb(OTf)3 as a catalyst by Biginelli cyclocondensation reaction.Safety of 3-Hydroxybenzaldehyde

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

《A novel catalyst-free mechanochemical protocol for the synthesis of 2,3-dihydro-1H-perimidines》 was published in Journal of Heterocyclic Chemistry in 2020. These research results belong to Harry, Nissy Ann; Radhika, Sankaran; Neetha, Mohan; Anilkumar, Gopinathan. Computed Properties of C7H6O2 The article mentions the following:

A catalyst-free, and green grinding assisted method for the synthesis of 2,3-dihydro-1H-perimidines I [R = Et, Ph, 2-pyridyl, etc.] was developed. 1,8-Diaminonaphthalene and aldehydes were grounded using mortar and pestle for 5 min affording the product in moderate to excellent yields. The methodol. minimized the use of conventional workup and column chromatog. techniques. In the part of experimental materials, we found many familiar compounds, such as 3-Hydroxybenzaldehyde(cas: 100-83-4Computed Properties of C7H6O2)

3-Hydroxybenzaldehyde(cas: 100-83-4) can be used as a reactant along with ethyl acetoacetate and thiourea in the synthesis of corresponding dihydropyrimidine-2-thione (monastrol), using Yb(OTf)3 as a catalyst by Biginelli cyclocondensation reaction.Computed Properties of C7H6O2

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

《Synthetic bioactive olivetol-related amides: The influence of the phenolic group in cannabinoid receptor activity》 was published in Bioorganic & Medicinal Chemistry in 2020. These research results belong to Brizzi, Antonella; Aiello, Francesca; Boccella, Serena; Cascio, Maria Grazia; De Petrocellis, Luciano; Frosini, Maria; Gado, Francesca; Ligresti, Alessia; Luongo, Livio; Marini, Pietro; Mugnaini, Claudia; Pessina, Federica; Corelli, Federico; Maione, Sabatino; Manera, Clementina; Pertwee, Roger G.; Di Marzo, Vincenzo. Category: alcohols-buliding-blocks The article mentions the following:

Focusing on the importance of the free phenolic hydroxyl moiety, a family of 23 alkylresorcinol-based compounds were developed and evaluated for their cannabinoid receptor binding properties. The non-sym. hexylresorcinol derivative 29 turned out to be a CB2-selective competitive antagonist/inverse agonist endowed with good potency. Both the olivetol- and 5-(2-methyloctan-2-yl)resorcinol-based derivatives 23 and 24 exhibited a significant antinociceptive activity. Interestingly, compound 24 proved to be able to activate both cannabinoid and TRPV1 receptors. Even if cannabinoid receptor subtype selectivity remained a goal only partially achieved, results confirm the validity of the alkylresorcinol nucleus as skeleton for the identification of potent cannabinoid receptor modulators. In the experiment, the researchers used 2-Aminopropane-1,3-diol(cas: 534-03-2Category: alcohols-buliding-blocks)

2-Aminopropane-1,3-diol(cas: 534-03-2) belongs to anime. Amines have a free lone pair with which they can coordinate to metal centers. Amine–metal bonds are weaker because amines are incapable of backbonding, but they are still important for sensing applications.While stronger than hydrogen bonds, amine–metal bonds are still weaker than both covalent and ionic bonds.Category: alcohols-buliding-blocks

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts