Month: October 2022

Pollastri, Sara; Delaunay, Clara; Thepaut, Michel; Fieschi, Franck; Bernardi, Anna published the artcile< Glycomimetic ligands block the interaction of SARS-CoV-2 spike protein with C-type lectin co-receptors>, Category: alcohols-buliding-blocks, the main research area is glycomimetic ligand synthesis L SIGN SARSCoV2 coronavirus spike protein.

The C-type lectin receptors DC-SIGN and L-SIGN bind to glycans on the SARS-CoV-2 spike glycoprotein and promote trans-infection of ACE2-expressing cells. We tested C2 triazole-modified mono- and pseudo-di-mannosides as inhibitors of DC/L-SIGN binding to a model mannosylated protein (Man-BSA) and to SARS-CoV2 spike, finding that they inhibit the interaction of both lectins with the spike glycoprotein in a Surface Plasmon Resonance (SPR) assay and are more potent than mannose by up to 36-fold (DC-SIGN) and 10-fold (L-SIGN). The mols. described here are the first known glycomimetic ligands of L-SIGN.

Chemical Communications (Cambridge, United Kingdom) published new progress about Anticoronaviral agents. 5505-63-5 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H14ClNO5, Category: alcohols-buliding-blocks.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Degraeuwe, Alexia; Jacobs, Marie-Claude; Herman, Anne published the artcile< Allergic contact dermatitis caused by resveratrol in a cosmetic cream.>, Reference of 501-36-0, the main research area is CAS number 501-36-0; allergic contact dermatitis; case report; cosmetics; resveratrol.

There is no abstract available for this document.

Contact dermatitis published new progress about 501-36-0. 501-36-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C14H12O3, Reference of 501-36-0.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Wang, Yu; Xu, Tie-Qi published the artcile< Topology-Controlled Ring-Opening Polymerization of O-Carboxyanhydride>, Recommanded Product: Triphenylmethanol, the main research area is topol controlled ring opening polymerization phenylmandelate carboxyanhydride; stereocomplex linear cyclic polyphenylmandelate enantiomer.

The ring-opening polymerization (ROP) of O-carboxyanhydride (OCA) is the most powerful approach to produce diverse poly(α-hydroxyalkanoic acid) (PAHA) with functional groups as an easy modification of the side group of OCA. Previous studies focus on the ROP of OCA to produce linear PAHA, whereas no example was reported regarding the cyclic PAHA. Here, a synthesis strategy is reported for controlling the topol. of stereoregular PAHA by the ROP of OCA. La[N(SiMe3)2]3 catalyst yields highly isotactic cyclic polymer, while Zn[N(SiMe3)2]2/BnOH catalyst system favors highly isotactic linear ones. The individual enantiomerically pure cyclic or linear PAHA generates homocrystallites, which displayed distinct melting temperature (Tm) up to 190°C. Mixing of these opposite enantiomerically pure cyclic or linear polymers in equivalent amounts affords the crystalline stereocomplexed PAHAs. This study provides a new approach to create crystalline polymers with controlled geometry, allowing a better understanding of the relationship between structure and properties to expand the potentials of their materials.

Macromolecules (Washington, DC, United States) published new progress about Crystallites. 76-84-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C19H16O, Recommanded Product: Triphenylmethanol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Li, Xuan; Jiang, Min; Zhu, Xiaolong; Song, Xiuyan; Deng, Qirong; Lv, Jian; Yang, Daoshan published the artcile< A desulphurization strategy for Sonogashira couplings by visible light/copper catalysis>, Name: (4-Ethynylphenyl)methanol, the main research area is alkyne sulfonium salt desulfurization Sonogashira coupling copper catalyst.

Herein, a new copper-based catalyst, [(binap)(tpy)Cu]Cl I applied in the visible-light promoted Sonogashira coupling reactions has been developed. This mild protocol results in various substituted alkynes RCCH (R = Ph, 2-naphthyl, 2-thienyl, etc.) from simple sulfonium salts II (R1 = Ph, 1-naphthyl, 2H-1,3-benzodioxol-5-yl, etc.) which can be easily prepared from com. available and inexpensive substrates. This study will broaden the still limited strategies of copper photocatalysts in organic transformations.

Organic Chemistry Frontiers published new progress about Alkynes, aryl Role: RCT (Reactant), RACT (Reactant or Reagent). 10602-04-7 belongs to class alcohols-buliding-blocks, and the molecular formula is C9H8O, Name: (4-Ethynylphenyl)methanol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Dong, Yi; Du, Nana; Li, Xueyuan; Zheng, Litao; Liu, Gang published the artcile< Tandem Chloropalladation/Cyclization and Dearomative Cyclization toward Functionalized Tricyclic Bridged [3.2.1] Skeleton Compounds>, SDS of cas: 4396-13-8, the main research area is fused tricyclic dienone chemoselective preparation; palladium copper catalyst aerobic dearomative cyclization alkenylphenylalkynyl carbonyl compound; tandem aerobic chloropalladation dearomative cyclization alkenylphenylalkynyl carbonyl compound; oxatricyclododecanecarboxamide mol crystal structure.

In the presence of PdCl2(MeCN)2 and CuCl2, o-alkenylphenylalkynyl carbonyl compounds such as allyloxyphenylpropynamide I underwent aerobic chemoselective dearomative cyclization reactions to yield fused tricyclic dienones such as II (R = MeO, BuO, EtO, PhCH2O, Me). The structure of II (R = PhCH2O) was determined by X-ray crystallog.

Organic Letters published new progress about Bicyclic compounds, ketones Role: PRP (Properties), RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation) (bridged). 4396-13-8 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H6O5, SDS of cas: 4396-13-8.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Meng, Xiangtai; Chen, Dengfeng; Liu, Rui; Jiang, Ping; Huang, Shenlin published the artcile< Synthesis of 2-(Cyanomethyl)benzoic Esters via Carbon-Carbon Bond Cleavage of Indanones>, Related Products of 627-27-0, the main research area is cyanomethyl benzoic ester preparation; indanone alc bond cleavage.

A novel synthesis of 2-(cyanomethyl)benzoic esters 2-C(R)CN-3-R1-4-R2-5-R3C6HC(O)OR4 (R = H, Me; R1 = H, Br, CN, CF3; R2 = H, Br, OMe, Cl, etc.; R3 = H, Me, OMe, Br; R4 = Me, Bn, furan-2-ylmethyl, 2H-1,3-benzodioxol-5-ylmethyl, etc.) and ethyl2-(3-cyanopropyl)benzoate from indanone derivatives I (R5 = Me, Ph, 4-trifluoromethylphenyl) and [5-oxo-6,7,8,9-tetrahydro-5H-benzo[7]annulen-6-ylidene]amino acetate has been established. This reaction proceeds via a deprotonation of alcs. R4OH with a chem. base, followed by a nucleophilic addition to indanones I and Beckmann fragmentation. In addition, this reaction could also work under electrochem. conditions, and no external chem. bases were needed. This mild method offers a novel strategy for the late-stage functionalization of various natural alcs. such as citronellol, nerol, abietyl alc., etc.

Journal of Organic Chemistry published new progress about Acid chlorides Role: RCT (Reactant), RACT (Reactant or Reagent). 627-27-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C4H8O, Related Products of 627-27-0.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Tran, Johan M.; Farrell, Melanie A.; Fanestil, Darrell D. published the artcile< Effect of ions on binding of the thiazide-type diuretic metolazone to kidney membrane>, Synthetic Route of 35564-86-4, the main research area is kidney metolazone sodium chloride transport.

The effect of a number of ions on the binding of the thiazide-type diuretic metolazone (MTZ) to rat renal cortical membranes was studied to elucidate the mechanism of NaCl transport in the kidney distal tubule. Among the cations tested, Na+ stimulated the binding up to 2.4-fold over control. The effective concentration of Na+ that produced half-maximal stimulation was 2-17 mM. Li+, K+, NH4+, Rb+, and Cs+ produced little stimulation of binding of MTZ. Several anions including Cl- inhibited binding. The inhibition of binding of MTZ by Cl- was enhanced by Na+ and Li+. Scatchard anal. revealed that 50 mM Na+ increased the affinity for binding of MTZ from a Kd = 3.56 nM to Kd = 1.32 nM. Chloride, in the presence of 50 mM Na+, competitively inhibited binding of MTZ by suppressing the affinity to Kd = 9.27 nM without changing the maximal number of binding sites (0.733 pmol/mg). A mechanism for the MTZ-sensitive NaCl transport is proposed, in which the transporter protein possesses a binding site for Na+ and a binding site for Cl-, which is also the binding site for MTZ. Na+ binds to its site and increases the affinity for Cl-/MTZ. The binding of Cl- to the transporter enables the import of Na+ and Cl- across the tubule membrane. MTZ, however, when present competes with Cl- for the binding site on the transporter and prevents the transport of Na+ and Cl-.

American Journal of Physiology published new progress about Biological cotransport. 35564-86-4 belongs to class alcohols-buliding-blocks, and the molecular formula is C7H18ClNO5, Synthetic Route of 35564-86-4.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Jia, Bing; Jiang, Xiaobo; Chen, Xiubin; Dong, Shihua published the artcile< Experimental determination and modeling of liquid-liquid equilibrium for ternary mixtures composed of water, epichlorohydrin and different solvents>, Safety of 2-Ethylhexan-1-ol, the main research area is water epichlorohydrin solvent ternary mixture liquid equilibrium modeling.

Liquid-liquid equilibrium (LLE) data for water + epichlorohydrin + {chloroform or iso-Pr ether or Me tert-Bu ether or iso-Pr acetate or ethylacetate or 2-ethyl-1-hexanol} systems at 308.2 K under 101.3 kPa were determined The distribution coefficient and the separation factor were used to judge the extraction efficiency of different solvents on epichlorohydrin removal from water. The Othmer-Tobias, Hand, and Bachman equations were applied to check the reliability of the exptl. LLE data. Furthermore, the exptl. LLE data were successfully correlated with the NRTL and UNIQUAC models with all the RMSD values were less than 0.57%.

Journal of Molecular Liquids published new progress about Extraction. 104-76-7 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H18O, Safety of 2-Ethylhexan-1-ol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Bera, Srikrishna; Hu, Xile published the artcile< Nickel-Catalyzed Regioselective Hydroalkylation and Hydroarylation of Alkenyl Boronic Esters>, Recommanded Product: ((3aR,5R,5aS,8aS,8bR)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-5-yl)methanol, the main research area is nickel catalyzed alkylation hydroarylation alkenyl boronic ester; aryl alkyl halide nickel catalyzed alkylation hydroarylation; alkenes; boron compounds; hydroalkylation; hydroarylation; nickel hydrides.

Metal hydride catalyzed hydrocarbonation reactions of alkenes are an efficient approach to construct new C-C bonds from readily available alkenes. However, the regioselectivity of hydrocarbonation remains challenging to be controlled. In Ni hydride (NiH) catalyzed hydrocarbonation, linear selectivity is most often obtained because of the relative stability of the linear Ni-alkyl intermediate over its branched counterpart. Herein, the boronic pinacol ester (Bpin) group directs a Ni-catalyzed hydrocarbonation to occur at its adjacent C center, resulting in formal branch selectivity. Both alkyl and aryl halides can be used as electrophiles in this hydrocarbonation, providing access to a wide range of secondary alkyl Bpin derivatives, which are valuable building blocks in synthetic chem. The utility of the method is demonstrated by the late-stage functionalization of natural products and drug mols., the synthesis of an anticancer agent, and iterative syntheses.

Angewandte Chemie, International Edition published new progress about Alkenes Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation) (alkenylboranes). 4064-06-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C12H20O6, Recommanded Product: ((3aR,5R,5aS,8aS,8bR)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-5-yl)methanol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Kim, Seon Woong; Lee, Taeho; Lee, Joo-Youn; Kim, Sanghee; Jun, Hee-Sook; Park, Eun-Young; Baek, Dong Jae published the artcile< Synthesis and Biological Evaluation of PF-543 Derivative>, Related Products of 10602-04-7, the main research area is phenylsulfonylmethylphenethyl benzylpyrrolidinyl methanol preparation antitumor mol docking sphingosine kinase.

Compared PF-543 I and synthesized a newly designed derivative of PF-543 II in which two aromatic structures were connected in para-form. The synthesized derivative II showed inhibitory effect on SK1, similar to that of PF-543 I. However, it was more cytotoxic to HT29, AGS, and PC3 cells than PF-543 I. Also carried out a docking study for SK1 and demonstrated that the synthesized derivative II showed interaction with SK1 similar to PF-543 I. Results obtained from this study suggest that the structure of II may be well substituted for the structure of PF-543 I in terms of biol. activity, providing important structural information for the design of new derivatives of PF-543 II.

Letters in Organic Chemistry published new progress about Antitumor agents. 10602-04-7 belongs to class alcohols-buliding-blocks, and the molecular formula is C9H8O, Related Products of 10602-04-7.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts