Month: October 2022

Rushworth, James L.; Montgomery, Katherine S.; Cao, Benjamin; Brown, Robert; Dibb, Nick J.; Nilsson, Susan K.; Chiefari, John; Fuchter, Matthew J. published the artcile< Glycosylated Nanoparticles Derived from RAFT Polymerization for Effective Drug Delivery to Macrophages>, Synthetic Route of 4064-06-6, the main research area is macrophage targeting drug carrier polymer; CD206; drug delivery; glycopolymers; macrophages; mannose; tumor-associated macrophages.

The functional group tolerance and simplicity of reversible addition fragmentation chain transfer (RAFT) polymerization enable its use in the preparation of a wide range of functional polymer architectures for a variety of applications, including drug delivery. Given the role of tumor-associated macrophages (TAMs) in cancer and their dependence on the tyrosine kinase receptor FMS (CSF-1R), the key aim of this work was to achieve effective delivery of an FMS inhibitor to cells using a polymer delivery system. Such a system has the potential to exploit biol. features specific to macrophages and therefore provide enhanced selectivity. Building on our prior work, we have prepared RAFT polymers based on a poly(Bu methacrylate-co-methacrylic acid) diblock, which were extended with a hydrophilic block, a cross-linker, and a mannose-based monomer scaffold, exploiting the abundance of macrophage mannose receptors (MMRs, CD206) on the surface of macrophages. We demonstrate that the prepared polymers can be assembled into nanoparticles and are successfully internalized into macrophages, in part, via the MMR (CD206). Finally, we showcase the developed nanoparticles in the delivery of an FMS inhibitor to cells, resulting in inhibition of the FMS receptor. As such, this study lays the groundwork for further drug-delivery studies aimed at specifically targeting TAMs with molecularly targeted therapeutics.

ACS Applied Bio Materials published new progress about Biological uptake. 4064-06-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C12H20O6, Synthetic Route of 4064-06-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Shen, Li; Cai, Kaimin; Yu, Jin; Cheng, Jianjun published the artcile< Novel Liposomal Azido Mannosamine Lipids on Metabolic Cell Labeling and Imaging via Cu-Free Click Chemistry>, Reference of 5505-63-5, the main research area is liposomal azido mannosamine lipid metabolic cell labeling imaging.

In comparison with the popular Ac4ManNAz applied as cell labels via Cu-free click chem., two novel azido mannosamine lipids with C6 and C12 esters on anomeric hydroxyl groups were prepared and encapsulated in a liposome delivery system, which enhanced chem. stabilities and showed good cell-metabolizable labeling efficiency on MDA-MB-231 cells with strong fluorescence after the treatment of DBCO-Cy5 by triazole formation via click chem.

Bioconjugate Chemistry published new progress about Confocal microscopy. 5505-63-5 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H14ClNO5, Reference of 5505-63-5.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Ferreira, Joana T.; Pina, Joao; Ribeiro, Carlos A. F.; Fernandes, Rosa; Tome, Joao P. C.; Rodriguez-Morgade, M. Salome; Torres, Tomas published the artcile< Highly Efficient Singlet Oxygen Generators Based on Ruthenium Phthalocyanines: Synthesis, Characterization and in vitro Evaluation for Photodynamic Therapy>, Quality Control of 4064-06-6, the main research area is glucose galactose mannose ruthenium phthalocyanine preparation photodynamic therapy; carbohydrates; photodynamic therapy; phthalocyanines; ruthenium; singlet oxygen.

The synthesis of ruthenium(II) phthalocyanines (RuPcs) endowed with one carbohydrate unit-i.e., glucose, galactose and mannose-and a dimethylsulfoxide (DMSO) ligand at the two axial coordination sites, resp., is described. Two series of compounds, one unsubstituted at the periphery, and the other one bearing eight PEG chains at the isoindole meta-positions, have been prepared The presence of the axial DMSO unit significantly increases the phthalocyanine singlet oxygen quantum yields, related to other comparable RuPcs. The compounds have been evaluated for PDT treatment in bladder cancer cells. In vitro studies have revealed high phototoxicity for RuPcs unsubstituted at their periphery. The phototoxicity of PEG-substituted RuPcs has been considerably improved by repeated light irradiation The choice of the axial carbohydrate introduced little differences in the cellular uptake for both series of photosensitizers, but the phototoxic effects were considerably higher for compounds bearing mannose units.

Chemistry – A European Journal published new progress about Bladder neoplasm. 4064-06-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C12H20O6, Quality Control of 4064-06-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Syed-Ab-Rahman, Sharifah Farhana; Carvalhais, Lilia C.; Chua, Elvis T.; Chung, Fong Yi; Moyle, Peter M.; Eltanahy, Eladl G.; Schenk, Peer M. published the artcile< Soil bacterial diffusible and volatile organic compounds inhibit Phytophthora capsici and promote plant growth>, Category: alcohols-buliding-blocks, the main research area is soil bacteria volatile antioomycete biocontrol Phytophthora plant growth; Anti-oomycete; Biocontrol; Phytophthora capsici; SPME-GC–MS; Soil bacteria; Volatile.

Biotic interactions through diffusible and volatile organic compounds (VOCs) are frequent in nature. Soil bacteria are well-known producers of a wide range of volatile compounds (both organic and inorganic) with various biol. relevant activities. Since the last decade, they have been identified as natural biocontrol agents. Volatiles are airborne chems., which when released by bacteria, can trigger plant responses such as defense and growth promotion. In this study, we tested whether diffusible and volatile organic compounds (VOCs) produced by soil bacterial isolates exert anti-oomycete and plant growth-promoting effects. We also investigated the effects of inoculation with VOC-producing bacteria on the growth and development of Capsicum annuum and Arabidopsis thaliana seedlings. Our results demonstrate that organic VOCs emitted by bacterial antagonists neg. influence mycelial growth of the soil-borne phytopathogenic oomycete Phytophthora capsici by 35% in vitro. The bacteria showed plant growth promoting effects by stimulating biomass production, primary root growth and root hair development. Addnl., we provide evidence to suggest that these activities were deployed by the emission of either diffusible organic compounds or VOCs. Bacterial VOC profiles were obtained through solid phase microextraction (SPME) and anal. by gas chromatog. coupled with mass spectrometry (GC-MS). This elucidated the main volatiles emitted by the isolates, which covered a wide range of aldehydes, alcs., esters, carboxylic acids, and ketones. Collectively, twenty-five VOCs were identified to be produced by three bacteria; some being species-specific. Our data show that bacterial volatiles inhibits P. capsici in vitro and modulate both plant growth promotion and root system development. These results confirm the significance of soil bacteria and highlights that ways of harnessing them to improve plant growth, and as a biocontrol agent for soil-borne oomycetes through their volatile emissions deserve further investigation.

Science of the Total Environment published new progress about Acinetobacter. 104-76-7 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H18O, Category: alcohols-buliding-blocks.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Rubin, David T.; LoSavio, Andelka; Yadron, Nicole; Huo, Dezheng; Hanauer, Stephen B. published the artcile< Aminosalicylate therapy in the prevention of dysplasia and colorectal cancer in ulcerative colitis>, Application In Synthesis of 6054-98-4, the main research area is dysplasia colorectal cancer ulcerative colitis asacol dipentum azulfidine antitumor.

Background & Aims: Aminosalicylates have been suggested as chemopreventive agents for colorectal cancer (CRC) in ulcerative colitis (UC). We studied the effect of aminosalicylate use on dysplasia and CRC risk in chronic UC. Methods: UC patients with dysplasia or CRC were matched with controls by disease duration, extent, and age at diagnosis. The total amount of aminosalicylates over the duration of the disease and the mean daily amount of drug was calculated Conditional logistic regression was used to examine the relationship of aminosalicylates to the risk of neoplasia; potential confounders were controlled in a multivariable model. Results: Twenty-six cases (8 CRC, 18 dysplasia) were matched with 96 controls. Cases and controls were similar in age (median, 43 vs 42.5 y), age at diagnosis of UC (median, 29.5 vs 30.5 y), duration of UC (median, 11.5 vs 9 y), and extent of disease (58% pancolitis), sex, family history of UC, history of primary sclerosing cholangitis, and smoking history. Cases were more likely to have a family history of CRC than controls (27% of cases, 9% of controls, P = .036). Conditional logistic regression adjusted for disease duration, age at diagnosis, and family history of CRC showed that aminosalicylate use of 1.2 g/day or more was associated with a 72% reduction in the odds of dysplasia/CRC (odds ratio, 0.28; 95% confidence interval, 0.09-0.85). As the total dose of aminosalicylates increased, the odds of dysplasia/CRC decreased (P = .056). Conclusions: This case-control study shows a significant risk reduction of dysplasia and CRC in UC patients exposed to aminosalicylate therapy.

Clinical Gastroenterology and Hepatology published new progress about Antitumor agents. 6054-98-4 belongs to class alcohols-buliding-blocks, and the molecular formula is C14H8N2Na2O6, Application In Synthesis of 6054-98-4.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Zhang, Yaoyao; Wang, Jin; Cao, Xianshuang; Liu, Wei; Yu, Hongwei; Ye, Lidan published the artcile< High-level production of linalool by engineered Saccharomyces cerevisiae harboring dual mevalonate pathways in mitochondria and cytoplasm>, Recommanded Product: 3,7-Dimethylocta-1,6-dien-3-ol, the main research area is ERG20 mutant; Linalool; MVA pathway; Pathway compartmentation; Saccharomyces cerevisiae.

Linalool, a valuable monoterpene alc., is widely used in cosmetics and flavoring ingredients. However, its scalable production by microbial fermentation is not yet achieved. In this work, considerable increase in linalool production was obtained in Saccharomyces cerevisiae by dual metabolic engineering of the mevalonic acid (MVA) pathway in both mitochondria and cytoplasm. A farnesyl pyrophosphate synthase mutant ERG20F96W/N127W and a linalool synthase from Cinnamomum osmophloeum (CoLIS) were introduced and meanwhile the endogenous ERG20 was down-regulated to prevent the competitive loss of precursor. In addition, overexpression of the proteins of CoLIS and ERG20F96W/N127W and another copy of the same enzymes CoLIS/ERG20F96W/N127W with mitochondrial localization signal (MLS) were carried out to further pull the flux to linalool. Finally, a maximum linalool titer of 23.45 mg/L was obtained in a batch fermentation with sucrose as carbon source. This combinatorial engineering strategy may provide hints for biosynthesis of other monoterpenes.

Enzyme and Microbial Technology published new progress about 78-70-6. 78-70-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C10H18O, Recommanded Product: 3,7-Dimethylocta-1,6-dien-3-ol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Arnold, Polly L.; Purkis, Jamie M.; Rutkauskaite, Ryte; Kovacs, Daniel; Love, Jason B.; Austin, Jonathan published the artcile< Controlled photocatalytic hydrocarbon oxidation by uranyl complexes>, Product Details of C19H16O, the main research area is uranyl phenanthroline hydrocarbon oxidation photocatalyst.

Controlled, photocatalytic C-H bond activations are key reactions in the toolkits of the modern synthetic chemist. While it is known that the uranyl(VI) ion, [UVIO2]2+, the environmentally dominant form of uranium, is photoactive, most literature examines its luminescent properties, neglecting its potential synthetic utility for photocatalytic C-H bond cleavage. Here, we synthesize and fully characterize an air-stable and hydrocarbon-soluble uranyl phenanthroline complex, [UVIO2(NO3)2(Ph2phen)], UPh2phen, and demonstrate that it can catalytically abstract hydrogen atoms from a variety of organic substrates under visible light irradiation We show that the com. available parent complex, uranyl nitrate ([UVIO2(NO3)2(OH2)2][n.8901]4H2O; UNO3), is also competent, but from electronic spectroscopy we attribute the higher rates and selectivity of UPh2phen to ligand-mediated electronic effects. Ketones are selectively formed over other oxygenated products (alcs., etc.), and the catalytic oxidation of substrates containing a benzylic C-H position is particularly improved for UPh2phen. We also show uranyl-mediated photocatalytic C-C bond cleavage in a model lignin compound for the first time.

ChemCatChem published new progress about Amines, rare earth complexes Role: CAT (Catalyst Use), PRP (Properties), SPN (Synthetic Preparation), USES (Uses), PREP (Preparation). 76-84-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C19H16O, Product Details of C19H16O.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Zhang, Jiahe; Shi, Jiaqi; Han, Shuo; Zheng, Pai; Chen, Zhangjian; Jia, Guang published the artcile< Titanium dioxide nanoparticles induced reactive oxygen species (ROS) related changes of metabolomics signatures in human normal bronchial epithelial (BEAS-2B) cells>, Name: (3S,9S,10R,13R,14R,17R)-10,13-Dimethyl-17-((R)-6-methylheptan-2-yl)-2,3,4,9,10,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-ol, the main research area is titanium dioxide nanoparticle reactive oxygen species bronchial epithelial; Lipid metabolism; Liquid chromatography; Metabolomics; Reactive oxygen pecies; Titanium dioxide nanoparticles.

Titanium dioxide often enters the respiratory tract in the form of nano-dust in occupational sites. Metabolomics may be a promising method for studying the toxicol. of nano titanium dioxide. The intention of this study was to explore the possible impact of titanium dioxide nanoparticles (TiO2 NPs) on the metabolomics signatures of human normal bronchial epithelial (BEAS-2B) cells and to search for investigate the role of reactive oxygen species (ROS). In this study, BEAS-2B cells were treated by TiO2 NPs (0, 25, 50 and 100μg/mL) for 48 h. The metabolites extracted from BEAS-2B cells were determined by untargeted metabolomics technique, and the differential metabolites and metabolic pathways were discovered by using multivariate anal. Intracellular ROS was detected by DCFH-DA probe and flow cytometry method. Machine learning was used to explore the relationship between ROS and metabolomics changes. Totally, seventy-six differential metabolites and the steroid biosynthesis pathway of BEAS-2B cells were observed after treatment of TiO2 NPs. Lipid and lipid-like metabolites were the most significant classes among the metabolite products induced by TiO2 NPs. TiO2 NPs resulted in a dose-dependent increase in intracellular ROS levels, and correlated with most of the differential metabolites. In conclusion, TiO2 NPs increased the level of the oxidative stress, which could contribute to the altered signature represented by lipid metabolism in BEAS-2B cells.

Toxicology and Applied Pharmacology published new progress about Bronchial epithelium. 434-16-2 belongs to class alcohols-buliding-blocks, and the molecular formula is C27H44O, Name: (3S,9S,10R,13R,14R,17R)-10,13-Dimethyl-17-((R)-6-methylheptan-2-yl)-2,3,4,9,10,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-ol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Stankovic, Ivana M.; Blagojevic Filipovic, Jelena P.; Zaric, Snezana D. published the artcile< Carbohydrate - Protein aromatic ring interactions beyond CH/π interactions: A Protein Data Bank survey and quantum chemical calculations>, Name: (2S,3R,4S,5S,6R)-6-(Hydroxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetraol, the main research area is glucose carbohydrate protein aromatic ring interaction quantum chem method; Aromatic amino acids; CH/π interactions; Carbohydrates; Stacking interactions.

The geometries of the contacts between monosaccharides and aromatic rings of amino acids found in X-ray crystallog. structures, in the Protein Data Bank (PDB), were analyzed, while the energies of the interactions were calculated using quantum chem. method. We found 1913 sugar/aromatic ring contacts, 1054 of them (55%) with CH/π interactions and 859 of them (45%) without CH/π interactions. We showed that only the carbohydrate/aromatic contacts with CH/π interactions are preferentially parallel and enable sliding in the plane parallel to aromatic ring. The calculated interaction energies in systems with CH/π interactions are in the range from -1.7 kcal/mol to -6.8 kcal/mol, while in the systems without CH/π interactions are in the range -0.2 to -3.2 kcal/mol. Hence, the binding that does not include CH/π interactions, can also be important for aromatic amino acid and carbohydrate binding processes, since some of these interactions can be as strong as the CH/π interactions. At the same time, these interactions can be weak enough to enable releasing of small carbohydrate fragments after the enzymic reaction. The anal. of the protein-substrate patterns showed that every second or third carbohydrate unit in long substrates stacks with protein aromatic amino acids.

International Journal of Biological Macromolecules published new progress about Carbohydrates Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 492-62-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H12O6, Name: (2S,3R,4S,5S,6R)-6-(Hydroxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetraol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Sidana, Jasmeen; Foley, William J.; Singh, Inder Pal published the artcile< Quantitative analysis of euglobals in Eucalyptus loxophleba leaves by qNMR>, Related Products of 4396-13-8, the main research area is euglobal analysis Eucalyptus leaf NMR diformylphloroglucinol monoterpene adduct; NMR analysis euglobal adduct sabinene alpha beta phellandrene adduct.

A simple, rapid, accurate and selective 1H NMR spectroscopic method to detect and quantify euglobals in the leaves of Eucalyptus loxophleba ssp. lissophloia has been developed. The method allows for the estimation of total concentration of diformylphloroglucinol-monoterpene adducts, as well as the quantitation of sabinene- and α/β-phellandrene-adducts, sep. The method was validated for accuracy, precision and linearity using as reference standards 2-Et phenol and mixtures of jensenone, a monomeric formylated phloroglucinol, and 2-ethyl phenol.

Natural Product Communications published new progress about Addition compounds Role: ANT (Analyte), BSU (Biological Study, Unclassified), ANST (Analytical Study), BIOL (Biological Study). 4396-13-8 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H6O5, Related Products of 4396-13-8.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts