Month: October 2022

Li, Zheqi; Wu, Dong; Ding, Chao; Yin, Guoyin published the artcile< Modular synthesis of diarylalkanes by nickel-catalyzed 1,1-diarylation of unactivated terminal alkenes>, Electric Literature of 627-27-0, the main research area is arylboronic acid terminal alkene bromoarene nickel catalyst regioselective diarylation; diaryl alkane preparation.

A nickel-catalyzed 1,1-diarylation of electronically unbiased alkenes was developed, providing straightforward access to diarylalkanes from readily available materials. Importantly, both the efficiency and the regioselectivity of this transformation were ensured by reaction conditions, rather than the coordinating group of substrates. It was also demonstrated that under balloon pressure, ethylene and propylene was also be utilized as substrates. Preliminary mechanistic experiments suggested that this transformation involves a Ni(0)/Ni(II) catalytic cycle rather than a Ni(I)/Ni(III) cycle.

CCS Chemistry published new progress about Alkenes Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 627-27-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C4H8O, Electric Literature of 627-27-0.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Zhang, Yu; Qin, Shaowei; Claes, Nathalie; Schilling, Waldemar; Sahoo, Prakash Kumar; Ching, H. Y. Vincent; Jaworski, Aleksander; Lemiere, Filip; Slabon, Adam; Van Doorslaer, Sabine; Bals, Sara; Das, Shoubhik published the artcile< Direct Solar Energy-Mediated Synthesis of Tertiary Benzylic Alcohols Using a Metal-Free Heterogeneous Photocatalyst>, Reference of 76-84-6, the main research area is tertiary benzylic alc preparation; carbon hydrogen bond hydroxylation photocatalyst solar energy.

Direct hydroxylation via the functionalization of tertiary benzylic C(sp3)-H bonds is of great significance for obtaining tertiary alcs., which find wide applications in pharmaceuticals as well as in fine chem. industries. However, current synthetic procedures use toxic reagents, and therefore, the development of a sustainable strategy for the synthesis of tertiary benzylic alcs. is highly desirable. To solve this problem, herein, a metal-free heterogeneous photocatalyst to synthesize the hydroxylated products using oxygen as the key reagent is reported. Various benzylic substrates were employed into the mild reaction conditions to afford the desirable products in good to excellent yields. More importantly, the gram-scale reaction was achieved via harvesting direct solar energy and exhibited high quantity of the product. The high stability of the catalyst was proved via recycling the catalyst and spectroscopic analyses. Finally, a possible mechanism was proposed based on the ESR and other exptl. evidence.

ACS Sustainable Chemistry & Engineering published new progress about Aromatic compounds Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 76-84-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C19H16O, Reference of 76-84-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Murcia, M. D.; Serrano-Arnaldos, M.; Ortega-Requena, S.; Maximo, F.; Bastida, J.; Montiel, M. C. published the artcile< Optimization of a sustainable biocatalytic process for the synthesis of ethylhexyl fatty acids esters>, Application of C8H18O, the main research area is lipase esterification ethylhexyl fatty acid ester.

Biocatalytic synthesis of ethylhexyl palmitate and ethylhexyl stearate as natural alternatives of cyclomethicone has been studied. In this work the esters have been obtained with two com. enzymes: Novozym435 and Novozym40086 in a “”solvent free”” system. Operational conditions have been optimized using exptl. design and response surface methodol. In the optimum reaction conditions conversion values were higher than 85% in one hour in all the cases. Operation in vacuum reactors with constant N2 bubbling improved the obtained results since it favors water removal and, in consequence, the shifting reaction equilibrium in the way of the synthesis. Besides, Candida antarctica lipase Novozym435 was the most effective, reaching a conversion value of 98% in 45 min. However, cost study revealed that the process is cheaper when using Novozym40086 in open-air reactors.

Catalysis Today published new progress about Biochemical reaction kinetics. 104-76-7 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H18O, Application of C8H18O.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Tekeli, Ibrahim Ozan; Atessahin, Ahmet; Sakin, Fatih; Aslan, Abdullah; Ceribasi, Songul; Yipel, Mustafa published the artcile< Protective effects of conventional and colon-targeted lycopene and linalool on ulcerative colitis induced by acetic acid in rats>, Reference of 78-70-6, the main research area is lycopene linalool sulfasalazine antiinflammatory agent ulcerative colitis; Colon targeting; Linalool; Lycopene; Rat; Ulcerative colitis.

Objective: To compare the potential protective effects of conventional and colon-targeted lycopene (TLC) and linalool (TLN) on acetic acid (AA)-induced ulcerative colitis (UC) in rats. Methods: Conventional and colon-targeted LC (10 mg/kg) and LN (200 mg/kg) were administered in vivo orally for 7 days and sulfasalazine (100 mg/kg) was also used as reference drug. Then, 4% AA was administered intrarectally to induce UC. Subsequently, the colon tissues were taken as samples for biochem. and histopathol. anal. Results: Malondialdehyde (MDA), interleukin 1β (IL-1β), IL-6, cyclooxygenase-2 (COX-2) and nuclear factor kappa B (NF-κB) levels were decreased (p < 0.05) in the targeted groups compared to the AA group, whereas nuclear factor-erythroid 2-related factor 2 (Nrf-2) level was increased (p < 0.05). Tumor necrosis factor α (TNF-α) level was also decreased (p < 0.05) and catalase activity (CAT) was increased (p < 0.05) in the TLC group compared to the AA group. IL-1β and IL-6 levels were lower in the TLC group compared to the conventional LC and sulfasalazine groups (p < 0.05). COX-2 and NF-κB levels were lower, while the Nrf-2 level was higher in the targeted groups compared to the conventional groups (p < 0.05). Furthermore, COX-2 level was lower and Nrf-2 level was higher in the targeted groups compared to the sulfasalazine group (p < 0.05). Conclusion: As expected, sulfasalazine was effective on all parameters analyzed, but the colon-targeted pretreatments were more effective from sulfasalazine on some parameters. Therefore, colon-targeted plant-derived therapies might be alternative approaches to provide protection against UC, which deserves to be investigated further. Inflammopharmacology published new progress about Anti-inflammatory agents. 78-70-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C10H18O, Reference of 78-70-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Liao, Yangzhen; Ran, Yu; Liu, Guijun; Liu, Peijun; Liu, Xiaozu published the artcile< Transition-metal-free radical relay cyclization of vinyl azides with 1,4-dihydropyridines involving a 1,5-hydrogen-atom transfer: access to α-tetralone scaffolds>, COA of Formula: C9H8O, the main research area is tetralone scaffold preparation green chem diastereoselective; vinyl azide dihydropyridine radical hydrogen transfer cyclization.

The remote C(sp3)-H functionalization enabled by a radical-mediated 1,5-hydrogen-atom transfer (HAT) process using 1,4-dihydropyridines I (R = cyclohexyl, 3-phenyl-2-methylpropyl, 1-cyclohexylethyl, etc.; R1 = C(O)OEt, CN) and vinyl azides R2C(=CH2)N3 (R2 = 2-chlorophenyl, 1-naphthyl, benzofuran-2-yl, etc.) as precursors has been described. In this study, 1,4-dihydropyridines I can function as 1,2-diradical synthons through sequential homolytic cleavage of an ipso-C-C bond and a β-C(sp3)-H bond. This reaction offers facile access to a diverse range of α-tetralones e.g., II with excellent stereoselectivity. The utility of the present method is further highlighted by its application to rapid assembly of the tetracyclic scaffold present in furanosteroids as well as the synthesis of aromatic amines.

Organic Chemistry Frontiers published new progress about Alkyl azides Role: RCT (Reactant), RGT (Reagent), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 10602-04-7 belongs to class alcohols-buliding-blocks, and the molecular formula is C9H8O, COA of Formula: C9H8O.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Brummel, Beau R.; Lee, Kinsey G.; McMillen, Colin D.; Kolis, Joseph W.; Whitehead, Daniel C. published the artcile< One-Pot Absolute Stereochemical Identification of Alcohols via Guanidinium Sulfate Crystallization>, Recommanded Product: ((3aR,5R,5aS,8aS,8bR)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-5-yl)methanol, the main research area is alc absolute configuration one pot determination guanidinium sulfate crystallization.

A novel technique for the absolute stereochem. determination of alcs. has been developed that uses crystallization of guanidinium salts of organosulfates. The simple one-pot, two-step process leverages facile formation of guanidinium organosulfate single crystals for the straightforward determination of the absolute stereochem. of enantiopure alcs. by means of X-ray crystallog. The strong hydrogen bonding network drives the stability of the crystal lattice and allows for a diverse range of organic alc. substrates to be analyzed.

Organic Letters published new progress about Absolute configuration. 4064-06-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C12H20O6, Recommanded Product: ((3aR,5R,5aS,8aS,8bR)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-5-yl)methanol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Tan, Hui Ru; Lau, Hazel; Liu, Shao Quan; Tan, Lay Peng; Sakumoto, Shunichi; Lassabliere, Benjamin; Leong, Kwong-Chee; Sun, Jingcan; Yu, Bin published the artcile< Characterisation of key odourants in Japanese green tea using gas chromatography-olfactometry and gas chromatography-mass spectrometry>, Quality Control of 104-76-7, the main research area is green tea odorant gas chromatog mass spectrometry olfactometry Japan.

Japanese green tea is becoming increasingly popular worldwide due to its pleasant aroma. The volatiles of four types of Japanese green tea (Sencha, Matcha, Gyokuro, and Hojicha) were extracted sep. by headspace solid-phase microextraction (HS-SPME) and solvent-assisted flavor evaporation (SAFE), and then analyzed using gas chromatog.-mass spectrometry (GC-MS). The aroma-active compounds in each type of green tea were identified by aroma extract dilution anal. (AEDA) of its SAFE extract The odourants exhibiting the highest flavor dilution (FD) factor of 27 in Sencha were indole and methional. For Matcha, nonanal had the highest FD factor of 243. The odourant in Gyokuro with the highest FD factor of 27 was indole. For Hojicha, the odor-active compounds exhibiting high FD factor of 729 and 243 were 2,3-diethylpyrazine and 2,3-diethyl-5-methylpyrazine, resp. Sensory evaluation was then done on the SAFE extract to understand the overall aroma profile of each type of green tea. Based on sensory evaluation results, steamed green teas (Sencha, Matcha, and Gyokuro) had leafier and higher floral notes while roasted green tea (Hojicha) showed higher roasty and woody notes. Finally, principal component anal. (PCA) of data obtained from GC-MS anal. demonstrated marked separation of these four types of Japanese green tea.

LWT–Food Science and Technology published new progress about Flavor. 104-76-7 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H18O, Quality Control of 104-76-7.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Reviejo, Irene; Tabernero, Vanessa; Mosquera, Marta E. G.; Ramos, Javier; Cuenca, Tomas; Jimenez, Gerardo published the artcile< Chiral Titanium(IV) Complexes Containing Polydentate Ligands Based on α-Pinene. Catalytic Activity in Sulfoxidation with Hydrogen Peroxide>, Formula: C8H10OS, the main research area is chiral aminoalkyliminopinene titanium isopropoxide preparation crystal mol structure catalyst; titanium polydentate alpha pinene complex preparation catalysis sulfoxidation; sulfoxidation catalyst terpenoid alpha pinene titanium isopropoxide preparation.

The reaction of TiCl4-n(OiPr)n (n = 0, 2, 4) with various terpenoid preligands based on α-pinene, C7H6Me3(OH)(NCH2CH2G) (G = NH2, I; NHMe, II; OH, III), stereoselectively affords a series of new chiral titanium(IV) complexes. Such complexes are either octahedral, [TiCl2X(OC7H6Me3NCH2CH2G-κ3N,N,O)] (X = Cl, G = NH2, 1; X = OiPr, G = NH2, 2; G = NHMe, 3), or trigonal bipyramidal, [Ti(OiPr)3(OC7H6Me3NCH2CH2G-κ2N,O)] (G = NH2, 4; NHMe, 5) and [TiX(OiPr)(OC7H6Me3NCH2CH2O-κ3N,O,O*)] (X = Cl, 6; OiPr, 8), depending on the acidity of titanium, the reaction conditions and the nature of the pendant ending group of the terpenoid ligand. D. functional theory (DFT) calculations have been carried out to assess the stability of the multiple possible diastereoisomers allowing to propose structural suggestions. The new titanium complexes efficiently catalyze the selective oxidation of various types of sulfides to either sulfoxides or sulfones using aqueous hydrogen peroxide, under mild conditions. All compounds have been characterized by multinuclear NMR spectroscopy and the mol. structure for some of them has been determined by x-ray diffraction.

Organometallics published new progress about Crystal structure. 699-12-7 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H10OS, Formula: C8H10OS.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Speen, Adam M.; Hoffman, Jessica R.; Kim, Hye-Young H.; Escobar, Yael N.; Nipp, Grace E.; Rebuli, Meghan E.; Porter, Ned A.; Jaspers, Ilona published the artcile< Small Molecule Antipsychotic Aripiprazole Potentiates Ozone-Induced Inflammation in Airway Epithelium>, Recommanded Product: (3S,9S,10R,13R,14R,17R)-10,13-Dimethyl-17-((R)-6-methylheptan-2-yl)-2,3,4,9,10,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-ol, the main research area is antipsychotic aripiprazole ozone inflammation airway epithelium.

Inhaled ground level ozone (O3) has well described adverse health effects, which may be augmented in susceptible populations. While conditions, such as pre-existing respiratory disease, have been identified as factors enhancing susceptibility to O3-induced health effects, the potential for chem. interactions in the lung to sensitize populations to pollutant-induced responses has not yet been studied. In the airways, inhaled O3 reacts with lipids, such as cholesterol, to generate reactive and electrophilic oxysterol species, capable of causing cellular dysfunction and inflammation. The enzyme regulating the final step of cholesterol biosynthesis, 7-dehydrocholesterol reductase (DHCR7), converts 7-dehydrocholesterol (7-DHC) to cholesterol. Inhibition of DHCR7 increases the levels of 7-DHC, which is much more susceptible to oxidation than cholesterol. Chem. anal. established the capacity for a variety of small mol. antipsychotic drugs, like Aripiprazole (APZ), to inhibit DHCR7 and elevate circulating 7-DHC. Our results show that APZ and the known DHCR7 inhibitor, AY9944, increase 7-DHC levels in airway epithelial cells and potentiate O3-induced IL-6 and IL-8 expression and cytokine release. Targeted immune-related gene array anal. demonstrates that APZ significantly modified O3-induced expression of 16 genes, causing dysregulation in expression of genes associated with leukocyte recruitment and inflammatory response. Addnl., we find that APZ increases O3-induced IL-6 and IL-8 expression in human nasal epithelial cells from male but not female donors. Overall, the evidence we provide describes a novel mol. mechanism by which chems., such as APZ, that perturb cholesterol biosynthesis affect O3-induced biol. responses.

Chemical Research in Toxicology published new progress about Animal gene Role: BSU (Biological Study, Unclassified), BIOL (Biological Study) (C1R). 434-16-2 belongs to class alcohols-buliding-blocks, and the molecular formula is C27H44O, Recommanded Product: (3S,9S,10R,13R,14R,17R)-10,13-Dimethyl-17-((R)-6-methylheptan-2-yl)-2,3,4,9,10,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-ol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Tamoradi, Taiebeh; Moeini, Nazanin; Ghadermazi, Mohammad; Ghorbani-Choghamarani, Arash published the artcile< Fe3O4-AMPD-Pd: A novel and efficient magnetic nanocatalyst for synthesis of sulfides and oxidation reactions>, Application of C8H10OS, the main research area is iron oxide amino methyl propanediol palladium magnetic nanocatalyst; magnetic nanocatalyst sulfide oxidation reaction efficiency.

A novel magnetic nanoparticle was synthesized with effective catalytic properties and recyclable ability. This heterogeneous nanocatalyst was identified using Fourier transform IR, scanning electron microscopies, X-ray diffraction, vibrating sample magnetometer, inductively coupled plasma at. emission spectroscopy and thermogravimetric anal. methods. The nanocatalyst was used for the synthesis of the one-pot C-S coupling synthesis of sulfide in the presence of KOH, S8 as the sulfur source in DMSO as the solvent at 100 °C. Also, the oxidation of sulfides to sulfoxides and oxidative coupling of thiols to disulfides in the presence of the catalyst was tested. The catalyst has unique properties such as ability of magnetic separation from the reaction, high repeatability, and high thermal and chem. stability.

Polyhedron published new progress about IR spectra (transmittance). 699-12-7 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H10OS, Application of C8H10OS.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts