Month: October 2022

In 2017,Su, Bo; Zhou, Tai-Gang; Li, Xian-Wei; Shao, Xiao-Ru; Xu, Pei-Lin; Wu, Wen-Lian; Hartwig, John F.; Shi, Zhang-Jie published 《A Chiral Nitrogen Ligand for Enantioselective, Iridium-Catalyzed Silylation of Aromatic C-H Bonds》.Angewandte Chemie, International Edition published the findings.Synthetic Route of C9H11NO The information in the text is summarized as follows:

Iridium catalysts containing dative nitrogen ligands are highly active for the borylation and silylation of C-H bonds, but chiral analogs of these catalysts for enantioselective silylation reactions have not been developed. We report a new chiral pyridinyloxazoline ligand for enantioselective, intramol. silylation of sym. diarylmethoxy diethylsilanes. Regioselective and enantioselective silylation of unsym. substrates was also achieved in the presence of this newly developed system. Preliminary mechanistic studies imply that C-H bond cleavage is irreversible, but not the rate-determining step. In the experiment, the researchers used many compounds, for example, (1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol(cas: 126456-43-7Synthetic Route of C9H11NO)

(1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol(cas: 126456-43-7) belongs to anime. Many important products require amines as part of their syntheses. Methylamine is utilized in the production of the analgesic meperidine (trade name Demerol) and the photographic developer Metol (trademark), and dimethylamine is used in the synthesis of the antihistamine diphenhydramine (trade name Benadryl), the solvent dimethylformamide (DMF), and the rocket propellant 1,1-dimethylhydrazine. The synthesis of the insect repellent N,N-diethyl-m-toluamide (DEET) incorporates diethylamine while that of the synthetic fibre Kevlar requires aromatic amines.Synthetic Route of C9H11NO

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

In 2017,Povedailo, V. A.; Stupak, A. P.; Tsybulsky, D. A.; Shmanai, V. V.; Yakovlev, D. L. published 《Fluorescence Quenching of Carboxyfluoresceins Conjugated Convalently to Oligonucleotides》.Journal of Applied Spectroscopy published the findings.Reference of trans-4-Aminocyclohexanol The information in the text is summarized as follows:

Dynamic and static quenching of 6-(2′,7′-dimethoxy-4′,5′-dichloro)carboxyfluorescein (JOE) by nucleosides (deoxyadenosine, deoxycytidine, deoxyguanosine, thymidine, and deoxyuridine) in Tris-acetate buffer solution was analyzed using the Stern-Volmer equation. Only one of the five nucleosides, deoxyguanosine, exhibited predominantly static quenching. The fluorescence quantum yields in buffer solution of 5- and 6-carboxyfluorescein (FAM) and 5-and 6-JOE bound covalently to the oligonucleotide by a rigid linker (4-trans-aminocyclohexanol) were greater than those of their analogs with a flexible linker (6-aminohexanol). It was shown that fluorescence quenching in systems with a flexible linker occurred mainly through van-der-Waals contact of the fluorophore with guanine. An increase in the number of consecutively located guanines in the oligonucleotides and their duplexes bound to the dye by a linker decreased the fluorescence quantum yield. Quantum-chem. calculations using the Gaussian 09 program provided an interpretation for the low-frequency shifts of 5-FAM and 5-JOE absorption and fluorescence spectra relative to those of the 6-isomers. In the experiment, the researchers used trans-4-Aminocyclohexanol(cas: 27489-62-9Reference of trans-4-Aminocyclohexanol)

trans-4-Aminocyclohexanol(cas: 27489-62-9) belongs to anime. Examples of direct uses of amines and their salts are as corrosion inhibitors in boilers and in lubricating oils (morpholine), as antioxidants for rubber and roofing asphalt (diarylamines), as stabilizers for cellulose nitrate explosives (diphenylamine), as protectants against damage from gamma radiation (diarylamines), as developers in photography (aromatic diamines), as flotation agents in mining, as anticling and waterproofing agents for textiles, as fabric softeners, in paper coating, and for solubilizing herbicides.Reference of trans-4-Aminocyclohexanol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

In 2018,Kurimoto, Yuji; Mitsudo, Koichi; Mandai, Hiroki; Wakamiya, Atsushi; Murata, Yasujiro; Mori, Hiroki; Nishihara, Yasushi; Suga, Seiji published 《Efficient Synthesis and Properties of [1]Benzothieno[3,2-b]thieno[2,3-d]furans and [1]Benzothieno[3,2-b]thieno[2,3-d]thiophenes》.Asian Journal of Organic Chemistry published the findings.SDS of cas: 6381-59-5 The information in the text is summarized as follows:

Efficient synthesis of benzodithienofurans (BDTF) e.g. I and benzodithienothiophenes (BDTT) e.g. II were achieved by the combination of an addition-elimination reaction, reduction and Pd-catalyzed dehydrogenative cyclization. The synthesis of Π-extended BDTF and BDTT derivatives through the use of coupling reactions was also achieved. The detailed phys. properties like DFT, cyclic voltametry, UV visible absorption and fluorescence of these compounds were investigated. The newly synthesized BDTFs exhibited strong fluorescence compared with BDTTs. 2,2′-bis([1]benzothieno[3,2-b]thieno[2,3-d]furan) (BBTTF) exhibited p-type organic field-effect transistor (OFET) properties. The experimental process involved the reaction of Potassium sodium (2R,3R)-2,3-dihydroxysuccinate tetrahydrate(cas: 6381-59-5SDS of cas: 6381-59-5)

Potassium sodium (2R,3R)-2,3-dihydroxysuccinate tetrahydrate(cas: 6381-59-5) is a ferroelectric crystal with a high piezoelectric effect and electromechanical coupling coefficient. SDS of cas: 6381-59-5 It may be used as a constituent to prepare DNS (3,5- dinitrosalicylic acid) reagent and Fehling′s solution B, which are used in the determination of reducing sugar.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

In 2018,Journal of Medicinal Chemistry included an article by Sellmer, Andreas; Stangl, Hubert; Beyer, Mandy; Gruenstein, Elisabeth; Leonhardt, Michel; Pongratz, Herwig; Eichhorn, Emerich; Elz, Sigurd; Striegl, Birgit; Jenei-Lanzl, Zsuzsa; Dove, Stefan; Straub, Rainer H.; Kraemer, Oliver H.; Mahboobi, Siavosh. Recommanded Product: 126456-43-7. The article was titled 《Marbostat-100 Defines a New Class of Potent and Selective Antiinflammatory and Antirheumatic Histone Deacetylase 6 Inhibitors》. The information in the text is summarized as follows:

Epigenetic modifiers of the histone deacetylase (HDAC) family contribute to autoimmunity, cancer, HIV infection, inflammation, and neurodegeneration. Hence, histone deacetylase inhibitors (HDACi), which alter protein acetylation, gene expression patterns, and cell fate decisions, represent promising new drugs for the therapy of these diseases. Whereas pan-HDACi inhibit all 11 Zn2+-dependent histone deacetylases (HDACs) and cause a broad spectrum of side effects, specific inhibitors of histone deacetylase 6 (HDAC6i) are supposed to have less side effects. The authors present the synthesis and biol. evaluation of Marbostats, novel HDAC6i that contain the hydroxamic acid moiety linked to tetrahydro-β-carboline derivatives The lead compound Marbostat-100 is a more potent and more selective HDAC6i than previously established well-characterized compounds in vitro as well as in cells. Moreover, Marbostat-100 is well tolerated by mice and effective against collagen type II induced arthritis. Thus, Marbostat-100 represents a most selective known HDAC6i and the possibility for clin. evaluation of a HDAC isoform-specific drug.(1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol(cas: 126456-43-7Recommanded Product: 126456-43-7) was used in this study.

(1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol(cas: 126456-43-7) belongs to anime. The methylamines occur in small amounts in some plants. Many polyfunctional amines (i.e., those having other functional groups in the molecule) occur as alkaloids in plants—for example, mescaline, 2-(3,4,5-trimethoxyphenyl)ethylamine; the cyclic amines nicotine, atropine, morphine, and cocaine; and the quaternary salt choline, N-(2-hydroxyethyl)trimethylammonium chloride, which is present in nerve synapses and in plant and animal cells.Recommanded Product: 126456-43-7

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

In 2019,Asian Journal of Organic Chemistry included an article by Xia, Qiangqiang; Shi, Zuodong; Yuan, Jiangpei; Bian, Qilong; Xu, Yuanqing; Liu, Baoying; Huang, Yongwei; Yang, Xiaobo; Xu, Hao. Formula: C7H7BrO. The article was titled 《Visible-light-enabled selective oxidation of primary alcohols through hydrogen-atom transfer and its application in the synthesis of quinazolinones》. The information in the text is summarized as follows:

A visible-light-enabled selective oxidation of alcs. to aldehydes RCHO [R = (CH2)4CH3, Ph, 2-thienyl, etc.] was developed under transition-metal-free conditions. Utilizing eosin Y as the direct hydrogen-atom transfer (HAT) photocatalyst and mol. oxygen as the terminal oxidant, both aromatic and aliphatic aldehydes could be obtained in moderate to good yields. Using this approach, various quinazolinones I [R1 = Me, Ph, 4-BrC6H4, etc.; R2 = H, Cl, Br, MeO, NO2; R3 = H, n-Pr, n-hexyl, etc.], including two real drug mols., were easily synthesized from the corresponding o-aminobenzamides and alcs. In the part of experimental materials, we found many familiar compounds, such as (4-Bromophenyl)methanol(cas: 873-75-6Formula: C7H7BrO)

(4-Bromophenyl)methanol(cas: 873-75-6) undergoes three-component reaction with acetylferrocene and arylboronic acid to give ferrocenyl ketones containing biaryls.Formula: C7H7BrO It undergoes efficient trimethylsilylation reaction with 1,1,1,3,3,3-hexamethyldisilazane in the presence of catalytic amount of aspartic acid in acetonitrile.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

In 2019,Journal of Physics: Conference Series included an article by Cantillo, R.; Percino, J.; Murillo, E. A.. Quality Control of (4-Bromophenyl)methanol. The article was titled 《Synthesis and characterization of a derivative of carbazole obtained from bromobenzyl alcohol》. The information in the text is summarized as follows:

4-(9H-Carbazol-9-yl)benzenemethanol has been prepared by the reaction of carbazole and 4-bromobenzyl alc. The compound has been characterized by X-ray diffraction, IR and UV-visible spectroscopies, and 1H NMR. Its thermal stability has been evaluated. 4-(9H-Carbazol-9-yl)benzenemethanol exhibits yellow fluorescence. In the part of experimental materials, we found many familiar compounds, such as (4-Bromophenyl)methanol(cas: 873-75-6Quality Control of (4-Bromophenyl)methanol)

(4-Bromophenyl)methanol(cas: 873-75-6) undergoes three-component reaction with acetylferrocene and arylboronic acid to give ferrocenyl ketones containing biaryls.Quality Control of (4-Bromophenyl)methanol It is used in the synthesis of amphiphilic, symmetric rod-coil, triblock copolymer of poly(9,9-didodecylfluorene-2,7-diyl) and poly(hydroxyl ethyl methacrylate)

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

In 2019,Asian Journal of Chemistry included an article by Tripathi, Vishwa Deepak; Shukla, Akhilesh Kumar; Mohammed, Hasan Shamran. Application of 100-83-4. The article was titled 《Regioselective three component domino synthesis of polyhydrospiro[indoline-3,3′-pyrrolizine]-2-one via [3+2] cycloaddition reaction》. The information in the text is summarized as follows:

The synthesis and characterization of novel hexahydrospiro[indoline-3,3′-pyrrolizine]-2-one derivatives in good to excellent yields via [3+2] cycloaddtion reaction in regioselective manner was reported. These compounds were synthesized via multicomponent reaction of substituted 3-cinnamoyl-4-hydroxy-6-methyl-2H-pyran-2-one, isatin, L-proline at room temperature All the synthesized hexahydrospiro mols. were characterized by 1H and 13C NMR, IR spectra, mass spectra and elemental anal. Regioselectivity in synthesized mols. were also explained on the basis of secondary orbital interactions. A simple and facile methodol. was developed which has great importance in synthetic chem. In addition to this study using 3-Hydroxybenzaldehyde, there are many other studies that have used 3-Hydroxybenzaldehyde(cas: 100-83-4Application of 100-83-4) was used in this study.

3-Hydroxybenzaldehyde(cas: 100-83-4) can be used as a reactant along with ethyl acetoacetate and thiourea in the synthesis of corresponding dihydropyrimidine-2-thione (monastrol), using Yb(OTf)3 as a catalyst by Biginelli cyclocondensation reaction.Application of 100-83-4

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

In 2019,Chemistry – A European Journal included an article by Timmer, Brian J. J.; Ramstroem, Olof. Name: 5-Hexen-1-ol. The article was titled 《Acid-Assisted Direct Olefin Metathesis of Unprotected Carbohydrates in Water》. The information in the text is summarized as follows:

The ability to use unprotected carbohydrates in olefin metathesis reactions in aqueous media is demonstrated. By using water-soluble, amine-functionalized Hoveyda-Grubbs catalysts under mildly acidic aqueous conditions, the self-metathesis of unprotected alkene-functionalized α-D-manno- and α-D-galactopyranosides could be achieved through minimization of non-productive chelation and isomerization. Cross-metathesis with allyl alc. could also be achieved with reasonable selectivity. The presence of small quantities (2.5 vol %) of acetic acid increased the formation of the self-metathesis product while significantly reducing the alkene isomerization process. These results demonstrate the potential of directly using unprotected carbohydrate structures in olefin metathesis reactions under mild conditions compatible with biol. systems, and thereby enabling their use in, for example, drug discovery and protein derivatization. In the experimental materials used by the author, we found 5-Hexen-1-ol(cas: 821-41-0Name: 5-Hexen-1-ol)

5-Hexen-1-ol(cas: 821-41-0) is a volatile organic compound. Further, it is used to prepare 6-bromo-hex-1-ene by reaction with phosphorus tribromide.Name: 5-Hexen-1-ol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

The author of 《A Self-Assembled Heterometallic {Co7-Ho1} Nanocluster: 3d-4f Trimeric Keggin-Type Silicotungstate [HoCo7Si3W29O108(OH)5 (H2O)4]18- and its Catalytic and Magnetic Applications》 were Das, Vivek; Khan, Imran; Hussain, Firasat; Sadakane, Masahiro; Hageo, Kazuki; Ichihashi, Katsuya; Inoue, Katsuya; Nishihara, Sadafumi. And the article was published in European Journal of Inorganic Chemistry in 2019. Recommanded Product: (4-Bromophenyl)methanol The author mentioned the following in the article:

A new self assembled Co2+ and Ho3+-substituted polyoxometalate have been synthesized using a trilacunary Keggin-type silicotungstate. The polyanion complex of the formula [HoCo7Si3W29O108(OH)5(H2O)4]18- (1) has a trimeric crystal structure which displayed an excellent catalytic and magnetic property. Here, the authors have carried out selective oxidation of various alc. substrates such as derivatives of benzyl alc., cyclohexanol etc. to its corresponding aldehydes/ketones. The paramagnetic nature of the compound was seen from the magnetic study. However, antiferromagnetic interaction was observed between Co2+-Co2+ or Co2+-Ho3+ at a very low temperature The compound was characterized by FTIR, UV/Visible spectroscopy, Single crystal x-ray diffraction, X-ray powder diffraction, high-resolution electrospray ionization mass spectroscopy (HR-ESI-MS) and TGA. The experimental part of the paper was very detailed, including the reaction process of (4-Bromophenyl)methanol(cas: 873-75-6Recommanded Product: (4-Bromophenyl)methanol)

(4-Bromophenyl)methanol(cas: 873-75-6) undergoes three-component reaction with acetylferrocene and arylboronic acid to give ferrocenyl ketones containing biaryls.Recommanded Product: (4-Bromophenyl)methanol It is used in the synthesis of amphiphilic, symmetric rod-coil, triblock copolymer of poly(9,9-didodecylfluorene-2,7-diyl) and poly(hydroxyl ethyl methacrylate)

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

The author of 《The Imine-Based COF TpPa-1 as an Efficient Cooling Adsorbent That Can Be Regenerated by Heat or Light》 were Perez-Carvajal, Javier; Boix, Gerard; Imaz, Inhar; Maspoch, Daniel. And the article was published in Advanced Energy Materials in 2019. Electric Literature of C9H6O6 The author mentioned the following in the article:

Adsorption-based cooling systems, which can be driven by waste heat and solar energy, are promising alternatives to conventional, compression-based cooling systems, as they demand less energy and emit less CO2. The performance of adsorption-based cooling systems relates directly to the performance of the working pairs (sorbent-water). Accordingly, improvement of these systems relies on the continual discovery of new sorbents that enable greater mass exchange while requiring less energy for regeneration. Here, it is proposed that covalent-organic frameworks (COFs) can replace traditional sorbents for adsorption-based cooling. In tests mimicking standard operating conditions for industry, the imine-based COF TpPa-1 exhibits a regeneration temperature below 65°C and a cooling coefficient of performance of 0.77 – values which are comparable to those reported for the best metal-organic framework sorbents described to date. Moreover, TpPa-1 exhibits a photothermal effect and can be regenerated by visible light, thereby opening the possibility for its use in solar-driven cooling. In addition to this study using 2,4,6-Trihydroxybenzene-1,3,5-tricarbaldehyde, there are many other studies that have used 2,4,6-Trihydroxybenzene-1,3,5-tricarbaldehyde(cas: 34374-88-4Electric Literature of C9H6O6) was used in this study.

2,4,6-Trihydroxybenzene-1,3,5-tricarbaldehyde(cas: 34374-88-4) is a member of phloroglucinol derivatives. Regarding monomeric phloroglucinols, this group encompasses acryl phloroglucinols, phloroglucinol-terpene adducts, phloroglucinol glycosides, halogenated phloroglucinols, prenylated phloroglucinols, and cyclicroup polyketides.Electric Literature of C9H6O6

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts